ES2666301T3 - Métodos y reactivos para crear anticuerpos monoclonales - Google Patents
Métodos y reactivos para crear anticuerpos monoclonales Download PDFInfo
- Publication number
- ES2666301T3 ES2666301T3 ES12711501.2T ES12711501T ES2666301T3 ES 2666301 T3 ES2666301 T3 ES 2666301T3 ES 12711501 T ES12711501 T ES 12711501T ES 2666301 T3 ES2666301 T3 ES 2666301T3
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- 238000000034 method Methods 0.000 title abstract description 3
- 239000003153 chemical reaction reagent Substances 0.000 title 1
- 241001465754 Metazoa Species 0.000 abstract description 34
- 150000007523 nucleic acids Chemical group 0.000 abstract description 29
- 239000000427 antigen Substances 0.000 abstract description 19
- 102000036639 antigens Human genes 0.000 abstract description 19
- 108091007433 antigens Proteins 0.000 abstract description 19
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 14
- 125000003275 alpha amino acid group Chemical group 0.000 abstract description 10
- 102000012745 Immunoglobulin Subunits Human genes 0.000 abstract description 9
- 108010079585 Immunoglobulin Subunits Proteins 0.000 abstract description 9
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 9
- 108060003951 Immunoglobulin Proteins 0.000 abstract description 8
- 102000018358 immunoglobulin Human genes 0.000 abstract description 8
- 238000001819 mass spectrum Methods 0.000 abstract description 6
- 241000894007 species Species 0.000 abstract description 5
- 102000007079 Peptide Fragments Human genes 0.000 abstract description 4
- 108010033276 Peptide Fragments Proteins 0.000 abstract description 4
- 229940072221 immunoglobulins Drugs 0.000 abstract description 3
- 230000003595 spectral effect Effects 0.000 abstract description 2
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 4
- 239000012634 fragment Substances 0.000 abstract 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 abstract 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 abstract 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 abstract 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 description 10
- 108020004707 nucleic acids Proteins 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 8
- 108090000623 proteins and genes Proteins 0.000 description 8
- 229920001184 polypeptide Polymers 0.000 description 6
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000002773 nucleotide Substances 0.000 description 3
- 125000003729 nucleotide group Chemical group 0.000 description 3
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 2
- 241000283690 Bos taurus Species 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- 241000124008 Mammalia Species 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 241000700159 Rattus Species 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 210000003719 b-lymphocyte Anatomy 0.000 description 2
- 239000004202 carbamide Substances 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 235000002198 Annona diversifolia Nutrition 0.000 description 1
- 241000282836 Camelus dromedarius Species 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 108090000317 Chymotrypsin Proteins 0.000 description 1
- 241000238586 Cirripedia Species 0.000 description 1
- 241000699800 Cricetinae Species 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- -1 Glu-C Proteins 0.000 description 1
- 108010027044 HIV Core Protein p24 Proteins 0.000 description 1
- 241000725303 Human immunodeficiency virus Species 0.000 description 1
- 241000283953 Lagomorpha Species 0.000 description 1
- 241000282842 Lama glama Species 0.000 description 1
- 101001018085 Lysobacter enzymogenes Lysyl endopeptidase Proteins 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000282577 Pan troglodytes Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 241000288906 Primates Species 0.000 description 1
- 241000283984 Rodentia Species 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
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- 125000000539 amino acid group Chemical group 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 229960002376 chymotrypsin Drugs 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 108060003552 hemocyanin Proteins 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 238000004949 mass spectrometry Methods 0.000 description 1
- 210000005087 mononuclear cell Anatomy 0.000 description 1
- 244000052769 pathogen Species 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000002797 proteolythic effect Effects 0.000 description 1
- 210000004988 splenocyte Anatomy 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/082—Hepadnaviridae, e.g. hepatitis B virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Virology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450922P | 2011-03-09 | 2011-03-09 | |
| US201161450922P | 2011-03-09 | ||
| US201161560006P | 2011-11-15 | 2011-11-15 | |
| US201161560006P | 2011-11-15 | ||
| US201161566876P | 2011-12-05 | 2011-12-05 | |
| US201161566876P | 2011-12-05 | ||
| US201261594729P | 2012-02-03 | 2012-02-03 | |
| US201261594729P | 2012-02-03 | ||
| PCT/US2012/028501 WO2012122484A1 (en) | 2011-03-09 | 2012-03-09 | Methods and reagents for creating monoclonal antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2666301T3 true ES2666301T3 (es) | 2018-05-03 |
Family
ID=45922811
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12711501.2T Active ES2666301T3 (es) | 2011-03-09 | 2012-03-09 | Métodos y reactivos para crear anticuerpos monoclonales |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US9920110B2 (OSRAM) |
| EP (2) | EP2683736B1 (OSRAM) |
| JP (3) | JP6211931B2 (OSRAM) |
| KR (3) | KR20190107761A (OSRAM) |
| CN (2) | CN103842379A (OSRAM) |
| AU (3) | AU2012225310B2 (OSRAM) |
| CA (1) | CA2829606C (OSRAM) |
| DK (1) | DK2683736T3 (OSRAM) |
| ES (1) | ES2666301T3 (OSRAM) |
| HK (1) | HK1256304A1 (OSRAM) |
| HU (1) | HUE037095T2 (OSRAM) |
| WO (1) | WO2012122484A1 (OSRAM) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8685898B2 (en) | 2009-01-15 | 2014-04-01 | Imdaptive, Inc. | Adaptive immunity profiling and methods for generation of monoclonal antibodies |
| EP2783214A2 (en) | 2011-11-23 | 2014-10-01 | The Board of Regents of The University of Texas System | Proteomic identification of antibodies |
| DK2823060T3 (en) | 2012-03-05 | 2018-05-28 | Adaptive Biotechnologies Corp | Determination of associated immune receptor chains from frequency-matched subunits |
| HUE029357T2 (en) | 2012-05-08 | 2017-02-28 | Adaptive Biotechnologies Corp | Preparations and devices for measuring and calibrating amplification distortion in multiplex PCR reactions |
| DK2861760T3 (da) | 2012-06-15 | 2020-03-09 | Univ Texas | Sekventering med høj kapacitet af flere udskrifter af en enkelt celle |
| AU2014232314B2 (en) * | 2013-03-15 | 2020-05-14 | Adaptive Biotechnologies Corporation | Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set |
| US9708657B2 (en) | 2013-07-01 | 2017-07-18 | Adaptive Biotechnologies Corp. | Method for generating clonotype profiles using sequence tags |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| PT3023777T (pt) * | 2013-09-09 | 2018-01-19 | Shimadzu Corp | Método para preparar fragmentos peptídicos, kit para preparar fragmentos peptídicos para serem utilizados neste, e método de análise |
| GB201316644D0 (en) * | 2013-09-19 | 2013-11-06 | Kymab Ltd | Expression vector production & High-Throughput cell screening |
| US10066265B2 (en) | 2014-04-01 | 2018-09-04 | Adaptive Biotechnologies Corp. | Determining antigen-specific t-cells |
| EP3132059B1 (en) | 2014-04-17 | 2020-01-08 | Adaptive Biotechnologies Corporation | Quantification of adaptive immune cell genomes in a complex mixture of cells |
| US20170212130A1 (en) * | 2014-06-25 | 2017-07-27 | The Rockefeller University | Compositions and methods for rapid production of versatile nanobody repertoires |
| CN105277638A (zh) * | 2014-07-22 | 2016-01-27 | 沈鹤霄 | 一种单克隆抗体IgG质谱测序方法 |
| US10392663B2 (en) | 2014-10-29 | 2019-08-27 | Adaptive Biotechnologies Corp. | Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from a large number of samples |
| US10246701B2 (en) | 2014-11-14 | 2019-04-02 | Adaptive Biotechnologies Corp. | Multiplexed digital quantitation of rearranged lymphoid receptors in a complex mixture |
| CN104560980B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠BCR轻链Lamda文库的多重PCR引物和方法 |
| CN104560979B (zh) * | 2015-01-20 | 2017-04-05 | 中国人民解放军第三军医大学 | 基于高通量测序构建鼠bcr重链文库的多重pcr引物和方法 |
| ES3002665T3 (en) | 2015-02-24 | 2025-03-07 | Adaptive Biotechnologies Corp | Methods for diagnosing infectious disease and determining hla status using immune repertoire sequencing |
| US10777398B2 (en) | 2015-03-06 | 2020-09-15 | Micromass Uk Limited | Spectrometric analysis |
| JP6783240B2 (ja) | 2015-03-06 | 2020-11-11 | マイクロマス ユーケー リミテッド | 生体内内視鏡的組織同定機器 |
| GB2553918B (en) | 2015-03-06 | 2022-10-12 | Micromass Ltd | Ambient ionization mass spectrometry imaging platform for direct mapping from bulk tissue |
| EP3265822B1 (en) | 2015-03-06 | 2021-04-28 | Micromass UK Limited | Tissue analysis by mass spectrometry or ion mobility spectrometry |
| US11282688B2 (en) | 2015-03-06 | 2022-03-22 | Micromass Uk Limited | Spectrometric analysis of microbes |
| CN108700590B (zh) | 2015-03-06 | 2021-03-02 | 英国质谱公司 | 细胞群体分析 |
| EP3570315B1 (en) * | 2015-03-06 | 2024-01-31 | Micromass UK Limited | Rapid evaporative ionisation mass spectrometry ("reims") and desorption electrospray ionisation mass spectrometry ("desi-ms") analysis of biopsy samples |
| US10513733B2 (en) | 2015-03-23 | 2019-12-24 | Board Of Regents, The University Of Texas System | High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies |
| WO2016161273A1 (en) | 2015-04-01 | 2016-10-06 | Adaptive Biotechnologies Corp. | Method of identifying human compatible t cell receptors specific for an antigenic target |
| EP3346912A4 (en) * | 2015-09-09 | 2019-08-21 | Ubiome Inc. | METHOD AND SYSTEM FOR MICROBIAL-DERIVED DIAGNOSTICS AND THERAPEUTIC FOR DISEASES RELATED TO CEREBRO-KRANIOFAZIAL HEALTH |
| EP3443354B1 (en) | 2016-04-14 | 2025-08-20 | Micromass UK Limited | Spectrometric analysis of plants |
| CN106047857B (zh) * | 2016-06-01 | 2020-04-03 | 苏州金唯智生物科技有限公司 | 一种发掘特异性功能抗体的方法 |
| CN107525934A (zh) * | 2016-06-21 | 2017-12-29 | 张效龙 | 一种测定血液中抗体氨基酸序列的方法 |
| US10428325B1 (en) | 2016-09-21 | 2019-10-01 | Adaptive Biotechnologies Corporation | Identification of antigen-specific B cell receptors |
| CN118497192A (zh) * | 2017-03-07 | 2024-08-16 | 豪夫迈·罗氏有限公司 | 发现替代性抗原特异性抗体变体的方法 |
| CN111201238B (zh) * | 2017-07-21 | 2023-09-08 | 诺夫免疫股份有限公司 | 产生多特异性抗体混合物及其使用方法 |
| CN109425662A (zh) * | 2017-08-23 | 2019-03-05 | 深圳华大基因研究院 | 一种鉴定蛋白的方法及系统 |
| WO2019084538A1 (en) | 2017-10-27 | 2019-05-02 | Board Of Regents, The University Of Texas System | TUMOR SPECIFIC ANTIBODIES, T CELL RECEPTORS AND METHODS OF IDENTIFICATION THEREOF |
| US11254980B1 (en) | 2017-11-29 | 2022-02-22 | Adaptive Biotechnologies Corporation | Methods of profiling targeted polynucleotides while mitigating sequencing depth requirements |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| WO2019183882A1 (zh) * | 2018-03-29 | 2019-10-03 | 深圳达闼科技控股有限公司 | 物质检测方法、装置、电子设备及计算机可读存储介质 |
| CN108530533B (zh) * | 2018-04-13 | 2020-09-04 | 吉林大学 | 猪瘟病毒单克隆抗体hk24及医用用途 |
| EP3894867A4 (en) * | 2018-12-11 | 2022-09-28 | Merck Sharp & Dohme Corp. | PROCEDURE FOR IDENTIFICATION OF HIGH-AFFINITY MONOCLONAL ANTIBODIES OF HEAVY AND LIGHT CHAIN FROM HIGH-THROUGHPUT SCREENS OF B-CELL AND HYBRIDOME LIBRARIES |
| WO2020246617A1 (ja) * | 2019-06-07 | 2020-12-10 | 中外製薬株式会社 | 情報処理システム、情報処理方法、プログラム、及び、抗原結合分子或いはタンパク質を製造する方法 |
| CN110452296A (zh) * | 2019-07-16 | 2019-11-15 | 福州精锐生物技术有限公司 | 一种兔单克隆抗体制备方法 |
| MX2022003244A (es) * | 2019-09-16 | 2022-04-26 | Regeneron Pharma | Metodos de lc-ms para la isotipificacion y cuantificacion de anticuerpos. |
| EP4074725A4 (en) * | 2019-12-09 | 2024-02-28 | Optolane Technologies Inc. | SWITCH BINDER, METHOD FOR PREPARING SAME, AND PHARMACEUTICAL COMPOSITION, ASSAY KIT, AND METHOD FOR DOSING ANTIGEN AND ANTIBODY, EACH USING THE SAME |
| WO2021222546A1 (en) * | 2020-05-01 | 2021-11-04 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Compositions and methods for identifying nanobodies and nanobody affinities |
| CA3214755A1 (en) * | 2021-04-09 | 2022-10-13 | Natalie CASTELLANA | Method for antibody identification from protein mixtures |
| IT202100019334A1 (it) * | 2021-07-21 | 2023-01-21 | Univ Degli Studi Di Pavia | Metodo per l’identificazione dell’intera sequenza della regione variabile delle catene pesanti e leggere di immunoglobuline |
| CN115894687B (zh) * | 2022-03-31 | 2024-06-07 | 台州恩泽医疗中心(集团) | 一种抗hla-g1，-g2，-g5及hla-g6异构体分子的单克隆抗体及其用途 |
| CN116779037B (zh) * | 2022-07-27 | 2025-08-05 | 北京理工大学 | 一种基于从头测序和同源标签图论的抗体序列鉴定方法 |
| CN117849159B (zh) * | 2024-01-09 | 2025-01-07 | 融智生物科技（青岛）有限公司 | M蛋白的检测方法、电子设备及存储介质 |
| CN120214310B (zh) * | 2025-05-20 | 2025-08-19 | 中国农业大学 | 一种禽白血病抗原检测试剂盒及其制备方法 |
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2012
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- 2012-03-09 CN CN201280021326.1A patent/CN103842379A/zh active Pending
- 2012-03-09 CN CN201810154961.6A patent/CN108220297A/zh active Pending
- 2012-03-09 CA CA2829606A patent/CA2829606C/en active Active
- 2012-03-09 KR KR1020197000660A patent/KR20190006083A/ko not_active Ceased
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| AU2017245395A2 (en) | 2017-11-23 |
| US20120308555A1 (en) | 2012-12-06 |
| CN103842379A (zh) | 2014-06-04 |
| KR101938343B1 (ko) | 2019-01-14 |
| CN108220297A (zh) | 2018-06-29 |
| AU2017245395B2 (en) | 2019-05-16 |
| HK1256304A1 (en) | 2019-09-20 |
| EP2683736A1 (en) | 2014-01-15 |
| JP6211931B2 (ja) | 2017-10-11 |
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| AU2012225310A1 (en) | 2013-09-26 |
| EP3345922A1 (en) | 2018-07-11 |
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| AU2017245395A1 (en) | 2017-11-02 |
| AU2019216660A1 (en) | 2019-09-05 |
| JP2019195335A (ja) | 2019-11-14 |
| CA2829606A1 (en) | 2012-09-13 |
| HUE037095T2 (hu) | 2018-08-28 |
| AU2012225310B2 (en) | 2017-08-03 |
| JP6557709B2 (ja) | 2019-08-07 |
| US20190002532A1 (en) | 2019-01-03 |
| US9920110B2 (en) | 2018-03-20 |
| EP2683736B1 (en) | 2018-01-17 |
| JP2018027090A (ja) | 2018-02-22 |
| KR20190006083A (ko) | 2019-01-16 |
| CA2829606C (en) | 2020-06-02 |
| KR20140010436A (ko) | 2014-01-24 |
| KR20190107761A (ko) | 2019-09-20 |
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