ES2579768T3 - Anticuerpos anti-KIR, formulaciones y usos de los mismos - Google Patents
Anticuerpos anti-KIR, formulaciones y usos de los mismos Download PDFInfo
- Publication number
- ES2579768T3 ES2579768T3 ES08707869.7T ES08707869T ES2579768T3 ES 2579768 T3 ES2579768 T3 ES 2579768T3 ES 08707869 T ES08707869 T ES 08707869T ES 2579768 T3 ES2579768 T3 ES 2579768T3
- Authority
- ES
- Spain
- Prior art keywords
- formulation
- kir
- antibody
- dose
- humans
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87996407P | 2007-01-11 | 2007-01-11 | |
| US879964P | 2007-01-11 | ||
| US91152707P | 2007-04-13 | 2007-04-13 | |
| US911527P | 2007-04-13 | ||
| PCT/EP2008/050306 WO2008084106A1 (en) | 2007-01-11 | 2008-01-11 | Anti-kir antibodies, formulations, and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2579768T3 true ES2579768T3 (es) | 2016-08-16 |
Family
ID=39144327
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08707869.7T Active ES2579768T3 (es) | 2007-01-11 | 2008-01-11 | Anticuerpos anti-KIR, formulaciones y usos de los mismos |
| ES13159380.8T Active ES2627923T3 (es) | 2007-01-11 | 2008-01-11 | Anticuerpos anti-KIR, formulaciones y usos de los mismos |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13159380.8T Active ES2627923T3 (es) | 2007-01-11 | 2008-01-11 | Anticuerpos anti-KIR, formulaciones y usos de los mismos |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100189723A1 (enExample) |
| EP (2) | EP2604278B1 (enExample) |
| JP (3) | JP5478261B2 (enExample) |
| CN (2) | CN101578113B (enExample) |
| AU (1) | AU2008204433B2 (enExample) |
| CA (1) | CA2675291C (enExample) |
| ES (2) | ES2579768T3 (enExample) |
| WO (1) | WO2008084106A1 (enExample) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| KR101420344B1 (ko) | 2003-07-02 | 2014-07-16 | 위니베르시따 디 제노바 | Ｐａｎ-ｋｉｒ2ｄｌ ｎｋ-수용체 항체 및 진단 및 치료에서의 그 사용 방법 |
| WO2006072625A2 (en) * | 2005-01-06 | 2006-07-13 | Novo Nordisk A/S | Anti-kir combination treatments and methods |
| US8709411B2 (en) | 2008-12-05 | 2014-04-29 | Novo Nordisk A/S | Combination therapy to enhance NK cell mediated cytotoxicity |
| PT3604510T (pt) | 2009-03-30 | 2025-06-24 | Alexion Pharma Inc | Antídotos para inibidores do fator xa e métodos de utilização dos mesmos |
| PT2453910T (pt) | 2009-07-15 | 2016-12-07 | Portola Pharm Inc | Formulação de dose unitária de antídoto contra inibidores de fator xa para uso na prevenção de sangramento |
| EP2630158B1 (en) * | 2010-10-22 | 2018-12-12 | Dana-Farber Cancer Institute, Inc. | Discovery of regulatory t cells programmed to suppress an immune response |
| CA2818684C (en) * | 2010-11-22 | 2023-02-21 | Innate Pharma Sa | Nk cell modulating treatments and methods for treatment of hematological malignancies |
| KR20120093002A (ko) | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Ｎｋ 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| TWI560200B (en) * | 2011-05-25 | 2016-12-01 | Innate Pharma Sa | Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders |
| KR102130865B1 (ko) * | 2012-10-02 | 2020-08-05 | 브리스톨-마이어스 스큅 컴퍼니 | 암을 치료하기 위한 항-kir 항체와 항-pd-1 항체의 조합물 |
| UY35460A (es) * | 2013-03-15 | 2014-10-31 | Bayer Healthcare Llc | Formulaciones de anticuerpos anti-receptor de prolactina |
| ES2707057T3 (es) | 2013-11-06 | 2019-04-02 | Bristol Myers Squibb Co | Combinación de anticuerpos anti-KIR y anti-CS1 para tratar el mieloma múltiple |
| US11639384B2 (en) | 2014-10-28 | 2023-05-02 | University Children's Hospital Tübingen | Treatment of pediatric BCP-ALL patients with an anti-KIR antibody |
| SG11201708223QA (en) | 2015-04-17 | 2017-11-29 | Bristol Myers Squibb Co | Compositions comprising a combination of an anti-pd-1 antibody and another antibody |
| PL3291679T3 (pl) | 2015-05-06 | 2022-04-25 | Snipr Technologies Limited | Zmiana populacji drobnoustrojowych i modyfikowanie mikrobioty |
| ES2889906T3 (es) | 2015-05-21 | 2022-01-14 | Harpoon Therapeutics Inc | Proteínas de unión triespecíficas y usos médicos |
| CN107921087A (zh) | 2015-07-16 | 2018-04-17 | 百欧肯治疗有限公司 | 治疗癌症的组合物及方法 |
| KR20180104597A (ko) | 2015-11-07 | 2018-09-21 | 멀티비르 인코포레이티드 | 암 치료를 위한 종양 억제 유전자 요법 및 면역관문 봉쇄를 포함하는 조성물 |
| JP2018536404A (ja) | 2015-11-09 | 2018-12-13 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | Ｃｈｏ細胞において産生したポリペプチドの品質特性を操作する方法 |
| AU2017223233A1 (en) * | 2016-02-24 | 2018-08-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| LT3458053T (lt) | 2016-05-20 | 2022-02-25 | Biohaven Pharmaceutical Holding Company Ltd. | Riluzolo, rilizolo provaistų arba riluzolo analogų panaudojimas kartu su imunoterapijomis vėžio formų gydymui |
| US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
| GB201609811D0 (en) | 2016-06-05 | 2016-07-20 | Snipr Technologies Ltd | Methods, cells, systems, arrays, RNA and kits |
| BR112019006041A2 (pt) | 2016-09-27 | 2019-09-03 | Board Of Regents, The University Of Texas System | métodos para aprimorar a terapia de bloqueio do ponto de verificação imunológico por modulação do microbioma |
| WO2018071668A1 (en) | 2016-10-12 | 2018-04-19 | Board Of Regents, The University Of Texas System | Methods and compositions for tusc2 immunotherapy |
| JP2020510624A (ja) | 2016-12-12 | 2020-04-09 | マルチビア インコーポレイテッド | がんおよび感染性疾患の治療および予防のための、ウイルス遺伝子治療および免疫チェックポイント阻害剤を含む方法および組成物 |
| IL269026B2 (en) | 2017-03-31 | 2024-12-01 | Bristol Myers Squibb Co | Anti-pd-1 antibodies for treating tumors in high tumor mutational burden (tmb) patients |
| BR112019023855B1 (pt) | 2017-05-12 | 2021-11-30 | Harpoon Therapeutics, Inc | Proteínas de ligação à mesotelina |
| JP7084990B2 (ja) | 2017-10-13 | 2022-06-15 | ハープーン セラピューティクス，インク． | 三重特異性タンパク質と使用方法 |
| IL315737A (en) | 2017-10-13 | 2024-11-01 | Harpoon Therapeutics Inc | B-cell maturation antigen-binding proteins |
| KR20200064132A (ko) | 2017-10-15 | 2020-06-05 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| US12454561B2 (en) | 2018-03-19 | 2025-10-28 | Multivir Inc. | Methods and compositions comprising tumor suppressor gene therapy and CD122/CD132 agonists for the treatment of cancer |
| BR112020018539A2 (pt) | 2018-03-23 | 2020-12-29 | Bristol-Myers Squibb Company | Anticorpos contra mica e/ou micb e usos dos mesmos |
| WO2019185551A1 (en) | 2018-03-25 | 2019-10-03 | Snipr Biome Aps. | Treating & preventing microbial infections |
| US10760075B2 (en) | 2018-04-30 | 2020-09-01 | Snipr Biome Aps | Treating and preventing microbial infections |
| KR20200139724A (ko) | 2018-03-30 | 2020-12-14 | 브리스톨-마이어스 스큅 컴퍼니 | 종양을 치료하는 방법 |
| KR20210035805A (ko) | 2018-06-15 | 2021-04-01 | 플래그쉽 파이어니어링 이노베이션스 브이, 인크. | 세포후 신호전달 인자의 조절을 통한 면역 활성의 증가 |
| US12195544B2 (en) | 2018-09-21 | 2025-01-14 | Harpoon Therapeutics, Inc. | EGFR binding proteins and methods of use |
| CN113286817B (zh) | 2018-09-25 | 2025-01-28 | 哈普恩治疗公司 | Dll3结合蛋白及使用方法 |
| EP3947715A4 (en) | 2018-11-21 | 2022-11-23 | Board of Regents, The University of Texas System | METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER |
| MX2021007271A (es) | 2018-12-21 | 2021-07-15 | Onxeo | Nuevas moleculas de acido nucleico conjugado y sus usos. |
| SG11202108627SA (en) | 2019-02-18 | 2021-09-29 | Lilly Co Eli | Therapeutic antibody formulation |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| WO2020243568A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy |
| WO2020243563A1 (en) | 2019-05-30 | 2020-12-03 | Bristol-Myers Squibb Company | Multi-tumor gene signatures for suitability to immuno-oncology therapy |
| CN114174537A (zh) | 2019-05-30 | 2022-03-11 | 百时美施贵宝公司 | 细胞定位特征和组合疗法 |
| WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
| WO2021113644A1 (en) | 2019-12-05 | 2021-06-10 | Multivir Inc. | Combinations comprising a cd8+ t cell enhancer, an immune checkpoint inhibitor and radiotherapy for targeted and abscopal effects for the treatment of cancer |
| EP4076434A1 (en) | 2019-12-17 | 2022-10-26 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
| WO2021249462A1 (zh) * | 2020-06-11 | 2021-12-16 | 南京北恒生物科技有限公司 | 表达nk抑制性分子的工程化免疫细胞及其用途 |
| TW202214857A (zh) | 2020-06-19 | 2022-04-16 | 法商昂席歐公司 | 新型結合核酸分子及其用途 |
| US20230355804A1 (en) | 2020-06-29 | 2023-11-09 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
| US20250262293A1 (en) | 2020-07-07 | 2025-08-21 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
| IL300916A (en) | 2020-08-31 | 2023-04-01 | Bristol Myers Squibb Co | Cell localization signature and immunotherapy |
| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
| TW202245808A (zh) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | 用於治療癌症之治療性ｒｎａ |
| WO2022135666A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Treatment schedule for cytokine proteins |
| WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
| MX2023007650A (es) | 2020-12-28 | 2023-09-11 | Bristol Myers Squibb Co | Metodos de tratamiento de tumores. |
| WO2022146947A1 (en) | 2020-12-28 | 2022-07-07 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| AU2022218137A1 (en) | 2021-02-03 | 2023-08-24 | Mozart Therapeutics, Inc. | Binding agents and methods of using the same |
| CA3214085A1 (en) | 2021-03-31 | 2022-10-06 | Darby Rye Schmidt | Thanotransmission polypeptides and their use in treating cancer |
| JP2024514530A (ja) | 2021-04-02 | 2024-04-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 切断型ｃｄｃｐ１に対する抗体およびその使用 |
| EP4363059A1 (en) | 2021-06-29 | 2024-05-08 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
| MX2024000674A (es) | 2021-07-13 | 2024-02-07 | BioNTech SE | Agentes de union multiespecificos contra cd40 y cd137 en terapia de combinacion. |
| TW202333802A (zh) | 2021-10-11 | 2023-09-01 | 德商拜恩迪克公司 | 用於肺癌之治療性rna(二) |
| US20240294926A1 (en) | 2021-12-16 | 2024-09-05 | Valerio Therapeutics | New conjugated nucleic acid molecules and their uses |
| JP2025509749A (ja) | 2022-03-18 | 2025-04-11 | ブリストル－マイヤーズ スクイブ カンパニー | ポリペプチドの単離方法 |
| EP4531916A1 (en) | 2022-06-02 | 2025-04-09 | Bristol-Myers Squibb Company | Antibody compositions and methods of use thereof |
| GB202209518D0 (en) | 2022-06-29 | 2022-08-10 | Snipr Biome Aps | Treating & preventing E coli infections |
| EP4598946A1 (en) | 2022-10-05 | 2025-08-13 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
| IL321098A (en) | 2022-12-14 | 2025-07-01 | Astellas Pharma Europe Bv | Combination therapy including bispecific binding agents that bind to CLDN18.2- and CD3- and immune checkpoint inhibitors |
| WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
| CN121712571A (zh) | 2023-08-15 | 2026-03-20 | 百时美施贵宝公司 | 陶瓷羟基磷灰石色谱流通法 |
| WO2025120866A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| WO2026033885A1 (en) | 2024-08-08 | 2026-02-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and agents stabilizing or increasing expression of cldn18.2 |
| TW202541837A (zh) | 2023-12-08 | 2025-11-01 | 日商安斯泰來製藥公司 | 含有結合至cldn18.2和cd3之雙特異性結合劑和穩定或增加cldn18.2表現之藥劑之組合療法 |
| WO2025120867A1 (en) | 2023-12-08 | 2025-06-12 | Astellas Pharma Inc. | Combination therapy involving bispecific binding agents binding to cldn18.2 and cd3 and anti-vegfr2 antibodies |
| US20250215087A1 (en) | 2023-12-29 | 2025-07-03 | Bristol-Myers Squibb Company | Combination therapy of kras inhibitor and treg depleting agent |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09512705A (ja) * | 1994-03-29 | 1997-12-22 | セルテック セラピューティクス リミテッド | Ｅ−セレクチンに対する抗体 |
| US6824780B1 (en) * | 1999-10-29 | 2004-11-30 | Genentech, Inc. | Anti-tumor antibody compositions and methods of use |
| US20010046496A1 (en) * | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
| AR035119A1 (es) * | 2001-08-16 | 2004-04-14 | Lilly Co Eli | Anticuerpos humanos antagonistas anti-htnfsf13b |
| AU2002359796B2 (en) | 2001-12-19 | 2007-07-05 | Biogen Ma Inc. | Methods for detecting half-antibodies using chip-based gel electrophoresis |
| AU2003208946A1 (en) | 2002-02-28 | 2003-09-16 | Eli Lilly And Company | Anti-interleukin-1 beta analogs |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| CN1842541B (zh) * | 2003-07-02 | 2013-03-27 | 诺沃挪第克公司 | 调节nk细胞活性的组合物和方法 |
| KR101420344B1 (ko) * | 2003-07-02 | 2014-07-16 | 위니베르시따 디 제노바 | Ｐａｎ-ｋｉｒ2ｄｌ ｎｋ-수용체 항체 및 진단 및 치료에서의 그 사용 방법 |
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| DK2311873T3 (en) | 2004-01-07 | 2018-11-26 | Novartis Vaccines & Diagnostics Inc | M-CSF-SPECIFIC MONOCLONAL ANTIBODY AND APPLICATIONS THEREOF |
| EP2394652A3 (en) * | 2004-02-06 | 2012-10-24 | Elan Pharmaceuticals Inc. | Methods and compositions for treating tumors and metastatic disease |
| DK2287195T3 (da) * | 2004-07-01 | 2019-08-19 | Innate Pharma | Pan-kir2dl nk-receptor-antistoffer og anvendelse heraf i diagnostik og terapi |
| WO2006050073A2 (en) * | 2004-10-29 | 2006-05-11 | Fargo Electronics, Inc. | Credential production using a secured consumable supply |
| SI1836225T1 (sl) * | 2005-01-06 | 2012-06-29 | Novo Nordisk As | Kir vezujoäśa sredstva in postopki za njihovo rabo |
| ZA200708857B (en) * | 2005-04-22 | 2009-01-28 | Genentech Inc | Method for treating dementia or alzheimer's disease with a CD30 antibody |
| US8709411B2 (en) * | 2008-12-05 | 2014-04-29 | Novo Nordisk A/S | Combination therapy to enhance NK cell mediated cytotoxicity |
| TWI560200B (en) * | 2011-05-25 | 2016-12-01 | Innate Pharma Sa | Anti-kir antibodies for the treatment of inflammatory and autoimmune disorders |
-
2008
- 2008-01-11 CN CN200880002001.2A patent/CN101578113B/zh not_active Expired - Fee Related
- 2008-01-11 WO PCT/EP2008/050306 patent/WO2008084106A1/en not_active Ceased
- 2008-01-11 AU AU2008204433A patent/AU2008204433B2/en not_active Ceased
- 2008-01-11 EP EP13159380.8A patent/EP2604278B1/en not_active Not-in-force
- 2008-01-11 ES ES08707869.7T patent/ES2579768T3/es active Active
- 2008-01-11 ES ES13159380.8T patent/ES2627923T3/es active Active
- 2008-01-11 CA CA2675291A patent/CA2675291C/en active Active
- 2008-01-11 US US12/521,105 patent/US20100189723A1/en not_active Abandoned
- 2008-01-11 JP JP2009545192A patent/JP5478261B2/ja not_active Expired - Fee Related
- 2008-01-11 CN CN201510142726.3A patent/CN105037549B/zh not_active Expired - Fee Related
- 2008-01-11 EP EP08707869.7A patent/EP2109460B1/en not_active Not-in-force
-
2013
- 2013-10-11 JP JP2013213757A patent/JP6223771B2/ja not_active Expired - Fee Related
-
2015
- 2015-01-27 US US14/606,814 patent/US9879082B2/en not_active Expired - Fee Related
- 2015-11-20 JP JP2015227492A patent/JP2016104728A/ja active Pending
-
2017
- 2017-12-20 US US15/849,128 patent/US10815299B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014050393A (ja) | 2014-03-20 |
| EP2604278B1 (en) | 2017-04-12 |
| CN105037549B (zh) | 2018-09-28 |
| ES2627923T3 (es) | 2017-08-01 |
| US20180208652A1 (en) | 2018-07-26 |
| AU2008204433B2 (en) | 2014-03-13 |
| CA2675291A1 (en) | 2008-07-17 |
| US20150197569A1 (en) | 2015-07-16 |
| CA2675291C (en) | 2017-05-23 |
| WO2008084106A9 (en) | 2009-09-17 |
| US9879082B2 (en) | 2018-01-30 |
| JP2016104728A (ja) | 2016-06-09 |
| EP2109460A1 (en) | 2009-10-21 |
| JP5478261B2 (ja) | 2014-04-23 |
| CN101578113B (zh) | 2015-04-22 |
| US20100189723A1 (en) | 2010-07-29 |
| CN105037549A (zh) | 2015-11-11 |
| JP6223771B2 (ja) | 2017-11-01 |
| EP2109460B1 (en) | 2016-05-18 |
| EP2604278A1 (en) | 2013-06-19 |
| AU2008204433A1 (en) | 2008-07-17 |
| CN101578113A (zh) | 2009-11-11 |
| JP2010515709A (ja) | 2010-05-13 |
| WO2008084106A1 (en) | 2008-07-17 |
| US10815299B2 (en) | 2020-10-27 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2579768T3 (es) | Anticuerpos anti-KIR, formulaciones y usos de los mismos | |
| RU2748046C2 (ru) | Препарат, содержащий антитело | |
| CN109937034B (zh) | 阿柏西普制剂及其用途 | |
| JP7473603B2 (ja) | 液体医薬組成物 | |
| ES2391407T3 (es) | Formulación de anticuerpos anti-a-beta | |
| ES2732861T3 (es) | Formulaciones en solución de anticuerpos anti-IL-23p19 manipulados por ingeniería | |
| ES2687600T3 (es) | Composición farmacéutica líquida | |
| ES2572919T3 (es) | Composición farmacéutica líquida | |
| ES2756275T3 (es) | Anticuerpos contra IL-6 mejorados | |
| ES3038408T3 (en) | Formulations with reduced degradation of polysorbate | |
| JP7183268B2 (ja) | 等張化剤としてリジン塩を含有するアフリベルセプト製剤及びその使用 | |
| ES2688895T3 (es) | Formulaciones con oxidación reducida | |
| EA030742B1 (ru) | Состав, содержащий антитело против ил-17 | |
| WO2019020777A1 (en) | LIQUID FORMULATION OF A VEGF ANTAGONIST | |
| JP6885875B2 (ja) | 液体医薬組成物 | |
| JP2021530458A (ja) | 高濃度液体抗体製剤 | |
| KR20210077645A (ko) | 신규 주사제 제형 | |
| WO2019106206A1 (en) | Stable, low viscosity, high concentration liquid formulations of an anti-il-12/23p40 antibody | |
| CN119997972A (zh) | 抗cd20抗体的药物组合物及其用途 | |
| BR112021015034A2 (pt) | Formulação de anticorpo terapêutico | |
| CN118056572A (zh) | 含有抗il-17抗体的稳定制剂 | |
| HK40022824A (en) | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof | |
| HK40008360A (en) | Aflibercept formulations and uses thereof | |
| BR112017008672B1 (pt) | Anticorpo ou fragmento de ligação ao antígeno, seu uso, fab isolado, composição, e vetor | |
| BR112015022484B1 (pt) | Formulação líquida, seu método de produção, e método para impedir a oxidação de uma proteína na dita formulação líquida |