ZA201103575B - Methods for selecting protease resistant polypeptides - Google Patents

Methods for selecting protease resistant polypeptides

Info

Publication number
ZA201103575B
ZA201103575B ZA2011/03575A ZA201103575A ZA201103575B ZA 201103575 B ZA201103575 B ZA 201103575B ZA 2011/03575 A ZA2011/03575 A ZA 2011/03575A ZA 201103575 A ZA201103575 A ZA 201103575A ZA 201103575 B ZA201103575 B ZA 201103575B
Authority
ZA
South Africa
Prior art keywords
methods
protease resistant
resistant polypeptides
selecting protease
selecting
Prior art date
Application number
ZA2011/03575A
Other languages
English (en)
Inventor
Carolyn Enever
Laurent Jespers
-Swider Malgorzata Pupecka
Ian M Tomlinson
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA201103575B publication Critical patent/ZA201103575B/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854Immunoglobulins
    • G01N33/6857Antibody fragments
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C40COMBINATORIAL TECHNOLOGY
    • C40BCOMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B40/00Libraries per se, e.g. arrays, mixtures
    • C40B40/04Libraries containing only organic compounds
    • C40B40/10Libraries containing peptides or polypeptides, or derivatives thereof
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/02Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
ZA2011/03575A 2008-12-05 2011-05-16 Methods for selecting protease resistant polypeptides ZA201103575B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12013508P 2008-12-05 2008-12-05
PCT/EP2009/066395 WO2010063818A2 (en) 2008-12-05 2009-12-04 Methods for selecting protease resistant polypeptides

Publications (1)

Publication Number Publication Date
ZA201103575B true ZA201103575B (en) 2012-01-25

Family

ID=42169477

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA2011/03575A ZA201103575B (en) 2008-12-05 2011-05-16 Methods for selecting protease resistant polypeptides

Country Status (15)

Country Link
US (3) US8685895B2 (enExample)
EP (1) EP2364326B1 (enExample)
JP (2) JP5840498B2 (enExample)
KR (1) KR101740066B1 (enExample)
CN (1) CN102307897B (enExample)
AU (1) AU2009324037B2 (enExample)
BR (1) BRPI0922772B1 (enExample)
CA (1) CA2745448C (enExample)
EA (1) EA026508B1 (enExample)
ES (1) ES2688621T3 (enExample)
IL (1) IL212923A0 (enExample)
MX (1) MX2011005874A (enExample)
SG (1) SG194383A1 (enExample)
WO (1) WO2010063818A2 (enExample)
ZA (1) ZA201103575B (enExample)

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EP2866029B1 (en) * 2012-06-22 2017-05-03 Olympus Corporation Method for preparing sample containing pancreatic juice component, and kit for storing biological sample containing pancreatic juice component at room temperature
AU2014290229A1 (en) * 2013-07-15 2016-02-18 North Carolina State University Protease-resistant peptide ligands
JP6422977B2 (ja) * 2013-08-30 2018-11-14 エイプリルバイオ カンパニー リミテッド 抗血清アルブミンfabエフェクター部分融合コンストラクト、およびその製造方法
WO2016191659A1 (en) * 2015-05-28 2016-12-01 Bio-Rad Laboratories, Inc. Affinity ligands and methods relating thereto
TWI726889B (zh) * 2015-06-10 2021-05-11 英商梅迪繆思有限公司 蛋白酶抗性之脂化肽
JP6766253B2 (ja) * 2017-03-28 2020-10-07 森永乳業株式会社 新規ビフィドバクテリウム属細菌
KR20210143766A (ko) * 2019-02-26 2021-11-29 트위스트 바이오사이언스 코포레이션 Glp1 수용체에 대한 변이체 핵산 라이브러리
US11584781B2 (en) * 2019-12-30 2023-02-21 Eligo Bioscience Chimeric receptor binding proteins resistant to proteolytic degradation
KR20210095781A (ko) 2020-01-24 2021-08-03 주식회사 에이프릴바이오 항원결합 단편 및 생리활성 이펙터 모이어티로 구성된 융합 컨스트럭트를 포함하는 다중결합항체 및 이를 포함하는 약학조성물
US12391762B2 (en) 2020-08-26 2025-08-19 Twist Bioscience Corporation Methods and compositions relating to GLP1R variants
US12122817B2 (en) * 2020-09-22 2024-10-22 Serpentide Inc. Long-lasting GLP1 analogue drug for type-2 diabetes

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Also Published As

Publication number Publication date
CA2745448A1 (en) 2010-06-10
CN102307897B (zh) 2016-01-20
JP2012510803A (ja) 2012-05-17
US20110229458A1 (en) 2011-09-22
EP2364326A2 (en) 2011-09-14
SG194383A1 (en) 2013-11-29
US20140187750A1 (en) 2014-07-03
IL212923A0 (en) 2011-07-31
AU2009324037B2 (en) 2015-07-30
KR101740066B1 (ko) 2017-05-25
EP2364326B1 (en) 2018-07-04
US8685895B2 (en) 2014-04-01
US20180088128A1 (en) 2018-03-29
BRPI0922772A2 (en) 2018-11-06
ES2688621T3 (es) 2018-11-05
CA2745448C (en) 2018-09-18
CN102307897A (zh) 2012-01-04
WO2010063818A3 (en) 2010-08-12
EA026508B1 (ru) 2017-04-28
WO2010063818A2 (en) 2010-06-10
US10466252B2 (en) 2019-11-05
MX2011005874A (es) 2011-06-27
AU2009324037A1 (en) 2010-06-10
JP2015231380A (ja) 2015-12-24
EA201170762A1 (ru) 2011-12-30
BRPI0922772B1 (pt) 2021-09-08
KR20110102397A (ko) 2011-09-16
JP5840498B2 (ja) 2016-01-06
US10302655B2 (en) 2019-05-28

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