ES2533622T3 - Virus de la gripe recombinantes para vacunas y terapia génica - Google Patents
Virus de la gripe recombinantes para vacunas y terapia génica Download PDFInfo
- Publication number
- ES2533622T3 ES2533622T3 ES10011896.7T ES10011896T ES2533622T3 ES 2533622 T3 ES2533622 T3 ES 2533622T3 ES 10011896 T ES10011896 T ES 10011896T ES 2533622 T3 ES2533622 T3 ES 2533622T3
- Authority
- ES
- Spain
- Prior art keywords
- linked
- virus
- influenza
- vector
- cdna
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Virology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12791299P | 1999-04-06 | 1999-04-06 | |
| US127912P | 1999-04-06 | ||
| US13283999P | 1999-05-06 | 1999-05-06 | |
| US132839P | 1999-05-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2533622T3 true ES2533622T3 (es) | 2015-04-13 |
Family
ID=26826080
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00920151T Expired - Lifetime ES2290024T3 (es) | 1999-04-06 | 2000-04-05 | Virus de la gripe recombinantes para vacunas y terapia genica. |
| ES07009953T Expired - Lifetime ES2373405T3 (es) | 1999-04-06 | 2000-04-05 | Virus de la gripe recombinantes para vacunas y terapia génica. |
| ES10011896.7T Expired - Lifetime ES2533622T3 (es) | 1999-04-06 | 2000-04-05 | Virus de la gripe recombinantes para vacunas y terapia génica |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES00920151T Expired - Lifetime ES2290024T3 (es) | 1999-04-06 | 2000-04-05 | Virus de la gripe recombinantes para vacunas y terapia genica. |
| ES07009953T Expired - Lifetime ES2373405T3 (es) | 1999-04-06 | 2000-04-05 | Virus de la gripe recombinantes para vacunas y terapia génica. |
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| Country | Link |
|---|---|
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| JP (3) | JP5543048B2 (OSRAM) |
| KR (1) | KR100702275B1 (OSRAM) |
| CN (2) | CN1350578B (OSRAM) |
| AT (2) | ATE368729T1 (OSRAM) |
| AU (1) | AU4073300A (OSRAM) |
| BR (1) | BRPI0009580B8 (OSRAM) |
| CA (2) | CA2928263A1 (OSRAM) |
| CY (2) | CY1108520T1 (OSRAM) |
| DE (6) | DE122008000061I1 (OSRAM) |
| DK (3) | DK1820853T3 (OSRAM) |
| ES (3) | ES2290024T3 (OSRAM) |
| FR (1) | FR11C0027I2 (OSRAM) |
| HK (1) | HK1214298A1 (OSRAM) |
| IL (2) | IL145702A0 (OSRAM) |
| MX (1) | MXPA01010082A (OSRAM) |
| NL (2) | NL300364I2 (OSRAM) |
| PT (2) | PT1820853E (OSRAM) |
| WO (1) | WO2000060050A2 (OSRAM) |
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| CN101580849B (zh) | 2000-04-28 | 2012-11-21 | 圣朱德儿童研究医院 | 用于产生感染性流感病毒的dna转染系统 |
| EP1862550A1 (en) * | 2000-06-23 | 2007-12-05 | Wyeth Holdings Corporation | Assembly of wild-type and chimeric influenza virus-like particles (VLPs) |
| CN1196788C (zh) * | 2000-06-23 | 2005-04-13 | 惠氏控股有限公司 | 野生型和嵌合流感病毒样颗粒(vlp)的装配 |
| US7211378B2 (en) | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
| EP1572910B1 (en) * | 2002-02-13 | 2015-12-02 | Wisconsin Alumni Research Foundation | Signal for packaging of influenza virus vectors |
| DK1499348T3 (en) * | 2002-04-26 | 2015-01-05 | Medimmune Llc | PROCEDURE FOR PREPARING INFECTIOUS INFLUENZA B-VIRA IN CELL CULTURE |
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| KR100908757B1 (ko) * | 2003-05-28 | 2009-07-22 | 위스콘신 얼럼나이 리서어치 화운데이션 | 백신 및 유전자 요법을 위한 고 역가 재조합 인플루엔자바이러스 |
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| ES2345492T3 (es) | 2003-12-23 | 2010-09-24 | Medimmune, Llc | Sistema multiplasmido para la produccion del virus de la gripe. |
| FR2866031B1 (fr) * | 2004-02-11 | 2012-10-19 | David Francois Joseph Millet | Chimere de virus pathogene emergent, medicament la contenant et utilisation en therapie antivirale |
| DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
| JP4980896B2 (ja) | 2004-05-25 | 2012-07-18 | メディミューン，エルエルシー | インフルエンザ赤血球凝集素およびノイラミニダーゼ変異体 |
| KR20070086344A (ko) | 2004-11-19 | 2007-08-27 | 위스콘신 얼럼나이 리서어치 화운데이션 | 탠덤 전사 유닛을 갖는 재조합 인플루엔자 벡터 |
| US7510719B2 (en) | 2004-12-08 | 2009-03-31 | Medimmune, Llc | Methods of producing influenza vaccine compositions |
| BRPI0518568A2 (pt) | 2004-12-24 | 2008-11-25 | Solvay Pharm Bv | mÉtodo para produzir uma partÍcula do vÍrus da influenza replicativo sem o uso de vÍrus auxiliar, partÍcula de vÍrus da influenza replicativo, cÉlula, composiÇço, uso de uma composiÇço, mÉtodo para gerar proteÇço imunolàgica contra infecÇço de um indivÍduo com um vÍrus da influenza, e, Ácido nuclÉico |
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| CN102220293B (zh) * | 2011-05-26 | 2012-12-19 | 中国农业科学院上海兽医研究所 | 犬流感重组病毒及其制备方法和应用 |
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| EP3022296B1 (en) | 2013-07-15 | 2022-12-28 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses with enhanced replication in mdck or vero cells or eggs |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| CN104450695B (zh) * | 2014-11-26 | 2017-08-25 | 扬州大学 | A型流感病毒基因pcr扩增引物及其快速克隆方法 |
| US10633422B2 (en) | 2015-06-01 | 2020-04-28 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication by inhibiting microRNA lec7C binding to influenza viral cRNA and mRNA |
| CA2987155A1 (en) * | 2015-06-10 | 2016-12-15 | Hookipa Biotech Ag | Hpv vaccines |
| HK1254344A1 (zh) | 2015-06-26 | 2019-07-19 | Seqirus UK Limited | 抗原匹配的流感疫苗 |
| WO2017007839A1 (en) | 2015-07-06 | 2017-01-12 | Wisconsin Alumni Research Foundation (Warf) | Improved influenza virus replication for vaccine development |
| JP6830070B2 (ja) | 2015-07-07 | 2021-02-17 | セキラス ユーケー リミテッドＳｅｑｉｒｕｓ ＵＫ Ｌｉｍｉｔｅｄ | インフルエンザ効力アッセイ |
| JP2018530314A (ja) * | 2015-08-28 | 2018-10-18 | ウィスコンシン アルムニ リサーチ ファンデイション | ウイルス様粒子からの感染性インフルエンザウイルスの生成 |
| EP3417056A1 (en) | 2016-02-19 | 2018-12-26 | Wisconsin Alumni Research Foundation (WARF) | Improved influenza b virus replication for vaccine development |
| CA3074202A1 (en) * | 2017-08-28 | 2019-03-07 | Wisconsin Alumni Research Foundation | Nanocapsules for delivering ribonucleoproteins |
| JP2021500891A (ja) | 2017-10-25 | 2021-01-14 | ウィスコンシン アルムニ リサーチ ファンデイション | 卵における複製のための安定化されたｈａを有する組換えインフルエンザウイルス |
| CN107964035B (zh) * | 2017-12-06 | 2020-07-24 | 中国科学院微生物研究所 | 一种用于流感病毒的有限复制型黏膜免疫疫苗 |
| US12343390B2 (en) | 2018-08-07 | 2025-07-01 | Wisconsin Alumni Research Foundation (Warf) | Recombinant biologically contained filovirus vaccine |
| JP7655849B2 (ja) | 2018-08-20 | 2025-04-02 | ウィスコンシン アルムニ リサーチ ファンデイション | ヘマグルチニン（ｈａ）タンパク質内の非ドミナントエピトープに対する免疫応答を誘起するためのベクター |
| CN109097341B (zh) * | 2018-08-28 | 2021-09-24 | 青岛农业大学 | 一种同时表达ha和hef的复制缺陷型重组流感病毒 |
| US11241492B2 (en) | 2019-01-23 | 2022-02-08 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to genes in influenza viruses |
| EP3921413A1 (en) | 2019-02-08 | 2021-12-15 | Wisconsin Alumni Research Foundation (WARF) | Humanized cell line |
| US11390649B2 (en) | 2019-05-01 | 2022-07-19 | Wisconsin Alumni Research Foundation (Warf) | Influenza virus replication for vaccine development |
| WO2021041624A2 (en) | 2019-08-27 | 2021-03-04 | Yoshihiro Kawaoka | Recombinant influenza viruses with stabilized ha for replication in eggs |
| JP2023511444A (ja) | 2020-01-24 | 2023-03-17 | ウィスコンシン アルムニ リサーチ ファンデイション | 安定化されたｎａを有する組換えインフルエンザウイルス |
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| US5840520A (en) * | 1989-08-28 | 1998-11-24 | Aviron | Recombinant negative strand RNA virus expression systems |
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| US5919676A (en) * | 1993-06-24 | 1999-07-06 | Advec, Inc. | Adenoviral vector system comprising Cre-loxP recombination |
| AU3760495A (en) * | 1994-09-30 | 1996-04-26 | Aviron | Chimeric Influenza Virus And Electroporation Method |
| EP0704533A1 (en) * | 1994-09-30 | 1996-04-03 | Bayer Ag | An attenuated vaccination virus, a method to make the virus and a pharmaceutical compositions comprising the virus |
| CN1200675A (zh) * | 1995-10-20 | 1998-12-02 | 耶路撒冷希伯来语大学依苏姆研究开发公司 | 流感疫苗 |
| US5994526A (en) * | 1996-06-21 | 1999-11-30 | Plant Genetic Systems | Gene expression in plants |
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| EP2910629B1 (en) * | 1999-04-06 | 2018-09-19 | Wisconsin Alumni Research Foundation | Recombinant influenza viruses for vaccines and gene therapy |
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2000
- 2000-04-05 EP EP14200291.4A patent/EP2910629B1/en not_active Expired - Lifetime
- 2000-04-05 DE DE122008000061C patent/DE122008000061I1/de active Pending
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- 2000-04-05 ES ES00920151T patent/ES2290024T3/es not_active Expired - Lifetime
- 2000-04-05 PT PT07009953T patent/PT1820853E/pt unknown
- 2000-04-05 BR BRPI0009580A patent/BRPI0009580B8/pt not_active IP Right Cessation
- 2000-04-05 CA CA2928263A patent/CA2928263A1/en not_active Abandoned
- 2000-04-05 DK DK07009953.6T patent/DK1820853T3/da active
- 2000-04-05 CN CN00807495XA patent/CN1350578B/zh not_active Expired - Lifetime
- 2000-04-05 KR KR1020017012743A patent/KR100702275B1/ko not_active Expired - Lifetime
- 2000-04-05 AT AT00920151T patent/ATE368729T1/de active
- 2000-04-05 AU AU40733/00A patent/AU4073300A/en not_active Abandoned
- 2000-04-05 IL IL14570200A patent/IL145702A0/xx unknown
- 2000-04-05 DE DE200812000014 patent/DE122008000014I1/de active Pending
- 2000-04-05 EP EP07009953A patent/EP1820853B1/en not_active Expired - Lifetime
- 2000-04-05 CN CN201010155623.8A patent/CN101851636B/zh not_active Expired - Lifetime
- 2000-04-05 AT AT07009953T patent/ATE525461T1/de active
- 2000-04-05 WO PCT/US2000/009021 patent/WO2000060050A2/en not_active Ceased
- 2000-04-05 MX MXPA01010082A patent/MXPA01010082A/es active IP Right Grant
- 2000-04-05 CA CA2365526A patent/CA2365526C/en not_active Expired - Lifetime
- 2000-04-05 DE DE60035778T patent/DE60035778T2/de not_active Expired - Lifetime
- 2000-04-05 ES ES07009953T patent/ES2373405T3/es not_active Expired - Lifetime
- 2000-04-05 ES ES10011896.7T patent/ES2533622T3/es not_active Expired - Lifetime
- 2000-04-05 DK DK00920151T patent/DK1185615T3/da active
- 2000-04-05 JP JP2000609542A patent/JP5543048B2/ja not_active Expired - Lifetime
- 2000-04-05 EP EP10011896.7A patent/EP2345716B1/en not_active Expired - Lifetime
- 2000-04-05 DE DE122008000035C patent/DE122008000035I1/de active Pending
- 2000-04-05 DK DK10011896.7T patent/DK2345716T3/en active
- 2000-04-05 DE DE122008000058C patent/DE122008000058I1/de active Pending
- 2000-04-05 PT PT00920151T patent/PT1185615E/pt unknown
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2001
- 2001-09-30 IL IL145702A patent/IL145702A/en not_active IP Right Cessation
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2007
- 2007-10-08 CY CY20071101295T patent/CY1108520T1/el unknown
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2008
- 2008-11-13 NL NL300364C patent/NL300364I2/nl unknown
- 2008-11-13 NL NL300365C patent/NL300365I2/nl unknown
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2011
- 2011-04-21 JP JP2011095240A patent/JP5775351B2/ja not_active Expired - Lifetime
- 2011-07-26 DE DE201112100037 patent/DE122011100037I1/de active Pending
- 2011-07-26 FR FR11C0027C patent/FR11C0027I2/fr active Active
- 2011-12-12 CY CY20111101234T patent/CY1112140T1/el unknown
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- 2015-03-31 JP JP2015071406A patent/JP6224645B2/ja not_active Expired - Lifetime
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