ES2632774T3 - Inhibidores de bromodominio de benzo[c]isoxazoloazepina y usos de los mismos - Google Patents
Inhibidores de bromodominio de benzo[c]isoxazoloazepina y usos de los mismos Download PDFInfo
- Publication number
- ES2632774T3 ES2632774T3 ES13729229.8T ES13729229T ES2632774T3 ES 2632774 T3 ES2632774 T3 ES 2632774T3 ES 13729229 T ES13729229 T ES 13729229T ES 2632774 T3 ES2632774 T3 ES 2632774T3
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- cancer
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- alkyl
- pharmaceutically acceptable
- methyl
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- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 1
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- 229960000237 vorinostat Drugs 0.000 description 1
- 229960001771 vorozole Drugs 0.000 description 1
- XLMPPFTZALNBFS-INIZCTEOSA-N vorozole Chemical compound C1([C@@H](C2=CC=C3N=NN(C3=C2)C)N2N=CN=C2)=CC=C(Cl)C=C1 XLMPPFTZALNBFS-INIZCTEOSA-N 0.000 description 1
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Classifications
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
- A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
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- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Transplantation (AREA)
- Virology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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| US201261656205P | 2012-06-06 | ||
| PCT/US2013/044444 WO2013184876A1 (en) | 2012-06-06 | 2013-06-06 | Benzo [c] isoxazoloazepine bromodomain inhibitors and uses thereof |
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| ES2632774T3 true ES2632774T3 (es) | 2017-09-15 |
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| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
| HK1214819A1 (zh) | 2013-02-19 | 2016-08-05 | Bayer Pharma Aktiengesellschaft | 二环2，3-苯并二氮杂䓬和螺环取代的2，3-苯并二氮杂䓬 |
| HK1212345A1 (en) | 2013-02-22 | 2016-06-10 | Bayer Pharma Aktiengesellschaft | 4-substituted pyrrolo- and pyrazolo-diazepines |
| EP2958922A1 (de) | 2013-02-22 | 2015-12-30 | Bayer Pharma Aktiengesellschaft | Pyrrolo- und pyrazolo-triazolodiazepine als bet-proteininhibitoren zur behandlung von hyper-proliferativen erkrankungen |
| PE20151990A1 (es) | 2013-03-15 | 2016-01-13 | Incyte Corp | Heterociclos triciclicos como inhibidores de la proteina bet |
| JP2016523964A (ja) | 2013-07-08 | 2016-08-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｂｅｔタンパク質阻害剤としての三環式複素環 |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| US9399640B2 (en) | 2013-11-26 | 2016-07-26 | Incyte Corporation | Substituted pyrrolo[2,3-c]pyridines and pyrazolo[3,4-c]pyridines as BET protein inhibitors |
| US9309246B2 (en) | 2013-12-19 | 2016-04-12 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| WO2015153871A2 (en) * | 2014-04-04 | 2015-10-08 | Constellation Pharmaceuticals, Inc. | EXPRESSION LEVELS OF BCL-xL, BCL2, BCL-w, AND BAD AND CANCER THERAPIES |
| AU2015249810B2 (en) | 2014-04-23 | 2019-04-18 | Incyte Holdings Corporation | 1H-pyrrolo[2,3-c]pyridin-7(6H)-ones and pyrazolo[3,4-c]pyridin-7(6H)-ones as inhibitors of BET proteins |
| WO2015195863A1 (en) * | 2014-06-20 | 2015-12-23 | Constellation Pharmaceuticals, Inc. | Hydrated 2-((4s)-6-(4-chlorophenyl)-1 -methyl-4h-benzo[c]isoxazolo[4,5-e]azepin-4-yl)acetamide |
| ES2855225T3 (es) | 2014-09-15 | 2021-09-23 | Incyte Corp | Heterociclos tricíclicos para su uso como inhibidores de proteínas BET |
| GB201504694D0 (en) | 2015-03-19 | 2015-05-06 | Glaxosmithkline Ip Dev Ltd | Covalent conjugates |
| CN107787227A (zh) | 2015-06-26 | 2018-03-09 | 腾沙治疗公司 | Nut中线癌的治疗 |
| MX382128B (es) * | 2015-09-09 | 2025-03-11 | Jubilant Biosys Ltd | Derivados de piridin-2-ona fusionados triciclicos, y su uso como inhibidores de brd4. |
| AR106520A1 (es) | 2015-10-29 | 2018-01-24 | Incyte Corp | Forma sólida amorfa de un inhibidor de proteína bet |
| WO2017114843A1 (en) | 2015-12-29 | 2017-07-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Xanthine derivative inhibitors of bet proteins |
| UA124106C2 (uk) | 2016-06-20 | 2021-07-21 | Інсайт Корпорейшн | Кристалічні тверді форми інгібітора bet |
| EP3533451B1 (en) | 2017-01-21 | 2022-07-27 | Guangzhou Hanfang Pharmaceuticals Co., Ltd. | Application of paeoniflorin-6'-o-benzene sulfonate in medicine for treating sjögren's syndrome |
| JP7254075B2 (ja) | 2017-11-06 | 2023-04-07 | サントル ナショナル ドゥ ラ ルシェルシュ シアンティフィック | キサンチン誘導体及びｂｅｔタンパク質のブロモドメインの阻害剤としてのその使用 |
| KR102026243B1 (ko) * | 2018-01-19 | 2019-09-27 | 연세대학교 산학협력단 | 백혈병 치료용 약학적 조성물 |
| CA3095415A1 (en) | 2018-03-30 | 2019-10-03 | Kyowa Kirin Co., Ltd. | Compound with anticancer activity |
| CN111518045A (zh) * | 2019-02-02 | 2020-08-11 | 博诺康源(北京)药业科技有限公司 | 一种具有苯并七元环结构的化合物、其制备方法及用途 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (144)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3523939A (en) | 1967-07-03 | 1970-08-11 | Hoffmann La Roche | 5-(2,6-disubstituted phenyl)-1,4-benzodiazepines and methods for their preparation |
| CH498846A (de) | 1967-08-09 | 1970-11-15 | Hoffmann La Roche | Verfahren zur Herstellung von Benzodiazepin-Derivaten |
| US3709898A (en) | 1971-02-09 | 1973-01-09 | Upjohn Co | Process for the production of triazolobenzodiazepines and intermediates |
| US3781289A (en) | 1971-02-09 | 1973-12-25 | Upjohn Co | 7-chloro-1-methyl-5-phenyl-s-triazolo (4,3-a)quinolines |
| US3681343A (en) | 1971-05-11 | 1972-08-01 | Upjohn Co | 6-phenyl-s-triazolo{8 4,3-a{9 {8 1,4{9 {0 benzodiazepines |
| US3903103A (en) | 1971-09-15 | 1975-09-02 | Upjohn Co | 4-Amino-s-triazolo-{8 4,3-a{9 {8 1,4{9 benzodiazepine |
| DE2242918A1 (de) | 1971-09-15 | 1973-03-22 | Upjohn Co | Neue 4-amino-s-triazolo eckige klammer auf 4,3-a eckige klammer zu eckige klammer auf 1,4 eckige klammer zu benzodiazepine |
| US3886141A (en) | 1971-10-07 | 1975-05-27 | Hoffmann La Roche | Preparation of 5-pyridyl benzodiazepine utilizing hexamethylenetetramine |
| BE795790A (fr) | 1972-02-22 | 1973-08-22 | Upjohn Co | Dibenzo-triazolo-azepine |
| US4155904A (en) | 1973-02-08 | 1979-05-22 | Schering Corporation | Process for the preparation of 1,4-benzo-diazepines and 1,4-benzodiazepinones |
| FR2220257A1 (en) | 1973-03-09 | 1974-10-04 | Lipha | 5,6-Dihydro-(4H)-s-triazolo-(4,3-a) (1,5)benzodiazepines - as antiinflam-matory and analgesic agents without tranquillising effects |
| IE38931B1 (en) | 1973-03-09 | 1978-07-05 | Lipha | Triazolobenzodiazepines |
| US3966736A (en) | 1975-04-07 | 1976-06-29 | The Upjohn Company | 2,9-Dihydro-3H-pyrido[3,2-c]-s-triazolo[4,3-a][1,5]-benzodiazepin-3-ones |
| AT350056B (de) | 1975-11-04 | 1979-05-10 | Degussa | Verfahren zur herstellung von neuen pyrido- (2,3-f)-(1,4)-diazepinen, deren optischen isomeren und salzen |
| DE2640599A1 (de) | 1976-09-09 | 1978-03-16 | Scherico Ltd | Verfahren zur herstellung von 1,4- benzodiazepinen |
| CA1152066A (en) | 1980-02-08 | 1983-08-16 | Hoffmann-La Roche Limited | Benzodiazepine derivatives |
| CA1163266A (en) | 1980-07-31 | 1984-03-06 | Albert E. Fischli | Benzodiazepine derivatives |
| CA1157855A (en) | 1980-07-31 | 1983-11-29 | Albert E. Fischli | Benzodiazepine derivatives |
| US4455307A (en) | 1982-01-04 | 1984-06-19 | The Upjohn Company | Antihypertensive use of triazolobenzodiazepines |
| US5004741A (en) | 1984-06-26 | 1991-04-02 | Merck & Co., Inc. | Methods of antagonizing CCK or gastrin with benzodiazepine analogs |
| US4820834A (en) | 1984-06-26 | 1989-04-11 | Merck & Co., Inc. | Benzodiazepine analogs |
| US4663321A (en) | 1984-06-26 | 1987-05-05 | Merck & Co., Inc. | Triazolobenzodiazepines and pharmaceutical use |
| EP0315698B1 (en) | 1987-05-28 | 1993-03-03 | Yoshitomi Pharmaceutical Industries, Ltd. | Thieno(triazolo)diazepine compounds and medicinal application of the same |
| US4959361A (en) | 1987-12-18 | 1990-09-25 | Hoffmann-La Roche Inc. | Triazolo(4,3-A)(1,4)benzodiazepines and thieno (3,2-F)(1,2,4)triazolo(4,3-A)(1,4)diazepine compounds which have useful activity as platelet activating factor (PAF) antagonists |
| MC1999A1 (fr) | 1987-12-18 | 1990-01-26 | Hoffmann La Roche | Composes tricycliques |
| EP0348523A4 (en) | 1987-12-22 | 1991-10-09 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compounds and their medicinal use |
| CA1324863C (en) | 1988-01-30 | 1993-11-30 | Minoru Moriwaki | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
| CA1322367C (en) | 1988-05-17 | 1993-09-21 | Yoshitomi Pharmaceutical Industries Ltd. | Thienotriazolodiazepine compounds and pharmaceutical uses thereof |
| FI95708C (fi) | 1988-10-31 | 1996-03-11 | Eisai Co Ltd | Analogiamenetelmä 1,4-diatsepiinijohdannaisen ja sen farmaseuttisesti sopivan suolan valmistamiseksi |
| US5382579A (en) | 1988-10-31 | 1995-01-17 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
| US5221671A (en) | 1988-10-31 | 1993-06-22 | Eisai Co., Ltd. | Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals |
| DE3936828A1 (de) | 1988-11-06 | 1990-05-10 | Boehringer Ingelheim Kg | Neue hetrazepine |
| DE4006471A1 (de) | 1989-03-03 | 1990-09-06 | Boehringer Ingelheim Kg | Neue thienodiazepine |
| EP0407955A1 (de) | 1989-07-12 | 1991-01-16 | Boehringer Ingelheim Kg | Neue Hetrazepine mit PAF-antagonistischer Wirkung, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| DK0411668T4 (da) | 1989-08-04 | 1999-08-09 | Merck Sharp & Dohme | Central-chlolecystokinin-antagonister til behandling af psykiske forstyrrelser |
| US5175159A (en) | 1989-10-05 | 1992-12-29 | Merck & Co., Inc. | 3-substituted-1,4-benzodiazepines as oxytocin antagonists |
| IL96613A0 (en) | 1989-12-18 | 1991-09-16 | Merck & Co Inc | Pharmaceutical compositions containing benzodiazepine analogs |
| CA2032427A1 (en) | 1989-12-18 | 1991-06-19 | Mark G. Bock | Benzodiazepines analogs |
| JP2959591B2 (ja) | 1990-05-23 | 1999-10-06 | 吉富製薬株式会社 | チエノトリアゾロジアゼピン化合物 |
| WO1994006801A1 (fr) | 1990-05-23 | 1994-03-31 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienodiazepine et son utilisation comme medicament |
| DE4027470A1 (de) | 1990-08-30 | 1992-03-05 | Boehringer Ingelheim Kg | Neue hetrazepinoide amide |
| JP2959598B2 (ja) | 1990-10-12 | 1999-10-06 | 吉富製薬株式会社 | 光学活性なチエノトリアゾロジアゼピン化合物 |
| US5206234A (en) | 1990-10-22 | 1993-04-27 | Merck & Co., Inc. | Benzolactam analogs as antagonists of cck |
| CA2056809A1 (en) | 1990-12-07 | 1992-06-08 | Mark G. Bock | Benzodiazepine analogs |
| DE4101146A1 (de) | 1991-01-16 | 1992-07-23 | Boehringer Ingelheim Kg | Neue in 6-position substituierte diazepine, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel |
| DE4107521A1 (de) | 1991-03-08 | 1992-09-10 | Boehringer Ingelheim Kg | Neue acylaminosubstituierte hetrazepine |
| US5683998A (en) | 1991-04-23 | 1997-11-04 | Toray Industries, Inc. | Tricyclic triazolo derivatives, processes for producing the same and the uses of the same |
| US5185331A (en) | 1991-05-14 | 1993-02-09 | Merck & Co., Inc. | Triazolobenzodiazepines |
| CA2071092A1 (en) | 1991-06-14 | 1992-12-15 | Roger M. Freidinger | 1,4-benzodiazepines with 5-membered heterocyclic rings |
| GB9117852D0 (en) | 1991-08-19 | 1991-10-09 | Merck Sharp & Dohme | Therapeutic agents |
| US5153191A (en) | 1991-08-20 | 1992-10-06 | Warner-Lambert Company | Cholecystokinin antagonists useful for treating depression |
| DE4128581A1 (de) | 1991-08-28 | 1993-03-04 | Boehringer Ingelheim Kg | Verwendung von paf-antagonisten hetrazepinoider struktur zur behandlung der allergischen rhinitis |
| ATE188702T1 (de) | 1991-09-30 | 2000-01-15 | Yoshitomi Pharmaceutical | Thienodiazepinverbindungen und ihre verwendung |
| EP0638560A4 (en) | 1991-10-11 | 1995-03-29 | Yoshitomi Pharmaceutical | MEDICINE FOR OSTEOPOROSIS AND DIAZEPINE COMPOUND *. |
| US5686479A (en) | 1991-12-11 | 1997-11-11 | Yoshitomi Pharmaceutical Industries, Ltd. | Immunosuppressive drug |
| WO1993012791A1 (en) | 1991-12-20 | 1993-07-08 | Merck Sharp & Dohme Limited | Central cholecystokinin antagonists having pharmaceutical activity |
| DE4200610A1 (de) | 1992-01-13 | 1993-07-15 | Boehringer Ingelheim Kg | Verwendung von paf-antagonisten zur behandlung der dysmenorrhea |
| EP0636123A1 (en) | 1992-03-24 | 1995-02-01 | MERCK SHARP & DOHME LTD. | 3-ureido substituted benzodiazepin-2-ones having cholecystokinin and/or gastrin antagonistic activity and their use in therapy |
| DE4219659A1 (de) | 1992-06-16 | 1993-12-23 | Boehringer Ingelheim Kg | Die Verwendung von PAF-Antagonisten in Kombination mit Anticholinergika |
| EP0661284A1 (en) | 1992-09-18 | 1995-07-05 | Yoshitomi Pharmaceutical Industries, Ltd. | Thienodiazepine compound and medicinal use thereof |
| JP3223290B2 (ja) | 1992-11-10 | 2001-10-29 | 日本電信電話株式会社 | マイクロ回転体およびその製造方法 |
| US5302590A (en) | 1992-12-18 | 1994-04-12 | Hoffmann-La Roche Inc. | Compounds useful as dual antagonists of platelet activating factor and leukotriene D4 |
| WO1994022872A1 (fr) | 1993-03-30 | 1994-10-13 | Yoshitomi Pharmaceutical Industries, Ltd. | Inhibiteur d'adhesion cellulaire et compose a base de thienotriazolodiazepine |
| EP0763537A3 (en) | 1993-05-14 | 1997-10-22 | Genentech Inc | Non-peptides farnesyl transfer inhibitors |
| US5733905A (en) | 1993-07-29 | 1998-03-31 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5516774A (en) | 1993-07-29 | 1996-05-14 | American Cyanamid Company | Tricyclic diazepine vasopressin antagonists and oxytocin antagonists |
| US5869483A (en) | 1993-07-29 | 1999-02-09 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| US5760031A (en) | 1993-07-29 | 1998-06-02 | American Cyanamid Company | Tricyclic benzazepine vasopressin antagonists |
| JP3633008B2 (ja) | 1993-11-15 | 2005-03-30 | 三菱ウェルファーマ株式会社 | チエノトリアゾロジアゼピン化合物 |
| CA2176020A1 (en) | 1993-11-22 | 1995-06-01 | John J. Baldwin | Benzodiazepines |
| ES2156933T3 (es) | 1993-12-28 | 2001-08-01 | Meiji Seika Co | Derivados triciclicos de benzazepina y benzotiazepina. |
| US5739129A (en) | 1994-04-14 | 1998-04-14 | Glaxo Wellcome Inc. | CCK or gastrin modulating 5-heterocyclic-1, 5 benzodiazepines |
| AU2446295A (en) | 1994-04-15 | 1995-11-10 | Glaxo Inc. | A method of inducing cholecystokinin agonist activity using 1,4-benzodiazepine compounds |
| JP3264588B2 (ja) | 1994-08-23 | 2002-03-11 | 松下電器産業株式会社 | 電子地図データの生成装置 |
| JP3264589B2 (ja) | 1994-09-07 | 2002-03-11 | 東芝機械株式会社 | 研磨装置 |
| US5929069A (en) | 1995-09-21 | 1999-07-27 | Institute Of Medicinal Molecular Design, Inc. | Compounds activating pharmacological effects of retinoids |
| EP0934940A1 (en) | 1996-06-12 | 1999-08-11 | Japan Tobacco Inc. | Cytokine production inhibitors, triazepine compounds, and intermediates thereof |
| PT989131E (pt) | 1996-09-13 | 2003-03-31 | Mitsubishi Pharma Corp | Compostos de trienotriazolodiazepina e suas utilizacoes com fins medicinais |
| NZ335583A (en) | 1996-12-23 | 2001-03-30 | Lilly Co Eli | Cycloalkyl, lactam, lactone and analogs, and pharmaceutical compositions |
| WO1998058930A1 (en) | 1997-06-25 | 1998-12-30 | Nikken Chemicals Co., Ltd. | Triazolo-1,4-diazepine compounds and medicinal composition containing the same |
| JP4204657B2 (ja) | 1997-12-05 | 2009-01-07 | 有限会社ケムフィズ | 糖尿病の予防・治療剤 |
| JPH11228576A (ja) | 1997-12-10 | 1999-08-24 | Japan Tobacco Inc | アポトーシス抑制剤 |
| FR2779652B1 (fr) | 1998-06-15 | 2001-06-08 | Sod Conseils Rech Applic | Utilisation de diazepines pour la preparation de medicaments destines a traiter les etats pathologiques ou les maladies dans lesquels un des recepteurs de la somatostatine est implique |
| PE20000944A1 (es) | 1998-07-31 | 2000-09-20 | Lilly Co Eli | Derivados de sulfonamida |
| CN1315963A (zh) | 1998-09-01 | 2001-10-03 | 基因创新有限公司 | 结合膜联蛋白的苯并二氮杂䓬类和苯并硫杂吖庚因衍生物和hbsag肽,其组合物和用途 |
| WO2000054778A1 (fr) | 1999-03-12 | 2000-09-21 | Welfide Corporation | Agents preventifs ou therapeutiques des dermatoses inflammatoires |
| FR2791980B1 (fr) | 1999-04-09 | 2001-07-06 | Sod Conseils Rech Applic | Pyrido-thieno-diazepines, leur procede de preparation, et les compositions pharmaceutiques les contenant |
| US7160880B1 (en) | 1999-05-14 | 2007-01-09 | Cenes Limited | Short-acting benzodiazepines |
| GB9911152D0 (en) | 1999-05-14 | 1999-07-14 | Glaxo Group Ltd | Short-acting benzodiazepines |
| DE60015392D1 (de) | 1999-12-29 | 2004-12-02 | Glaxo Group Ltd | Verwendung von annexin-modulatoren zur herstellung eines medikaments zur behandlung und/oder vorbeugung von arthritis und arthritischen erkrankungen |
| AU2001264303A1 (en) | 2000-06-16 | 2001-12-24 | Mitsubishi Pharma Corporation | Compositions controlling release ph range and/or speed |
| US7250410B2 (en) | 2001-06-07 | 2007-07-31 | Via Pharmaceuticals, Inc. | Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof |
| AU2003211424A1 (en) | 2002-03-01 | 2003-09-16 | Yamanouchi Pharmaceutical Co., Ltd. | Nitrogen-containing heterocyclic compound |
| EP1556055B1 (fr) | 2002-10-30 | 2008-10-29 | Via Pharmaceuticals, Inc. | Inhibiteurs des phosphodiesterases des nucleotides cycliques, ayant une structure benzodiazepinique, et leur utilisation en therapie |
| DE10251927A1 (de) | 2002-11-08 | 2004-05-19 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
| US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
| KR100562489B1 (ko) | 2002-11-11 | 2006-03-21 | 삼성전자주식회사 | 셔터 타이밍 조절 가능한 로우 디코더를 갖는 이미지 센서 |
| KR101075812B1 (ko) | 2002-12-18 | 2011-10-25 | 버텍스 파마슈티칼스 인코포레이티드 | 단백질 키나제 억제제로서의 트리아졸로피리다진 |
| US7119088B2 (en) | 2003-02-19 | 2006-10-10 | Pfizer Inc. | Triazole compounds useful in therapy |
| CA2529558A1 (en) | 2003-07-01 | 2005-01-13 | Astellas Pharma Inc. | Agent inducing increase in bone mass |
| WO2005099759A1 (ja) | 2004-04-16 | 2005-10-27 | Institute Of Medicinal Molecular Design. Inc. | 動脈硬化症の予防及び／又は治療のための医薬 |
| EP1806070A1 (en) | 2004-10-05 | 2007-07-11 | Pioneer Corporation | Audio rack |
| EP1887008B1 (en) | 2005-05-30 | 2021-04-21 | Mitsubishi Tanabe Pharma Corporation | Thienotriazolodiazepine compound and a medicinal use thereof |
| CN101232887A (zh) | 2005-07-29 | 2008-07-30 | 默克公司 | 杂环苯并二氮杂䓬cgrp受体拮抗剂 |
| US20070105844A1 (en) | 2005-10-26 | 2007-05-10 | Regents Of The University Of Michigan | Therapeutic compositions and methods |
| JP2009513644A (ja) | 2005-10-26 | 2009-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ ミシガン | 治療組成物および方法 |
| DE102005061840A1 (de) | 2005-12-23 | 2007-06-28 | Merck Patent Gmbh | Triazolderivate |
| EP2058304A4 (en) | 2006-08-25 | 2012-10-10 | Nippon Chemiphar Co | P2X4 RECEPTOR ANTAGONIST |
| WO2008109856A2 (en) | 2007-03-07 | 2008-09-12 | Xenon Pharmaceuticals Inc. | Methods of using diazepinone compounds in treating sodium channel-mediated diseases or conditions |
| US20090111780A1 (en) | 2007-10-31 | 2009-04-30 | Everett Laboratories, Inc. | Compositions and methods for treatment of ear canal infection and inflammation |
| ITFI20070288A1 (it) | 2007-12-21 | 2009-06-22 | A I L Firenze Sezione Autonoma | Inibitori delle deacetilasi istoniche |
| WO2009084693A1 (ja) | 2007-12-28 | 2009-07-09 | Mitsubishi Tanabe Pharma Corporation | 抗癌剤 |
| EP2349257B1 (en) | 2008-06-17 | 2013-11-27 | Universidade Federal de Minas Gerais-UFMG | Use of paf receptor for treating infections caused by flaviviridae |
| JP5634990B2 (ja) | 2008-06-23 | 2014-12-03 | バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ | タンパク質キナーゼ阻害剤 |
| JP5490811B2 (ja) | 2008-10-30 | 2014-05-14 | スルコメッド エルエルシー | アポａに対して活性なチエノトリアゾロジアゼピン誘導体 |
| US8591943B2 (en) | 2009-04-09 | 2013-11-26 | Merck Sharp & Dohme Corp. | Pyrazolo[1,5-a]pyrimidine derivatives as mTOR inhibitors |
| WO2010121164A2 (en) | 2009-04-17 | 2010-10-21 | The Regents Of The University Of Michigan | 1,4-benzodiazepinone compounds and their use in treating cancer |
| CN102482258B (zh) | 2009-05-07 | 2014-06-25 | 株式会社棱镜制药 | α-螺旋模拟物和与其相关的方法 |
| US9062024B2 (en) | 2009-09-28 | 2015-06-23 | Nippon Soda Co., Ltd. | Nitrogen-containing heterocyclic compound and salt thereof, and a fungicide for agricultural and horticultural use |
| GB0919431D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919423D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919434D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| GB0919426D0 (en) * | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Novel compounds |
| NZ599258A (en) | 2009-11-05 | 2014-05-30 | Glaxosmithkline Llc | Benzodiazepine bromodomain inhibitor |
| ES2654423T3 (es) | 2009-11-05 | 2018-02-13 | Glaxosmithkline Llc | Inhibidor de bromodominio de benzodiacepina |
| ES2539964T3 (es) | 2009-11-05 | 2015-07-07 | Glaxosmithkline Llc | Procedimiento novedoso |
| GB0919432D0 (en) | 2009-11-05 | 2009-12-23 | Glaxosmithkline Llc | Use |
| US8765920B2 (en) | 2009-12-23 | 2014-07-01 | The Scripps Research Institute | Tyrosine bioconjugation through aqueous Ene-like reactions |
| WO2011123678A2 (en) | 2010-03-31 | 2011-10-06 | Arqule, Inc. | Substituted benzo-pyrido-triazolo-diazepine compounds |
| JP5935030B2 (ja) | 2010-05-14 | 2016-06-15 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 白血病を治療するための組成物および方法 |
| CA2799381A1 (en) | 2010-05-14 | 2011-11-17 | Dana-Farber Cancer Institute, Inc. | Male contraceptive compositions and methods of use |
| JP5913292B2 (ja) | 2010-05-14 | 2016-04-27 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | 代謝を調節する組成物および方法 |
| DK2571503T3 (en) | 2010-05-14 | 2015-04-20 | Dana Farber Cancer Inst Inc | COMPOSITIONS AND THEIR USE IN THE TREATMENT OF NEOPLASIA, INFLAMMATORY DISEASE AND OTHER DISORDERS |
| WO2011161031A1 (en) * | 2010-06-22 | 2011-12-29 | Glaxosmithkline Llc | Benzotriazolodiazepine compounds inhibitors of bromodomains |
| AR084070A1 (es) * | 2010-12-02 | 2013-04-17 | Constellation Pharmaceuticals Inc | Inhibidores del bromodominio y usos de los mismos |
| US9249161B2 (en) | 2010-12-02 | 2016-02-02 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| US9422292B2 (en) | 2011-05-04 | 2016-08-23 | Constellation Pharmaceuticals, Inc. | Bromodomain inhibitors and uses thereof |
| GB201114103D0 (en) | 2011-08-17 | 2011-09-28 | Glaxosmithkline Llc | Novel compounds |
| WO2013033268A2 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bivalent bromodomain ligands, and methods of using same |
| WO2013033269A1 (en) | 2011-08-29 | 2013-03-07 | Coferon, Inc. | Bioorthogonal monomers capable of dimerizing and targeting bromodomains and methods of using same |
| US10071129B2 (en) | 2011-08-30 | 2018-09-11 | Whitehead Institute For Biomedical Research Dana-Farber Cancer Institute, Inc. | Method for identifying bromodomain inhibitors |
| DE102011082013A1 (de) | 2011-09-01 | 2013-03-07 | Bayer Pharma AG | 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine |
| TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
| US9624244B2 (en) | 2012-06-06 | 2017-04-18 | Constellation Pharmaceuticals, Inc. | Benzo [B] isoxazoloazepine bromodomain inhibitors and uses thereof |
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| WO2013184876A1 (en) | 2013-12-12 |
| US9493483B2 (en) | 2016-11-15 |
| HK1207372A1 (en) | 2016-01-29 |
| EA026894B1 (ru) | 2017-05-31 |
| IL235844A (en) | 2017-04-30 |
| ZA201408720B (en) | 2018-05-30 |
| US20150148337A1 (en) | 2015-05-28 |
| JP6154004B2 (ja) | 2017-06-28 |
| EA201492216A1 (ru) | 2015-03-31 |
| WO2013184876A8 (en) | 2014-11-27 |
| SG11201407900WA (en) | 2014-12-30 |
| AU2013271569B2 (en) | 2017-09-14 |
| NZ702458A (en) | 2016-11-25 |
| IL235844A0 (en) | 2015-02-01 |
| AR091285A1 (es) | 2015-01-21 |
| JP2015518899A (ja) | 2015-07-06 |
| US9925197B2 (en) | 2018-03-27 |
| CA2874774C (en) | 2022-10-04 |
| KR20150023562A (ko) | 2015-03-05 |
| US20170079984A1 (en) | 2017-03-23 |
| AU2013271569A1 (en) | 2014-12-18 |
| CN104428304A (zh) | 2015-03-18 |
| EP2859000B1 (en) | 2017-04-26 |
| MX360598B (es) | 2018-11-08 |
| CA2874774A1 (en) | 2013-12-12 |
| IN2014DN10386A (enExample) | 2015-08-14 |
| BR112014030165A2 (pt) | 2017-06-27 |
| TW201402580A (zh) | 2014-01-16 |
| CN104428304B (zh) | 2016-09-21 |
| EP2859000A1 (en) | 2015-04-15 |
| TWI602820B (zh) | 2017-10-21 |
| MX2014015004A (es) | 2015-03-05 |
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