ES2641779T3 - Derivados de estradiol 6-sustituidos y métodos de uso - Google Patents
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- ES2641779T3 ES2641779T3 ES09759335.4T ES09759335T ES2641779T3 ES 2641779 T3 ES2641779 T3 ES 2641779T3 ES 09759335 T ES09759335 T ES 09759335T ES 2641779 T3 ES2641779 T3 ES 2641779T3
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- 230000002685 pulmonary effect Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000025053 regulation of cell proliferation Effects 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 102000027483 retinoid hormone receptors Human genes 0.000 description 1
- 108091008679 retinoid hormone receptors Proteins 0.000 description 1
- 102200082402 rs751610198 Human genes 0.000 description 1
- 239000000333 selective estrogen receptor modulator Substances 0.000 description 1
- 229940095743 selective estrogen receptor modulator Drugs 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000011664 signaling Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 102000005969 steroid hormone receptors Human genes 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 231100000057 systemic toxicity Toxicity 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960003604 testosterone Drugs 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 102000004217 thyroid hormone receptors Human genes 0.000 description 1
- 108090000721 thyroid hormone receptors Proteins 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 210000005166 vasculature Anatomy 0.000 description 1
- 102000009310 vitamin D receptors Human genes 0.000 description 1
- 108050000156 vitamin D receptors Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J13/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having a carbon-to-carbon double bond from or to position 17
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0693—Tumour cells; Cancer cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/30—Hormones
- C12N2501/38—Hormones with nuclear receptors
- C12N2501/39—Steroid hormones
- C12N2501/392—Sexual steroids
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biotechnology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US132857 | 2008-06-04 | ||
| US12/132,857 US8168621B2 (en) | 2005-09-30 | 2008-06-04 | 6-substituted estradiol derivatives and methods of use |
| PCT/US2009/046120 WO2009149176A1 (en) | 2008-06-04 | 2009-06-03 | 6-substituted estradiol derivatives and methods of use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2641779T3 true ES2641779T3 (es) | 2017-11-13 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES09759335.4T Active ES2641779T3 (es) | 2008-06-04 | 2009-06-03 | Derivados de estradiol 6-sustituidos y métodos de uso |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US8168621B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2300016B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5727370B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR101769152B1 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102076343B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009256237B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0913632A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2726364C (cg-RX-API-DMAC7.html) |
| DK (1) | DK2300016T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2641779T3 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010013288A (cg-RX-API-DMAC7.html) |
| NO (1) | NO2300016T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009149176A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20080091866A (ko) * | 2001-05-16 | 2008-10-14 | 노파르티스 아게 | Ν-｛5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐｝-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를 포함하는 배합물 |
| US10174070B2 (en) * | 2005-09-30 | 2019-01-08 | Endece Llc | 6-substituted estradiol derivatives and methods of use |
| US20090028895A1 (en) * | 2007-07-27 | 2009-01-29 | Smith Walter P | Methods and compositions for reducing facial lines and wrinkles |
| BR112013005843A2 (pt) | 2010-09-14 | 2019-12-10 | Endece Llc | derivativos de er-beta 6-substituído por desmetil-estradiol |
| WO2012129324A2 (en) | 2011-03-21 | 2012-09-27 | Endece Llc | 6-substituted estradiol derivatives for use in remyelination of nerve axons |
| US11624095B2 (en) | 2017-09-27 | 2023-04-11 | Case Western Reserve University | Method of quantifying HIV reservoirs by induced transcription based sequencing |
| US20210024568A1 (en) * | 2019-07-23 | 2021-01-28 | Endece Llc | Methods for modulation of lipoprotein lipase and apolipoprotein c2 expression and/or activity in the treatment of peripheral and central nervous system tissue disease states |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL122154C (cg-RX-API-DMAC7.html) | 1963-10-18 | |||
| GB8517360D0 (en) | 1985-07-09 | 1985-08-14 | Erba Farmitalia | Substituted androsta-1,4-diene-3,17-diones |
| GB8615092D0 (en) | 1986-06-20 | 1986-07-23 | Erba Farmitalia | Androst-4-ene-317-diones |
| GB8801697D0 (en) | 1988-01-26 | 1988-02-24 | Erba Farmitalia | Improvements in synthesis of 6-methylene derivatives of androsta-1 4-diene-3 17-dione |
| US4904950A (en) | 1988-11-04 | 1990-02-27 | Medical Data Electronics, Inc. | Telemetry digital subcarrier demodulator |
| US5504074A (en) | 1993-08-06 | 1996-04-02 | Children's Medical Center Corporation | Estrogenic compounds as anti-angiogenic agents |
| JPH07215992A (ja) | 1993-12-07 | 1995-08-15 | Teikoku Hormone Mfg Co Ltd | ６−又は７−置換アンドロスタ−１，４−ジエン誘導体 |
| DE19633349A1 (de) | 1996-08-19 | 1998-02-26 | Sigma Tau Ind Farmaceuti | Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten |
| JP2002522477A (ja) | 1998-08-11 | 2002-07-23 | エントレメッド インコーポレイテッド | 抗真菌薬としてのエストロゲン様化合物の使用 |
| WO2001058919A2 (en) | 2000-02-11 | 2001-08-16 | Sri International | Synthesis of anti-estrogenic and other therapeutic steroids from 21-hydroxy-19-norpregna-4-en-3-one |
| IT1317031B1 (it) | 2000-05-17 | 2003-05-26 | Sigma Tau Ind Farmaceuti | Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi. |
| AU2001296872A1 (en) | 2000-09-14 | 2002-03-26 | Accelerated Pharmaceuticals, Inc. | Method of making 7alpha-methyl-11beta-methoxy estradiol and related compounds with estrogenic activity |
| JP2006526025A (ja) | 2003-05-28 | 2006-11-16 | エントレメッド インコーポレイテッド | 抗血管新生剤 |
| US8088758B2 (en) | 2003-11-12 | 2012-01-03 | Abbott Products Gmbh | 17β-hydroxysteroid dehydrogenase type I inhibitors |
| EP1709062B9 (en) | 2004-01-16 | 2013-02-13 | Cedarburg Pharmaceuticals, Inc. | Exemestane and its intermediates and methods of making the same |
| US7419972B2 (en) | 2004-07-02 | 2008-09-02 | Schering Ag | 2-substituted estra-1,3,5(10)-trien-17-ones as inhibitors of 17β-hydroxy steroid dehydrogenase type 1 |
| EP1931385B1 (en) | 2005-09-30 | 2018-02-28 | Endece, LLC | (s)-6-methyloxaalkyl exemestane compounds and related methods of use |
| US20080119447A1 (en) | 2005-09-30 | 2008-05-22 | James Yarger | 6-alkoxyalkyl estradiol derivatives and methods of use |
| TWI392682B (zh) | 2006-04-13 | 2013-04-11 | Sigma Tau Ind Farmaceuti | 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物 |
-
2008
- 2008-06-04 US US12/132,857 patent/US8168621B2/en not_active Expired - Fee Related
-
2009
- 2009-06-03 EP EP09759335.4A patent/EP2300016B1/en not_active Not-in-force
- 2009-06-03 ES ES09759335.4T patent/ES2641779T3/es active Active
- 2009-06-03 MX MX2010013288A patent/MX2010013288A/es active IP Right Grant
- 2009-06-03 DK DK09759335.4T patent/DK2300016T3/en active
- 2009-06-03 JP JP2011512613A patent/JP5727370B2/ja active Active
- 2009-06-03 AU AU2009256237A patent/AU2009256237B2/en not_active Ceased
- 2009-06-03 BR BRPI0913632A patent/BRPI0913632A2/pt not_active Application Discontinuation
- 2009-06-03 CN CN200980124997.9A patent/CN102076343B/zh not_active Expired - Fee Related
- 2009-06-03 NO NO09759335A patent/NO2300016T3/no unknown
- 2009-06-03 WO PCT/US2009/046120 patent/WO2009149176A1/en not_active Ceased
- 2009-06-03 KR KR1020107029911A patent/KR101769152B1/ko not_active Expired - Fee Related
- 2009-06-03 CA CA2726364A patent/CA2726364C/en not_active Expired - Fee Related
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2012
- 2012-04-30 US US13/459,665 patent/US8629130B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| DK2300016T3 (en) | 2017-09-18 |
| KR101769152B1 (ko) | 2017-08-17 |
| EP2300016A4 (en) | 2012-01-18 |
| AU2009256237A1 (en) | 2009-12-10 |
| JP2011522825A (ja) | 2011-08-04 |
| CN102076343B (zh) | 2015-04-01 |
| KR20110019767A (ko) | 2011-02-28 |
| NO2300016T3 (cg-RX-API-DMAC7.html) | 2018-01-06 |
| US8168621B2 (en) | 2012-05-01 |
| CN102076343A (zh) | 2011-05-25 |
| EP2300016A1 (en) | 2011-03-30 |
| US20080312202A1 (en) | 2008-12-18 |
| US20120270817A1 (en) | 2012-10-25 |
| MX2010013288A (es) | 2010-12-21 |
| WO2009149176A1 (en) | 2009-12-10 |
| EP2300016B1 (en) | 2017-08-09 |
| BRPI0913632A2 (pt) | 2017-01-24 |
| AU2009256237B2 (en) | 2015-11-26 |
| CA2726364A1 (en) | 2009-12-10 |
| US8629130B2 (en) | 2014-01-14 |
| JP5727370B2 (ja) | 2015-06-03 |
| CA2726364C (en) | 2016-10-11 |
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