ES2600354T3 - Acil-ACP reductasa con propiedades mejoradas - Google Patents
Acil-ACP reductasa con propiedades mejoradas Download PDFInfo
- Publication number
- ES2600354T3 ES2600354T3 ES14716444.6T ES14716444T ES2600354T3 ES 2600354 T3 ES2600354 T3 ES 2600354T3 ES 14716444 T ES14716444 T ES 14716444T ES 2600354 T3 ES2600354 T3 ES 2600354T3
- Authority
- ES
- Spain
- Prior art keywords
- acyl
- fatty
- coli
- coa
- acp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 101710129019 Long-chain acyl-[acyl-carrier-protein] reductase Proteins 0.000 title abstract description 24
- 229920001184 polypeptide Polymers 0.000 abstract description 16
- 102000004196 processed proteins & peptides Human genes 0.000 abstract description 16
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 16
- 150000002192 fatty aldehydes Chemical class 0.000 abstract description 13
- 230000035772 mutation Effects 0.000 abstract description 12
- 238000006243 chemical reaction Methods 0.000 abstract description 2
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 description 39
- 102220184507 rs763093375 Human genes 0.000 description 31
- 102220535257 A disintegrin and metalloproteinase with thrombospondin motifs 9_S96T_mutation Human genes 0.000 description 30
- 102220027168 rs63749950 Human genes 0.000 description 29
- 102220105307 rs879254427 Human genes 0.000 description 23
- 241000588724 Escherichia coli Species 0.000 description 22
- 150000002191 fatty alcohols Chemical class 0.000 description 22
- 235000014113 dietary fatty acids Nutrition 0.000 description 20
- 239000000194 fatty acid Substances 0.000 description 20
- 229930195729 fatty acid Natural products 0.000 description 20
- 150000004665 fatty acids Chemical class 0.000 description 20
- 102000005488 Thioesterase Human genes 0.000 description 18
- 108020002982 thioesterase Proteins 0.000 description 18
- 210000004027 cell Anatomy 0.000 description 17
- 102220519085 Cytochrome P450 1A2_S18C_mutation Human genes 0.000 description 14
- 102220058681 rs786202185 Human genes 0.000 description 14
- 108090000623 proteins and genes Proteins 0.000 description 12
- 102200080102 rs121908643 Human genes 0.000 description 12
- 241001646716 Escherichia coli K-12 Species 0.000 description 11
- 230000015572 biosynthetic process Effects 0.000 description 11
- 108091033319 polynucleotide Proteins 0.000 description 11
- 102000040430 polynucleotide Human genes 0.000 description 11
- 239000002157 polynucleotide Substances 0.000 description 11
- 108010078791 Carrier Proteins Proteins 0.000 description 10
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 10
- 125000002252 acyl group Chemical group 0.000 description 8
- 150000001413 amino acids Chemical group 0.000 description 7
- 238000000034 method Methods 0.000 description 7
- 239000000203 mixture Substances 0.000 description 7
- 102220222142 rs780470521 Human genes 0.000 description 7
- 102220094196 rs876660097 Human genes 0.000 description 7
- 241000219195 Arabidopsis thaliana Species 0.000 description 6
- 108010018763 Biotin carboxylase Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 6
- 108090000854 Oxidoreductases Proteins 0.000 description 6
- 230000000875 corresponding effect Effects 0.000 description 6
- 125000003729 nucleotide group Chemical group 0.000 description 6
- 102200158393 rs5030732 Human genes 0.000 description 6
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 6
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 6
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 5
- 102000004316 Oxidoreductases Human genes 0.000 description 5
- 102220471966 Single-stranded DNA cytosine deaminase_R19V_mutation Human genes 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 235000019270 ammonium chloride Nutrition 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 238000009396 hybridization Methods 0.000 description 5
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 4
- 102000000452 Acetyl-CoA carboxylase Human genes 0.000 description 4
- 108010016219 Acetyl-CoA carboxylase Proteins 0.000 description 4
- 241000588625 Acinetobacter sp. Species 0.000 description 4
- 101100388296 Arabidopsis thaliana DTX51 gene Proteins 0.000 description 4
- 108020004414 DNA Proteins 0.000 description 4
- LTYOQGRJFJAKNA-KKIMTKSISA-N Malonyl CoA Natural products S(C(=O)CC(=O)O)CCNC(=O)CCNC(=O)[C@@H](O)C(CO[P@](=O)(O[P@](=O)(OC[C@H]1[C@@H](OP(=O)(O)O)[C@@H](O)[C@@H](n2c3ncnc(N)c3nc2)O1)O)O)(C)C LTYOQGRJFJAKNA-KKIMTKSISA-N 0.000 description 4
- 101100215626 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ADP1 gene Proteins 0.000 description 4
- 230000002596 correlated effect Effects 0.000 description 4
- 230000002068 genetic effect Effects 0.000 description 4
- 108090001018 hexadecanal dehydrogenase (acylating) Proteins 0.000 description 4
- 239000000543 intermediate Substances 0.000 description 4
- LTYOQGRJFJAKNA-DVVLENMVSA-N malonyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)=O)O[C@H]1N1C2=NC=NC(N)=C2N=C1 LTYOQGRJFJAKNA-DVVLENMVSA-N 0.000 description 4
- 239000011159 matrix material Substances 0.000 description 4
- 239000002773 nucleotide Substances 0.000 description 4
- -1 polypropylene Polymers 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 102220049163 rs35498994 Human genes 0.000 description 4
- 102200007298 rs587777310 Human genes 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 101150087812 tesA gene Proteins 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- 102000007698 Alcohol dehydrogenase Human genes 0.000 description 3
- 108010021809 Alcohol dehydrogenase Proteins 0.000 description 3
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 3
- 240000006262 Cuphea hookeriana Species 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 3
- 108090001042 Hydro-Lyases Proteins 0.000 description 3
- 102000004195 Isomerases Human genes 0.000 description 3
- 108090000769 Isomerases Proteins 0.000 description 3
- 108091028043 Nucleic acid sequence Proteins 0.000 description 3
- OWMVSZAMULFTJU-UHFFFAOYSA-N bis-tris Chemical compound OCCN(CCO)C(CO)(CO)CO OWMVSZAMULFTJU-UHFFFAOYSA-N 0.000 description 3
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 3
- 239000001110 calcium chloride Substances 0.000 description 3
- 235000011148 calcium chloride Nutrition 0.000 description 3
- 229910001628 calcium chloride Inorganic materials 0.000 description 3
- 150000002185 fatty acyl-CoAs Chemical class 0.000 description 3
- 238000000855 fermentation Methods 0.000 description 3
- 230000004151 fermentation Effects 0.000 description 3
- 239000008103 glucose Substances 0.000 description 3
- 229910052943 magnesium sulfate Inorganic materials 0.000 description 3
- 235000019341 magnesium sulphate Nutrition 0.000 description 3
- 230000002018 overexpression Effects 0.000 description 3
- 239000013612 plasmid Substances 0.000 description 3
- 102220201747 rs140921822 Human genes 0.000 description 3
- 102200043783 rs17850684 Human genes 0.000 description 3
- 102220227358 rs748198457 Human genes 0.000 description 3
- 241000894007 species Species 0.000 description 3
- UNFWWIHTNXNPBV-WXKVUWSESA-N spectinomycin Chemical compound O([C@@H]1[C@@H](NC)[C@@H](O)[C@H]([C@@H]([C@H]1O1)O)NC)[C@]2(O)[C@H]1O[C@H](C)CC2=O UNFWWIHTNXNPBV-WXKVUWSESA-N 0.000 description 3
- 229960000268 spectinomycin Drugs 0.000 description 3
- 229940101691 thiamine 10 mg Drugs 0.000 description 3
- 102220556912 ATPase WRNIP1_V18A_mutation Human genes 0.000 description 2
- 102100027841 Acyl-CoA wax alcohol acyltransferase 2 Human genes 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 101100098786 Bacillus subtilis (strain 168) tapA gene Proteins 0.000 description 2
- 241000255789 Bombyx mori Species 0.000 description 2
- 241000080039 Candidatus Protochlamydia amoebophila UWE25 Species 0.000 description 2
- 108010019670 Chimeric Antigen Receptors Proteins 0.000 description 2
- 241000193454 Clostridium beijerinckii Species 0.000 description 2
- 101000836720 Dictyostelium discoideum Aldose reductase A Proteins 0.000 description 2
- 101100321116 Escherichia coli (strain K12) yqhD gene Proteins 0.000 description 2
- 241001302584 Escherichia coli str. K-12 substr. W3110 Species 0.000 description 2
- 101150071111 FADD gene Proteins 0.000 description 2
- 108010001483 Glycogen Synthase Proteins 0.000 description 2
- 102000004867 Hydro-Lyases Human genes 0.000 description 2
- 102220508034 Mitochondrial folate transporter/carrier_R19A_mutation Human genes 0.000 description 2
- 102220630776 Presenilin-1_S18F_mutation Human genes 0.000 description 2
- 102220469615 Protein unc-13 homolog B_Y23N_mutation Human genes 0.000 description 2
- 241000858013 Shigella sonnei Ss046 Species 0.000 description 2
- 241001313699 Thermosynechococcus elongatus Species 0.000 description 2
- 102000004357 Transferases Human genes 0.000 description 2
- 108090000992 Transferases Proteins 0.000 description 2
- 101100119785 Vibrio anguillarum (strain ATCC 68554 / 775) fatB gene Proteins 0.000 description 2
- 101150070497 accC gene Proteins 0.000 description 2
- 101150008263 accD gene Proteins 0.000 description 2
- 101150079502 acr1 gene Proteins 0.000 description 2
- 125000000539 amino acid group Chemical group 0.000 description 2
- 238000004364 calculation method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 101150015067 fabB gene Proteins 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 2
- VOFUROIFQGPCGE-UHFFFAOYSA-N nile red Chemical compound C1=CC=C2C3=NC4=CC=C(N(CC)CC)C=C4OC3=CC(=O)C2=C1 VOFUROIFQGPCGE-UHFFFAOYSA-N 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 description 2
- 239000012074 organic phase Substances 0.000 description 2
- 101710197907 rDNA transcriptional regulator pol5 Proteins 0.000 description 2
- 238000010188 recombinant method Methods 0.000 description 2
- 102220007531 rs387906616 Human genes 0.000 description 2
- 102220054936 rs727504169 Human genes 0.000 description 2
- 102220105306 rs879254426 Human genes 0.000 description 2
- 101150004862 secG gene Proteins 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- 108010055682 3-hydroxybutyryl-CoA dehydrogenase Proteins 0.000 description 1
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 description 1
- 241000023308 Acca Species 0.000 description 1
- 102000005345 Acetyl-CoA C-acetyltransferase Human genes 0.000 description 1
- 108010006229 Acetyl-CoA C-acetyltransferase Proteins 0.000 description 1
- 241000589291 Acinetobacter Species 0.000 description 1
- 101710146995 Acyl carrier protein Proteins 0.000 description 1
- 102000057234 Acyl transferases Human genes 0.000 description 1
- 108700016155 Acyl transferases Proteins 0.000 description 1
- 102000002735 Acyl-CoA Dehydrogenase Human genes 0.000 description 1
- 108010001058 Acyl-CoA Dehydrogenase Proteins 0.000 description 1
- 101710104255 Acyl-CoA wax alcohol acyltransferase 2 Proteins 0.000 description 1
- 108020002663 Aldehyde Dehydrogenase Proteins 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 101100499137 Arabidopsis thaliana DGAT1 gene Proteins 0.000 description 1
- 101100225658 Arabidopsis thaliana ELP4 gene Proteins 0.000 description 1
- 208000000659 Autoimmune lymphoproliferative syndrome Diseases 0.000 description 1
- NTTIDCCSYIDANP-UHFFFAOYSA-N BCCP Chemical compound BCCP NTTIDCCSYIDANP-UHFFFAOYSA-N 0.000 description 1
- 101100012355 Bacillus anthracis fabH1 gene Proteins 0.000 description 1
- 241000498991 Bacillus licheniformis DSM 13 = ATCC 14580 Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 235000014469 Bacillus subtilis Nutrition 0.000 description 1
- 101100378010 Bacillus subtilis (strain 168) accC1 gene Proteins 0.000 description 1
- 101100322122 Bacillus subtilis (strain 168) accC2 gene Proteins 0.000 description 1
- 101100012357 Bacillus subtilis (strain 168) fabHA gene Proteins 0.000 description 1
- 101100280474 Bacillus subtilis (strain 168) fabL gene Proteins 0.000 description 1
- 101100228546 Bacillus subtilis (strain 168) folE2 gene Proteins 0.000 description 1
- 208000016444 Benign adult familial myoclonic epilepsy Diseases 0.000 description 1
- 101710201279 Biotin carboxyl carrier protein Proteins 0.000 description 1
- 101710180532 Biotin carboxyl carrier protein of acetyl-CoA carboxylase Proteins 0.000 description 1
- 244000178993 Brassica juncea Species 0.000 description 1
- 235000011332 Brassica juncea Nutrition 0.000 description 1
- 235000014700 Brassica juncea var napiformis Nutrition 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- 241000605900 Butyrivibrio fibrisolvens Species 0.000 description 1
- 108010068197 Butyryl-CoA Dehydrogenase Proteins 0.000 description 1
- 102000014914 Carrier Proteins Human genes 0.000 description 1
- 102220587391 Cellular tumor antigen p53_S95T_mutation Human genes 0.000 description 1
- 101000709520 Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) Atypical response regulator protein ChxR Proteins 0.000 description 1
- 241000193468 Clostridium perfringens Species 0.000 description 1
- RGJOEKWQDUBAIZ-IBOSZNHHSA-N CoASH Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCS)O[C@H]1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-IBOSZNHHSA-N 0.000 description 1
- 102000005870 Coenzyme A Ligases Human genes 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 101100269671 Dictyostelium discoideum alrA gene Proteins 0.000 description 1
- 101100378121 Drosophila melanogaster nAChRalpha1 gene Proteins 0.000 description 1
- 101100322246 Drosophila melanogaster nAChRbeta2 gene Proteins 0.000 description 1
- 240000005636 Dryobalanops aromatica Species 0.000 description 1
- 101100296146 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) pab1 gene Proteins 0.000 description 1
- 101000717864 Escherichia coli (strain K12) Lactaldehyde dehydrogenase Proteins 0.000 description 1
- 101100394050 Escherichia coli (strain K12) gyrB gene Proteins 0.000 description 1
- 241001522750 Escherichia coli CFT073 Species 0.000 description 1
- 102220482312 Exostosin-like 1_R58S_mutation Human genes 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 241000589602 Francisella tularensis Species 0.000 description 1
- 241001307979 Geobacillus thermodenitrificans NG80-2 Species 0.000 description 1
- 102000003886 Glycoproteins Human genes 0.000 description 1
- 108090000288 Glycoproteins Proteins 0.000 description 1
- 244000020551 Helianthus annuus Species 0.000 description 1
- 235000003222 Helianthus annuus Nutrition 0.000 description 1
- 241000282414 Homo sapiens Species 0.000 description 1
- 101000937642 Homo sapiens Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Proteins 0.000 description 1
- 108010058996 Long-chain-aldehyde dehydrogenase Proteins 0.000 description 1
- 108010011449 Long-chain-fatty-acid-CoA ligase Proteins 0.000 description 1
- 102100027329 Malonyl-CoA-acyl carrier protein transacylase, mitochondrial Human genes 0.000 description 1
- 241000206597 Marinobacter hydrocarbonoclasticus Species 0.000 description 1
- 102100025169 Max-binding protein MNT Human genes 0.000 description 1
- 241000187480 Mycobacterium smegmatis Species 0.000 description 1
- 101100269700 Mycolicibacterium smegmatis alr gene Proteins 0.000 description 1
- ACFIXJIJDZMPPO-NNYOXOHSSA-N NADPH Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](OP(O)(O)=O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 ACFIXJIJDZMPPO-NNYOXOHSSA-N 0.000 description 1
- 102220624011 Non-histone chromosomal protein HMG-14_R19S_mutation Human genes 0.000 description 1
- 101710102974 O-acetyl transferase Proteins 0.000 description 1
- 241000320412 Ogataea angusta Species 0.000 description 1
- 101100008883 Oryza sativa subsp. japonica DGAT1-1 gene Proteins 0.000 description 1
- 101710116435 Outer membrane protein Proteins 0.000 description 1
- 102000008172 Palmitoyl-CoA Hydrolase Human genes 0.000 description 1
- 108010035473 Palmitoyl-CoA Hydrolase Proteins 0.000 description 1
- 241000588701 Pectobacterium carotovorum Species 0.000 description 1
- 102220511855 Peptide chain release factor 1-like, mitochondrial_L177F_mutation Human genes 0.000 description 1
- 241001260361 Photobacterium profundum Species 0.000 description 1
- 101001135788 Pinus taeda (+)-alpha-pinene synthase, chloroplastic Proteins 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 101710091608 Probable diacyglycerol O-acyltransferase tgs2 Proteins 0.000 description 1
- 101710181816 Pyruvate-formate-lyase deactivase Proteins 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 241000187562 Rhodococcus sp. Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 1
- 101100118655 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) ELO1 gene Proteins 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 102100024639 Short-chain specific acyl-CoA dehydrogenase, mitochondrial Human genes 0.000 description 1
- 102220517259 Signal transducing adapter molecule 1_W34F_mutation Human genes 0.000 description 1
- 101000621436 Simmondsia chinensis Long-chain-alcohol O-fatty-acyltransferase Proteins 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 241000194019 Streptococcus mutans Species 0.000 description 1
- 241000193998 Streptococcus pneumoniae Species 0.000 description 1
- 241001453296 Synechococcus elongatus Species 0.000 description 1
- 241000192589 Synechococcus elongatus PCC 7942 Species 0.000 description 1
- 244000025271 Umbellularia californica Species 0.000 description 1
- 235000008674 Umbellularia californica Nutrition 0.000 description 1
- 241000607626 Vibrio cholerae Species 0.000 description 1
- 239000004164 Wax ester Substances 0.000 description 1
- 101150057540 aar gene Proteins 0.000 description 1
- 101150013885 accB gene Proteins 0.000 description 1
- 101150004068 acrB gene Proteins 0.000 description 1
- PEJLNXHANOHNSU-UHFFFAOYSA-N acridine-3,6-diamine;10-methylacridin-10-ium-3,6-diamine;chloride Chemical compound [Cl-].C1=CC(N)=CC2=NC3=CC(N)=CC=C3C=C21.C1=C(N)C=C2[N+](C)=C(C=C(N)C=C3)C3=CC2=C1 PEJLNXHANOHNSU-UHFFFAOYSA-N 0.000 description 1
- 230000010933 acylation Effects 0.000 description 1
- 238000005917 acylation reaction Methods 0.000 description 1
- 150000001299 aldehydes Chemical class 0.000 description 1
- OBETXYAYXDNJHR-UHFFFAOYSA-N alpha-ethylcaproic acid Natural products CCCCC(CC)C(O)=O OBETXYAYXDNJHR-UHFFFAOYSA-N 0.000 description 1
- 229940053200 antiepileptics fatty acid derivative Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 101150006429 atoB gene Proteins 0.000 description 1
- 230000002238 attenuated effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000001588 bifunctional effect Effects 0.000 description 1
- 230000008436 biogenesis Effects 0.000 description 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
- 102220414540 c.56G>C Human genes 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 239000006143 cell culture medium Substances 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 230000002759 chromosomal effect Effects 0.000 description 1
- 238000003776 cleavage reaction Methods 0.000 description 1
- RGJOEKWQDUBAIZ-UHFFFAOYSA-N coenzime A Natural products OC1C(OP(O)(O)=O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 RGJOEKWQDUBAIZ-UHFFFAOYSA-N 0.000 description 1
- 239000005516 coenzyme A Substances 0.000 description 1
- 229940093530 coenzyme a Drugs 0.000 description 1
- 239000002299 complementary DNA Substances 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- KDTSHFARGAKYJN-UHFFFAOYSA-N dephosphocoenzyme A Natural products OC1C(O)C(COP(O)(=O)OP(O)(=O)OCC(C)(C)C(O)C(=O)NCCC(=O)NCCS)OC1N1C2=NC=NC(N)=C2N=C1 KDTSHFARGAKYJN-UHFFFAOYSA-N 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 108010083294 ethanol acyltransferase Proteins 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 101150026389 fabF gene Proteins 0.000 description 1
- 101150090981 fabG gene Proteins 0.000 description 1
- 101150035981 fabH gene Proteins 0.000 description 1
- 101150104461 fabM gene Proteins 0.000 description 1
- 101150061398 fabR gene Proteins 0.000 description 1
- 101150072202 fabV gene Proteins 0.000 description 1
- 101150084167 fabZ gene Proteins 0.000 description 1
- 101150039130 fadM gene Proteins 0.000 description 1
- 101150115959 fadR gene Proteins 0.000 description 1
- 208000016427 familial adult myoclonic epilepsy Diseases 0.000 description 1
- 230000004133 fatty acid degradation Effects 0.000 description 1
- 150000002190 fatty acyls Chemical group 0.000 description 1
- 229940118764 francisella tularensis Drugs 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- BPHPUYQFMNQIOC-NXRLNHOXSA-N isopropyl beta-D-thiogalactopyranoside Chemical compound CC(C)S[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O BPHPUYQFMNQIOC-NXRLNHOXSA-N 0.000 description 1
- 238000002789 length control Methods 0.000 description 1
- 101150068528 mabA gene Proteins 0.000 description 1
- 108020004999 messenger RNA Proteins 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- BOPGDPNILDQYTO-NNYOXOHSSA-N nicotinamide-adenine dinucleotide Chemical compound C1=CCC(C(=O)N)=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2[C@H]([C@@H](O)[C@@H](O2)N2C3=NC=NC(N)=C3N=C2)O)O1 BOPGDPNILDQYTO-NNYOXOHSSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 101150057826 plsC gene Proteins 0.000 description 1
- 101150073820 pntA gene Proteins 0.000 description 1
- 101150011666 pntB gene Proteins 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 150000003138 primary alcohols Chemical class 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 102220235007 rs1131691186 Human genes 0.000 description 1
- 102220279228 rs1320222638 Human genes 0.000 description 1
- 102200006436 rs17183814 Human genes 0.000 description 1
- 102200052312 rs3218773 Human genes 0.000 description 1
- 102220008303 rs4904 Human genes 0.000 description 1
- 102220250393 rs553900705 Human genes 0.000 description 1
- 102220234440 rs572685299 Human genes 0.000 description 1
- 102220095302 rs587780004 Human genes 0.000 description 1
- 102220046407 rs587782904 Human genes 0.000 description 1
- 102220063378 rs786201995 Human genes 0.000 description 1
- 230000007017 scission Effects 0.000 description 1
- 238000002864 sequence alignment Methods 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229940031000 streptococcus pneumoniae Drugs 0.000 description 1
- 101150026728 tesB gene Proteins 0.000 description 1
- 108091006107 transcriptional repressors Proteins 0.000 description 1
- 102000035160 transmembrane proteins Human genes 0.000 description 1
- 108091005703 transmembrane proteins Proteins 0.000 description 1
- 101150115617 umuC gene Proteins 0.000 description 1
- 101150046028 umuD gene Proteins 0.000 description 1
- 229940118696 vibrio cholerae Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 235000019386 wax ester Nutrition 0.000 description 1
- 101150102457 ybgC gene Proteins 0.000 description 1
- 101150103853 yciA gene Proteins 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
- C12P7/6409—Fatty acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
- C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
- C12Y102/0108—Long-chain acyl-[acyl-carrier-protein] reductase (1.2.1.80)
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/52—Improvements relating to the production of bulk chemicals using catalysts, e.g. selective catalysts
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Fats And Perfumes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361753273P | 2013-01-16 | 2013-01-16 | |
| US201361753273P | 2013-01-16 | ||
| PCT/US2014/011859 WO2014113571A2 (en) | 2013-01-16 | 2014-01-16 | Acyl-acp reductase with improved properties |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2600354T3 true ES2600354T3 (es) | 2017-02-08 |
Family
ID=50473752
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES14716444.6T Active ES2600354T3 (es) | 2013-01-16 | 2014-01-16 | Acil-ACP reductasa con propiedades mejoradas |
| ES16181205.2T Active ES2675224T3 (es) | 2013-01-16 | 2014-01-16 | Acil-ACP reductasa con propiedades mejoradas |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES16181205.2T Active ES2675224T3 (es) | 2013-01-16 | 2014-01-16 | Acil-ACP reductasa con propiedades mejoradas |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9683219B2 (https=) |
| EP (3) | EP3103867B1 (https=) |
| JP (5) | JP6063585B2 (https=) |
| KR (4) | KR101746040B1 (https=) |
| CN (3) | CN105051189B (https=) |
| AU (3) | AU2014207522B2 (https=) |
| BR (1) | BR112015017005A2 (https=) |
| CA (2) | CA3143642A1 (https=) |
| CO (1) | CO7461134A2 (https=) |
| ES (2) | ES2600354T3 (https=) |
| MX (2) | MX346830B (https=) |
| MY (1) | MY167434A (https=) |
| WO (1) | WO2014113571A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2487866A (en) | 2009-09-27 | 2012-08-08 | Opx Biotechnologies Inc | Method for producing 3-Hydroxypropionic acid and other products |
| SG11201501013PA (en) | 2012-08-10 | 2015-04-29 | Opx Biotechnologies Inc | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| KR101746040B1 (ko) * | 2013-01-16 | 2017-06-13 | 알이지 라이프 사이언시스, 엘엘씨 | 개선된 특성들을 갖는 아실-acp 레덕타아제 |
| WO2014146026A1 (en) | 2013-03-15 | 2014-09-18 | Opx Biotechnologies, Inc. | Bioproduction of chemicals |
| US11408013B2 (en) | 2013-07-19 | 2022-08-09 | Cargill, Incorporated | Microorganisms and methods for the production of fatty acids and fatty acid derived products |
| CN106795483A (zh) | 2013-07-19 | 2017-05-31 | 嘉吉公司 | 用于生产脂肪酸和脂肪酸衍生产物的微生物及方法 |
| KR20170029625A (ko) * | 2014-07-18 | 2017-03-15 | 알이지 라이프 사이언시스, 엘엘씨 | 지방 디올의 미생물 생산 |
| EP2993228B1 (en) | 2014-09-02 | 2019-10-09 | Cargill, Incorporated | Production of fatty acid esters |
| EP3577227A4 (en) | 2017-02-02 | 2020-12-30 | Cargill Inc. | GENETICALLY MODIFIED CELLS PRODUCING C6-C10 FATTY ACID DERIVATIVES |
| CN111094558A (zh) | 2017-04-03 | 2020-05-01 | 基因组股份公司 | 对产生中链脂肪酸衍生物具有改善的活性的硫酯酶变体 |
| US12098168B2 (en) | 2018-08-31 | 2024-09-24 | Genomatica, Inc. | XylR mutant for improved xylose utilization or improved co-utilization of glucose and xylose preliminary |
| WO2020047088A1 (en) * | 2018-08-31 | 2020-03-05 | Genomatica, Inc. | Production of non-native monounsaturated fatty acids in bacteria |
| WO2023178193A1 (en) | 2022-03-16 | 2023-09-21 | Genomatica, Inc. | Acyl-acp thioesterase variants and uses thereof |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5000000A (en) | 1988-08-31 | 1991-03-19 | University Of Florida | Ethanol production by Escherichia coli strains co-expressing Zymomonas PDC and ADH genes |
| US5028539A (en) | 1988-08-31 | 1991-07-02 | The University Of Florida | Ethanol production using engineered mutant E. coli |
| US5424202A (en) | 1988-08-31 | 1995-06-13 | The University Of Florida | Ethanol production by recombinant hosts |
| US5482846A (en) | 1988-08-31 | 1996-01-09 | University Of Florida | Ethanol production in Gram-positive microbes |
| WO1991016427A1 (en) | 1990-04-24 | 1991-10-31 | Stratagene | Methods for phenotype creation from multiple gene populations |
| US5602030A (en) | 1994-03-28 | 1997-02-11 | University Of Florida Research Foundation | Recombinant glucose uptake system |
| US6428767B1 (en) | 1995-05-12 | 2002-08-06 | E. I. Du Pont De Nemours And Company | Method for identifying the source of carbon in 1,3-propanediol |
| US5965408A (en) | 1996-07-09 | 1999-10-12 | Diversa Corporation | Method of DNA reassembly by interrupting synthesis |
| US5939250A (en) | 1995-12-07 | 1999-08-17 | Diversa Corporation | Production of enzymes having desired activities by mutagenesis |
| DE50115107D1 (de) | 2000-02-09 | 2009-10-29 | Basf Se | Neues elongasegen und verfahren zur herstellung mehrfach ungesättigter fettsäuren |
| US8110670B2 (en) | 2006-05-19 | 2012-02-07 | Ls9, Inc. | Enhanced production of fatty acid derivatives |
| EP2024491B1 (en) | 2006-05-19 | 2014-11-19 | LS9, Inc. | Production of fatty acids and derivatives thereof |
| US8110093B2 (en) | 2007-03-14 | 2012-02-07 | Ls9, Inc. | Process for producing low molecular weight hydrocarbons from renewable resources |
| CA3178593A1 (en) | 2007-03-28 | 2008-10-02 | Genomatica, Inc. | Enhanced production of fatty acid derivatives |
| TWI351779B (en) | 2007-12-03 | 2011-11-01 | Advance Smart Ind Ltd | Apparatus and method for correcting residual capac |
| US8183028B2 (en) | 2007-12-21 | 2012-05-22 | Ls9, Inc. | Methods and compositions for producing olefins |
| JP2011520455A (ja) | 2008-05-16 | 2011-07-21 | エルエス9・インコーポレイテッド | 炭化水素を製造するための方法および組成物 |
| WO2009142983A1 (en) | 2008-05-23 | 2009-11-26 | Alliant Techsystems Inc. | Broadband patch antenna and antenna system |
| JP2012504963A (ja) | 2008-10-07 | 2012-03-01 | エルエス9・インコーポレイテッド | 脂肪アルデヒドを生産するための方法および組成物 |
| KR101700296B1 (ko) | 2008-10-28 | 2017-01-26 | 알이지 라이프 사이언시스, 엘엘씨 | 지방족 알코올들을 생산하기 위한 방법들과 조성물들 |
| BRPI1009980A2 (pt) | 2009-05-01 | 2015-08-25 | Univ California | Produtos de ésteres de ácidos graxos a partir de polímeros de biomassa |
| EP2432890B1 (en) * | 2009-05-22 | 2015-09-02 | Codexis, Inc. | Engineered biosynthesis of fatty alcohols |
| US7794969B1 (en) * | 2009-07-09 | 2010-09-14 | Joule Unlimited, Inc. | Methods and compositions for the recombinant biosynthesis of n-alkanes |
| US8867042B2 (en) * | 2009-09-07 | 2014-10-21 | National Institute Of Information And Communications Technology | Method for evaluating characteristic of optical modulator having mach-zehnder interferometer |
| CN105969710A (zh) * | 2009-09-25 | 2016-09-28 | Reg生命科学有限责任公司 | 脂肪酸衍生物的产生 |
| GB2487866A (en) * | 2009-09-27 | 2012-08-08 | Opx Biotechnologies Inc | Method for producing 3-Hydroxypropionic acid and other products |
| US8530221B2 (en) | 2010-01-14 | 2013-09-10 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| WO2011100667A1 (en) | 2010-02-14 | 2011-08-18 | Ls9, Inc. | Surfactant and cleaning compositions comprising microbially produced branched fatty alcohols |
| US20110250663A1 (en) * | 2010-04-08 | 2011-10-13 | Ls9, Inc. | Methods and compositions related to fatty alcohol biosynthetic enzymes |
| US8372610B2 (en) | 2010-09-15 | 2013-02-12 | Ls9, Inc. | Production of odd chain fatty acid derivatives in recombinant microbial cells |
| US20140004580A1 (en) | 2010-12-20 | 2014-01-02 | Matrix Genetics, Llc | Modified photosynthetic microorganisms for producing lipids |
| CA2823928C (en) * | 2011-01-14 | 2020-09-22 | Ls9, Inc. | Production of branched chain fatty acids and derivatives thereof in recombinant microbial cells |
| CN102719467A (zh) * | 2012-07-09 | 2012-10-10 | 武汉大学 | 一种利用脂肪酰acp还原酶生物合成脂肪醇的方法 |
| KR101746040B1 (ko) | 2013-01-16 | 2017-06-13 | 알이지 라이프 사이언시스, 엘엘씨 | 개선된 특성들을 갖는 아실-acp 레덕타아제 |
| JP7478517B2 (ja) | 2019-04-24 | 2024-05-07 | 三菱商事ライフサイエンス株式会社 | 脂質活性代謝改善組成物 |
-
2014
- 2014-01-16 KR KR1020157021992A patent/KR101746040B1/ko active Active
- 2014-01-16 KR KR1020217017654A patent/KR20210072147A/ko not_active Ceased
- 2014-01-16 ES ES14716444.6T patent/ES2600354T3/es active Active
- 2014-01-16 EP EP16181205.2A patent/EP3103867B1/en active Active
- 2014-01-16 US US14/761,299 patent/US9683219B2/en active Active
- 2014-01-16 AU AU2014207522A patent/AU2014207522B2/en not_active Ceased
- 2014-01-16 BR BR112015017005A patent/BR112015017005A2/pt not_active IP Right Cessation
- 2014-01-16 CA CA3143642A patent/CA3143642A1/en active Pending
- 2014-01-16 KR KR1020207004969A patent/KR102265148B1/ko not_active Expired - Fee Related
- 2014-01-16 CN CN201480004992.3A patent/CN105051189B/zh active Active
- 2014-01-16 CN CN201910169609.4A patent/CN109897834A/zh active Pending
- 2014-01-16 EP EP14716444.6A patent/EP2946009B1/en active Active
- 2014-01-16 CA CA2898317A patent/CA2898317C/en active Active
- 2014-01-16 ES ES16181205.2T patent/ES2675224T3/es active Active
- 2014-01-16 MX MX2015009138A patent/MX346830B/es active IP Right Grant
- 2014-01-16 MY MYPI2015001785A patent/MY167434A/en unknown
- 2014-01-16 EP EP18172072.3A patent/EP3385375B1/en active Active
- 2014-01-16 JP JP2015553830A patent/JP6063585B2/ja active Active
- 2014-01-16 KR KR1020177015121A patent/KR102082247B1/ko not_active Expired - Fee Related
- 2014-01-16 CN CN201910693927.0A patent/CN110387352A/zh active Pending
- 2014-01-16 WO PCT/US2014/011859 patent/WO2014113571A2/en not_active Ceased
- 2014-01-16 MX MX2017003816A patent/MX356997B/es unknown
-
2015
- 2015-07-28 CO CO15173779A patent/CO7461134A2/es unknown
-
2016
- 2016-07-28 US US15/222,657 patent/US10208294B2/en active Active
- 2016-10-14 JP JP2016202155A patent/JP6211162B2/ja not_active Expired - Fee Related
-
2017
- 2017-01-30 AU AU2017200596A patent/AU2017200596B2/en not_active Ceased
- 2017-06-13 US US15/621,430 patent/US9873865B2/en active Active
- 2017-09-12 JP JP2017174449A patent/JP6523393B2/ja not_active Expired - Fee Related
-
2019
- 2019-02-11 US US16/272,303 patent/US11130944B2/en not_active Expired - Fee Related
- 2019-04-18 AU AU2019202790A patent/AU2019202790A1/en not_active Abandoned
- 2019-04-25 JP JP2019084119A patent/JP6926143B2/ja active Active
-
2020
- 2020-10-26 JP JP2020178581A patent/JP7094343B2/ja active Active
-
2021
- 2021-08-18 US US17/405,685 patent/US20220090028A1/en not_active Abandoned
-
2023
- 2023-07-20 US US18/355,990 patent/US12173329B2/en active Active
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2600354T3 (es) | Acil-ACP reductasa con propiedades mejoradas | |
| AU2013243601B2 (en) | Improved production of fatty acid derivatives | |
| ES2666157T3 (es) | Enzimas CAR y producción mejorada de alcoholes grasos | |
| JP6820888B2 (ja) | 改善されたエステルシンターゼ特性を有する酵素変種 | |
| US20140212935A1 (en) | Short chain fatty acids from bacteria | |
| US20150125933A1 (en) | Production of fatty acids and derivatives thereof having improved aliphatic chain length and saturation characteristics | |
| US9598696B2 (en) | Bacteria and method for synthesizing fatty acids | |
| ES2693753T3 (es) | Producción de ácidos grasos de cadena ramificada y derivados de los mismos en células microbianas recombinantes | |
| US11142756B2 (en) | Acetyl-CoA carboxylase variants | |
| BR112019020784A2 (pt) | variantes de tioesterase com atividade melhorada para a produção de derivados de ácidos graxos de cadeia média | |
| CN117083382A (zh) | 细菌中非天然单不饱和脂肪酸的产生 | |
| BR122017000806A2 (pt) | polipeptídeo da variante acil-acp redutase (aar), célula hospedeira recombinante, cultura celular, método de produção de composição de álcool graxo tendo aumento do título | |
| San et al. | Synthesis of short chain fatty acids from bacteria |