ES2629502T3 - Métodos y composiciones relacionados con exosomas de células madre mesenquimales - Google Patents

Métodos y composiciones relacionados con exosomas de células madre mesenquimales Download PDF

Info

Publication number
ES2629502T3
ES2629502T3 ES12709484.5T ES12709484T ES2629502T3 ES 2629502 T3 ES2629502 T3 ES 2629502T3 ES 12709484 T ES12709484 T ES 12709484T ES 2629502 T3 ES2629502 T3 ES 2629502T3
Authority
ES
Spain
Prior art keywords
exosomes
isolated
msc
subject
pulmonary
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES12709484.5T
Other languages
English (en)
Spanish (es)
Inventor
S. Alexander MITSIALIS
Changjin Lee
Stella KOUREMBANAS
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boston Childrens Hospital
Original Assignee
Boston Childrens Hospital
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boston Childrens Hospital filed Critical Boston Childrens Hospital
Application granted granted Critical
Publication of ES2629502T3 publication Critical patent/ES2629502T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/42Respiratory system, e.g. lungs, bronchi or lung cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0082Lung surfactant, artificial mucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/10Anthelmintics
    • A61P33/12Schistosomicides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0652Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662Stem cells
    • C12N5/0663Bone marrow mesenchymal stem cells (BM-MSC)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biotechnology (AREA)
  • Hematology (AREA)
  • Virology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Dermatology (AREA)
  • Otolaryngology (AREA)
  • Dispersion Chemistry (AREA)
  • Rheumatology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Cardiology (AREA)
ES12709484.5T 2011-03-11 2012-03-09 Métodos y composiciones relacionados con exosomas de células madre mesenquimales Active ES2629502T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161451981P 2011-03-11 2011-03-11
US201161451981P 2011-03-11
PCT/US2012/028524 WO2012125471A1 (en) 2011-03-11 2012-03-09 Methods and compositions relating to mesenchymal stem cell exosomes

Publications (1)

Publication Number Publication Date
ES2629502T3 true ES2629502T3 (es) 2017-08-10

Family

ID=45852770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES12709484.5T Active ES2629502T3 (es) 2011-03-11 2012-03-09 Métodos y composiciones relacionados con exosomas de células madre mesenquimales

Country Status (8)

Country Link
US (3) US9901600B2 (https=)
EP (1) EP2683389B1 (https=)
JP (2) JP6204830B2 (https=)
KR (2) KR102063069B1 (https=)
CN (2) CN103648509B (https=)
CA (1) CA2829586C (https=)
ES (1) ES2629502T3 (https=)
WO (1) WO2012125471A1 (https=)

Families Citing this family (98)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11660317B2 (en) 2004-11-08 2023-05-30 The Johns Hopkins University Compositions comprising cardiosphere-derived cells for use in cell therapy
CA2829586C (en) * 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
ITRM20110403A1 (it) * 2011-07-28 2013-01-29 Ospedale Pediatrico Bambino Gesu Microvescicole isolate da cellule mesenchimali come agenti immunosoppressori.
US9427450B2 (en) 2012-01-31 2016-08-30 Xon Cells, Inc. Therapeutic immune modulation by stem cell secreted exosomes
GB201202319D0 (en) 2012-02-10 2012-03-28 Orbsen Therapeutics Ltd Stromal stem cells
AU2013302799B2 (en) 2012-08-13 2018-03-01 Cedars-Sinai Medical Center Exosomes and micro-ribonucleic acids for tissue regeneration
CN103865873B (zh) * 2012-12-12 2017-04-05 中国医学科学院基础医学研究所 亚全能干细胞分泌的外来体及其应用
CN115919901A (zh) * 2012-12-12 2023-04-07 麦瑟布莱斯特公司 治疗或预防呼吸病症的方法
CN105264092B (zh) * 2013-03-15 2019-02-22 得克萨斯州大学系统董事会 用于诊断和疗法的外来体中的miRNA生物发生
WO2014197421A1 (en) 2013-06-05 2014-12-11 Biotime, Inc. Compositions and methods for induced tissue regeneration in mammalian species
ES2909752T3 (es) * 2013-08-01 2022-05-10 Swedish Stromabio Ab MSC en el tratamiento de enfermedades pulmonares inflamatorias
GB201317887D0 (en) 2013-10-09 2013-11-20 Reneuron Ltd Product
CN104694466A (zh) * 2013-12-06 2015-06-10 山西医科大学 间充质干细胞来源的胞外体制备及在急性肺损伤中的应用
KR101662405B1 (ko) * 2013-12-12 2016-10-05 사회복지법인 삼성생명공익재단 줄기세포 유래 엑소좀을 유효성분으로 포함하는 뇌혈관 질환 치료용 약학적 조성물
US11078462B2 (en) 2014-02-18 2021-08-03 ReCyte Therapeutics, Inc. Perivascular stromal cells from primate pluripotent stem cells
US9919011B2 (en) 2014-03-18 2018-03-20 Samsung Life Public Welfare Foundation Method for treating an inflammatory brain disease comprising administering a stem cell-derived exosome
CA2949083C (en) 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes
WO2015191545A1 (en) * 2014-06-09 2015-12-17 University Of Washington Methods of protection against ischemia reperfusion injury
WO2016001846A1 (en) * 2014-06-30 2016-01-07 Tigenix S.A.U. Mesenchymal stromal cells for treating sepsis
US10240127B2 (en) 2014-07-03 2019-03-26 ReCyte Therapeutics, Inc. Exosomes from clonal progenitor cells
EP3209768A1 (en) 2014-07-25 2017-08-30 Recellerate Inc. Methods of treating exercise-induced pulmonary hemorrhage
CA2962444C (en) 2014-10-03 2023-09-05 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of muscular dystrophy
EP3204117A4 (en) * 2014-10-06 2018-05-09 Cedars-Sinai Medical Center Polarization of macrophages to a healing phenotype by cardiosphere-derived cells and by the exosomes secreted by such cells
WO2016072821A1 (ko) * 2014-11-07 2016-05-12 한양대학교 에리카산학협력단 줄기세포 유래 엑소좀을 함유하는 지방세포 분화유도, 지방조직 재생, 피부 미백 또는 주름개선용 조성물
JP6683700B2 (ja) * 2014-11-07 2020-04-22 株式会社エキソステムテックExostemtech Co.,Ltd. 幹細胞由来のエキソソームを含有する脂肪細胞分化誘導、または脂肪組織の再生用組成物の製造方法
JP6716564B2 (ja) * 2014-12-03 2020-07-01 カプリコール,インコーポレイテッド 安定したエクソソーム製剤の製造方法
CN104560877B (zh) * 2014-12-18 2017-07-28 福州市传染病医院 一种快速分离细胞外吐小体的方法
US20180264047A1 (en) * 2014-12-24 2018-09-20 Ube Industries, Ltd. Cell culture supernatant fluid derived from lung tissue
WO2016111899A1 (en) * 2015-01-05 2016-07-14 Petrucci Gary M Methods and materials for treating lung disorders
US20180325830A1 (en) 2017-05-09 2018-11-15 Vivex Biomedical, Inc. Coated biological composition
US11160904B2 (en) * 2017-05-09 2021-11-02 Vivex Biologies Group, Inc. Biological composition in a protectant shroud and methods
US9687511B2 (en) 2015-03-06 2017-06-27 Vivex Biomedical, Inc. Acellular biologic composition and method of manufacture
KR101566450B1 (ko) * 2015-04-03 2015-11-05 (유)스템메디케어 중간엽 줄기세포에서 단백질의 대량 생산 방법
US11160834B2 (en) 2015-04-28 2021-11-02 The Texas A&M University System Scalable production of standardized extracellular vesicles, extracellular vesicle preparations and uses thereof
US20180177727A1 (en) * 2015-06-10 2018-06-28 Board Of Regents, The University Of Texas System Use of exosomes for the treatment of disease
US11320441B2 (en) 2015-06-10 2022-05-03 Children's National Medical Center Adipocyte-derived exosomes, and compositions, kits, and methods of using the same for detection and screening
CN114984054B (zh) * 2015-06-12 2025-04-01 哈德逊医学研究中心 一种治疗方法
US11077147B2 (en) * 2015-07-20 2021-08-03 Vivex Biologics Group, Inc. Acellular biologic composition and method of manufacture
WO2017023690A1 (en) * 2015-07-31 2017-02-09 Exoceuticals, Inc. Exosome compositions and methods for preparation and use thereof for regulating and conditioning skin and hair
CA3202332A1 (en) 2015-12-07 2017-06-15 Agex Therapeutics, Inc. Methods for the re-derivation of diverse pluripotent stem cell-derived brown fat cells
EP3402543B1 (en) 2016-01-11 2021-09-08 Cedars-Sinai Medical Center Cardiosphere-derived cells and exosomes secreted by such cells in the treatment of heart failure with preserved ejection fraction
EP3922253A1 (en) * 2016-01-15 2021-12-15 Orbsen Therapeutics Limited Sdc-2 exosome compositions and methods of isolation and use
EP3407844A4 (en) 2016-01-29 2019-10-16 Qool Therapeutics, Inc. AEROSOLISATION OF STEM CELLS OR STEM CELL DERIVATIVES FOR PULMONARY ADMINISTRATION
KR101843634B1 (ko) * 2016-04-15 2018-03-30 사회복지법인 삼성생명공익재단 트롬빈 처리 줄기세포에서 유래된 엑소좀을 포함하는 만성폐질환 치료용 조성물
WO2017210652A1 (en) 2016-06-03 2017-12-07 Cedars-Sinai Medical Center Cdc-derived exosomes for treatment of ventricular tachyarrythmias
KR20250037589A (ko) * 2016-06-17 2025-03-17 유나이티드 쎄러퓨틱스 코포레이션 향상된 효능을 가진 세포외 소포
US10946047B2 (en) * 2016-06-17 2021-03-16 United Therapeutics Corporation Extracellular vesicles with enhanced potency
KR102503101B1 (ko) * 2016-08-03 2023-02-23 고쿠리츠 다이가쿠 호우징 도우카이 고쿠리츠 다이가쿠 기코우 다능성 간세포에 따른 만성폐질환의 개선 및 치료
CA3032925A1 (en) * 2016-08-03 2018-02-08 Life Science Institute, Inc. Alleviation and treatment of ischemia reperfusion-induced lung injury using pluripotent stem cells
EP3494977A4 (en) * 2016-08-05 2020-03-18 Exostemtech Co., Ltd. COMPOSITION FOR THE PREVENTION OR TREATMENT OF LUNG FIBROSE WITH FAT TISSUE EXOSOM OBTAINED FROM STEM CELLS AS AN ACTIVE SUBSTANCE
US11541078B2 (en) 2016-09-20 2023-01-03 Cedars-Sinai Medical Center Cardiosphere-derived cells and their extracellular vesicles to retard or reverse aging and age-related disorders
WO2018071677A1 (en) * 2016-10-13 2018-04-19 Vbc Holdings Llc Medical uses of exosomes
CN110072991A (zh) * 2016-10-13 2019-07-30 Vbc控股有限责任公司 来源于发炎的细胞或组织的抗炎外泌体
JP7248984B2 (ja) * 2017-02-28 2023-03-30 ユニバーシティ デ ロライン 敗血症の治療のための、ワルトンジェリーから取得された間葉系幹細胞
US20180291336A1 (en) * 2017-04-07 2018-10-11 Robert John Petcavich Method of manufacturing and purifying exosomes from non-terminally differentiated cells
EP4699658A2 (en) 2017-04-19 2026-02-25 Cedars-Sinai Medical Center Methods and compositions for treating skeletal muscular dystrophy
TWI704923B (zh) * 2017-06-26 2020-09-21 台灣基督長老教會馬偕醫療財團法人馬偕紀念醫院 包含胞外囊泡之製劑、用以製備該製劑之方法及其用途
US12377120B2 (en) 2017-07-06 2025-08-05 Children's National Medical Center Exosomes and methods of use thereof
KR20190011213A (ko) * 2017-07-24 2019-02-01 한양대학교 에리카산학협력단 줄기세포로부터 추출된 엑소좀을 유효성분으로 포함하는 골다공증 예방 또는 치료용 조성물
CA3072562A1 (en) 2017-08-15 2019-02-21 Children's Medical Center Corporation Purified mesenchymal stem cell exosomes and uses thereof
US11471559B2 (en) * 2017-11-20 2022-10-18 Vivex Biologics Group, Inc. Bioenergetic bone
US11660355B2 (en) 2017-12-20 2023-05-30 Cedars-Sinai Medical Center Engineered extracellular vesicles for enhanced tissue delivery
US12146137B2 (en) 2018-02-05 2024-11-19 Cedars-Sinai Medical Center Methods for therapeutic use of exosomes and Y-RNAS
CN112334190B (zh) 2018-04-30 2024-09-20 儿童医学中心公司 间充质基质细胞外排体及其用途
US12031976B2 (en) 2018-05-04 2024-07-09 Samsung Life Public Welfare Foundation Screening method for therapeutic substance for preventing or treating bronchopulmonary dysplasia (BPD)
JP2021526556A (ja) * 2018-05-30 2021-10-07 ダイレクト バイオロジクス エルエルシー 成長因子および細胞外小胞を凍結または粉状にした、間葉系幹細胞(msc)の調製物を含む助剤、ならびにその使用方法
KR102863376B1 (ko) * 2018-06-11 2025-09-24 헬스 앤드 바이오테크 프랑스 (에이치 앤드 비 프랑스) 중간엽 줄기 세포로부터 유래된 세포외 소포
EP3813858B1 (en) * 2018-06-29 2023-11-01 North Carolina State University Therapeutic lung repair by inhalation of lung spheroid exosomes
AU2019312212B2 (en) * 2018-07-24 2024-10-10 Mayo Foundation For Medical Education And Research Compositions and methods involving transforming extracellular vesicles
MA53273A (fr) 2018-08-10 2021-06-16 Omnispirant Ltd Vésicules extracellulaires pour inhalation
EP3879980A4 (en) * 2018-11-15 2022-08-24 Washington University EXTRACELLULAR VESICLES DERIVED FROM STEM CELLS AND METHODS OF USE THEREOF
BR112021015549A2 (pt) 2019-02-07 2021-10-26 Direct Biologics Llc Método para tratar osteoartrite com uma combinação de exossomos de células tronco mesenquimais, células tronco mesenquimais sinoviais e andaimes
AU2020228303B2 (en) * 2019-02-28 2025-09-18 Merakris Therapeutics Llc Amniotic fluid-derived extracellular vesicles and uses thereof for wound healing
JP7372518B2 (ja) * 2019-06-27 2023-11-01 国立大学法人山口大学 骨髄由来間葉系幹細胞の培養方法
CA3146433A1 (en) 2019-07-18 2021-01-21 Direct Biologics Llc Preparations comprising mesenchymal stem cells and cannabinoids and methods of their use
CN114269358A (zh) * 2019-07-31 2022-04-01 上海圣特佳健康科技发展有限公司 针对纤维化、炎症、和/或老化疾病的治疗药物
US20210052641A1 (en) * 2019-08-23 2021-02-25 United Therapeutics Corporation Pre-conditioned extracellular vesicles and methods of production
CN110777113B (zh) * 2019-09-10 2021-09-24 中山大学 一种用于日本血吸虫感染治疗的间质干细胞处理方法
CA3163871A1 (en) * 2019-12-04 2021-06-10 United Therapeutics Corporation Extracellular vesicles and their uses
CN113384597A (zh) * 2020-03-13 2021-09-14 西比曼生物科技(上海)有限公司 含人体细胞衍生的细胞膜外囊泡的雾化吸入制剂、制法及其应用
CN111346110A (zh) * 2020-03-17 2020-06-30 遵义医学院附属医院 间充质干细胞上清液在制备治疗肺细胞损伤制剂中的应用
US12590310B2 (en) 2020-04-22 2026-03-31 Direct Biologics, Llc Methods and compositions for treating inflammatory conditions associated with infectious disease
EP4179072B1 (en) * 2020-07-09 2025-09-03 Exo Biologics Sa Process for the manufacturing of protein-associated extracellular vesicles
US20230248773A1 (en) 2020-07-09 2023-08-10 Exo Biologics Sa Extracellular Vesicles and Compositions Thereof
WO2022018729A1 (en) * 2020-07-20 2022-01-27 Brainstorm Cell Therapeutics Ltd. Methods and compositions for treating lung conditions
CN112043686A (zh) * 2020-09-21 2020-12-08 沈阳三禾生物科技有限公司 脐带间充质干细胞外泌体雾化液在制备治疗哮喘产品中的应用
CN112007049A (zh) * 2020-09-21 2020-12-01 济南磐升生物技术有限公司 一种用于治疗膝骨关节炎的干细胞外泌体组合物
EP4240323A1 (en) * 2020-11-06 2023-09-13 AATEC Medical GmbH A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections
EP3995130A1 (en) * 2020-11-06 2022-05-11 JunctuCell Biomed Manufacturing GmbH A composition comprising extra-cellular vesicles from mesenchymal stem cells and alpha-1 antitrypsin for the treatment of viral infections
EP4252761A4 (en) * 2020-11-26 2024-06-05 Samsung Life Public Welfare Foundation COMPOSITION FOR THE TREATMENT OF INFECTIOUS DISEASES, COMPRISING EXOSOMES DERIVED FROM THROMBIN-PROCESSED STEM CELLS
USD1046870S1 (en) 2020-12-08 2024-10-15 Samsung Electronics Co., Ltd. Accessory panel for television receiver
CN112675203A (zh) * 2021-02-08 2021-04-20 瑞太生物科技(沈阳)有限公司 一种细胞来源的外泌体在制备治疗哮喘和/或肺纤维化生物制剂中的应用
US20240376434A1 (en) 2021-09-16 2024-11-14 Life Technologies Corporation Cell expansion methods and compositions for use therein
JP7773257B2 (ja) 2022-03-28 2025-11-19 合同会社HiRoko Science miR-140を含む医薬組成物及びその製造方法
CN115725499B (zh) * 2022-08-15 2025-08-15 哈尔滨医科大学 一种人脐带间充质干细胞膜仿生纳米囊泡的制备方法和应用
CN116897887A (zh) * 2023-07-31 2023-10-20 湖南中医药大学 一种病毒性哮喘动物模型的构建方法
US12502407B2 (en) 2024-04-25 2025-12-23 Direct Biologics, Llc Treatment of fistula with bone marrow mesenchymal stem cell derived extracellular vesicles
WO2025250774A1 (en) * 2024-05-31 2025-12-04 Leksum LLC Extracellular vesicles for therapy

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
FR2766205B1 (fr) * 1997-07-16 2002-08-30 Inst Nat Sante Rech Med Nouveau procede de sensibilisation de cellules presentatrices d'antigene et nouveaux moyens pour la mise en oeuvre du procede
US20030221199A1 (en) * 1998-10-20 2003-11-27 Whitsett Jeffrey A. Surfactant protein D for the prevention and diagnosis of pulmonary emphysema
US20040214783A1 (en) * 2002-05-08 2004-10-28 Terman David S. Compositions and methods for treatment of neoplastic disease
US20080095749A1 (en) * 2004-03-22 2008-04-24 Sudeepta Aggarwal Mesenchymal stem cells and uses therefor
US8021847B2 (en) 2004-06-02 2011-09-20 Proxy Life Science Holdings, Inc. Microvesicle-based compositions and methods
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
WO2006110582A1 (en) 2005-04-08 2006-10-19 Xcyte Therapies, Inc. Compositions and methods for the treatment of burns and sepsis
BRPI0617085A2 (pt) 2005-09-02 2016-11-08 Agency Science Tech & Res método para obter uma célula-tronco mesenquimal (msc), célula ou linhagem celular, método para derivar uma cultura celular a partir de uma célula-tronco embrionária, método para tratamento de uma doença, uso de uma célula-tronco mesenquimal, linhagem diferenciada, composição farmacêutica, método para condicionar um meio de cultura celular, meio condicionado e uso do mesmo, mpetodo para obterum polipeptídeo, método para obtar uma cultura celular, cultura celular, célula-tronco mesenquimal, linhagem de célula-tronco mesenquimal ou uma célula mesenquimal diferenciada
WO2007124594A1 (en) * 2006-04-27 2007-11-08 Cell Therapy Technologies, Inc. Et Al. Stem cells for treating lung diseases
EP2617428A1 (en) 2006-08-15 2013-07-24 Agency for Science, Technology and Research Mesenchymal stem cell conditioned medium
EP2076116A4 (en) * 2006-10-11 2010-04-07 Gen Hospital Corp COMPOSITIONS, METHODS, AND DEVICES FOR TREATING HEPATIC DISEASES
CN102014934B (zh) * 2008-02-22 2014-08-20 新加坡科技研究局 间充质干细胞颗粒
EP2456861A4 (en) 2009-07-23 2013-12-04 Agency Science Tech & Res PRENATAL MESENCHYMAL STEM CELLS
SG2014010698A (en) 2009-11-02 2014-05-29 Agency Science Tech & Res Methods of monitoring cellular states
KR101189655B1 (ko) * 2010-06-30 2012-10-11 성균관대학교산학협력단 줄기세포 배양액을 포함하는 폐질환 치료용 조성물
CN101890050B (zh) 2010-07-14 2012-07-04 江苏大学 脐带间质干细胞来源膜性囊泡及其应用
CA2845280A1 (en) 2010-08-13 2012-02-16 Paul Shiels Therapeutic uses of microvesicles and related micrornas
WO2012115885A1 (en) 2011-02-22 2012-08-30 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Circulating biomarkers
CA2829586C (en) * 2011-03-11 2021-03-02 Children's Medical Center Corporation Methods and compositions relating to mesenchymal stem cell exosomes
SG11201406336YA (en) 2012-04-03 2014-11-27 Reneuron Ltd Stem cell microparticles
CA2949083C (en) 2014-05-18 2023-10-10 Children's Medical Center Corporation Methods and compositions relating to exosomes

Also Published As

Publication number Publication date
KR102063069B1 (ko) 2020-01-08
US20220096560A1 (en) 2022-03-31
JP2014507482A (ja) 2014-03-27
JP2018030845A (ja) 2018-03-01
JP6204830B2 (ja) 2017-09-27
CN109432126B (zh) 2022-06-14
JP6524162B2 (ja) 2019-06-05
CA2829586A1 (en) 2012-09-20
KR101947699B1 (ko) 2019-02-14
US9901600B2 (en) 2018-02-27
KR20190018536A (ko) 2019-02-22
CA2829586C (en) 2021-03-02
US20140065240A1 (en) 2014-03-06
EP2683389B1 (en) 2017-05-03
US20180221412A1 (en) 2018-08-09
EP2683389A1 (en) 2014-01-15
WO2012125471A9 (en) 2012-11-08
CN103648509B (zh) 2019-02-22
CN109432126A (zh) 2019-03-08
WO2012125471A1 (en) 2012-09-20
CN103648509A (zh) 2014-03-19
KR20140024310A (ko) 2014-02-28

Similar Documents

Publication Publication Date Title
ES2629502T3 (es) Métodos y composiciones relacionados con exosomas de células madre mesenquimales
US11759481B2 (en) Methods and compositions relating to exosomes
JP6796143B2 (ja) トロンビン処理幹細胞に由来するエキソソームを含む慢性肺疾患治療用組成物
JP2020531011A (ja) 精製された間葉系幹細胞エキソソームおよびその使用
US20230141224A1 (en) Fibroblast mediated expansion and augmentation of immune regulatory cells for treatment of acute respiratory distress syndrome (ards)
Bisaccia Study of the mechanism of action of extracellular vesicles derived from umbilical cord stromal cells in a rat model of bronchopulmonary dysplasia: focus on oxidative stress and fibrosis processes.