ES2605801T3 - Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia - Google Patents
Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia Download PDFInfo
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- ES2605801T3 ES2605801T3 ES10737699.8T ES10737699T ES2605801T3 ES 2605801 T3 ES2605801 T3 ES 2605801T3 ES 10737699 T ES10737699 T ES 10737699T ES 2605801 T3 ES2605801 T3 ES 2605801T3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6432—Coagulation factor Xa (3.4.21.6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21006—Coagulation factor Xa (3.4.21.6)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22588709P | 2009-07-15 | 2009-07-15 | |
| US225887P | 2009-07-15 | ||
| PCT/US2010/042015 WO2011008885A1 (en) | 2009-07-15 | 2010-07-14 | Unit dose formulation of antidotes for factor xa inhibitors and methods of using the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2605801T3 true ES2605801T3 (es) | 2017-03-16 |
Family
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| ES10737699.8T Active ES2605801T3 (es) | 2009-07-15 | 2010-07-14 | Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia |
Country Status (8)
| Country | Link |
|---|---|
| US (8) | US9056106B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2453910B1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP6163304B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN102625712B (cg-RX-API-DMAC7.html) |
| CA (1) | CA2767858C (cg-RX-API-DMAC7.html) |
| ES (1) | ES2605801T3 (cg-RX-API-DMAC7.html) |
| PT (1) | PT2453910T (cg-RX-API-DMAC7.html) |
| WO (1) | WO2011008885A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2016072B1 (en) | 2006-05-05 | 2014-07-16 | Millennium Pharmaceuticals, Inc. | Factor xa inhibitors |
| EP3824902A1 (en) | 2007-09-28 | 2021-05-26 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| LT3604510T (lt) * | 2009-03-30 | 2025-07-10 | Alexion Pharmaceuticals, Inc. | Faktoriaus xa inhibitorius neutralizuojančios medžiagos ir jų naudojimo būdai |
| PT2453910T (pt) * | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
| US8742120B2 (en) * | 2009-12-17 | 2014-06-03 | Millennium Pharmaceuticals, Inc. | Methods of preparing factor xa inhibitors and salts thereof |
| US8530501B2 (en) * | 2009-12-17 | 2013-09-10 | Millennium Pharmaceuticals, Inc. | Salts and crystalline forms of a factor Xa inhibitor |
| HK1205188A1 (en) * | 2012-02-14 | 2015-12-11 | Portola Pharmaceuticals, Inc. | Process for making recombinant antidote to factor xa inhibitor |
| WO2013123248A1 (en) | 2012-02-16 | 2013-08-22 | Portola Pharmaceuticals, Inc. | MODULATION OF FACTOR Xa INHIBITOR MEDIATED BLOOD LOSS BY PARTIAL AND TRANSIENT ADMINISTRATION OF ANTIDOTE |
| IN2015DN01404A (cg-RX-API-DMAC7.html) | 2012-07-25 | 2015-07-03 | Catalyst Biosciences Inc | |
| FR3000895B1 (fr) * | 2013-01-11 | 2017-02-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies Sa | Utilisation d'antidotes d'inhibiteurs de la coagulation indiques dans la prevention ou le traitement de pathologies thromboemboliques |
| EP2948168B1 (en) * | 2013-01-24 | 2018-07-18 | Portola Pharmaceuticals, Inc. | Inhibition of tissue factor pathway inhibitor with factor xa derivatives |
| HK1215196A1 (zh) * | 2013-01-31 | 2016-08-19 | 辉瑞公司 | 用於抵消因子xa抑制的组合物和方法 |
| SG11201601221XA (en) | 2013-09-24 | 2016-04-28 | Pfizer | Compositions comprising heterogeneous populations of recombinant human clotting factor xa proteins |
| WO2015066606A2 (en) * | 2013-11-01 | 2015-05-07 | The Children's Hospital Of Philadelphia | Compositions and methods for increasing the half-life of factor xa |
| EP3096779B1 (en) * | 2014-01-24 | 2019-12-18 | Pfizer Inc | Compositions and methods for treating intracerebral hemorrhage |
| US9545383B2 (en) | 2014-04-01 | 2017-01-17 | Massachusetts Institute Of Technology | Blood clotting control |
| MA40042B1 (fr) | 2014-05-26 | 2020-08-31 | Academisch Ziekenhuis Leiden | Protéines prohémostatiques pour le traitement de saignement |
| US10676731B2 (en) | 2014-08-19 | 2020-06-09 | The Children's Hospital Of Philadelphia | Compositions and methods for modulating factor IX function |
| KR20250150675A (ko) * | 2014-08-20 | 2025-10-20 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
| CN108883160B (zh) * | 2016-02-24 | 2022-06-28 | 博尔托拉制药公司 | 因子xa解毒剂的冻干制剂 |
| TW201802121A (zh) | 2016-05-25 | 2018-01-16 | 諾華公司 | 抗因子XI/XIa抗體之逆轉結合劑及其用途 |
| CN116425860B (zh) | 2016-06-17 | 2025-03-04 | 阿雷克森制药公司 | 因子xa衍生物的制备 |
| US11168147B2 (en) | 2016-12-23 | 2021-11-09 | Novartis Ag | Factor XI antibodies and methods of use |
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2010
- 2010-07-14 PT PT107376998T patent/PT2453910T/pt unknown
- 2010-07-14 WO PCT/US2010/042015 patent/WO2011008885A1/en not_active Ceased
- 2010-07-14 JP JP2012520756A patent/JP6163304B2/ja active Active
- 2010-07-14 EP EP10737699.8A patent/EP2453910B1/en active Active
- 2010-07-14 CN CN201080040105.XA patent/CN102625712B/zh active Active
- 2010-07-14 US US12/836,536 patent/US9056106B2/en active Active
- 2010-07-14 ES ES10737699.8T patent/ES2605801T3/es active Active
- 2010-07-14 CA CA2767858A patent/CA2767858C/en active Active
-
2014
- 2014-06-30 US US14/320,199 patent/US20150025011A1/en not_active Abandoned
-
2015
- 2015-08-10 JP JP2015158084A patent/JP2015205933A/ja active Pending
-
2016
- 2016-07-15 US US15/212,105 patent/US20170014492A1/en not_active Abandoned
-
2017
- 2017-12-06 US US15/833,520 patent/US10765726B2/en active Active
-
2020
- 2020-07-30 US US16/943,933 patent/US20210085762A1/en not_active Abandoned
-
2022
- 2022-01-05 US US17/569,402 patent/US20230000957A1/en not_active Abandoned
-
2023
- 2023-07-14 US US18/352,637 patent/US20240189401A1/en not_active Abandoned
-
2024
- 2024-10-08 US US18/909,369 patent/US20250186563A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US20170014492A1 (en) | 2017-01-19 |
| US9056106B2 (en) | 2015-06-16 |
| US20250186563A1 (en) | 2025-06-12 |
| WO2011008885A1 (en) | 2011-01-20 |
| US20240189401A1 (en) | 2024-06-13 |
| US10765726B2 (en) | 2020-09-08 |
| US20180236049A1 (en) | 2018-08-23 |
| JP6163304B2 (ja) | 2017-07-12 |
| US20110015128A1 (en) | 2011-01-20 |
| JP2015205933A (ja) | 2015-11-19 |
| US20230000957A1 (en) | 2023-01-05 |
| EP2453910A1 (en) | 2012-05-23 |
| CN102625712A (zh) | 2012-08-01 |
| PT2453910T (pt) | 2016-12-07 |
| US20150025011A1 (en) | 2015-01-22 |
| US20210085762A1 (en) | 2021-03-25 |
| CN102625712B (zh) | 2017-07-25 |
| JP2012533552A (ja) | 2012-12-27 |
| CA2767858A1 (en) | 2011-01-20 |
| CA2767858C (en) | 2019-02-12 |
| EP2453910B1 (en) | 2016-08-31 |
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