ES2678497T3 - Ácidos nucleicos que se unen a SDF-1 y su uso en el tratamiento del cáncer - Google Patents
Ácidos nucleicos que se unen a SDF-1 y su uso en el tratamiento del cáncer Download PDFInfo
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- ES2678497T3 ES2678497T3 ES11757776.7T ES11757776T ES2678497T3 ES 2678497 T3 ES2678497 T3 ES 2678497T3 ES 11757776 T ES11757776 T ES 11757776T ES 2678497 T3 ES2678497 T3 ES 2678497T3
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/16—Aptamers
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/351—Conjugate
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- Chemical Kinetics & Catalysis (AREA)
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| EP10009397 | 2010-09-09 | ||
| EP10009397 | 2010-09-09 | ||
| PCT/EP2011/004554 WO2012031773A1 (en) | 2010-09-09 | 2011-09-09 | Sdf-1 binding nucleic acids and the use thereof in cancer treatment |
Publications (1)
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|---|---|
| ES2678497T3 true ES2678497T3 (es) | 2018-08-13 |
Family
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| US20130310442A1 (en) * | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
| WO2017178119A1 (en) * | 2016-04-15 | 2017-10-19 | Noxxon Pharma Ag | Method of modulating the number and the distribution of tumor-infiltrating leukocytes in tumors |
| US20230301950A1 (en) | 2020-06-26 | 2023-09-28 | Raqualia Pharma Inc. | Method for selecting cancer patients for whom combination therapy with retinoid and cancer therapeutic agent is effective, and combination medicament with retinoid and cancer therapeutic agent |
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| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5840867A (en) | 1991-02-21 | 1998-11-24 | Gilead Sciences, Inc. | Aptamer analogs specific for biomolecules |
| US5582981A (en) | 1991-08-14 | 1996-12-10 | Gilead Sciences, Inc. | Method for identifying an oligonucleotide aptamer specific for a target |
| ATE333896T1 (de) | 1998-03-24 | 2006-08-15 | Chugai Pharmaceutical Co Ltd | Vaskularisierungsinhibitoren |
| NZ507161A (en) * | 1998-03-30 | 2003-12-19 | Northwest Biotherapeutics Inc | Theraupeutic and diagonistic applications based on the role of the CXCR-4 gene in tumorigenesis |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| DE60110593T2 (de) * | 2000-06-26 | 2006-01-19 | Wellstat Biologics Corp. | Entfernung von zellen mit viren |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| US20060019917A1 (en) * | 2001-05-18 | 2006-01-26 | Sirna Therapeutics, Inc. | RNA interference mediated inhibition of stromal cell-derived factor-1 (SDF-1) gene expression using short interfering nucleic acid (siNA) |
| US7468253B2 (en) | 2001-06-07 | 2008-12-23 | Chemocentryx, Inc. | Method for multiple chemokine receptor screening for antagonists using RAM assay |
| EP1717583A3 (en) | 2001-06-07 | 2007-10-10 | ChemoCentryx Inc | Cell migration assay |
| US7629456B2 (en) | 2001-10-26 | 2009-12-08 | Noxxon Pharma Ag | Modified L-nucleic acid |
| EP1306382A1 (de) | 2001-10-26 | 2003-05-02 | Noxxon Pharma AG | Modifizierte L-Nukleinsäure |
| ATE441706T1 (de) | 2002-02-20 | 2009-09-15 | Gen Hospital Corp | Konjugate mit biologisch abbaubarem polymer und verwendung dafür |
| JP2006524242A (ja) * | 2003-03-27 | 2006-10-26 | エモリー ユニバーシティー | Ｃｘｃｒ４アンタゴニストおよびそれらの使用方法 |
| KR20060015505A (ko) | 2003-04-13 | 2006-02-17 | 엔존 파마슈티컬즈, 인코포레이티드 | 올리고뉴클레오타이드 전구약물 |
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| EP2087910B1 (en) | 2004-03-23 | 2022-05-04 | Ascendis Pharma GmbH | Polymeric prodrugs |
| CN101098703B (zh) | 2004-11-05 | 2011-08-03 | 费城儿童医院 | 用于分子治疗的生物降解连接剂 |
| EP1883651A1 (en) * | 2005-05-26 | 2008-02-06 | Rappaport Family Institute For Research in the Medical Sciences | Polypeptides and compositions comprising same and methods of using same for treating cxcr4 associated medical conditions |
| US20070043012A1 (en) * | 2005-08-19 | 2007-02-22 | Bridger Gary J | Methods to enhance chemotherapy |
| RU2590709C2 (ru) * | 2006-07-18 | 2016-07-10 | Ноксон Фарма Аг | Sdf-1-связывающие нуклеиновые кислоты |
| WO2008018641A1 (en) * | 2006-08-11 | 2008-02-14 | Ono Pharmaceutical Co., Ltd. | Monoclonal antibodies against stromal derived factor-1 (sdf-1) |
| MX2009002859A (es) | 2006-09-15 | 2009-03-30 | Enzon Pharmaceuticals Inc | Enlazadores biodegradables a base de ester impedido para suministro de oligonucleotidos. |
| WO2008077945A2 (en) * | 2006-12-22 | 2008-07-03 | Ablynx N.V. | Anti-chemokine (ccl2, ccl3, ccl5, cxcl11, cxcl12) single-domain antibodies |
| PT2190991T (pt) * | 2007-08-06 | 2019-12-16 | Noxxon Pharma Ag | Ácidos nucleicos que se ligam a sdf 1 e a sua utilização |
| US20130310442A1 (en) * | 2010-09-09 | 2013-11-21 | Noxxon Pharma Ag | SDF-1 Binding Nucleic Acids and the use Thereof in Cancer Treatment |
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Also Published As
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| EP2613789B1 (en) | 2018-04-18 |
| JP6243736B2 (ja) | 2017-12-06 |
| SG10201506725QA (en) | 2015-10-29 |
| US10093934B2 (en) | 2018-10-09 |
| CA2810950A1 (en) | 2012-03-15 |
| US9387221B2 (en) | 2016-07-12 |
| MX357770B (es) | 2018-07-24 |
| EP2613789A1 (en) | 2013-07-17 |
| HK1184699A1 (zh) | 2014-01-30 |
| US20160355821A1 (en) | 2016-12-08 |
| CN103108641A (zh) | 2013-05-15 |
| CN103108641B (zh) | 2016-01-13 |
| KR20130114094A (ko) | 2013-10-16 |
| US20160095875A1 (en) | 2016-04-07 |
| BR112013005664B8 (pt) | 2023-04-25 |
| JP2013540725A (ja) | 2013-11-07 |
| KR101937939B1 (ko) | 2019-01-11 |
| AU2011300818B2 (en) | 2015-11-12 |
| RU2679495C2 (ru) | 2019-02-11 |
| US20130310442A1 (en) | 2013-11-21 |
| SG188220A1 (en) | 2013-04-30 |
| WO2012031773A1 (en) | 2012-03-15 |
| AU2011300818A1 (en) | 2013-03-07 |
| MX2013002722A (es) | 2013-06-28 |
| BR112013005664A2 (pt) | 2020-08-04 |
| DK2613789T3 (en) | 2018-07-23 |
| BR112013005664B1 (pt) | 2021-11-03 |
| CA2810950C (en) | 2023-02-14 |
| RU2013115739A (ru) | 2014-10-20 |
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