ES2655589T3 - Aptámeros frente al inhibidor de la vía del factor tisular y su uso como agentes terapéuticos frente a trastornos hemorrágicos - Google Patents
Aptámeros frente al inhibidor de la vía del factor tisular y su uso como agentes terapéuticos frente a trastornos hemorrágicos Download PDFInfo
- Publication number
- ES2655589T3 ES2655589T3 ES10810508.1T ES10810508T ES2655589T3 ES 2655589 T3 ES2655589 T3 ES 2655589T3 ES 10810508 T ES10810508 T ES 10810508T ES 2655589 T3 ES2655589 T3 ES 2655589T3
- Authority
- ES
- Spain
- Prior art keywords
- amino acid
- acid residues
- amino acids
- tfpi
- aptamer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 102100030951 Tissue factor pathway inhibitor Human genes 0.000 title abstract description 76
- 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 title abstract description 76
- 108091023037 Aptamer Proteins 0.000 title abstract description 73
- 239000003814 drug Substances 0.000 title description 8
- 208000031169 hemorrhagic disease Diseases 0.000 title 1
- 229940124597 therapeutic agent Drugs 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 description 116
- 125000000539 amino acid group Chemical group 0.000 description 114
- 210000002381 plasma Anatomy 0.000 description 39
- 108090000190 Thrombin Proteins 0.000 description 33
- 229960004072 thrombin Drugs 0.000 description 33
- 150000007523 nucleic acids Chemical class 0.000 description 22
- 230000000694 effects Effects 0.000 description 21
- 208000009292 Hemophilia A Diseases 0.000 description 20
- 108020004707 nucleic acids Proteins 0.000 description 18
- 102000039446 nucleic acids Human genes 0.000 description 18
- 102100026735 Coagulation factor VIII Human genes 0.000 description 16
- 201000003542 Factor VIII deficiency Diseases 0.000 description 16
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 16
- 108010013773 recombinant FVIIa Proteins 0.000 description 14
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 12
- 108010000499 Thromboplastin Proteins 0.000 description 11
- 102000002262 Thromboplastin Human genes 0.000 description 11
- 238000002474 experimental method Methods 0.000 description 11
- 108090000765 processed proteins & peptides Proteins 0.000 description 9
- 208000026552 Severe hemophilia A Diseases 0.000 description 8
- 239000000203 mixture Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- 229920001223 polyethylene glycol Polymers 0.000 description 7
- 239000003446 ligand Substances 0.000 description 6
- 229920001184 polypeptide Polymers 0.000 description 6
- 102000004196 processed proteins & peptides Human genes 0.000 description 6
- 238000003556 assay Methods 0.000 description 5
- 230000006870 function Effects 0.000 description 5
- 239000003112 inhibitor Substances 0.000 description 5
- 102000004169 proteins and genes Human genes 0.000 description 5
- 108090000623 proteins and genes Proteins 0.000 description 5
- 102100022641 Coagulation factor IX Human genes 0.000 description 4
- 208000031220 Hemophilia Diseases 0.000 description 4
- 108091028043 Nucleic acid sequence Proteins 0.000 description 4
- 125000003275 alpha amino acid group Chemical group 0.000 description 4
- 208000009429 hemophilia B Diseases 0.000 description 4
- 229940112216 novoseven Drugs 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- 101000635804 Homo sapiens Tissue factor Proteins 0.000 description 3
- 101000653189 Homo sapiens Tissue factor pathway inhibitor Proteins 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000010432 diamond Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000037361 pathway Effects 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical group C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 description 2
- 108010054265 Factor VIIa Proteins 0.000 description 2
- 108010074860 Factor Xa Proteins 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 230000023555 blood coagulation Effects 0.000 description 2
- 230000001419 dependent effect Effects 0.000 description 2
- 238000010494 dissociation reaction Methods 0.000 description 2
- 230000005593 dissociations Effects 0.000 description 2
- 229940012414 factor viia Drugs 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 1
- 238000000149 argon plasma sintering Methods 0.000 description 1
- 210000004899 c-terminal region Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000015271 coagulation Effects 0.000 description 1
- 238000005345 coagulation Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 230000005714 functional activity Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 229920001427 mPEG Polymers 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000017570 negative regulation of blood coagulation Effects 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 230000006320 pegylation Effects 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/16—Aptamers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Marine Sciences & Fisheries (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US367766P | 2002-03-28 | ||
| US23493909P | 2009-08-18 | 2009-08-18 | |
| US234939P | 2009-08-18 | ||
| US35337410P | 2010-06-10 | 2010-06-10 | |
| US353374P | 2010-06-10 | ||
| US36636210P | 2010-07-21 | 2010-07-21 | |
| US366362P | 2010-07-21 | ||
| US36776610P | 2010-07-26 | 2010-07-26 | |
| PCT/US2010/045797 WO2011022427A1 (en) | 2009-08-18 | 2010-08-17 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2655589T3 true ES2655589T3 (es) | 2018-02-20 |
Family
ID=43607310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES10810508.1T Active ES2655589T3 (es) | 2009-08-18 | 2010-08-17 | Aptámeros frente al inhibidor de la vía del factor tisular y su uso como agentes terapéuticos frente a trastornos hemorrágicos |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8252913B2 (enExample) |
| EP (1) | EP2467167B1 (enExample) |
| JP (1) | JP2013502218A (enExample) |
| KR (1) | KR20120061086A (enExample) |
| CN (1) | CN102869385A (enExample) |
| AU (1) | AU2010284329B2 (enExample) |
| BR (1) | BR112012003806A2 (enExample) |
| CA (1) | CA2770762A1 (enExample) |
| CO (1) | CO6531414A2 (enExample) |
| ES (1) | ES2655589T3 (enExample) |
| IL (1) | IL218048A0 (enExample) |
| IN (1) | IN2012DN01984A (enExample) |
| MX (1) | MX2012002133A (enExample) |
| NZ (1) | NZ598557A (enExample) |
| RU (1) | RU2012110221A (enExample) |
| SG (1) | SG178408A1 (enExample) |
| WO (1) | WO2011022427A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070166741A1 (en) | 1998-12-14 | 2007-07-19 | Somalogic, Incorporated | Multiplexed analyses of test samples |
| US7947447B2 (en) | 2007-01-16 | 2011-05-24 | Somalogic, Inc. | Method for generating aptamers with improved off-rates |
| JP5714505B2 (ja) | 2008-12-22 | 2015-05-07 | ノヴォ ノルディスク アー／エス | 組織因子経路阻害因子に対する抗体 |
| EP2673364A1 (en) * | 2011-02-11 | 2013-12-18 | Baxter International Inc | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| KR20140066977A (ko) * | 2011-06-08 | 2014-06-03 | 미에드지나로도위 인스티투트 바이오로지 모레쿠라네지 아이 코모르코웨즈 | 서열-특이적 조작된 리보뉴클레아제 ｈ 및 ｄｎａ－ｒｎａ 하이브리드 결합 단백질의 서열 선호도를 측정하는 방법 |
| AU2013235567A1 (en) * | 2012-03-22 | 2014-10-09 | Baxalta GmbH | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
| WO2014205426A1 (en) * | 2013-06-21 | 2014-12-24 | Imigene, Inc. | Blood analysis |
| US10457743B2 (en) | 2013-07-19 | 2019-10-29 | Novo Nordisk A/S | Antibodies recognizing the N-terminal part of tissue factor pathway inhibitor capable of eliciting pro-coagulant activity |
| WO2015035305A1 (en) | 2013-09-09 | 2015-03-12 | Somalogic, Inc. | Pdgf and vegf aptamers having improved stability and their use in treating pdgf and vegf mediated diseases and disorders |
| US11181534B2 (en) | 2014-04-04 | 2021-11-23 | Bloodworks | Routine laboratory and point-of-care (POC) testing for hemostasis |
| SG10202100131WA (en) * | 2015-06-23 | 2021-02-25 | Childrens Hospital Philadelphia | Modified factor ix, and compositions, methods and uses for gene transfer to cells, organs and tissues |
| US20170232079A1 (en) * | 2015-10-06 | 2017-08-17 | Kieu Hoang | Method of manufacturing prothrombin complex concentrate from fraction iii and non-prothrombin complex concentrate from fraction iv |
| CN108368509B (zh) | 2015-12-04 | 2022-03-22 | 全药工业株式会社 | 改善了血中滞留性的抗il－17适体 |
| CN112442127A (zh) * | 2019-08-29 | 2021-03-05 | 苏州康宁杰瑞生物科技有限公司 | 针对tfpi的单克隆抗体 |
| CN115792231B (zh) * | 2022-11-04 | 2023-07-25 | 中拓生物有限公司 | 一种基于凝血酶适配体调节的酶级联反应的DNase I生物传感器 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US5981471A (en) * | 1997-02-06 | 1999-11-09 | Entremed, Inc. | Compositions and methods for inhibiting cellular proliferation |
| AU738513B2 (en) | 1997-02-28 | 2001-09-20 | University Of Iowa Research Foundation, The | Use of nucleic acids containing unmethylated CpG dinucleotide in the treatment of LPS-associated disorders |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| CA2302805A1 (en) | 1997-09-05 | 1999-03-11 | The Regents Of The University Of California | Use of immunostimulatory oligonucleotides for preventing or reducing antigen-stimulated, granulocyte-mediated inflammation |
| DE69940623D1 (de) * | 1998-11-09 | 2009-04-30 | Eiken Chemical | Prozess zur Synthetisierung von Nukleinsäure |
| US6514948B1 (en) | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
| WO2003102212A2 (en) * | 2002-05-31 | 2003-12-11 | Regents Of The University Of Minnesota | In vitro evaluation of nucleic acid ligands |
| US7250496B2 (en) * | 2002-11-14 | 2007-07-31 | Rosetta Genomics Ltd. | Bioinformatically detectable group of novel regulatory genes and uses thereof |
| EP1919499A2 (en) | 2005-07-29 | 2008-05-14 | Universiteit van Maastricht | Regulation of tissue factor activity by protein s and tissue factor pathway inhibitor |
-
2010
- 2010-08-17 RU RU2012110221/10A patent/RU2012110221A/ru unknown
- 2010-08-17 CA CA2770762A patent/CA2770762A1/en not_active Abandoned
- 2010-08-17 CN CN2010800457286A patent/CN102869385A/zh active Pending
- 2010-08-17 SG SG2012010245A patent/SG178408A1/en unknown
- 2010-08-17 ES ES10810508.1T patent/ES2655589T3/es active Active
- 2010-08-17 NZ NZ598557A patent/NZ598557A/xx unknown
- 2010-08-17 JP JP2012525649A patent/JP2013502218A/ja not_active Withdrawn
- 2010-08-17 AU AU2010284329A patent/AU2010284329B2/en active Active
- 2010-08-17 BR BR112012003806A patent/BR112012003806A2/pt not_active Application Discontinuation
- 2010-08-17 US US12/858,369 patent/US8252913B2/en active Active
- 2010-08-17 EP EP10810508.1A patent/EP2467167B1/en active Active
- 2010-08-17 KR KR1020127007005A patent/KR20120061086A/ko not_active Withdrawn
- 2010-08-17 WO PCT/US2010/045797 patent/WO2011022427A1/en not_active Ceased
- 2010-08-17 IN IN1984DEN2012 patent/IN2012DN01984A/en unknown
- 2010-08-17 MX MX2012002133A patent/MX2012002133A/es active IP Right Grant
-
2012
- 2012-02-12 IL IL218048A patent/IL218048A0/en unknown
- 2012-03-16 CO CO12046249A patent/CO6531414A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20110098345A1 (en) | 2011-04-28 |
| EP2467167A1 (en) | 2012-06-27 |
| EP2467167A4 (en) | 2013-12-25 |
| AU2010284329A1 (en) | 2012-03-29 |
| RU2012110221A (ru) | 2013-09-27 |
| BR112012003806A2 (pt) | 2016-11-16 |
| CN102869385A (zh) | 2013-01-09 |
| IL218048A0 (en) | 2012-04-30 |
| KR20120061086A (ko) | 2012-06-12 |
| NZ598557A (en) | 2013-08-30 |
| IN2012DN01984A (enExample) | 2015-07-24 |
| MX2012002133A (es) | 2013-02-15 |
| WO2011022427A1 (en) | 2011-02-24 |
| CO6531414A2 (es) | 2012-09-28 |
| AU2010284329B2 (en) | 2015-04-16 |
| US8252913B2 (en) | 2012-08-28 |
| EP2467167B1 (en) | 2017-08-16 |
| SG178408A1 (en) | 2012-03-29 |
| CA2770762A1 (en) | 2011-02-24 |
| JP2013502218A (ja) | 2013-01-24 |
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