ES2596402T3 - Proteasas estabilizadas para su uso en el cuidado de la piel - Google Patents
Proteasas estabilizadas para su uso en el cuidado de la piel Download PDFInfo
- Publication number
- ES2596402T3 ES2596402T3 ES11735144.5T ES11735144T ES2596402T3 ES 2596402 T3 ES2596402 T3 ES 2596402T3 ES 11735144 T ES11735144 T ES 11735144T ES 2596402 T3 ES2596402 T3 ES 2596402T3
- Authority
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- Prior art keywords
- protease
- papain
- stabilized
- dma
- weeks
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
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- C—CHEMISTRY; METALLURGY
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29605210P | 2010-01-19 | 2010-01-19 | |
| US296052P | 2010-01-19 | ||
| PCT/US2011/021773 WO2011091084A2 (en) | 2010-01-19 | 2011-01-19 | Stabilized proteases for use in skin care |
Publications (1)
| Publication Number | Publication Date |
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| ES2596402T3 true ES2596402T3 (es) | 2017-01-09 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES11735144.5T Active ES2596402T3 (es) | 2010-01-19 | 2011-01-19 | Proteasas estabilizadas para su uso en el cuidado de la piel |
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| Country | Link |
|---|---|
| US (1) | US8778336B2 (enExample) |
| EP (1) | EP2525828B1 (enExample) |
| JP (1) | JP5848260B2 (enExample) |
| KR (1) | KR101759755B1 (enExample) |
| CN (2) | CN106480008A (enExample) |
| ES (1) | ES2596402T3 (enExample) |
| WO (1) | WO2011091084A2 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
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| KR20140051425A (ko) | 2011-08-17 | 2014-04-30 | 바스프 코포레이션 | 해양 기반 화장품 활성 성분 및 그의 용도 |
| JP6162449B2 (ja) * | 2012-03-28 | 2017-07-12 | 株式会社コーセー | （カルボマー／パパイン）クロスポリマー含有組成物 |
| JP5912759B2 (ja) * | 2012-03-29 | 2016-04-27 | 株式会社コーセー | （カルボマー／パパイン）クロスポリマー含有組成物 |
| KR101936687B1 (ko) * | 2012-04-06 | 2019-01-11 | (주)아모레퍼시픽 | 파우더 타입 화장료 조성물 |
| GB201305023D0 (en) | 2013-03-19 | 2013-05-01 | Biocant Associa O De Transfer Ncia De Tecnologia | Aspartic proteases |
| JP6292602B2 (ja) * | 2013-04-15 | 2018-03-14 | 学校法人神奈川大学 | 濡れ性低減又は増加に用いられる製剤及びその製造用原料、並びに濡れ性を低減又は増加させる方法 |
| JP6182975B2 (ja) * | 2013-05-21 | 2017-08-23 | 日油株式会社 | ジェル状皮膚化粧料 |
| CN105053811A (zh) * | 2015-08-18 | 2015-11-18 | 凤台县龙泰面粉有限责任公司 | 一种咖喱味虾仁面粉及其制备方法 |
| CN105192017A (zh) * | 2015-08-18 | 2015-12-30 | 凤台县龙泰面粉有限责任公司 | 一种蓝莓枸杞明目保健面粉及其制备方法 |
| CN105145717A (zh) * | 2015-08-18 | 2015-12-16 | 凤台县永新工贸有限责任公司 | 一种高血脂人群食用的降脂面粉及其制备方法 |
| CN105165953A (zh) * | 2015-08-18 | 2015-12-23 | 凤台县龙泰面粉有限责任公司 | 一种红曲米健胃消食面粉及其制备方法 |
| CN105053812A (zh) * | 2015-08-18 | 2015-11-18 | 凤台县龙泰面粉有限责任公司 | 一种高蛋白含量木耳莲子补血面粉及其制备方法 |
| CN105077064A (zh) * | 2015-08-18 | 2015-11-25 | 凤台县永新工贸有限责任公司 | 一种具有健脾益肾功效的蔬菜面粉及其制备方法 |
| CN105053809A (zh) * | 2015-08-18 | 2015-11-18 | 凤台县永新工贸有限责任公司 | 一种香菇鸡肉味营养面粉及其制备方法 |
| CN105211695A (zh) * | 2015-09-30 | 2016-01-06 | 安徽省达亿粮油食品有限公司 | 一种山慈菇木瓜益气生津保健面粉及其制备方法 |
| CN105166658A (zh) * | 2015-09-30 | 2015-12-23 | 安徽省达亿粮油食品有限公司 | 一种辣木籽健胃消食面粉及其制备方法 |
| CN105166660A (zh) * | 2015-09-30 | 2015-12-23 | 安徽省达亿粮油食品有限公司 | 一种益气健脾保健面粉及其制备方法 |
| CN105211696A (zh) * | 2015-09-30 | 2016-01-06 | 安徽省达亿粮油食品有限公司 | 一种苦瓜杏仁营养面粉及其制备方法 |
| CN105166657A (zh) * | 2015-09-30 | 2015-12-23 | 安徽省达亿粮油食品有限公司 | 一种补肾强筋保健面粉及其制备方法 |
| CA3012299C (en) * | 2016-01-31 | 2022-05-31 | Mediwound Ltd. | Debriding composition for treating wounds |
| NZ748416A (en) * | 2016-04-18 | 2022-12-23 | Mediwound Ltd | Methods of debridement of chronic wounds |
| US9763976B1 (en) | 2016-08-02 | 2017-09-19 | Zo Skin Health, Inc. | Composition and method for treating skin conditions |
| CN109248326A (zh) * | 2018-11-09 | 2019-01-22 | 深圳先进技术研究院 | 一种骨靶向纳米粒递送系统及其制备方法 |
| EP4763215A2 (en) * | 2019-10-09 | 2026-06-24 | Phoenix Eagle Company Pty Ltd | Enhancement and stabilisation of proteolytic activity of proteases |
| JP7708744B2 (ja) * | 2019-10-09 | 2025-07-15 | フェニックス イーグル カンパニー ピーティーワイ リミテッド | プロテアーゼのタンパク質分解活性の増強及び安定化 |
| KR102792840B1 (ko) * | 2019-10-25 | 2025-04-11 | (주)아모레퍼시픽 | 프로테이스 보관용 조성물 및 프로테이스를 포함하는 화장 키트 |
| JP2023553332A (ja) * | 2020-11-25 | 2023-12-21 | トピックス ファーマシューティカルズ，インコーポレイテッド | 瘢痕治療用組成物 |
| CA3199921A1 (en) * | 2020-11-25 | 2022-06-02 | Steven M. Hernandez | Scar treatment composition |
| KR20230029260A (ko) * | 2021-08-24 | 2023-03-03 | (주)아모레퍼시픽 | 효소 손상을 방지하는 화장료 조성물 및 이를 저장하는 화장품 용기 |
| WO2023101047A1 (ko) * | 2021-12-01 | 2023-06-08 | 주식회사 휴메디솔 | 프로테아제 기반의 콘택트렌즈 세정액 및 이의 제조방법 |
| WO2023159123A1 (en) * | 2022-02-16 | 2023-08-24 | Guild Associates Inc. | Immobilized enzyme-based wound debridement |
Family Cites Families (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS61257906A (ja) * | 1985-05-10 | 1986-11-15 | Kanebo Ltd | パツク化粧料 |
| JPH0612992B2 (ja) * | 1986-02-26 | 1994-02-23 | 日清製粉株式会社 | 固定化プロテア−ゼの製法 |
| CA2071867A1 (en) * | 1989-11-06 | 1991-05-07 | Edith Mathiowitz | Method for producing protein microspheres |
| DK194990D0 (da) | 1990-08-16 | 1990-08-16 | Novo Nordisk As | Aldc-derivat og anvendelse deraf |
| FR2738835B1 (fr) | 1995-09-18 | 1997-10-17 | Oreal | Composition epaissie en milieu aqueux, procede d'epaississement d'un milieu aqueux et utilisations en cosmetique |
| US5961990A (en) | 1997-05-02 | 1999-10-05 | Kobo Products S.A.R.L. | Cosmetic particulate gel delivery system and method of preparing complex gel particles |
| US6319507B1 (en) | 1997-05-02 | 2001-11-20 | Kobo Products, Inc. | Agar gel bead composition and method |
| US6416769B1 (en) * | 2000-03-03 | 2002-07-09 | Australian Importers, Ltd. | Cosmetic compositions comprising exfoliating enzymes and uses thereof |
| US7241456B2 (en) | 2002-10-25 | 2007-07-10 | Australian Importers Ltd. | Formulations for topical delivery of bioactive substances and methods for their use |
| US7691296B2 (en) | 2002-11-25 | 2010-04-06 | Amorepacific Corporation | Method for stabilizing active components using polyol/polymer microcapsule, and cosmetic composition containing the microcapsule |
| FR2848847B1 (fr) * | 2002-12-18 | 2005-10-14 | Coletica | Composition cosmetique ou dermopharmaceutique comprenant une enzyme insoluble en milieu aqueux, ainsi que ses utilisations |
| US7311926B2 (en) | 2002-12-20 | 2007-12-25 | Battelle Memorial Institute | Biocomposite materials and methods for making the same |
| AU2003219351A1 (en) | 2003-04-09 | 2004-11-01 | Harold Armando Gomez Torres | Topical composition in the form of a gel for treating skin burns |
| US20060210500A1 (en) * | 2003-04-18 | 2006-09-21 | Merck Patent Gmbh | Formulations |
| US20040228831A1 (en) | 2003-05-15 | 2004-11-18 | Belinka Benjamin A. | Polymeric conjugates for tissue activated drug delivery |
| US20050013925A1 (en) | 2003-07-17 | 2005-01-20 | Melvin Cabey | Immobilization methods for organic molecules telomers and polymers on solid substrates |
| WO2005034886A1 (ja) | 2003-10-10 | 2005-04-21 | Picaso Cosmetic Laboratory, Ltd. | 化粧料 |
| US7416869B2 (en) | 2004-08-19 | 2008-08-26 | Lonza Ltd. | Enzyme delivery systems, application in water based products |
| US7928282B2 (en) | 2004-04-30 | 2011-04-19 | Kimberly-Clark Worldwide, Inc. | Absorbent products with a linked enzyme treatment |
| CN1997352B (zh) | 2004-06-17 | 2010-12-01 | 天野酶制品美国有限公司 | 含粘膜粘附性聚合物的酶、微生物和抗体的控释制剂 |
| KR100804096B1 (ko) | 2006-08-31 | 2008-02-18 | (주)아모레퍼시픽 | 고농도 계면활성제 계에서도 안정한 효소 캡슐 제제를포함하는 피부 세정용 조성물 및 그 제조방법 |
| CN101396341A (zh) * | 2006-12-01 | 2009-04-01 | 山东蓝金生物工程有限公司 | 一种抗癌缓释剂 |
| CN101396328A (zh) | 2007-09-26 | 2009-04-01 | 孙海 | 一种祛角质化妆品的制备和使用方法 |
| US8062663B2 (en) | 2008-05-23 | 2011-11-22 | National Health Research Instittues | Methods and compostions for enhancing transdermal drug delivery |
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| JP5848260B2 (ja) | 2016-01-27 |
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| CN106480008A (zh) | 2017-03-08 |
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| US8778336B2 (en) | 2014-07-15 |
| JP2013517328A (ja) | 2013-05-16 |
| EP2525828A4 (en) | 2013-07-31 |
| KR101759755B1 (ko) | 2017-07-19 |
| US20110177052A1 (en) | 2011-07-21 |
| WO2011091084A3 (en) | 2011-12-29 |
| KR20120118040A (ko) | 2012-10-25 |
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