ES2632748T3 - Anticuerpos anti-C4.4a y usos de los mismos - Google Patents

Anticuerpos anti-C4.4a y usos de los mismos Download PDF

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Publication number
ES2632748T3
ES2632748T3 ES10798996.4T ES10798996T ES2632748T3 ES 2632748 T3 ES2632748 T3 ES 2632748T3 ES 10798996 T ES10798996 T ES 10798996T ES 2632748 T3 ES2632748 T3 ES 2632748T3
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Prior art keywords
antibody
antigen
antibodies
sequences
binding
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Application number
ES10798996.4T
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English (en)
Spanish (es)
Inventor
Lars Linden
Yong-Jiang Cao
Gabriele Leder
Beatrix Stelte-Ludwig
Axel Harrenga
Ricarda Finnern
Frank Dittmer
Anke Mayer-Bartschmid
Juergen Franz
Simone Greven
Jörg WILLUDA
Jan Tebbe
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Bayer Pharma AG
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Bayer Pharma AG
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • A61K49/14Peptides, e.g. proteins
    • A61K49/16Antibodies; Immunoglobulins; Fragments thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55Fab or Fab'
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Toxicology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ES10798996.4T 2009-12-09 2010-12-08 Anticuerpos anti-C4.4a y usos de los mismos Active ES2632748T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP09178474 2009-12-09
EP09178474 2009-12-09
EP10170797 2010-07-26
EP10170797 2010-07-26
PCT/EP2010/069216 WO2011070088A1 (en) 2009-12-09 2010-12-08 Anti-c4.4a antibodies and uses thereof

Publications (1)

Publication Number Publication Date
ES2632748T3 true ES2632748T3 (es) 2017-09-15

Family

ID=43629588

Family Applications (1)

Application Number Title Priority Date Filing Date
ES10798996.4T Active ES2632748T3 (es) 2009-12-09 2010-12-08 Anticuerpos anti-C4.4a y usos de los mismos

Country Status (27)

Country Link
US (2) US20120321619A1 (enExample)
EP (2) EP2510012B1 (enExample)
JP (3) JP5989544B2 (enExample)
KR (1) KR101931820B1 (enExample)
CN (1) CN102812047B (enExample)
AR (1) AR079340A1 (enExample)
AU (1) AU2010329904B2 (enExample)
BR (1) BR112012013915A8 (enExample)
CA (1) CA2783338A1 (enExample)
CY (1) CY1119051T1 (enExample)
DK (1) DK2510012T3 (enExample)
ES (1) ES2632748T3 (enExample)
HR (1) HRP20170973T1 (enExample)
HU (1) HUE034847T2 (enExample)
IL (1) IL219801A (enExample)
IN (1) IN2012DN05175A (enExample)
LT (1) LT2510012T (enExample)
MX (1) MX2012006593A (enExample)
NZ (1) NZ600470A (enExample)
PL (1) PL2510012T3 (enExample)
PT (1) PT2510012T (enExample)
RS (1) RS56161B1 (enExample)
RU (1) RU2577977C2 (enExample)
SI (1) SI2510012T1 (enExample)
TW (1) TWI488642B (enExample)
WO (1) WO2011070088A1 (enExample)
ZA (1) ZA201203498B (enExample)

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WO2011158883A1 (ja) * 2010-06-15 2011-12-22 国立大学法人大阪大学 癌予後判定可能な抗体、および癌予後判定方法
RU2610336C2 (ru) 2011-04-21 2017-02-09 Сиэтл Дженетикс, Инк. Новые конъюгаты связывающее соединение - активное соединение (adc) и их применение
JP2014117191A (ja) * 2012-12-13 2014-06-30 Fisheries Research Agency リン酸化中性スフィンゴミエリナーゼ1、抗リン酸化中性スフィンゴミエリナーゼ1抗体、中性スフィンゴミエリナーゼ1変異体、及びそれらの用途
WO2016040321A1 (en) * 2014-09-09 2016-03-17 Board Of Regents, The University Of Texas System Blocking monoclonal antibodies to agr2 and its receptor c4.4a
EP3283522A1 (en) 2015-04-17 2018-02-21 Spring Bioscience Corporation Antibodies, compositions, and immunohistochemistry methods for detecting c4.4a
BR112018011270A2 (en) * 2015-12-04 2018-11-21 The Regents Of The University Of California isolated antibody, pharmaceutical composition, and methods for treating or reducing the recurrence rate of a cancer in a patient and for detecting cancer stem cells.
WO2017156280A1 (en) * 2016-03-09 2017-09-14 Viba Therapeutics, Inc. Methods of treating cancer using monoclonal antibodies to agr2 and c4.4a
AU2018207440B2 (en) 2017-01-11 2022-06-02 The Board Of Trustees Of The Leland Stanford Junior University R-spondin (RSPO) surrogate molecules
CN110234662A (zh) 2017-01-26 2019-09-13 瑟罗泽恩公司 组织特异性wnt信号增强分子和其用途
JP7052389B2 (ja) * 2018-02-07 2022-04-12 株式会社三洋物産 遊技機
US12466884B2 (en) 2018-07-09 2025-11-11 Surrozen Operating, Inc. Tissue-specific WNT signal enhancing molecules and uses
AU2019305223A1 (en) * 2018-07-20 2021-02-18 Duke University Anti-LYPD3 car T-cell therapy for the treatment of cancer
MX2021005433A (es) * 2018-11-08 2021-06-15 Univ Kagawa Nat Univ Corp Metodo para producir una composicion que contiene azucar raro y una composicion que contiene el azucar raro.
CN111349164B (zh) * 2018-12-21 2023-05-26 艾比玛特医药科技(上海)有限公司 糖基磷脂酰肌醇锚定糖蛋白(c4.4a)的单克隆抗体及其应用
EP3986461A4 (en) * 2019-06-21 2023-07-05 Children's National Medical Center METHOD AND COMPOSITION FOR A BINDING MOLECULE TARGETED AGAINST CANCER CELLS EXPRESSING SSX2 PEPTIDE 41-49 IN THE HLA-A1 0201 CONTEXT
US20220395532A1 (en) 2019-11-08 2022-12-15 Humanigen, Inc. Epha3 directed car-t cells for treatment of tumors
TW202233656A (zh) 2020-11-16 2022-09-01 美商蘇羅森營運公司 肝特異性wnt訊號增強分子及其用途
EP4493595A1 (en) 2022-03-16 2025-01-22 Pentixapharm AG Antibodies against lypd3
CA3258344A1 (en) 2022-06-07 2023-12-14 Actinium Pharmaceuticals, Inc. CHELETARIANS AND BIFUNCTIONAL CONJUGATES

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Also Published As

Publication number Publication date
LT2510012T (lt) 2017-07-25
EP2510012A1 (en) 2012-10-17
EP3144323A3 (en) 2017-05-31
PL2510012T3 (pl) 2017-09-29
JP2013513369A (ja) 2013-04-22
IL219801A0 (en) 2012-07-31
AR079340A1 (es) 2012-01-18
EP3144323A2 (en) 2017-03-22
PT2510012T (pt) 2017-07-13
WO2011070088A1 (en) 2011-06-16
HUE034847T2 (en) 2018-03-28
TW201134485A (en) 2011-10-16
BR112012013915A8 (pt) 2017-12-26
JP2018019721A (ja) 2018-02-08
DK2510012T3 (en) 2017-07-31
RS56161B1 (sr) 2017-11-30
AU2010329904B2 (en) 2015-07-09
US20120321619A1 (en) 2012-12-20
CA2783338A1 (en) 2011-06-16
CY1119051T1 (el) 2018-01-10
NZ600470A (en) 2015-02-27
RU2012128343A (ru) 2014-01-20
BR112012013915A2 (pt) 2017-01-10
SI2510012T1 (sl) 2017-08-31
KR101931820B1 (ko) 2018-12-21
KR20120116958A (ko) 2012-10-23
JP2016104820A (ja) 2016-06-09
IL219801A (en) 2016-08-31
EP2510012B1 (en) 2017-04-19
CN102812047A (zh) 2012-12-05
MX2012006593A (es) 2012-06-28
CN102812047B (zh) 2015-08-26
IN2012DN05175A (enExample) 2015-10-23
RU2577977C2 (ru) 2016-03-20
ZA201203498B (en) 2015-10-28
JP5989544B2 (ja) 2016-09-07
HRP20170973T1 (hr) 2017-09-22
HK1178920A1 (en) 2013-09-19
JP6240696B2 (ja) 2017-11-29
TWI488642B (zh) 2015-06-21
AU2010329904A1 (en) 2012-06-14
US20170158775A1 (en) 2017-06-08

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