ES2572001T3 - Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo - Google Patents
Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismoInfo
- Publication number
- ES2572001T3 ES2572001T3 ES12192910T ES12192910T ES2572001T3 ES 2572001 T3 ES2572001 T3 ES 2572001T3 ES 12192910 T ES12192910 T ES 12192910T ES 12192910 T ES12192910 T ES 12192910T ES 2572001 T3 ES2572001 T3 ES 2572001T3
- Authority
- ES
- Spain
- Prior art keywords
- bisfuran
- antiviral
- intermediates
- derived
- protease inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 229940122440 HIV protease inhibitor Drugs 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 239000004030 hiv protease inhibitor Substances 0.000 title 1
- 239000000543 intermediate Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/38—Amides of thiocarboxylic acids
- C07C327/40—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C327/42—Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of a saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/38—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reaction of ammonia or amines with sulfonic acids, or with esters, anhydrides, or halides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/22—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms
- C07C311/29—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound oxygen atoms having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4006—Esters of acyclic acids which can have further substituents on alkyl
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4084—Esters with hydroxyaryl compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- AIDS & HIV (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US78712606P | 2006-03-29 | 2006-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2572001T3 true ES2572001T3 (es) | 2016-05-27 |
Family
ID=38323963
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12192910T Active ES2572001T3 (es) | 2006-03-29 | 2007-03-29 | Derivado de bisfurano antivírico como inhibidor de la proteasa del VIH e intermedios del mismo |
| ES07754134T Active ES2430557T3 (es) | 2006-03-29 | 2007-03-29 | Proceso para la preparación de inhibidores de la proteasa del VIH |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES07754134T Active ES2430557T3 (es) | 2006-03-29 | 2007-03-29 | Proceso para la preparación de inhibidores de la proteasa del VIH |
Country Status (24)
| Country | Link |
|---|---|
| US (4) | US20110065631A1 (enExample) |
| EP (2) | EP2570416B1 (enExample) |
| JP (2) | JP5430395B2 (enExample) |
| KR (2) | KR101395377B1 (enExample) |
| CN (2) | CN101448838B (enExample) |
| AP (2) | AP2013006690A0 (enExample) |
| AU (1) | AU2007245194B2 (enExample) |
| BR (1) | BRPI0710199A2 (enExample) |
| CA (1) | CA2647316C (enExample) |
| DK (1) | DK1999133T3 (enExample) |
| EA (2) | EA020088B1 (enExample) |
| ES (2) | ES2572001T3 (enExample) |
| HR (2) | HRP20080554B1 (enExample) |
| IL (2) | IL194122A (enExample) |
| MX (1) | MX2008012398A (enExample) |
| NO (2) | NO342102B1 (enExample) |
| NZ (2) | NZ596074A (enExample) |
| PL (1) | PL1999133T3 (enExample) |
| PT (1) | PT1999133E (enExample) |
| SG (1) | SG170794A1 (enExample) |
| SI (1) | SI1999133T1 (enExample) |
| UA (1) | UA97241C2 (enExample) |
| WO (1) | WO2007126812A2 (enExample) |
| ZA (1) | ZA200808046B (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8921415B2 (en) | 2009-01-29 | 2014-12-30 | Mapi Pharma Ltd. | Polymorphs of darunavir |
| BR112012018862A2 (pt) | 2010-01-28 | 2015-10-13 | Mapi Pharma Ltd | processo para a preparação de darunavir e intermediários de darunavir |
| CN102190638A (zh) * | 2010-03-16 | 2011-09-21 | 中国科学院上海药物研究所 | 联芳基醇二胺类化合物、其药物组合物、制备方法及应用 |
| CN102584748B (zh) * | 2011-01-13 | 2015-02-11 | 浙江九洲药业股份有限公司 | 夫沙那韦中间体的制备方法 |
| PL2702045T3 (pl) * | 2011-04-26 | 2018-04-30 | Mylan Laboratories Ltd. | Nowy sposób sporządzania Etrawiryny |
| CN113264959A (zh) * | 2011-10-07 | 2021-08-17 | 吉利德科学公司 | 制备抗病毒核苷酸类似物的方法 |
| EP2634180A1 (en) | 2012-03-01 | 2013-09-04 | Lonza Ltd. | Enzymatic process for the preparation of butyrolactones |
| CN103664976B (zh) * | 2013-12-12 | 2015-11-04 | 惠州市莱佛士制药技术有限公司 | 一种顺式六氢呋喃并[2,3-b]呋喃-3-醇的制备方法 |
| ES2802376T3 (es) * | 2014-02-12 | 2021-01-19 | Firmenich Incorporated | Procedimiento mejorado para la síntesis de 1-bencil-3-(1-(isoxazol-4-ilmetil)-1h-pirazol-4-il)imidazolidin-2,4-dionas sustituidas |
| CN118286245A (zh) | 2014-12-26 | 2024-07-05 | 埃莫里大学 | N4-羟基胞苷和衍生物及与其相关的抗病毒用途 |
| JP6435907B2 (ja) * | 2015-02-16 | 2018-12-12 | 住友化学株式会社 | ヘキサヒドロフロフラノール誘導体の製造方法 |
| CN108610227B (zh) * | 2016-12-10 | 2021-02-09 | 中国科学院大连化学物理研究所 | 一种制备双环芳香化合物的方法 |
| RS66222B1 (sr) | 2017-12-07 | 2024-12-31 | Univ Emory | N4-hidroksicitidin i derivati i antivirusne upotrebe povezane sa njim |
| CA3125991A1 (en) | 2019-01-25 | 2020-07-30 | Brown University | Compositions and methods for treating, preventing or reversing age-associated inflammation and disorders |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU6828894A (en) * | 1993-05-14 | 1994-12-12 | Merck & Co., Inc. | Hiv protease inhibitors |
| AU1369001A (en) * | 1995-12-13 | 2001-03-22 | Abbott Laboratories | Retroviral protease inhibiting compounds |
| EP2314563A3 (en) | 1999-12-23 | 2012-04-04 | Ampac Fine Chemicals LLC | Improved preparation of 2S,3S-N-isobutyl-N-(2-hydroxy-3-amino-4-phenylbutyl)-p-nitrobenzenesulfonylamide hydrochloride and other derivatives of 2-hydroxy-1,3-diamines |
| WO2002067239A2 (en) * | 2000-10-24 | 2002-08-29 | Glaxo Group Limited | Process for preparing intermediates of hiv protease inhibitors |
| WO2003009690A2 (en) | 2001-07-20 | 2003-02-06 | Koninklijke Philips Electronics N.V. | Oscillating circuit, converter with such oscillating circuit, and preconditioner with such converter |
| US20050239054A1 (en) * | 2002-04-26 | 2005-10-27 | Arimilli Murty N | Method and compositions for identifying anti-HIV therapeutic compounds |
| EP1509537B9 (en) * | 2002-04-26 | 2007-11-14 | Gilead Sciences, Inc. | Cellular accumulation of phosphonate analogs of hiv protease inhibitor compounds and the compounds as such |
| EP1678322A2 (en) * | 2003-10-24 | 2006-07-12 | Gilead Sciences, Inc. | Methods and compositions for identifying therapeutic compounds |
-
2007
- 2007-03-29 PT PT77541340T patent/PT1999133E/pt unknown
- 2007-03-29 JP JP2009502946A patent/JP5430395B2/ja active Active
- 2007-03-29 KR KR1020137034899A patent/KR101395377B1/ko active Active
- 2007-03-29 ES ES12192910T patent/ES2572001T3/es active Active
- 2007-03-29 UA UAA200811574A patent/UA97241C2/uk unknown
- 2007-03-29 AP AP2013006690A patent/AP2013006690A0/xx unknown
- 2007-03-29 HR HRP20080554AA patent/HRP20080554B1/hr not_active IP Right Cessation
- 2007-03-29 EP EP12192910.3A patent/EP2570416B1/en active Active
- 2007-03-29 US US12/293,450 patent/US20110065631A1/en not_active Abandoned
- 2007-03-29 NZ NZ596074A patent/NZ596074A/xx not_active IP Right Cessation
- 2007-03-29 CN CN2007800178888A patent/CN101448838B/zh active Active
- 2007-03-29 WO PCT/US2007/007564 patent/WO2007126812A2/en not_active Ceased
- 2007-03-29 CN CN201110315578.2A patent/CN102516259B/zh active Active
- 2007-03-29 PL PL07754134T patent/PL1999133T3/pl unknown
- 2007-03-29 KR KR1020087026569A patent/KR101429300B1/ko active Active
- 2007-03-29 SG SG201102217-5A patent/SG170794A1/en unknown
- 2007-03-29 US US11/729,522 patent/US8173623B2/en active Active
- 2007-03-29 BR BRPI0710199-6A patent/BRPI0710199A2/pt not_active IP Right Cessation
- 2007-03-29 CA CA2647316A patent/CA2647316C/en active Active
- 2007-03-29 ES ES07754134T patent/ES2430557T3/es active Active
- 2007-03-29 SI SI200731323T patent/SI1999133T1/sl unknown
- 2007-03-29 EP EP07754134.0A patent/EP1999133B1/en active Active
- 2007-03-29 EA EA201100994A patent/EA020088B1/ru not_active IP Right Cessation
- 2007-03-29 AP AP2008004641A patent/AP2757A/xx active
- 2007-03-29 HR HRP20140626AA patent/HRP20140626A2/hr not_active Application Discontinuation
- 2007-03-29 AU AU2007245194A patent/AU2007245194B2/en active Active
- 2007-03-29 NZ NZ571302A patent/NZ571302A/en not_active IP Right Cessation
- 2007-03-29 DK DK07754134.0T patent/DK1999133T3/da active
- 2007-03-29 EA EA200802074A patent/EA016140B1/ru not_active IP Right Cessation
- 2007-03-29 MX MX2008012398A patent/MX2008012398A/es active IP Right Grant
-
2008
- 2008-09-16 IL IL194122A patent/IL194122A/en not_active IP Right Cessation
- 2008-09-19 ZA ZA200808046A patent/ZA200808046B/xx unknown
- 2008-10-28 NO NO20084547A patent/NO342102B1/no unknown
-
2012
- 2012-02-21 US US13/401,659 patent/US8431745B2/en active Active
- 2012-12-12 JP JP2012271186A patent/JP2013082717A/ja not_active Withdrawn
-
2013
- 2013-02-27 US US13/779,188 patent/US20130172295A1/en not_active Abandoned
- 2013-03-12 IL IL225167A patent/IL225167A/en not_active IP Right Cessation
-
2018
- 2018-01-17 NO NO20180086A patent/NO342965B1/no unknown
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