ES2608483T3 - Método mejorado de administración de beta-hidroxi-beta-metilbutirato (HMB) - Google Patents
Método mejorado de administración de beta-hidroxi-beta-metilbutirato (HMB) Download PDFInfo
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- ES2608483T3 ES2608483T3 ES10838355.5T ES10838355T ES2608483T3 ES 2608483 T3 ES2608483 T3 ES 2608483T3 ES 10838355 T ES10838355 T ES 10838355T ES 2608483 T3 ES2608483 T3 ES 2608483T3
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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Applications Claiming Priority (3)
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| US28785709P | 2009-12-18 | 2009-12-18 | |
| US287857P | 2009-12-18 | ||
| PCT/US2010/061367 WO2011075741A1 (en) | 2009-12-18 | 2010-12-20 | Improved method of administering beta-hydroxy-beta-methylbutyrate (hmb) |
Publications (1)
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| ES2608483T3 true ES2608483T3 (es) | 2017-04-11 |
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| ES10838355.5T Active ES2608483T3 (es) | 2009-12-18 | 2010-12-20 | Método mejorado de administración de beta-hidroxi-beta-metilbutirato (HMB) |
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| EP (1) | EP2512236B1 (enExample) |
| JP (2) | JP6077857B2 (enExample) |
| CN (1) | CN102762097B (enExample) |
| CA (1) | CA2784836C (enExample) |
| DK (1) | DK2512236T3 (enExample) |
| ES (1) | ES2608483T3 (enExample) |
| HU (1) | HUE032486T2 (enExample) |
| PL (1) | PL2512236T3 (enExample) |
| PT (1) | PT2512236T (enExample) |
| WO (1) | WO2011075741A1 (enExample) |
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| MX2014000419A (es) * | 2011-07-15 | 2014-09-22 | Nusirt Sciences Inc | Composicones y metodos para modular trayectorias metabolicas. |
| BR112015005199B1 (pt) * | 2012-09-10 | 2022-09-06 | Metabolic Technologies, Inc | Composição, e, método para fornecer um benefício a um animal em necessidade do mesmo |
| EP2993994A4 (en) * | 2013-03-14 | 2016-11-23 | Metabolic Technologies Inc | LIQUIDS AND FOODS WITH BETA-HYDROXY-BETA-METHYLBUTYRATE (HMB) IN A FREE ACID FORM |
| WO2014152606A2 (en) | 2013-03-14 | 2014-09-25 | Abbott Laboratories | Treatment of insulin resistance associated with prolonged physical inactivity |
| US20140272000A1 (en) * | 2013-03-14 | 2014-09-18 | Metabolic Technologies, Inc. | Liquids and Foodstuffs Containing beta-hydroxy-beta-methylbutyrate (HMB) in the Free Acid Form and Methods of Manufacturing or Producing the Same |
| CA2903561C (en) * | 2013-03-15 | 2017-09-26 | Abbott Laboratories | Nutritional compositions including calcium beta-hydroxy-beta-methylbutyrate, casein phosphopeptide, and protein |
| US20150057350A1 (en) * | 2013-08-23 | 2015-02-26 | Abbott Laboratories | Fibrosis biomarkers and methods of using same |
| EP3082778B1 (en) * | 2013-12-18 | 2019-04-03 | Capsugel Belgium NV | Stable liquid filled hard capsule comprising beta-hydroxy-beta-methylbutyric acid |
| WO2015105981A2 (en) * | 2014-01-09 | 2015-07-16 | Abbott Laboratories | Conditional essentiality of hmb |
| CN106536060A (zh) | 2014-01-28 | 2017-03-22 | 卫理公会医院 | 包括单细胞移液器手柄和单细胞移液器尖端的单细胞移液器组件 |
| JP6309287B2 (ja) * | 2014-01-29 | 2018-04-11 | 協和発酵バイオ株式会社 | ３−ヒドロキシ−３−メチル酪酸カルシウム含有飲料 |
| CN118844612A (zh) * | 2014-03-14 | 2024-10-29 | 代谢科技有限公司 | 含有游离酸形式的β-羟基-β-甲基丁酸盐(HMB)的液体和食品 |
| US20160184248A1 (en) * | 2014-12-15 | 2016-06-30 | University Of Central Florida Research Foundation Inc. | Compositions and methods of use of -hydroxy-methylbutyrate (hmb) resulting in an acute endocrine response |
| ES2937282T3 (es) * | 2015-06-01 | 2023-03-27 | Metabolic Tech Llc | Composiciones y métodos de uso del beta-hidroxi-beta-metilbutirato (HMB) para disminuir la masa grasa |
| AU2016323779B2 (en) * | 2015-09-16 | 2022-03-17 | Metabolic Technologies, Inc. | Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma |
| US12208073B2 (en) | 2015-09-16 | 2025-01-28 | Metabolic Technologies, LLC | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) for enhancing recovery from soft tissue trauma |
| BR112018009406A8 (pt) | 2015-11-10 | 2019-02-26 | Metabolic Tech Inc | ?composição de aditivo de ração, produto de ração, método para prevenir, eliminar e/ou reduzir crescimento microbiano, e, revestimento para um produto de ração animal? |
| AU2017207910B2 (en) * | 2016-01-13 | 2022-09-01 | Metabolic Technologies, Inc. | Compositions and methods of use of β-hydroxy-β-methylbutyrate (HMB) for joint stability |
| CN121695115A (zh) | 2016-01-21 | 2026-03-20 | 代谢科技有限责任公司 | β-羟基-β-甲基丁酸(HMB)用于调节自噬和噬脂的组合物和方法 |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US12496283B2 (en) | 2016-04-19 | 2025-12-16 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
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| US12109182B2 (en) | 2016-04-19 | 2024-10-08 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate and related compounds in humans |
| US12521378B2 (en) | 2016-04-19 | 2026-01-13 | Axcess Global Sciences, Llc | Administration of R-beta-hydroxybutyrate salt blend and related compounds in humans |
| US20230346721A1 (en) | 2018-04-18 | 2023-11-02 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for delivery of ketone bodies |
| US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
| US12533346B2 (en) | 2016-04-19 | 2026-01-27 | Axcess Global Sciences, Llc | Administration of berberine metabolites |
| US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
| US12622889B2 (en) | 2016-04-19 | 2026-05-12 | Axcess Global Sciences, Llc | S-β-hydroxybutyrate esters for improving metabolic function |
| US12329734B2 (en) | 2017-12-19 | 2025-06-17 | Axcess Global Sciences, Llc | Use of S-beta-hydroxybutyrate compounds for induction and maintenance of flow |
| US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
| US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
| RU2018145520A (ru) * | 2016-05-25 | 2020-06-25 | ТиЭсАй ГРУП ЛТД. | Стабилизация композиций бета-гидроксиизовалериановых кислот в мягких гелевых капсулах |
| US10588877B2 (en) | 2016-07-21 | 2020-03-17 | Savind, Inc. | Compositions comprising β-hydroxybutyric acid and salt, and methods of using the same |
| JP7583523B2 (ja) | 2016-10-21 | 2024-11-14 | メタボリック・テクノロジーズ，インコーポレーテッド | β－ヒドロキシ－β－メチルブチレート（ＨＭＢ）およびプロバイオティックを使用する組成物および方法 |
| US12370159B2 (en) * | 2016-10-21 | 2025-07-29 | Metabolic Technologies, LLC | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (HMB) and probiotics |
| JP7022420B2 (ja) * | 2017-06-30 | 2022-02-18 | 株式会社東洋新薬 | 経口組成物 |
| US12090129B2 (en) | 2017-11-22 | 2024-09-17 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US20190209501A1 (en) * | 2018-01-05 | 2019-07-11 | Texas Tech University Office of Research Commercialization | Compositions and methods of use of beta-hydroxy-beta-methylbutyrate (hmb) assosiated with intermittent fasting |
| US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
| US10888576B2 (en) | 2018-10-08 | 2021-01-12 | Metabolic Technologies, Inc. | Composition of HMB and ATP and methods of use |
| US12472200B2 (en) | 2019-05-15 | 2025-11-18 | Axcess Global Sciences, Llc | Autobiotic compositions and method for promoting healthy gut microbiome |
| US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US12167993B2 (en) | 2019-06-21 | 2024-12-17 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
| US11969430B1 (en) | 2023-03-10 | 2024-04-30 | Axcess Global Sciences, Llc | Compositions containing paraxanthine and beta-hydroxybutyrate or precursor for increasing neurological and physiological performance |
| US12186297B2 (en) | 2020-08-26 | 2025-01-07 | Axcess Global Sciences, Llc | Compositions and methods for increasing lean-to-fat mass ratio |
| CN121695118A (zh) * | 2026-02-13 | 2026-03-20 | 中国科学技术大学 | Hmb或含hmb物质在制备用于预防和/或减轻酒精宿醉和/或缓解急性酒精性肝损伤药物的应用 |
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| US4857552A (en) * | 1988-06-08 | 1989-08-15 | E. I. Du Pont De Nemours And Co. | Stable pharmaceutical composition |
| US5087472A (en) * | 1990-01-30 | 1992-02-11 | Iowa State University Research Foundation, Inc. | Feed compositions for domestics animals containing hydroxymethylbutyrate |
| US5028440A (en) * | 1990-01-30 | 1991-07-02 | Iowa State University Research Foundation, Inc. | Method of raising meat producing animals to increase lean tissue development |
| US4992470A (en) * | 1990-02-08 | 1991-02-12 | Iowa State University Research Foundation, Inc. | Method of enhancing immune response of mammals |
| US5348979A (en) * | 1992-12-23 | 1994-09-20 | Iowa State University Research Foundation Inc. | Method of promoting nitrogen retention in humans |
| US6103764A (en) * | 1997-11-07 | 2000-08-15 | Iowa State University Research Foundation, Inc. | Method for increasing the aerobic capacity of muscle |
| US6031000A (en) * | 1998-06-23 | 2000-02-29 | Iowa State University Research Foundation, Inc. | Composition comprising β-hydroxy-β-methylbutyric acid and at least one amino acid and methods of use |
| US20010008641A1 (en) * | 1998-11-25 | 2001-07-19 | R. Douglas Krotzer | Nutritionally active composition for bodybuilding |
| JP4744081B2 (ja) * | 2001-08-31 | 2011-08-10 | ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー | 植物抽出物を用いて障害を処置するための方法 |
| DE10215007A1 (de) * | 2002-04-05 | 2003-10-16 | Degussa Bioactives Deutschland | Verwendung von Kreatinpyruvat zur Steigerung der Ausdauer bei hochintensiven körperlichen Intervallbelastungen |
| US20040220266A1 (en) * | 2002-09-09 | 2004-11-04 | Wiley David B. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
| WO2005096846A1 (en) * | 2004-03-11 | 2005-10-20 | Wiley Organics, Inc. | Composition and method for enhancing the bioavailability of calcium and magnesium in dietary supplements and food additives |
| US20050215640A1 (en) * | 2004-03-26 | 2005-09-29 | Baxter Jeffrey H | HMB compositions and uses thereof |
| US20080317886A1 (en) * | 2005-11-03 | 2008-12-25 | Sparkman Dennis R | Compositions for Preventing and Reducing Delayed Onset Muscle Soreness |
| DK2381784T3 (en) * | 2008-12-09 | 2018-10-22 | Metabolic Tech Inc | Nutritional intervention to improve muscle function and strength |
| JP2009155336A (ja) * | 2009-03-31 | 2009-07-16 | Tsujido Chemical Corp | 治療剤 |
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- 2010-12-20 PL PL10838355T patent/PL2512236T3/pl unknown
- 2010-12-20 CA CA2784836A patent/CA2784836C/en active Active
- 2010-12-20 US US12/973,803 patent/US20120053240A1/en not_active Abandoned
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- 2010-12-20 WO PCT/US2010/061367 patent/WO2011075741A1/en not_active Ceased
- 2010-12-20 PT PT108383555T patent/PT2512236T/pt unknown
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- 2010-12-20 CN CN201080064031.3A patent/CN102762097B/zh active Active
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2015
- 2015-09-25 JP JP2015188107A patent/JP2016026181A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| PL2512236T3 (pl) | 2017-06-30 |
| PT2512236T (pt) | 2016-12-29 |
| EP2512236B1 (en) | 2016-10-19 |
| DK2512236T3 (en) | 2017-01-16 |
| CN102762097A (zh) | 2012-10-31 |
| JP6077857B2 (ja) | 2017-02-08 |
| US20120053240A1 (en) | 2012-03-01 |
| JP2016026181A (ja) | 2016-02-12 |
| JP2013515009A (ja) | 2013-05-02 |
| WO2011075741A1 (en) | 2011-06-23 |
| EP2512236A4 (en) | 2013-06-19 |
| EP2512236A1 (en) | 2012-10-24 |
| HUE032486T2 (en) | 2018-05-02 |
| CN102762097B (zh) | 2015-06-17 |
| CA2784836A1 (en) | 2011-06-23 |
| CA2784836C (en) | 2019-08-20 |
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