ES2541306T3 - Determinados compuestos de fosfato de aminoalquil-glucosaminida y sus usos - Google Patents
Determinados compuestos de fosfato de aminoalquil-glucosaminida y sus usos Download PDFInfo
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- ES2541306T3 ES2541306T3 ES05785550.4T ES05785550T ES2541306T3 ES 2541306 T3 ES2541306 T3 ES 2541306T3 ES 05785550 T ES05785550 T ES 05785550T ES 2541306 T3 ES2541306 T3 ES 2541306T3
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- -1 aminoalkyl glucosaminide phosphate compounds Chemical class 0.000 title abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000001476 phosphono group Chemical group [H]OP(*)(=O)O[H] 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 description 9
- 102000004127 Cytokines Human genes 0.000 description 9
- 108091033319 polynucleotide Proteins 0.000 description 7
- 102000040430 polynucleotide Human genes 0.000 description 7
- 239000002157 polynucleotide Substances 0.000 description 7
- 239000000203 mixture Substances 0.000 description 6
- 239000002245 particle Substances 0.000 description 5
- 239000013598 vector Substances 0.000 description 5
- 108020004414 DNA Proteins 0.000 description 4
- 239000007789 gas Substances 0.000 description 3
- 230000006698 induction Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 108090000174 Interleukin-10 Proteins 0.000 description 2
- 108090000978 Interleukin-4 Proteins 0.000 description 2
- 108010002616 Interleukin-5 Proteins 0.000 description 2
- 108090001005 Interleukin-6 Proteins 0.000 description 2
- 230000028993 immune response Effects 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000004044 response Effects 0.000 description 2
- 229960005486 vaccine Drugs 0.000 description 2
- 241000710929 Alphavirus Species 0.000 description 1
- 108091029430 CpG site Proteins 0.000 description 1
- 208000000832 Equine Encephalomyelitis Diseases 0.000 description 1
- 108010033040 Histones Proteins 0.000 description 1
- 102100037850 Interferon gamma Human genes 0.000 description 1
- 108010074328 Interferon-gamma Proteins 0.000 description 1
- 102000013462 Interleukin-12 Human genes 0.000 description 1
- 108010065805 Interleukin-12 Proteins 0.000 description 1
- 108010002350 Interleukin-2 Proteins 0.000 description 1
- 102000000588 Interleukin-2 Human genes 0.000 description 1
- 108091034117 Oligonucleotide Proteins 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 230000003416 augmentation Effects 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 238000001476 gene delivery Methods 0.000 description 1
- 239000001307 helium Substances 0.000 description 1
- 229910052734 helium Inorganic materials 0.000 description 1
- SWQJXJOGLNCZEY-UHFFFAOYSA-N helium atom Chemical compound [He] SWQJXJOGLNCZEY-UHFFFAOYSA-N 0.000 description 1
- 230000006801 homologous recombination Effects 0.000 description 1
- 238000002744 homologous recombination Methods 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000002163 immunogen Effects 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000010354 integration Effects 0.000 description 1
- 230000021633 leukocyte mediated immunity Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H5/00—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium
- C07H5/02—Compounds containing saccharide radicals in which the hetero bonds to oxygen have been replaced by the same number of hetero bonds to halogen, nitrogen, sulfur, selenium, or tellurium to halogen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
- C07H11/04—Phosphates; Phosphites; Polyphosphates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Immunology (AREA)
- Pulmonology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Lift-Guide Devices, And Elevator Ropes And Cables (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Un compuesto que tiene la fórmula (III)**Fórmula** en donde X se selecciona del grupo que consiste en O y S, en la posición axial o ecuatorial; Y se selecciona del grupo que consiste de O y NH; n, m, p y q son enteros de 0 a 6; R1, R2 y R3 son iguales o diferentes y son grupos alquilo de cadena recta no sustituidos que tienen de 6 a 14 átomos de carbono, y en donde uno de R1, R2 o R3 es opcionalmente hidrógeno; R4 y R5 son iguales o diferentes y se seleccionan del grupo que consiste en H y metilo; R6 y R7 son iguales o diferentes y se seleccionan del grupo que consiste en H, hidroxi, alcoxi, fosfono, fosfonoxi, sulfo, sulfoxi, amino, mercapto, ciano, nitro, formilo y carboxi, y ésteres y amidas de los mismos; R8 y R9 son iguales o diferentes y se seleccionan del grupo que consiste en fosfono y H, y por lo menos uno de R8 y R9 es fosfono; R10, R11 y R12 se seleccionan independientemente de grupos alifáticos saturados no sustituidos, de cadena recta, que tienen de 1 a 11 átomos de carbono; dado que R1, R2 o R3 son grupos alquilo de cadena recta C6-C10 no sustituidos o una sal farmacéuticamente aceptable de los mismos.
Description
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E05785550
01-07-2015
También se puede utilizar cualquiera de una cantidad de vectores de alfavirus para el suministro de composiciones de polinucleótido de la presente invención, tales como aquellos vectores descritos en las Patentes Estadounidenses Nos. 5,843,723; 6,015,686; 6,008,035 y 6,015,694. También se pueden utilizar determinados vectores de encefalitis equina de Venezuela (VEE), cuyos ejemplos ilustrativos se pueden encontrar en las Patentes Estadounidenses Nos. 5,505,947 y 5,643,576.
Más aún, también se pueden utilizar vectores conjugados moleculares, tales como vectores quiméricos de adenovirus descritos en Michael et al., J. Biol. Chem. (1993) 268:6866-6869 y Wagner et al., Proc. Natl. Acad. Sci. USA (1992) 89:60996103, para suministro de gen bajo la invención.
La información ilustrativa adicional sobre estos y otros sistemas de suministro con base viral conocidos se pueden encontrar por ejemplo en Fisher-Hoch et al., Proc. Natl. Acad. Sci. USA 86:317-321,1989; Flexner et al., Ann. N. Y. Acad. Sci. 569:86103, 1989; Flexner et al., Vaccine 8:17-21, 1990; Patentes Estadounidenses Nos. 4,603,112, 4,769,330 y 5,017,487; WO 89/01973; Patente Estadounidense No. 4,777,127; GB 2,200,651; EP 0,345,242; WO 91/02805; Berkner, Biotechniques 6:616-627, 1988; Roschfeld et al., Science 252:431-434,1991; Kolls et al., Proc. Natl. Acad. Sci. USA 91:215-219, 1994; Kass-Eisler et al., Proc. Natl. Acad. Sci. USA 90:11498-11502, 1993; Guzmán et al., Circulation 88:2838-2848, 1993; y Guzman et al., Cir. Res. 73:1202-1207,1993.
En determinadas realizaciones se puede integrar un polinucleótido en el genoma de una célula objetivo. Esta integración puede estar en la localización y orientación específica a través de recombinación homóloga (reemplazo de gen), o se puede integrar en una localización aleatoria, no específica (aumento de gen). En todavía realizaciones adicionales, el polinucleótido se puede mantener establemente en la célula como un segmento episómico separado de ADN. Dichos segmentos de polinucleótido o “episomas” codifican secuencias suficientes para permitir el mantenimiento y réplica independientes o en sincronización con el ciclo celular del anfitrión. La manera en la cual se suministra la construcción de expresión a una célula, y en donde permanece el polinucleótido en la célula, dependen del tipo de construcción de expresión empleada.
En otra realización de la invención, un polinucleótido se administra/suministra como un ADN “libre de histona”, por ejemplo como se describe en Ulmer et al., Science 259:1745-1749, 1993, y revisado por Cohen, Science 259:1691-1692,1993. La absorción de ADN libre de histona se puede incrementar al recubrir el ADN sobre glóbulos biodegradables que son transportados de forma eficiente a las células.
En aún otra realización, una composición de la presente invención se puede suministrar por medio de un método de bombardeo de partículas, muchos de los cuales se han descrito. En un ejemplo ilustrativo, se puede lograr aceleración de partículas impulsada por gas con dispositivos tales como aquellos fabricados por Powderject Pharmaceuticals PLC (Oxford, Reino Unido) y Powderject Vaccines Inc. (Madison, WI), algunos ejemplos de los cuales se describen en las Patentes Estadounidenses Nos. 5,846,796; 6,010,478; 5,865,796; 5,584,807 y Patente Europea No. 0500 799. Este método ofrece un método de suministro sin aguja, en donde una formulación de polvo seco de partículas microscópicas, tales como partículas de polinucleótido o polipéptido, son aceleradas a alta velocidad dentro de un chorro de gas helio generado por un dispositivo manual, que impulsa las partículas hacia el tejido objetivo de interés.
En una realización relacionada, otros dispositivos y métodos que pueden ser útiles para la inyección sin aguja, impulsada por gas de las composiciones de la presente invención, incluyen aquellos proporcionados por Bioject, Inc. (Portland, OR), algunos ejemplos de los cuales se describen en las Patentes Estadounidenses Nos. 4,790,824; 5,064,413; 5,312,335; 5,383,851; 5,399,163; 5,520,639 y 5,993,412.
Dentro de determinadas realizaciones de la invención, la composición farmacéutica es preferiblemente una que induce una respuesta inmune predominantemente del tipo Th1. Altos niveles de citoquinas del tipo Th1 (por ejemplo, IFN-γ, TNFα, IL-2 e IL-12) tienden a favorecer la inducción de las respuestas inmunes mediadas por célula a un antígeno administrado. En contraste, altos niveles de citoquinas del tipo Th2 (por ejemplo, IL-4, IL-5, IL-6 e IL-10) tienden a favorecer la inducción de respuestas inmunes humorales. Después de la aplicación de una composición inmunogénica como la proporcionada aquí, un paciente soportará una respuesta inmune que incluye respuestas de tipo Th1 y Th2. Dentro de una realización preferida, en la cual una respuesta es predominantemente del tipo Th1, el nivel de las citoquinas del tipo Th1 aumentará a un mayor grado que el nivel de citoquinas de tipo Th2. los niveles de estas citoquinas se pueden determinar fácilmente utilizando ensayos estándares. Alternativamente, o adicionalmente, para determinadas aplicaciones terapéuticas pueden ser deseables altos niveles de citoquinas de tipo Th2 (por ejemplo, IL-4, IL-5, IL-6 e IL-10). Los niveles de estas citoquinas se pueden evaluar fácilmente utilizando ensayos estándares. Para una revisión de las familias de citoquinas véase Mosmann and Coffman, Ann. Rev. Immunol. 7:145-173,1989.
Las composiciones ilustrativas para uso en la inducción de citoquinas de tipo Th1 incluyen, por ejemplo, una combinación de oligonucleótidos que contienen CpG (en el que el dinucleótido CpG no está metilado) como se describe por ejemplo en los
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Claims (1)
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imagen1 imagen2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US888683 | 1986-07-24 | ||
| US10/888,683 US7960522B2 (en) | 2003-01-06 | 2004-07-08 | Certain aminoalkyl glucosaminide phosphate compounds and their use |
| PCT/US2005/022522 WO2006016997A2 (en) | 2004-07-08 | 2005-06-24 | Certain aminoalkyl glucosaminide phosphate compounds and their use |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2541306T3 true ES2541306T3 (es) | 2015-07-17 |
Family
ID=35839700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES05785550.4T Active ES2541306T3 (es) | 2004-07-08 | 2005-06-24 | Determinados compuestos de fosfato de aminoalquil-glucosaminida y sus usos |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7960522B2 (es) |
| EP (2) | EP2940027A1 (es) |
| JP (1) | JP2008505897A (es) |
| CN (1) | CN101010328A (es) |
| AU (1) | AU2005272076B2 (es) |
| BR (1) | BRPI0513144A (es) |
| CA (1) | CA2573059A1 (es) |
| CY (1) | CY1116571T1 (es) |
| DK (1) | DK1776375T3 (es) |
| ES (1) | ES2541306T3 (es) |
| HK (2) | HK1099308A1 (es) |
| HU (1) | HUE025324T2 (es) |
| IL (1) | IL180599A (es) |
| MA (1) | MA28758B1 (es) |
| MX (1) | MX2007000331A (es) |
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- 2005-06-24 EP EP05785550.4A patent/EP1776375B1/en active Active
- 2005-06-24 CA CA002573059A patent/CA2573059A1/en not_active Abandoned
- 2005-06-24 MX MX2007000331A patent/MX2007000331A/es unknown
- 2005-06-24 SI SI200531983T patent/SI1776375T1/sl unknown
-
2007
- 2007-01-08 IL IL180599A patent/IL180599A/en active IP Right Grant
- 2007-01-31 MA MA29644A patent/MA28758B1/fr unknown
- 2007-02-07 NO NO20070699A patent/NO340869B1/no unknown
- 2007-04-30 HK HK07104639.2A patent/HK1099308A1/xx not_active IP Right Cessation
-
2008
- 2008-06-05 ZA ZA200804906A patent/ZA200804906B/en unknown
-
2011
- 2011-05-24 US US13/115,011 patent/US20120058148A1/en not_active Abandoned
-
2015
- 2015-07-01 CY CY20151100568T patent/CY1116571T1/el unknown
-
2016
- 2016-05-04 HK HK16105082.0A patent/HK1217105A1/zh unknown
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