ES2546808T3 - Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo - Google Patents
Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo Download PDFInfo
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- ES2546808T3 ES2546808T3 ES07714522.5T ES07714522T ES2546808T3 ES 2546808 T3 ES2546808 T3 ES 2546808T3 ES 07714522 T ES07714522 T ES 07714522T ES 2546808 T3 ES2546808 T3 ES 2546808T3
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- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 2
- 125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 2
- SJHPCNCNNSSLPL-CSKARUKUSA-N (4e)-4-(ethoxymethylidene)-2-phenyl-1,3-oxazol-5-one Chemical group O1C(=O)C(=C/OCC)\N=C1C1=CC=CC=C1 SJHPCNCNNSSLPL-CSKARUKUSA-N 0.000 description 1
- 125000003088 (fluoren-9-ylmethoxy)carbonyl group Chemical group 0.000 description 1
- BDNKZNFMNDZQMI-UHFFFAOYSA-N 1,3-diisopropylcarbodiimide Chemical compound CC(C)N=C=NC(C)C BDNKZNFMNDZQMI-UHFFFAOYSA-N 0.000 description 1
- ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
- MKLNXCHCBVTRIH-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]-3-(3,4,5-trioctadecoxyphenyl)urea Chemical compound CCCCCCCCCCCCCCCCCCOC1=C(OCCCCCCCCCCCCCCCCCC)C(OCCCCCCCCCCCCCCCCCC)=CC(NC(=O)NCC=2C=CC(Cl)=CC=2)=C1 MKLNXCHCBVTRIH-UHFFFAOYSA-N 0.000 description 1
- MCDJYAYOEMBQRK-UHFFFAOYSA-N 1-[chloro(diphenyl)methyl]-3,5-di(docosoxy)benzene Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC(OCCCCCCCCCCCCCCCCCCCCCC)=CC(C(Cl)(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 MCDJYAYOEMBQRK-UHFFFAOYSA-N 0.000 description 1
- QYOXLKAKUAASNA-UHFFFAOYSA-N 1-bromodocosane Chemical compound CCCCCCCCCCCCCCCCCCCCCCBr QYOXLKAKUAASNA-UHFFFAOYSA-N 0.000 description 1
- NQQCLUUOIHXCFY-UHFFFAOYSA-N 2,4-di(docosoxy)benzaldehyde Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC=C(C=O)C(OCCCCCCCCCCCCCCCCCCCCCC)=C1 NQQCLUUOIHXCFY-UHFFFAOYSA-N 0.000 description 1
- BJRNQGBSGKWNCB-UHFFFAOYSA-N 2-[[3,5-di(docosoxy)phenyl]methyl]-4-diphenylphosphanylbenzoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC(OCCCCCCCCCCCCCCCCCCCCCC)=CC(CC=2C(=CC=C(C=2)P(C=2C=CC=CC=2)C=2C=CC=CC=2)C(O)=O)=C1 BJRNQGBSGKWNCB-UHFFFAOYSA-N 0.000 description 1
- CFOCOVNPZDVGDV-UHFFFAOYSA-N 3,4,5-trihydroxy-2-methylbenzoic acid Chemical compound CC1=C(O)C(O)=C(O)C=C1C(O)=O CFOCOVNPZDVGDV-UHFFFAOYSA-N 0.000 description 1
- YJLXJPHAFLSYKQ-UHFFFAOYSA-N 3,4,5-trioctadecoxybenzoic acid Chemical compound CCCCCCCCCCCCCCCCCCOC1=CC(C(O)=O)=CC(OCCCCCCCCCCCCCCCCCC)=C1OCCCCCCCCCCCCCCCCCC YJLXJPHAFLSYKQ-UHFFFAOYSA-N 0.000 description 1
- WADSJYLPJPTMLN-UHFFFAOYSA-N 3-(cycloundecen-1-yl)-1,2-diazacycloundec-2-ene Chemical compound C1CCCCCCCCC=C1C1=NNCCCCCCCC1 WADSJYLPJPTMLN-UHFFFAOYSA-N 0.000 description 1
- GXMHDTPYKRTARV-UHFFFAOYSA-N 4-diphenylphosphanylbenzoic acid Chemical compound C1=CC(C(=O)O)=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 GXMHDTPYKRTARV-UHFFFAOYSA-N 0.000 description 1
- UTUKHRWZEYOXML-UHFFFAOYSA-N 5-(bromomethyl)-1,2,3-trioctadecoxybenzene Chemical compound CCCCCCCCCCCCCCCCCCOC1=CC(CBr)=CC(OCCCCCCCCCCCCCCCCCC)=C1OCCCCCCCCCCCCCCCCCC UTUKHRWZEYOXML-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
- QOSSAOTZNIDXMA-UHFFFAOYSA-N Dicylcohexylcarbodiimide Chemical compound C1CCCCC1N=C=NC1CCCCC1 QOSSAOTZNIDXMA-UHFFFAOYSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- JQRFZHLSVNTDMO-UHFFFAOYSA-N N-[[2,4-di(docosoxy)phenyl]methylidene]hydroxylamine Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC=C(C=NO)C(OCCCCCCCCCCCCCCCCCCCCCC)=C1 JQRFZHLSVNTDMO-UHFFFAOYSA-N 0.000 description 1
- PHSPJQZRQAJPPF-UHFFFAOYSA-N N-alpha-Methylhistamine Chemical compound CNCCC1=CN=CN1 PHSPJQZRQAJPPF-UHFFFAOYSA-N 0.000 description 1
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Chemical compound OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 description 1
- LNUFLCYMSVYYNW-ZPJMAFJPSA-N [(2r,3r,4s,5r,6r)-2-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[(2r,3r,4s,5r,6r)-6-[[(3s,5s,8r,9s,10s,13r,14s,17r)-10,13-dimethyl-17-[(2r)-6-methylheptan-2-yl]-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthren-3-yl]oxy]-4,5-disulfo Chemical compound O([C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1[C@@H](COS(O)(=O)=O)O[C@H]([C@@H]([C@H]1OS(O)(=O)=O)OS(O)(=O)=O)O[C@@H]1C[C@@H]2CC[C@H]3[C@@H]4CC[C@@H]([C@]4(CC[C@@H]3[C@@]2(C)CC1)C)[C@H](C)CCCC(C)C)[C@H]1O[C@H](COS(O)(=O)=O)[C@@H](OS(O)(=O)=O)[C@H](OS(O)(=O)=O)[C@H]1OS(O)(=O)=O LNUFLCYMSVYYNW-ZPJMAFJPSA-N 0.000 description 1
- QDBGTPIUAHDASH-UHFFFAOYSA-N [3,5-di(docosoxy)phenyl]methanol Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC(CO)=CC(OCCCCCCCCCCCCCCCCCCCCCC)=C1 QDBGTPIUAHDASH-UHFFFAOYSA-N 0.000 description 1
- BLWWLFLHBATVGY-UHFFFAOYSA-M [Br-].C1CCOC1.[Mg+]C1=CC=C(Cl)C=C1 Chemical compound [Br-].C1CCOC1.[Mg+]C1=CC=C(Cl)C=C1 BLWWLFLHBATVGY-UHFFFAOYSA-M 0.000 description 1
- OFJJGSAYWPNTEW-UHFFFAOYSA-M [Br-].C1CCOC1.[Mg+]C1=CC=CC=C1 Chemical compound [Br-].C1CCOC1.[Mg+]C1=CC=CC=C1 OFJJGSAYWPNTEW-UHFFFAOYSA-M 0.000 description 1
- RAYIJRRLHAWAFV-UHFFFAOYSA-N [carboxy-[[3,5-di(docosoxy)phenyl]methyl]amino]-ethylcarbamic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCCOC1=CC(CN(N(CC)C(O)=O)C(O)=O)=CC(OCCCCCCCCCCCCCCCCCCCCCC)=C1 RAYIJRRLHAWAFV-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- DORMTBIPKNPJPY-UHFFFAOYSA-N acetic acid;iodobenzene Chemical compound CC(O)=O.IC1=CC=CC=C1 DORMTBIPKNPJPY-UHFFFAOYSA-N 0.000 description 1
- WETWJCDKMRHUPV-UHFFFAOYSA-N acetyl chloride Chemical compound CC(Cl)=O WETWJCDKMRHUPV-UHFFFAOYSA-N 0.000 description 1
- 239000012346 acetyl chloride Substances 0.000 description 1
- 238000010306 acid treatment Methods 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 150000001408 amides Chemical class 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- 150000007514 bases Chemical class 0.000 description 1
- 239000011324 bead Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 150000001735 carboxylic acids Chemical class 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- FZFAMSAMCHXGEF-UHFFFAOYSA-N chloro formate Chemical compound ClOC=O FZFAMSAMCHXGEF-UHFFFAOYSA-N 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 239000012297 crystallization seed Substances 0.000 description 1
- UURSXESKOOOTOV-UHFFFAOYSA-N dec-5-ene Chemical compound CCCCC=CCCCC UURSXESKOOOTOV-UHFFFAOYSA-N 0.000 description 1
- VILAVOFMIJHSJA-UHFFFAOYSA-N dicarbon monoxide Chemical group [C]=C=O VILAVOFMIJHSJA-UHFFFAOYSA-N 0.000 description 1
- BGRWYRAHAFMIBJ-UHFFFAOYSA-N diisopropylcarbodiimide Natural products CC(C)NC(=O)NC(C)C BGRWYRAHAFMIBJ-UHFFFAOYSA-N 0.000 description 1
- 229910001873 dinitrogen Inorganic materials 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000007350 electrophilic reaction Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- VYSYZMNJHYOXGN-UHFFFAOYSA-N ethyl n-aminocarbamate Chemical compound CCOC(=O)NN VYSYZMNJHYOXGN-UHFFFAOYSA-N 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 238000004811 liquid chromatography Methods 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- ANSUDRATXSJBLY-VKHMYHEASA-N methyl (2s)-2-amino-3-hydroxypropanoate Chemical compound COC(=O)[C@@H](N)CO ANSUDRATXSJBLY-VKHMYHEASA-N 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012038 nucleophile Substances 0.000 description 1
- 238000005935 nucleophilic addition reaction Methods 0.000 description 1
- QDYGCAOQFANHSG-UHFFFAOYSA-N octadecoxybenzene Chemical compound CCCCCCCCCCCCCCCCCCOC1=CC=CC=C1 QDYGCAOQFANHSG-UHFFFAOYSA-N 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229940127557 pharmaceutical product Drugs 0.000 description 1
- 238000005191 phase separation Methods 0.000 description 1
- 125000004437 phosphorous atom Chemical group 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 238000010992 reflux Methods 0.000 description 1
- 150000003335 secondary amines Chemical class 0.000 description 1
- 238000010898 silica gel chromatography Methods 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 238000000956 solid--liquid extraction Methods 0.000 description 1
- DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- UCPYLLCMEDAXFR-UHFFFAOYSA-N triphosgene Chemical compound ClC(Cl)(Cl)OC(=O)OC(Cl)(Cl)Cl UCPYLLCMEDAXFR-UHFFFAOYSA-N 0.000 description 1
- PXXNTAGJWPJAGM-UHFFFAOYSA-N vertaline Natural products C1C2C=3C=C(OC)C(OC)=CC=3OC(C=C3)=CC=C3CCC(=O)OC1CC1N2CCCC1 PXXNTAGJWPJAGM-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/96—Esters of carbonic or haloformic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/54—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C217/56—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms
- C07C217/58—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by singly-bound oxygen atoms with amino groups and the six-membered aromatic ring, or the condensed ring system containing that ring, bound to the same carbon atom of the carbon chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C265/00—Derivatives of isocyanic acid
- C07C265/12—Derivatives of isocyanic acid having isocyanate groups bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C281/00—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group
- C07C281/20—Derivatives of carbonic acid containing functional groups covered by groups C07C269/00 - C07C279/00 in which at least one nitrogen atom of these functional groups is further bound to another nitrogen atom not being part of a nitro or nitroso group the two nitrogen atoms of the functional groups being doubly-bound to each other, e.g. azoformamide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/60—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by oxygen or sulfur atoms, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/50—Organo-phosphines
- C07F9/5022—Aromatic phosphines (P-C aromatic linkage)
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Peptides Or Proteins (AREA)
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|---|---|---|---|
| JP2006084019 | 2006-03-24 | ||
| JP2006084019 | 2006-03-24 | ||
| PCT/JP2007/052996 WO2007122847A1 (ja) | 2006-03-24 | 2007-02-19 | 有機合成用試薬、及び当該試薬を用いた有機合成反応方法 |
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|---|---|
| ES2546808T3 true ES2546808T3 (es) | 2015-09-28 |
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| ES07714522.5T Active ES2546808T3 (es) | 2006-03-24 | 2007-02-19 | Reactivo para síntesis orgánica y método de reacción de síntesis orgánica con dicho reactivo |
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| Country | Link |
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| US (2) | US8093435B2 (enExample) |
| EP (1) | EP2003104B1 (enExample) |
| JP (2) | JPWO2007122847A1 (enExample) |
| CN (1) | CN101405240B (enExample) |
| AU (1) | AU2007242276A1 (enExample) |
| DK (1) | DK2003104T3 (enExample) |
| ES (1) | ES2546808T3 (enExample) |
| WO (1) | WO2007122847A1 (enExample) |
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| EP2003104B1 (en) * | 2006-03-24 | 2015-07-01 | Jitsubo Co., Ltd. | Reagent for organic synthesis and method of organic synthesis reaction with the reagent |
| EP2415744A4 (en) | 2009-03-12 | 2014-03-19 | Ajinomoto Kk | FLUORENE COMPOUND |
| JP5768712B2 (ja) | 2009-03-30 | 2015-08-26 | 味の素株式会社 | ジフェニルメタン化合物 |
| EP2518041A4 (en) | 2009-12-25 | 2013-12-11 | Ajinomoto Kk | benzyl |
| DK2612845T3 (da) * | 2010-08-30 | 2020-11-02 | Ajinomoto Kk | Aromatisk forbindelse som indeholder specifik forgrening |
| ES2742299T3 (es) | 2011-03-09 | 2020-02-13 | Jitsubo Co Ltd | Nuevos péptidos entrecruzados que contienen una estructura entrecruzada no peptídica, método para sintetizar péptidos entrecruzados y nuevo compuesto orgánico utilizado en el método |
| JP5979139B2 (ja) | 2011-05-17 | 2016-08-24 | 味の素株式会社 | オリゴヌクレオチドの製造方法 |
| WO2012165545A1 (ja) | 2011-05-31 | 2012-12-06 | 味の素株式会社 | ペプチドの製造方法 |
| EP2716650A1 (en) * | 2011-05-31 | 2014-04-09 | Ajinomoto Co., Inc. | Method for producing peptide |
| CN102584546A (zh) * | 2011-09-26 | 2012-07-18 | 盘锦兴福化工有限公司 | 2,3—二氟苯乙醚的合成方法 |
| US9057712B1 (en) | 2011-10-27 | 2015-06-16 | Copilot Ventures Fund Iii Llc | Methods of delivery of encapsulated perfluorocarbon taggants |
| JP6218333B2 (ja) | 2012-11-14 | 2017-10-25 | 武田薬品工業株式会社 | 核酸の液相合成方法 |
| US9504747B2 (en) | 2013-03-08 | 2016-11-29 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| WO2014136086A1 (en) * | 2013-03-08 | 2014-09-12 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
| EP3015467B1 (en) | 2013-05-24 | 2024-12-04 | Ajinomoto Co., Inc. | Morpholino oligonucleotide manufacturing method |
| US9365615B2 (en) | 2013-09-09 | 2016-06-14 | Jitsubo Co., Ltd. | Cross-linked peptides containing non-peptide cross-linked structure, method for synthesizing cross-linked peptides, and novel organic compound used in method |
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| US4014937A (en) * | 1974-08-26 | 1977-03-29 | Pfizer Inc. | 3,4-And 3,5-dialkoxyphenethylamines |
| JPH06239995A (ja) | 1993-02-22 | 1994-08-30 | Matsushita Electric Works Ltd | ポリアニリン誘導体およびその製造方法 |
| WO1997042166A1 (fr) | 1996-05-02 | 1997-11-13 | Terumo Kabushiki Kaisha | Derives amidines et vecteurs de medicaments les contenant |
| JP2000044493A (ja) * | 1998-07-27 | 2000-02-15 | Asahi Chem Ind Co Ltd | 化合物ライブラリー合成用保護基 |
| JP2001122889A (ja) | 1999-10-26 | 2001-05-08 | Noguchi Inst | 糖脂質アナログ化合物 |
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| US20040214989A1 (en) | 2001-08-24 | 2004-10-28 | Kazuhiro Chiba | Compatible-multiphase organic solvent system |
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| JP2004059509A (ja) | 2002-07-30 | 2004-02-26 | Nokodai Tlo Kk | 液相ペプチド合成用アミノ酸試薬 |
| EP1621249A4 (en) | 2003-02-24 | 2007-05-02 | Univ Tokyo Agriculture & Technology Tlo Co Ltd | CHEMICAL PROCESSES USING SOLVENT COMPOSITIONS CAPABLE OF ASSUMING A REVERSIBLE HOMOGENEOUS MIXING STATUS AND SEPARATE STATUS DEPENDING ON THE TEMPERATURE |
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| WO2006104166A1 (ja) | 2005-03-29 | 2006-10-05 | National University Corporation, Tokyo University Of Agriculture And Technology | 晶析分離用担体及び化合物の分離方法 |
| EP2003104B1 (en) * | 2006-03-24 | 2015-07-01 | Jitsubo Co., Ltd. | Reagent for organic synthesis and method of organic synthesis reaction with the reagent |
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2007
- 2007-02-19 EP EP07714522.5A patent/EP2003104B1/en active Active
- 2007-02-19 CN CN2007800103222A patent/CN101405240B/zh active Active
- 2007-02-19 WO PCT/JP2007/052996 patent/WO2007122847A1/ja not_active Ceased
- 2007-02-19 JP JP2008511981A patent/JPWO2007122847A1/ja active Pending
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| CN101405240B (zh) | 2012-07-25 |
| US8093435B2 (en) | 2012-01-10 |
| US8293948B2 (en) | 2012-10-23 |
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| JP2009185063A (ja) | 2009-08-20 |
| US20090299103A1 (en) | 2009-12-03 |
| EP2003104B1 (en) | 2015-07-01 |
| JPWO2007122847A1 (ja) | 2009-09-03 |
| AU2007242276A1 (en) | 2007-11-01 |
| EP2003104A4 (en) | 2010-01-06 |
| DK2003104T3 (en) | 2015-08-10 |
| CN101405240A (zh) | 2009-04-08 |
| US20120108788A1 (en) | 2012-05-03 |
| JP5113118B2 (ja) | 2013-01-09 |
| EP2003104A9 (en) | 2009-04-15 |
| EP2003104A2 (en) | 2008-12-17 |
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