ES2515095T3 - Derivados de adamantil acetamida como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1 - Google Patents

Derivados de adamantil acetamida como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1 Download PDF

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ES2515095T3
ES2515095T3 ES05742013.5T ES05742013T ES2515095T3 ES 2515095 T3 ES2515095 T3 ES 2515095T3 ES 05742013 T ES05742013 T ES 05742013T ES 2515095 T3 ES2515095 T3 ES 2515095T3
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alkyl
heterocycle
cycloalkyl
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aryl
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James T. Link
Marina A. Pliushchev
Jeffrey J. Rohde
Dariusz Wodka
Jyoti R. Patel
Qi Shuai
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AbbVie Inc
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Abstract

Un compuesto de acuerdo con formula (I), o una sal terapéuticamente aceptable del mismo, donde A1 se selecciona entre el grupo que consiste en alquil-NH-alquilo, alquilcarbonilo, alquilsulfonilo, cicloalquilo, cicloalquilcarbonilo, cicloalquilsulfonilo, arilcarbonilo, arilsulfonilo, heterociclocarbonilo, heterociclosulfonilo, arilalquilo, ariloxialquilo, carboxialquilo, carboxicicloalquilo, haloalquilo, heterociclo, heterocicloalquilo, heterociclooxialquilo, -NR7-[C(R8R9]n-C(O)-R10, -O-[C(R11R12)]-C(O)-R13, -N(R15R16), -CO2R17, -C(O)-N(R18R19), - C(R20R21)-OR22 y -C(R23R24)-N(R25R26); cada uno de A2, A3 y A4 se selecciona independientemente entre el grupo que consiste en hidrógeno, alquilo, alquil- NH-alquilo, alquil-carbonilo, alquilsulfonilo, cicloalquilo, cicloalquilcarbonilo, cicloalquilsulfonilo, arilcarbonilo, arilsulfonilo, heterociclocarbonilo, heterociclosulfonilo, arilo, arilalquilo, ariloxialquilo, carboxialquilo, carboxicicloalquilo, halógeno, haloalquilo, heterociclo, heterocicloalquilo, heterociclooxialquilo, -NR7-[C(R8 R9)]n- C(O)-R10, -O-[C(R11R12)]p-C(O)-R13, -OR14, -N(R15R16), - CO2R17, -C(O)-N(R18R19), -C(R20R21)-OR22 y -C(R23R24)- N(R25R26); n es 0 o 1; p es 0 o 1; cada uno de R1 y R2 se selecciona independientemente entre el grupo que consiste en hidrógeno, alquilo, alcoxialquilo, alquil-NH-alquilo, ariloxialquilo, aril-NH-alquilo, carboxialquilo, carboxicicloalquilo, heterociclooxialquilo, heterociclo-NH-alquilo, cicloalquilo, arilo, arilalquilo, haloalquilo, heterociclo, heterocicloalquilo, heterocicloheterociclo y aril-heterociclo, o R1 y R2 junto con el átomo al que están unidos, forman un heterociclo; cada uno de R3 y R4 se selecciona independientemente entre el grupo que consiste en hidrógeno, alquilo, carboxialquilo, carboxicicloalquilo, cicloalquilo, haloalquilo, arilo y heterociclo, o R3 y R4 junto con el átomo al que están unidos, forman un anillo seleccionado entre el grupo que consiste en cicloalquilo y heterociclo no aromático; o R2 y R3 junto con los átomos a los que están unidos, forman un heterociclo no aromático; R5 se selecciona entre el grupo que consiste en hidrógeno, alquilo, carboxialquilo, carboxicicloalquilo, -cicloalquilo, arilo, arilalquilo, ariloxialquilo, heterociclo, heterocicloalquilo y heterociclooxialquilo; R6 se selecciona entre el grupo que consiste en hidrógeno, alquilo, carboxi, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, arilalquilo, ariloxialquilo, heterociclo, heterocicloalquilo y heterociclooxialquilo; R7 se selecciona entre el grupo que consiste en hidrógeno, alquilo, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, arilalquilo, ariloxialquilo, ariloxi, hidroxi, alcoxi, cicloalquiloxi, heterociclooxi, heterociclo, heterocicloalquilo y heterociclooxialquilo; cada uno de R8 y R9 se selecciona independientemente entre el grupo que consiste en hidrógeno, alquilo, carboxi, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, arilalquilo, ariloxialquilo, heterociclo, heterocicloalquilo y heterociclooxialquilo, o R8 y R9 junto con el átomo al que están unidos, forman un anillo seleccionado entre el grupo que consiste en cicloalquilo y heterociclo no aromático; R10 se selecciona entre el grupo que consiste en hidrógeno, alquilo, carboxi, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, ariloxi, arilalquilo, ariloxialquilo, hidroxi, alcoxi, cicloalquiloxi, heterociclooxi, heterociclo, heterocicloalquilo, heterociclooxialquilo y -N(R27R28); cada uno de R11 y R12 se selecciona independientemente entre el grupo que consiste en hidrógeno, alquilo, carboxi, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, arilalquilo, ariloxialquilo, heterociclo, heterocicloalquilo y heterociclooxialquilo, o R11 y R12 junto con el átomo al que están unidos, forman un anillo seleccionado entre el grupo que consiste en cicloalquilo y heterociclo no aromático; R13 se selecciona entre el grupo que consiste en hidrógeno, alquilo, carboxi, carboxialquilo, cicloalquilo, carboxicicloalquilo, arilo, arilalquilo, ariloxi, ariloxialquilo, hidroxi, alcoxi, cicloalquiloxi, heterociclooxi, heterociclo, heterocicloalquilo, heterociclooxialquilo y -N(R29R30).

Description

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ES05742013.5T 2004-04-29 2005-04-29 Derivados de adamantil acetamida como inhibidores de la enzima 11-beta-hidroxiesteroide deshidrogenasa tipo 1 Active ES2515095T3 (es)

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US965591 1978-12-01
US10/834,459 US20050245745A1 (en) 2004-04-29 2004-04-29 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
US834459 2004-04-29
US10/965,591 US20050245534A1 (en) 2004-04-29 2004-10-14 Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme
PCT/US2005/015304 WO2005108368A1 (en) 2004-04-29 2005-04-29 Adamantyl-acetamide derivatives as inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme

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AU2005241073A1 (en) 2005-11-17
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DK1751108T3 (da) 2014-11-03
KR20070005014A (ko) 2007-01-09
NZ587997A (en) 2012-04-27
IL179626A (en) 2014-12-31
PT1751108E (pt) 2014-11-06
EP1751108B1 (en) 2014-07-30
IL231576A (en) 2015-09-24
SI1751108T1 (sl) 2014-11-28
IL231576A0 (en) 2014-04-30
US20050245534A1 (en) 2005-11-03
NZ551508A (en) 2010-10-29
EP1751108A1 (en) 2007-02-14
AU2005241073B2 (en) 2011-03-17
CA2568241C (en) 2015-01-20
MX347145B (es) 2017-04-17
IL221770A (en) 2015-06-30
EP2345640A1 (en) 2011-07-20
KR101235863B1 (ko) 2013-02-20
KR101321728B1 (ko) 2013-10-29
IL236013A0 (en) 2015-01-29
IL236013A (en) 2016-04-21
CA2568241A1 (en) 2005-11-17
MXPA06013980A (es) 2007-03-15
PL1751108T3 (pl) 2015-01-30
WO2005108368A1 (en) 2005-11-17
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