ES2617484T3 - Derivado de piridona - Google Patents

Derivado de piridona Download PDF

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Publication number
ES2617484T3
ES2617484T3 ES13743985.7T ES13743985T ES2617484T3 ES 2617484 T3 ES2617484 T3 ES 2617484T3 ES 13743985 T ES13743985 T ES 13743985T ES 2617484 T3 ES2617484 T3 ES 2617484T3
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ES
Spain
Prior art keywords
group
substituents selected
halogen atom
compound
alkyl group
Prior art date
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Active
Application number
ES13743985.7T
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English (en)
Spanish (es)
Inventor
Hitoshi Ohki
Masahiro Ota
Kosuke Takeuchi
Hideaki Watanabe
Akitake YAMAGUCHI
Yoshihiro Shibata
Yuichi Tominaga
Takeshi Jimbo
Keijiro Kobayashi
Katsuhiro Kobayashi
Daisuke FUKATSU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Daiichi Sankyo Co Ltd
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Daiichi Sankyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Application granted granted Critical
Publication of ES2617484T3 publication Critical patent/ES2617484T3/es
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D213/00Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81Amides; Imides
    • C07D213/82Amides; Imides in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D451/00Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES13743985.7T 2012-01-31 2013-01-30 Derivado de piridona Active ES2617484T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JP2012017971 2012-01-31
JP2012017971 2012-01-31
US201261746039P 2012-12-26 2012-12-26
US201261746039P 2012-12-26
PCT/JP2013/052111 WO2013115280A1 (ja) 2012-01-31 2013-01-30 ピリドン誘導体

Publications (1)

Publication Number Publication Date
ES2617484T3 true ES2617484T3 (es) 2017-06-19

Family

ID=48905312

Family Applications (1)

Application Number Title Priority Date Filing Date
ES13743985.7T Active ES2617484T3 (es) 2012-01-31 2013-01-30 Derivado de piridona

Country Status (30)

Country Link
US (1) US8933103B2 (enExample)
EP (1) EP2810937B1 (enExample)
JP (1) JP6006241B2 (enExample)
KR (1) KR102078530B1 (enExample)
CN (1) CN104185627B (enExample)
AU (1) AU2013216006B2 (enExample)
BR (1) BR112014018702B1 (enExample)
CA (1) CA2863515C (enExample)
CO (1) CO7071126A2 (enExample)
CY (1) CY1118656T1 (enExample)
DK (1) DK2810937T3 (enExample)
ES (1) ES2617484T3 (enExample)
HR (1) HRP20170303T1 (enExample)
HU (1) HUE031624T2 (enExample)
IL (1) IL233863A (enExample)
LT (1) LT2810937T (enExample)
MX (1) MX351812B (enExample)
MY (1) MY165215A (enExample)
NZ (1) NZ627586A (enExample)
PH (1) PH12014501719B1 (enExample)
PL (1) PL2810937T3 (enExample)
PT (1) PT2810937T (enExample)
RS (1) RS55728B1 (enExample)
RU (1) RU2632885C2 (enExample)
SG (1) SG11201404505PA (enExample)
SI (1) SI2810937T1 (enExample)
SM (2) SMT201700065T1 (enExample)
TW (1) TWI537259B (enExample)
WO (1) WO2013115280A1 (enExample)
ZA (1) ZA201405486B (enExample)

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JP6885390B2 (ja) 2016-02-26 2021-06-16 小野薬品工業株式会社 Axl阻害剤と免疫チェックポイント阻害剤とを組み合わせて投与することを特徴とする癌治療のための医薬
KR102744951B1 (ko) 2016-03-28 2024-12-23 인사이트 코포레이션 Tam 억제제로서 피롤로트리아진 화합물
CN108250200A (zh) * 2016-12-28 2018-07-06 中国科学院上海药物研究所 一种具有Axl抑制活性的化合物及其制备和应用
WO2019039525A1 (ja) 2017-08-23 2019-02-28 小野薬品工業株式会社 Axl阻害剤を有効成分として含むがん治療剤
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CN112625026B (zh) * 2019-09-24 2022-09-09 药捷安康(南京)科技股份有限公司 Tam家族激酶抑制剂的喹啉衍生物
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AU2020391425A1 (en) * 2019-11-26 2022-06-16 Board Of Regents, The University Of Texas System Inhibitors of Receptor Interacting Protein Kinase 1 for the treatment of disease
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Also Published As

Publication number Publication date
NZ627586A (en) 2016-08-26
HK1203504A1 (en) 2015-10-30
BR112014018702A2 (enExample) 2017-06-20
AU2013216006A1 (en) 2014-08-28
CN104185627A (zh) 2014-12-03
MY165215A (en) 2018-03-09
SMT201700065T1 (it) 2017-03-08
CA2863515C (en) 2018-02-27
PH12014501719B1 (en) 2019-07-17
MX351812B (es) 2017-10-27
LT2810937T (lt) 2017-02-10
TWI537259B (zh) 2016-06-11
SG11201404505PA (en) 2014-10-30
CY1118656T1 (el) 2017-07-12
JPWO2013115280A1 (ja) 2015-05-11
CA2863515A1 (en) 2013-08-08
KR20140117439A (ko) 2014-10-07
JP6006241B2 (ja) 2016-10-12
HUE031624T2 (en) 2017-07-28
IL233863A0 (en) 2014-09-30
EP2810937A1 (en) 2014-12-10
AU2013216006B2 (en) 2017-06-08
US8933103B2 (en) 2015-01-13
PT2810937T (pt) 2017-03-03
KR102078530B1 (ko) 2020-02-18
EP2810937B1 (en) 2016-11-30
TW201335148A (zh) 2013-09-01
SI2810937T1 (sl) 2017-01-31
BR112014018702B1 (pt) 2021-12-14
CO7071126A2 (es) 2014-09-30
SMT201700065B (it) 2017-03-08
PH12014501719A1 (en) 2014-11-10
RS55728B1 (sr) 2017-07-31
CN104185627B (zh) 2018-01-12
US20130281428A1 (en) 2013-10-24
ZA201405486B (en) 2015-11-25
HRP20170303T1 (hr) 2017-04-21
RU2014135401A (ru) 2016-03-20
MX2014009246A (es) 2014-10-14
PL2810937T3 (pl) 2017-07-31
EP2810937A4 (en) 2015-07-22
RU2632885C2 (ru) 2017-10-11
WO2013115280A1 (ja) 2013-08-08
DK2810937T3 (en) 2017-03-13
BR112014018702A8 (pt) 2017-07-11
IL233863A (en) 2017-08-31

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