ES2662380T3 - Método para detectar nucleosomas que contienen variantes de histonas - Google Patents

Método para detectar nucleosomas que contienen variantes de histonas Download PDF

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Publication number
ES2662380T3
ES2662380T3 ES12762367.6T ES12762367T ES2662380T3 ES 2662380 T3 ES2662380 T3 ES 2662380T3 ES 12762367 T ES12762367 T ES 12762367T ES 2662380 T3 ES2662380 T3 ES 2662380T3
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Prior art keywords
histone
nucleosomes
body fluid
nucleosome
cancer
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English (en)
Spanish (es)
Inventor
Jacob Vincent Micallef
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Belgian Volition SPRL
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Belgian Volition SPRL
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875Nucleoproteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/5308Immunoassay; Biospecific binding assay; Materials therefor for analytes not provided for elsewhere, e.g. nucleic acids, uric acid, worms, mites
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57488Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds identifable in body fluids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/577Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/102Arthritis; Rheumatoid arthritis, i.e. inflammation of peripheral joints
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/10Musculoskeletal or connective tissue disorders
    • G01N2800/101Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
    • G01N2800/104Lupus erythematosus [SLE]
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/12Pulmonary diseases
    • G01N2800/122Chronic or obstructive airway disorders, e.g. asthma COPD
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/32Cardiovascular disorders
    • G01N2800/325Heart failure or cardiac arrest, e.g. cardiomyopathy, congestive heart failure
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/52Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
ES12762367.6T 2011-09-01 2012-08-31 Método para detectar nucleosomas que contienen variantes de histonas Active ES2662380T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161530304P 2011-09-01 2011-09-01
GBGB1115098.4A GB201115098D0 (en) 2011-09-01 2011-09-01 Method for detecting nucleosomes containing histone variants
GB201115098 2011-09-01
US201161530304P 2011-09-01
PCT/GB2012/052131 WO2013030579A1 (en) 2011-09-01 2012-08-31 Method for detecting nucleosomes containing histone variants

Publications (1)

Publication Number Publication Date
ES2662380T3 true ES2662380T3 (es) 2018-04-06

Family

ID=44882049

Family Applications (2)

Application Number Title Priority Date Filing Date
ES12762367.6T Active ES2662380T3 (es) 2011-09-01 2012-08-31 Método para detectar nucleosomas que contienen variantes de histonas
ES17201723T Active ES2955475T3 (es) 2011-09-01 2012-08-31 Método para detectar nucleosomas que contienen variantes de histonas

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES17201723T Active ES2955475T3 (es) 2011-09-01 2012-08-31 Método para detectar nucleosomas que contienen variantes de histonas

Country Status (20)

Country Link
US (5) US9400276B2 (enExample)
EP (2) EP2751569B1 (enExample)
JP (2) JP2014529405A (enExample)
KR (1) KR102130855B1 (enExample)
CN (2) CN108107215A (enExample)
AU (1) AU2012300643B2 (enExample)
BR (1) BR112014004584B1 (enExample)
CA (1) CA2845994C (enExample)
DK (1) DK2751569T3 (enExample)
ES (2) ES2662380T3 (enExample)
GB (1) GB201115098D0 (enExample)
HR (1) HRP20180362T1 (enExample)
HU (1) HUE038517T2 (enExample)
MX (1) MX349561B (enExample)
PL (1) PL2751569T3 (enExample)
PT (1) PT2751569T (enExample)
RU (2) RU2716494C2 (enExample)
SG (2) SG11201400202SA (enExample)
WO (1) WO2013030579A1 (enExample)
ZA (1) ZA201401296B (enExample)

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EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN107209190B (zh) 2014-10-29 2021-07-16 比利时意志有限责任公司 用于富集循环肿瘤dna的方法
CN107250799B (zh) * 2015-02-10 2019-09-10 B.R.A.H.M.S 有限公司 作为生物标志物的游离组蛋白
GB201511542D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell free nucleosomes as biomarkers
GB201511512D0 (en) * 2015-07-01 2015-08-12 Singapore Volition Pte Ltd Use of cell-free nucleosomes as biomarkers
GB201518674D0 (en) * 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for detecting nuleosomes containing histone modifications and variants
GB201518665D0 (en) * 2015-10-21 2015-12-02 Singapore Volition Pte Ltd Method for enrichment of cell free nucleosomes
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JP7228514B2 (ja) 2016-12-09 2023-02-24 ザ・ブロード・インスティテュート・インコーポレイテッド Crisprエフェクターシステムベースの診断法
BR112019019087A2 (pt) 2017-03-15 2020-05-12 The Broad Institute, Inc. Diagnóstico baseado em sistema efetor de crispr para detecção de vírus
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CA3087362A1 (en) 2018-01-29 2019-08-01 The Broad Institute, Inc. Crispr effector system based diagnostics
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AU2019351130B2 (en) 2018-09-27 2025-10-23 GRAIL, Inc Methylation markers and targeted methylation probe panel
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
GB201912251D0 (en) 2019-08-27 2019-10-09 Belgian Volition Sprl Method of isolating circulating nucleosomes
AU2020336928A1 (en) 2019-08-27 2022-03-24 Belgian Volition Srl Method of isolating circulating nucleosomes
ES2988371T3 (es) 2019-12-02 2024-11-20 Belgian Volition Srl Uso de nucleosomas libres de células como biomarcadores
WO2021186037A1 (en) 2020-03-20 2021-09-23 Belgian Volition Sprl Triaging method using cell free nucleosome levels
EP4213909A1 (en) 2020-09-21 2023-07-26 Belgian Volition SRL Device for inline monitoring of free nucleosomes in blood
TW202238131A (zh) 2020-11-25 2022-10-01 比利時商比利時意志有限公司 測量無細胞核蛋白染色質片段之方法
TW202238132A (zh) 2020-12-08 2022-10-01 比利時商比利時意志有限公司 多發性硬化症之診斷方法
TW202242145A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 核小體耗盡循環無細胞染色質片段之轉錄因子結合位點分析
TW202242130A (zh) 2020-12-29 2022-11-01 比利時商比利時意志有限公司 循環轉錄因子分析
TW202242146A (zh) 2021-01-13 2022-11-01 比利時商比利時意志有限公司 肺癌的檢測方法
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GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
EP4490323A1 (en) 2022-03-11 2025-01-15 Belgian Volition SRL Differential diagnosis method
GB202205212D0 (en) 2022-04-08 2022-05-25 Belgian Volition Sprl Method for transplant organ health assessment
WO2024042210A1 (en) 2022-08-25 2024-02-29 Belgian Volition Srl Method for measuring cell free chromatin
WO2024042208A1 (en) 2022-08-25 2024-02-29 Belgian Volition Srl Method for the detection of dementia
WO2024133222A1 (en) 2022-12-19 2024-06-27 Belgian Volition Srl Assessment of biological samples for nucleic acid analysis
EP4639173A1 (en) 2022-12-19 2025-10-29 Belgian Volition SRL Calibration
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Publication number Publication date
HRP20180362T1 (hr) 2018-06-01
JP2017215338A (ja) 2017-12-07
US9400276B2 (en) 2016-07-26
CN104053993A (zh) 2014-09-17
US20190120853A1 (en) 2019-04-25
BR112014004584A2 (pt) 2017-05-16
HK1199758A1 (en) 2015-07-17
JP2014529405A (ja) 2014-11-13
EP3301449C0 (en) 2023-08-09
RU2716494C2 (ru) 2020-03-12
AU2012300643B2 (en) 2017-06-15
KR102130855B1 (ko) 2020-07-09
EP3301449B1 (en) 2023-08-09
US10184945B2 (en) 2019-01-22
KR20140078638A (ko) 2014-06-25
RU2018101257A (ru) 2019-02-21
US20200341006A1 (en) 2020-10-29
ES2955475T3 (es) 2023-12-01
EP2751569A1 (en) 2014-07-09
CN108107215A (zh) 2018-06-01
RU2014112348A (ru) 2015-10-10
MX349561B (es) 2017-08-02
EP3301449A1 (en) 2018-04-04
US20160299152A1 (en) 2016-10-13
EP2751569B1 (en) 2017-12-27
SG10201601168QA (en) 2016-03-30
CA2845994A1 (en) 2013-03-07
PT2751569T (pt) 2018-03-28
MX2014002444A (es) 2014-10-23
ZA201401296B (en) 2014-12-23
PL2751569T3 (pl) 2018-06-29
WO2013030579A1 (en) 2013-03-07
CA2845994C (en) 2020-10-13
SG11201400202SA (en) 2014-03-28
DK2751569T3 (en) 2018-03-12
JP6494703B2 (ja) 2019-04-03
US20230116530A1 (en) 2023-04-13
BR112014004584B1 (pt) 2021-07-06
RU2018101257A3 (enExample) 2019-02-21
AU2012300643A1 (en) 2014-03-06
US20140206014A1 (en) 2014-07-24
HUE038517T2 (hu) 2018-10-29
HK1253354A1 (en) 2019-06-14
GB201115098D0 (en) 2011-10-19

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