DE60035778D1 - Rekombinante influenzaviren zur vakzinherstellung und gentherapie - Google Patents
Rekombinante influenzaviren zur vakzinherstellung und gentherapieInfo
- Publication number
- DE60035778D1 DE60035778D1 DE60035778T DE60035778T DE60035778D1 DE 60035778 D1 DE60035778 D1 DE 60035778D1 DE 60035778 T DE60035778 T DE 60035778T DE 60035778 T DE60035778 T DE 60035778T DE 60035778 D1 DE60035778 D1 DE 60035778D1
- Authority
- DE
- Germany
- Prior art keywords
- vaccination
- gene therapy
- influenza viruses
- recombinant influenza
- viruses
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 241000700605 Viruses Species 0.000 title abstract 2
- 238000001415 gene therapy Methods 0.000 title 1
- 206010022000 influenza Diseases 0.000 title 1
- 238000002255 vaccination Methods 0.000 title 1
- 241000712431 Influenza A virus Species 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16123—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16141—Use of virus, viral particle or viral elements as a vector
- C12N2760/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2800/00—Nucleic acids vectors
- C12N2800/30—Vector systems comprising sequences for excision in presence of a recombinase, e.g. loxP or FRT
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6072—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses
- C12N2810/6081—Vectors comprising as targeting moiety peptide derived from defined protein from viruses negative strand RNA viruses rhabdoviridae, e.g. VSV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Virology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US12791299P | 1999-04-06 | 1999-04-06 | |
US127912P | 1999-04-06 | ||
US13283999P | 1999-05-06 | 1999-05-06 | |
US132839P | 1999-05-06 | ||
PCT/US2000/009021 WO2000060050A2 (en) | 1999-04-06 | 2000-04-05 | Recombinant influenza viruses for vaccines and gene therapy |
Publications (2)
Publication Number | Publication Date |
---|---|
DE60035778D1 true DE60035778D1 (de) | 2007-09-13 |
DE60035778T2 DE60035778T2 (de) | 2008-04-30 |
Family
ID=26826080
Family Applications (6)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122008000035C Pending DE122008000035I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE122008000061C Pending DE122008000061I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE122008000058C Pending DE122008000058I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE200812000014 Pending DE122008000014I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie. |
DE60035778T Expired - Lifetime DE60035778T2 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE201112100037 Pending DE122011100037I1 (de) | 1999-04-06 | 2011-07-26 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie. |
Family Applications Before (4)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE122008000035C Pending DE122008000035I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE122008000061C Pending DE122008000061I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE122008000058C Pending DE122008000058I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie |
DE200812000014 Pending DE122008000014I1 (de) | 1999-04-06 | 2000-04-05 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie. |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE201112100037 Pending DE122011100037I1 (de) | 1999-04-06 | 2011-07-26 | Rekombinante influenzaviren zur vakzinherstellung und gentherapie. |
Country Status (19)
Country | Link |
---|---|
EP (4) | EP2910629B1 (de) |
JP (3) | JP5543048B2 (de) |
KR (1) | KR100702275B1 (de) |
CN (2) | CN1350578B (de) |
AT (2) | ATE525461T1 (de) |
AU (1) | AU4073300A (de) |
BR (1) | BRPI0009580B8 (de) |
CA (2) | CA2928263A1 (de) |
CY (2) | CY1108520T1 (de) |
DE (6) | DE122008000035I1 (de) |
DK (3) | DK1820853T3 (de) |
ES (3) | ES2533622T3 (de) |
FR (1) | FR11C0027I2 (de) |
HK (2) | HK1148778A1 (de) |
IL (2) | IL145702A0 (de) |
MX (1) | MXPA01010082A (de) |
NL (2) | NL300364I2 (de) |
PT (2) | PT1185615E (de) |
WO (1) | WO2000060050A2 (de) |
Families Citing this family (78)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6544785B1 (en) | 1998-09-14 | 2003-04-08 | Mount Sinai School Of Medicine Of New York University | Helper-free rescue of recombinant negative strand RNA viruses |
BRPI0009580B8 (pt) * | 1999-04-06 | 2021-05-25 | Wisconsin Alumni Res Found | processo para preparar vírus influenza infecciosos na ausência de um vírus auxiliar, preparação de vírus influenza infeccioso recombinante, e, composição. |
US8715940B2 (en) | 1999-04-06 | 2014-05-06 | Wisconsin Alumni Research Foundation | Method of making recombinant influenza virus |
GB9916794D0 (en) * | 1999-07-16 | 1999-09-22 | Isis Innovation | In vitro virus reconstitution |
DK1194580T4 (da) * | 1999-07-14 | 2011-01-03 | Sinai School Medicine | In-vitro rekonstitution af segmenterede negativstrengede RNA-virus |
ATE420189T1 (de) | 2000-04-28 | 2009-01-15 | St Jude Childrens Res Hospital | Dna-transfektionssystem zur erzeugung von infektiösen negativsträngigen rna virus |
EP1862550A1 (de) * | 2000-06-23 | 2007-12-05 | Wyeth Holdings Corporation | Anordnung wilder und chimärer grippevirusähnlicher Partikel |
KR100877019B1 (ko) * | 2000-06-23 | 2009-01-07 | 와이어쓰 홀딩스 코포레이션 | 야생형 및 키메릭 인플루엔자 바이러스성입자(브이엘피)의 조립 |
US7211378B2 (en) | 2002-01-31 | 2007-05-01 | Wisconsin Alumni Research Foundation | Filovirus vectors and noninfectious filovirus-based particles |
BRPI0307679A2 (pt) | 2002-02-13 | 2016-11-08 | Wisconsin Alumni Res Found | vetor viral de influenza, vírus recombinate de influenza, molécula isolada de ácido nucleico e métodos para expressar um segmento heterólogo de ácido nucleico em uma célula e para preparar vírus semelhante a influenza incompetente na replicação. |
EP1499348B1 (de) | 2002-04-26 | 2014-10-01 | MedImmune, LLC | Verfahren zur erzeugung von infectiösen grippevirus b in zellkultur |
US7465456B2 (en) | 2002-04-26 | 2008-12-16 | Medimmune, Llc | Multi plasmid system for the production of influenza virus |
UA92132C2 (ru) * | 2003-05-28 | 2010-10-11 | Висконсин Алюмни Рисьёч Фаундейшн | Высокоактивные рекомбинантные вирусы гриппа для вакцин и генотерапии |
US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
CA2551489C (en) | 2003-12-23 | 2013-09-03 | Gregory Duke | Multi plasmid system for the production of influenza virus |
FR2866031B1 (fr) * | 2004-02-11 | 2012-10-19 | David Francois Joseph Millet | Chimere de virus pathogene emergent, medicament la contenant et utilisation en therapie antivirale |
US20080254065A1 (en) | 2004-03-09 | 2008-10-16 | Chiron Corporation | Influenza Virus Vaccines |
ES2394033T3 (es) | 2004-05-25 | 2013-01-15 | Medimmune, Llc | Variantes de hemaglutinina y neuraminidasa de influenza |
EP1814990A2 (de) | 2004-11-19 | 2007-08-08 | Wisconsin Alumni Research Foundation | Rekombinante influenza-vektoren mit transkriptionseinheiten, die in tandem vorliegen |
PT1824990E (pt) | 2004-12-08 | 2015-06-11 | Medimmune Llc | Métodos de produção de composições de vacinas contra a gripe |
CN101379183B (zh) | 2004-12-24 | 2013-07-03 | 雅培生物学有限责任公司 | 流感病毒的拯救 |
EP1856271A4 (de) | 2005-03-08 | 2009-11-18 | Medimmune Vaccines Inc | Influenza-hämagglutinin- und neuraminidase-varianten |
US11707520B2 (en) | 2005-11-03 | 2023-07-25 | Seqirus UK Limited | Adjuvanted vaccines with non-virion antigens prepared from influenza viruses grown in cell culture |
PT1951299E (pt) | 2005-11-04 | 2012-02-28 | Novartis Vaccines & Diagnostic | Vacinas contra a gripe que incluem combinações de adjuvantes particulados e imuno-potenciadores |
NZ592713A (en) | 2005-11-04 | 2012-12-21 | Novartis Vaccines & Diagnostic | Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9 |
US20090220541A1 (en) | 2005-11-04 | 2009-09-03 | Novartis Vaccines And Diagnostics Srl | Emulsions with free aqueous-phase surfactant for adjuvanting split influenza vaccines |
DK2368572T3 (da) | 2005-11-04 | 2020-05-25 | Seqirus Uk Ltd | Adjuvansvacciner med ikke-virionantigener fremstillet fra influenza-virusser dyrket i cellekultur |
GEP20135924B (en) | 2005-12-02 | 2013-10-10 | The Mount Sinai School Of Medicine Of New York Univ | Chimeric viruses presenting non-native surface proteins and usage thereof |
EP2478916B1 (de) | 2006-01-27 | 2020-04-01 | Seqirus UK Limited | Influenzaimpfstoffe mit Hämagglutinin und Matrixproteinen |
EP2382987A1 (de) | 2006-03-24 | 2011-11-02 | Novartis Vaccines and Diagnostics GmbH | Lagerung von Influenza-Impfstoffen ohne Kühlung |
US9254318B2 (en) | 2006-03-31 | 2016-02-09 | Wisconsin Alumni Research Foundation | High titer recombinant influenza viruses for vaccines |
US20090017444A1 (en) * | 2006-06-09 | 2009-01-15 | Wisconsin Alumni Research Foundation | Screening method for modulators of viral transcription or replication |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
WO2008133701A1 (en) | 2006-07-21 | 2008-11-06 | Medimmune, Llc. | Methods and compositions for increasing replication capacity of an influenza virus |
WO2008021959A2 (en) | 2006-08-09 | 2008-02-21 | Medimmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
AU2007297178B2 (en) | 2006-09-11 | 2014-07-24 | Novartis Ag | Making influenza virus vaccines without using eggs |
CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
US8597661B2 (en) | 2007-05-04 | 2013-12-03 | Wisconsin Alumni Research Foundation | Neuraminidase-deficient live influenza vaccines |
US8673613B2 (en) | 2007-06-18 | 2014-03-18 | Medimmune, Llc | Influenza B viruses having alterations in the hemaglutinin polypeptide |
WO2008156778A2 (en) | 2007-06-18 | 2008-12-24 | Tokiko Watanabe | Influenza m2 protein mutant viruses as live influenza attenuated vaccines |
EP2045323A1 (de) * | 2007-10-05 | 2009-04-08 | Avir Green Hills Biotechnology Research Development Trade Ag | Linearische Expressionskonstrukte zur Herstellung von Partikeln des Influenzavirus |
NZ582595A (en) | 2007-06-27 | 2012-07-27 | Novartis Ag | Low-additive influenza vaccines |
CN101497877B (zh) * | 2008-01-28 | 2012-09-05 | 河北摩百生物科技有限公司 | 流感全病毒减活疫苗重组体、其构建方法及应用 |
AU2009227674C1 (en) | 2008-03-18 | 2015-01-29 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
CN102149405A (zh) | 2008-07-11 | 2011-08-10 | 米迪缪尼股份有限公司 | 流感血凝素和神经氨酸酶变体 |
EP2329845A4 (de) | 2008-08-18 | 2013-08-14 | Kitasato Daiichi Sankyo Vaccine Co Ltd | Vogelgrippevirus-antigen und boosterimmunisierungsverfahren für vogelgrippeimpfstoff in kombination mit einem mukosalen adjuvans mit wirksamkeit durch orale verabreichung |
EP2233568A1 (de) | 2009-03-19 | 2010-09-29 | Avir Green Hills Biotechnology Research Development Trade AG | Neues Verfahren zur Herstellung eines RNA Virus |
CA2752039A1 (en) | 2009-02-10 | 2010-08-19 | Novartis Ag | Influenza vaccine regimens for pandemic-associated strains |
EP2396031A1 (de) | 2009-02-10 | 2011-12-21 | Novartis AG | Grippeimpfstoffe mit erhöhten h3-antigen-mengen |
DK2396032T3 (en) | 2009-02-10 | 2016-12-19 | Seqirus Uk Ltd | Influenza vaccines with reduced amounts of squalene |
MX2011008497A (es) | 2009-02-12 | 2011-12-16 | Us Gov Nat Inst Health | Variantes de hemaglutinina y neuraminidasa de influenza. |
FR2949344A1 (fr) | 2009-04-27 | 2011-03-04 | Novartis Ag | Vaccins de protection contre la grippe |
AU2010293902A1 (en) | 2009-09-10 | 2012-03-22 | Novartis Ag | Combination vaccines against respiratory tract diseases |
JP2013507990A (ja) | 2009-10-26 | 2013-03-07 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | ベロ細胞において増強された複製を有する高力価の組換えインフルエンザウイルス |
US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
EP2576773A2 (de) | 2010-06-02 | 2013-04-10 | Avir Green Hills Biotechnology Research Development Trade AG | Verfahren und helferviren zur erzeugung von rna-viren |
CN102220293B (zh) * | 2011-05-26 | 2012-12-19 | 中国农业科学院上海兽医研究所 | 犬流感重组病毒及其制备方法和应用 |
EP2747778B1 (de) | 2011-08-26 | 2017-12-06 | Wisconsin Alumni Research Foundation | Influenza-viren mit einem mutanten pb2-gensegment als lebende abgeschwächte impfstoffe |
US20140302077A1 (en) | 2011-09-02 | 2014-10-09 | Westfaelische Wilhelms-Universitaet Munester | Live attenuated influenza virus |
AU2012324398A1 (en) | 2011-10-20 | 2014-05-01 | Seqirus UK Limited | Adjuvanted influenza B virus vaccines for pediatric priming |
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