JP5478261B2 - 抗kir抗体、製剤、およびその使用 - Google Patents
抗kir抗体、製剤、およびその使用 Download PDFInfo
- Publication number
- JP5478261B2 JP5478261B2 JP2009545192A JP2009545192A JP5478261B2 JP 5478261 B2 JP5478261 B2 JP 5478261B2 JP 2009545192 A JP2009545192 A JP 2009545192A JP 2009545192 A JP2009545192 A JP 2009545192A JP 5478261 B2 JP5478261 B2 JP 5478261B2
- Authority
- JP
- Japan
- Prior art keywords
- kir
- antibody
- seq
- dose
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87996407P | 2007-01-11 | 2007-01-11 | |
| US60/879,964 | 2007-01-11 | ||
| US91152707P | 2007-04-13 | 2007-04-13 | |
| US60/911,527 | 2007-04-13 | ||
| PCT/EP2008/050306 WO2008084106A1 (en) | 2007-01-11 | 2008-01-11 | Anti-kir antibodies, formulations, and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013213757A Division JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010515709A JP2010515709A (ja) | 2010-05-13 |
| JP2010515709A5 JP2010515709A5 (enExample) | 2011-03-03 |
| JP5478261B2 true JP5478261B2 (ja) | 2014-04-23 |
Family
ID=39144327
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009545192A Expired - Fee Related JP5478261B2 (ja) | 2007-01-11 | 2008-01-11 | 抗kir抗体、製剤、およびその使用 |
| JP2013213757A Expired - Fee Related JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
| JP2015227492A Pending JP2016104728A (ja) | 2007-01-11 | 2015-11-20 | 抗kir抗体、製剤、およびその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013213757A Expired - Fee Related JP6223771B2 (ja) | 2007-01-11 | 2013-10-11 | 抗kir抗体、製剤、およびその使用 |
| JP2015227492A Pending JP2016104728A (ja) | 2007-01-11 | 2015-11-20 | 抗kir抗体、製剤、およびその使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20100189723A1 (enExample) |
| EP (2) | EP2109460B1 (enExample) |
| JP (3) | JP5478261B2 (enExample) |
| CN (2) | CN105037549B (enExample) |
| AU (1) | AU2008204433B2 (enExample) |
| CA (1) | CA2675291C (enExample) |
| ES (2) | ES2627923T3 (enExample) |
| WO (1) | WO2008084106A1 (enExample) |
Families Citing this family (81)
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| HRP20120845T1 (hr) | 2003-07-02 | 2012-11-30 | Innate Pharma | Protutijela za pan-kir2dl nk-receptor i njihova uporaba u dijagnostici i lijeäśenju |
| US20090191213A9 (en) * | 2003-07-02 | 2009-07-30 | Novo Nordisk A/S | Compositions and methods for regulating NK cell activity |
| US20090196850A1 (en) * | 2005-01-06 | 2009-08-06 | Novo Nordisk A/S | Anti-Kir Combination Treatments and Methods |
| EP2367553B1 (en) * | 2008-12-05 | 2017-05-03 | Novo Nordisk A/S | Combination therapy to enhance nk cell mediated cytotoxicity |
| EP3121271B1 (en) | 2009-03-30 | 2019-07-24 | Portola Pharmaceuticals, Inc. | Antidotes for factor xa inhibitors and methods of using the same |
| ES2605801T3 (es) * | 2009-07-15 | 2017-03-16 | Portola Pharmaceuticals, Inc. | Formulación de dosis unitaria de antídoto para inhibidores del factor Xa para su uso en la prevención de la hemorragia |
| WO2012054509A2 (en) * | 2010-10-22 | 2012-04-26 | Dana-Farber Cancer Institute, Inc. | Discovery of regulatory t cells programmed to suppress an immune response |
| EP2643350A4 (en) * | 2010-11-22 | 2015-01-07 | Innate Pharma Sa | TREATMENTS WITH NK CELL MODULATION AND METHOD FOR THE TREATMENT OF HEMATOLOGICAL MALIGNOMES |
| KR20120093002A (ko) * | 2011-02-14 | 2012-08-22 | (주)에이티젠 | Nk 세포의 활성 측정을 이용한 암 진단 방법 및 진단 키트 |
| ES2765874T3 (es) | 2011-05-25 | 2020-06-11 | Innate Pharma Sa | Anticuerpos anti-KIR para el tratamiento de trastornos inflamatorios |
| PL2904011T3 (pl) | 2012-10-02 | 2018-01-31 | Bristol Myers Squibb Co | Połączenie przeciwciał anty-kir i przeciwciał anty-pd-1 w leczeniu raka |
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| US11639384B2 (en) | 2014-10-28 | 2023-05-02 | University Children's Hospital Tübingen | Treatment of pediatric BCP-ALL patients with an anti-KIR antibody |
| KR20250004095A (ko) | 2015-04-17 | 2025-01-07 | 브리스톨-마이어스 스큅 컴퍼니 | 항-pd-1 항체 및 또 다른 항체의 조합물을 포함하는 조성물 |
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| JP2016104728A (ja) | 2016-06-09 |
| US10815299B2 (en) | 2020-10-27 |
| AU2008204433A1 (en) | 2008-07-17 |
| JP2014050393A (ja) | 2014-03-20 |
| CA2675291A1 (en) | 2008-07-17 |
| CN101578113A (zh) | 2009-11-11 |
| JP6223771B2 (ja) | 2017-11-01 |
| WO2008084106A9 (en) | 2009-09-17 |
| EP2109460B1 (en) | 2016-05-18 |
| EP2604278A1 (en) | 2013-06-19 |
| US20100189723A1 (en) | 2010-07-29 |
| AU2008204433B2 (en) | 2014-03-13 |
| JP2010515709A (ja) | 2010-05-13 |
| CN105037549B (zh) | 2018-09-28 |
| ES2627923T3 (es) | 2017-08-01 |
| ES2579768T3 (es) | 2016-08-16 |
| WO2008084106A1 (en) | 2008-07-17 |
| CN105037549A (zh) | 2015-11-11 |
| CN101578113B (zh) | 2015-04-22 |
| EP2109460A1 (en) | 2009-10-21 |
| EP2604278B1 (en) | 2017-04-12 |
| US9879082B2 (en) | 2018-01-30 |
| US20150197569A1 (en) | 2015-07-16 |
| CA2675291C (en) | 2017-05-23 |
| US20180208652A1 (en) | 2018-07-26 |
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