ES2389864T3 - Composiciones de polvo seco y sistemas para la vacunación de aves de corral - Google Patents
Composiciones de polvo seco y sistemas para la vacunación de aves de corral Download PDFInfo
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- ES2389864T3 ES2389864T3 ES07711957T ES07711957T ES2389864T3 ES 2389864 T3 ES2389864 T3 ES 2389864T3 ES 07711957 T ES07711957 T ES 07711957T ES 07711957 T ES07711957 T ES 07711957T ES 2389864 T3 ES2389864 T3 ES 2389864T3
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06005245A EP1834651A1 (en) | 2006-03-15 | 2006-03-15 | Compositions and methods for veterinary vaccination |
| EP06005245 | 2006-03-15 | ||
| PCT/EP2007/002284 WO2007104562A1 (en) | 2006-03-15 | 2007-03-15 | Dry powder compositions and systems for poultry vaccination |
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| ES2389864T3 true ES2389864T3 (es) | 2012-11-02 |
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|---|---|---|---|
| ES07711957T Active ES2389864T3 (es) | 2006-03-15 | 2007-03-15 | Composiciones de polvo seco y sistemas para la vacunación de aves de corral |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20090041852A1 (enExample) |
| EP (2) | EP1834651A1 (enExample) |
| JP (1) | JP2009529558A (enExample) |
| CN (1) | CN101415437A (enExample) |
| BR (1) | BRPI0708983A2 (enExample) |
| DK (1) | DK1993605T3 (enExample) |
| ES (1) | ES2389864T3 (enExample) |
| MX (1) | MX2008011701A (enExample) |
| PL (1) | PL1993605T3 (enExample) |
| PT (1) | PT1993605E (enExample) |
| RU (1) | RU2450828C2 (enExample) |
| SI (1) | SI1993605T1 (enExample) |
| UA (1) | UA96754C2 (enExample) |
| WO (1) | WO2007104562A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP1834651A1 (en) * | 2006-03-15 | 2007-09-19 | Universiteit Gent | Compositions and methods for veterinary vaccination |
| US8778384B2 (en) | 2008-03-24 | 2014-07-15 | Advanced Bionutrition Corporation | Compositions and methods for encapsulating vaccines for the oral vaccination and boostering of fish and other animals |
| EP2105129B1 (en) | 2008-03-24 | 2018-01-17 | Intervet International B.V. | Encapsulated Vaccines for the Oral Vaccination and Boostering of Fish and Other Animals |
| JP2012504140A (ja) * | 2008-09-26 | 2012-02-16 | オーバーン・ユニバーシティ | 非複製性ベクターワクチンの粘膜投与による鳥類の免疫処置 |
| CN102481356A (zh) | 2009-05-20 | 2012-05-30 | Aeras全球Tb疫苗基金会 | 稳定的经喷雾干燥的免疫原性的病毒组合物 |
| JP5550277B2 (ja) * | 2009-07-23 | 2014-07-16 | 長谷川香料株式会社 | 保存安定性に優れた粉末組成物 |
| RU2592544C2 (ru) * | 2009-08-21 | 2016-07-20 | Мериал, Инк. | Способ получения рекомбинантного вирусного вектора apmv-8 |
| WO2011041788A2 (en) * | 2009-10-02 | 2011-04-07 | The Trustees Of Columbia University In The City Of New York | Turkey viral hepatitis virus and uses thereof |
| CN102772799A (zh) * | 2012-05-31 | 2012-11-14 | 郑州后羿制药有限公司 | 一种鸭病毒性肝炎、鸭瘟二联卵黄抗体冻干粉及其制备方法 |
| CN103083659B (zh) * | 2013-01-18 | 2015-05-13 | 北京华夏兴洋生物科技有限公司 | 新型无油佐剂制备方法及用途 |
| US11510871B2 (en) | 2016-09-16 | 2022-11-29 | Leukocare Ag | Method for producing low viscous and highly concentrated biopharmaceutical drug products in liquid formulation |
| JP7051132B2 (ja) | 2016-09-16 | 2022-04-11 | ロイコケア・アクチェンゲゼルシャフト | ワクチン接種または遺伝子治療のための効率的なウイルスベクターベースの組成物を得るための新規方法 |
| CN107019707A (zh) * | 2017-03-14 | 2017-08-08 | 杨凌绿方生物工程有限公司 | 一种鸡胚成纤维细胞产品冻干工艺方法 |
| TR201718859A2 (tr) * | 2017-11-27 | 2017-12-21 | Bilge Kaan Tekelioglu | Siğirlarin gangrenli̇ nezlesi̇ i̇çi̇n aşi ve aşinin üreti̇m yöntemi̇ |
| CN109260467B (zh) * | 2018-08-17 | 2021-08-20 | 山东信得科技股份有限公司 | 一种预防雏鹅痛风症状的疫苗 |
| EP3698773A1 (en) | 2019-02-21 | 2020-08-26 | Università degli Studi di Parma | Composition and manufacturing of powders containing nanoadjuvants for mucosal vaccination |
| CN113599513A (zh) * | 2020-10-23 | 2021-11-05 | 青岛大学 | 一种适用于咽喉部接种的新型冠状病毒疫苗的制备方法及接种方法 |
| WO2023094818A1 (en) * | 2021-11-25 | 2023-06-01 | Orexo Ab | Pharmaceutical composition comprising biopharmaceutical drug compounds |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS58105310U (ja) * | 1982-01-11 | 1983-07-18 | 貝原 睦衛 | ひよこ用ワクチン点眼装置 |
| JPS5924019U (ja) * | 1982-08-05 | 1984-02-15 | イカリ消毒株式会社 | 動物用ワクチン投与装置 |
| RU2035909C1 (ru) * | 1993-06-02 | 1995-05-27 | Виноходов Владимир Олегович | Препарат для профилактики и лечения заболеваний птиц |
| GB9607035D0 (en) * | 1996-04-03 | 1996-06-05 | Andaris Ltd | Spray-dried microparticles as therapeutic vehicles |
| SE9801288D0 (sv) * | 1998-04-14 | 1998-04-14 | Astra Ab | Vaccine delivery system and metod of production |
| US6651655B1 (en) * | 2000-01-18 | 2003-11-25 | Quadrant Technologies Limited | Inhaled vaccines |
| WO2003087335A2 (en) * | 2002-04-11 | 2003-10-23 | Medimmune Vaccines, Inc. | Preservation of bioactive materials by spray drying |
| AU2002951692A0 (en) * | 2002-09-23 | 2002-10-17 | Vital Biotech (Hong Kong) Limited | Improvements in or relating to vaccines |
| WO2004058156A2 (en) * | 2002-12-17 | 2004-07-15 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
| US20050207983A1 (en) * | 2004-03-05 | 2005-09-22 | Pulmatrix, Inc. | Formulations decreasing particle exhalation |
| CA2564791A1 (en) * | 2004-06-14 | 2005-12-29 | Medimmune Vaccines, Inc. | High pressure spray-dry of bioactive materials |
| EP1834651A1 (en) * | 2006-03-15 | 2007-09-19 | Universiteit Gent | Compositions and methods for veterinary vaccination |
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2006
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2007
- 2007-03-15 SI SI200731007T patent/SI1993605T1/sl unknown
- 2007-03-15 EP EP07711957A patent/EP1993605B1/en not_active Not-in-force
- 2007-03-15 UA UAA200812168A patent/UA96754C2/ru unknown
- 2007-03-15 ES ES07711957T patent/ES2389864T3/es active Active
- 2007-03-15 RU RU2008140745/15A patent/RU2450828C2/ru not_active IP Right Cessation
- 2007-03-15 MX MX2008011701A patent/MX2008011701A/es active IP Right Grant
- 2007-03-15 JP JP2008558721A patent/JP2009529558A/ja active Pending
- 2007-03-15 WO PCT/EP2007/002284 patent/WO2007104562A1/en not_active Ceased
- 2007-03-15 CN CNA2007800089704A patent/CN101415437A/zh active Pending
- 2007-03-15 PL PL07711957T patent/PL1993605T3/pl unknown
- 2007-03-15 PT PT07711957T patent/PT1993605E/pt unknown
- 2007-03-15 DK DK07711957.6T patent/DK1993605T3/da active
- 2007-03-15 BR BRPI0708983-0A patent/BRPI0708983A2/pt not_active Application Discontinuation
- 2007-03-15 US US12/293,019 patent/US20090041852A1/en not_active Abandoned
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Also Published As
| Publication number | Publication date |
|---|---|
| RU2450828C2 (ru) | 2012-05-20 |
| US20110150940A1 (en) | 2011-06-23 |
| MX2008011701A (es) | 2008-11-27 |
| WO2007104562A1 (en) | 2007-09-20 |
| UA96754C2 (ru) | 2011-12-12 |
| BRPI0708983A2 (pt) | 2011-06-21 |
| SI1993605T1 (sl) | 2012-11-30 |
| EP1993605B1 (en) | 2012-06-27 |
| US20090041852A1 (en) | 2009-02-12 |
| EP1834651A1 (en) | 2007-09-19 |
| JP2009529558A (ja) | 2009-08-20 |
| CN101415437A (zh) | 2009-04-22 |
| PL1993605T3 (pl) | 2012-12-31 |
| EP1993605A1 (en) | 2008-11-26 |
| RU2008140745A (ru) | 2010-04-20 |
| DK1993605T3 (da) | 2012-09-10 |
| PT1993605E (pt) | 2012-09-17 |
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