ES2381828B1 - PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO - Google Patents

PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO Download PDF

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Publication number
ES2381828B1
ES2381828B1 ES201230413A ES201230413A ES2381828B1 ES 2381828 B1 ES2381828 B1 ES 2381828B1 ES 201230413 A ES201230413 A ES 201230413A ES 201230413 A ES201230413 A ES 201230413A ES 2381828 B1 ES2381828 B1 ES 2381828B1
Authority
ES
Spain
Prior art keywords
igg
solution
application
document
diafiltration
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
ES201230413A
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English (en)
Spanish (es)
Other versions
ES2381828A1 (es
Inventor
Pere Ristol Debart
Salvador Grancha Gamon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Grifols SA
Original Assignee
Grifols SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46053016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2381828(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to ES201230413A priority Critical patent/ES2381828B1/es
Application filed by Grifols SA filed Critical Grifols SA
Publication of ES2381828A1 publication Critical patent/ES2381828A1/es
Application granted granted Critical
Publication of ES2381828B1 publication Critical patent/ES2381828B1/es
Priority to PT131585523T priority patent/PT2641912T/pt
Priority to ES13158552.3T priority patent/ES2590045T3/es
Priority to EP13158552.3A priority patent/EP2641912B1/en
Priority to HUE13158552A priority patent/HUE027915T2/en
Priority to PL13158552.3T priority patent/PL2641912T3/pl
Priority to CL2013000688A priority patent/CL2013000688A1/es
Priority to IL225197A priority patent/IL225197A/en
Priority to ARP130100825A priority patent/AR090337A1/es
Priority to MX2013002910A priority patent/MX339268B/es
Priority to CA2809513A priority patent/CA2809513C/en
Priority to US13/838,424 priority patent/US9200032B2/en
Priority to UY0001034679A priority patent/UY34679A/es
Priority to TW102109161A priority patent/TWI554283B/zh
Priority to MYPI2013700437A priority patent/MY165024A/en
Priority to BRBR102013006411-4A priority patent/BR102013006411A2/pt
Priority to RU2013112276A priority patent/RU2636049C2/ru
Priority to AU2013201853A priority patent/AU2013201853B2/en
Priority to SG2013020169A priority patent/SG193738A1/en
Priority to JP2013056191A priority patent/JP6048936B2/ja
Priority to CN201310090730.0A priority patent/CN103319592B/zh
Priority to KR1020130029551A priority patent/KR101840064B1/ko
Priority to HK13113003.3A priority patent/HK1185625B/en
Priority to JP2016160479A priority patent/JP2016199586A/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Confectionery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
ES201230413A 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO Expired - Fee Related ES2381828B1 (es)

Priority Applications (24)

Application Number Priority Date Filing Date Title
ES201230413A ES2381828B1 (es) 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
PT131585523T PT2641912T (pt) 2012-03-20 2013-03-11 Processo para a obtenção de uma composição de igg através de tratamento térmico
ES13158552.3T ES2590045T3 (es) 2012-03-20 2013-03-11 Procedimiento para obtener una composición de IgG mediante tratamiento térmico
EP13158552.3A EP2641912B1 (en) 2012-03-20 2013-03-11 Process for obtaining an IgG composition through heat treatment
HUE13158552A HUE027915T2 (en) 2012-03-20 2013-03-11 A method for preparing an IgG composition by heat treatment
PL13158552.3T PL2641912T3 (pl) 2012-03-20 2013-03-11 Proces otrzymywania kompozycji IgG poprzez traktowanie cieplne
CL2013000688A CL2013000688A1 (es) 2012-03-20 2013-03-13 Procedimiento para obtener una composicion de igg a partir de una composicion de igg parcialmente purificada.
IL225197A IL225197A (en) 2012-03-20 2013-03-13 Process for obtaining IgG preparation by heat treatment
CA2809513A CA2809513C (en) 2012-03-20 2013-03-14 Process for obtaining an igg composition through heat treatment
MX2013002910A MX339268B (es) 2012-03-20 2013-03-14 Procedimiento para obtener una composicion de igg mediante tratamiento termico.
ARP130100825A AR090337A1 (es) 2012-03-20 2013-03-14 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
UY0001034679A UY34679A (es) 2012-03-20 2013-03-15 ?PROCEDIMIENTO PARA OBTENER UNA COMPOSICIÓN DE IgG MEDIANTE TRATAMIENTO TÉRMICO?
US13/838,424 US9200032B2 (en) 2012-03-20 2013-03-15 Process for obtaining an IgG composition through heat treatment
TW102109161A TWI554283B (zh) 2012-03-20 2013-03-15 經由熱處理獲得ＩｇＧ組成物的方法
MYPI2013700437A MY165024A (en) 2012-03-20 2013-03-18 PROCESS FOR OBTAINING AN IgG COMPOSITION THROUGH HEAT TREATMENT
BRBR102013006411-4A BR102013006411A2 (pt) 2012-03-20 2013-03-18 Processo para a obtenção de uma composição de igg através de tratamento térmico
JP2013056191A JP6048936B2 (ja) 2012-03-20 2013-03-19 熱処理を通じてＩｇＧ組成物を得るための方法
SG2013020169A SG193738A1 (en) 2012-03-20 2013-03-19 Process for obtaining an igg composition through heat treatment
RU2013112276A RU2636049C2 (ru) 2012-03-20 2013-03-19 СПОСОБ ПОЛУЧЕНИЯ КОМПОЗИЦИИ IgG ПОСРЕДСТВОМ ТЕПЛОВОЙ ОБРАБОТКИ
AU2013201853A AU2013201853B2 (en) 2012-03-20 2013-03-19 Process for obtaining an lgG composition through heat treatment
CN201310090730.0A CN103319592B (zh) 2012-03-20 2013-03-20 通过热处理获得IgG组合物的方法
KR1020130029551A KR101840064B1 (ko) 2012-03-20 2013-03-20 열처리를 통해 IgG 조성물을 획득하는 방법
HK13113003.3A HK1185625B (en) 2012-03-20 2013-11-21 Process for obtaining an igg composition through heat treatment
JP2016160479A JP2016199586A (ja) 2012-03-20 2016-08-18 熱処理を通じてＩｇＧ組成物を得るための方法

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201230413A ES2381828B1 (es) 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO

Publications (2)

Publication Number Publication Date
ES2381828A1 ES2381828A1 (es) 2012-06-01
ES2381828B1 true ES2381828B1 (es) 2012-11-16

Family

ID=46053016

Family Applications (2)

Application Number Title Priority Date Filing Date
ES201230413A Expired - Fee Related ES2381828B1 (es) 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO
ES13158552.3T Active ES2590045T3 (es) 2012-03-20 2013-03-11 Procedimiento para obtener una composición de IgG mediante tratamiento térmico

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES13158552.3T Active ES2590045T3 (es) 2012-03-20 2013-03-11 Procedimiento para obtener una composición de IgG mediante tratamiento térmico

Country Status (21)

Country Link
US (1) US9200032B2 (enExample)
EP (1) EP2641912B1 (enExample)
JP (2) JP6048936B2 (enExample)
KR (1) KR101840064B1 (enExample)
CN (1) CN103319592B (enExample)
AR (1) AR090337A1 (enExample)
AU (1) AU2013201853B2 (enExample)
BR (1) BR102013006411A2 (enExample)
CA (1) CA2809513C (enExample)
CL (1) CL2013000688A1 (enExample)
ES (2) ES2381828B1 (enExample)
HU (1) HUE027915T2 (enExample)
IL (1) IL225197A (enExample)
MX (1) MX339268B (enExample)
MY (1) MY165024A (enExample)
PL (1) PL2641912T3 (enExample)
PT (1) PT2641912T (enExample)
RU (1) RU2636049C2 (enExample)
SG (1) SG193738A1 (enExample)
TW (1) TWI554283B (enExample)
UY (1) UY34679A (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990033A1 (fr) * 2014-08-26 2016-03-02 Carlina Technologies Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire
PL3135687T3 (pl) * 2015-08-31 2019-09-30 Instituto Grifols, S.A. Sposób wytwarzania immunoglobulin
RU2708394C2 (ru) * 2016-09-26 2019-12-06 Институто Грифольс,С.А. Способ получения иммуноглобулинов
MA52204A (fr) * 2018-04-12 2021-02-17 Amgen Inc Procédés de préparation de compositions protéiques stables
CN112557643B (zh) * 2019-09-26 2023-04-14 菲鹏生物股份有限公司 变性IgG和类风湿因子免疫抗原及制备方法
CN112858671B (zh) * 2019-11-27 2022-12-27 菲鹏生物股份有限公司 制备类风湿因子检测试剂的方法、类风湿因子检测试剂、试剂盒和检测方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514375A (en) 1894-02-06 miller
CA1064396A (en) 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
US4165370A (en) 1976-05-21 1979-08-21 Coval M L Injectable gamma globulin
DE3176491D1 (en) 1980-03-05 1987-11-26 Miles Lab Pasteurized therapeutically active protein compositions
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
ES8206184A1 (es) 1981-10-29 1982-08-16 Green Cross Corp Un procedimiento para preparar una immunoglobulina adecuada para inyeccion intravenosa
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
JPH0825902B2 (ja) 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
JPH0662436B2 (ja) 1986-05-19 1994-08-17 株式会社ミドリ十字 静注用免疫グロブリン製剤の製造方法
CA1310267C (en) 1986-07-09 1992-11-17 Yutaka Hirao Process for heat treating chemically unmodified _-globulin
JP2547556B2 (ja) 1987-02-06 1996-10-23 株式会社 ミドリ十字 ｒ−グロブリンの液状製剤
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
ES2091161B1 (es) * 1995-04-12 1997-05-16 Grifols Grupo Sa Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion.
AT403989B (de) * 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
UA64742C2 (uk) * 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ)
ES2421736T3 (es) * 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
TR200100303T2 (tr) * 1998-06-09 2001-06-21 Statens Serum Institut Damardan uygulanacak immünoglobülinler üretmek için yöntem ve başka immünoglobülin ürünleri.
CN1137727C (zh) * 1998-06-25 2004-02-11 四川远大蜀阳药业有限公司 无保护剂双重病毒灭活制备静注免疫球蛋白工艺
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ATE468755T1 (de) * 2004-05-07 2010-06-15 Wisconsin Alumni Res Found Verfahren und zusammensetzungen mit molkeproteinisolaten
KR101226353B1 (ko) * 2007-06-01 2013-01-24 에프. 호프만-라 로슈 아게 면역글로불린 정제
US8796430B2 (en) * 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield

Also Published As

Publication number Publication date
AU2013201853A1 (en) 2013-10-10
TW201343179A (zh) 2013-11-01
IL225197A0 (en) 2013-06-27
EP2641912B1 (en) 2016-06-15
SG193738A1 (en) 2013-10-30
MX339268B (es) 2016-05-18
MX2013002910A (es) 2013-09-19
KR101840064B1 (ko) 2018-03-19
UY34679A (es) 2013-10-31
ES2381828A1 (es) 2012-06-01
US20140113355A1 (en) 2014-04-24
TWI554283B (zh) 2016-10-21
AR090337A1 (es) 2014-11-05
JP6048936B2 (ja) 2016-12-21
IL225197A (en) 2017-06-29
HK1185625A1 (en) 2014-02-21
JP2016199586A (ja) 2016-12-01
CN103319592A (zh) 2013-09-25
PT2641912T (pt) 2016-08-12
CL2013000688A1 (es) 2014-02-28
CA2809513A1 (en) 2013-09-20
MY165024A (en) 2018-02-28
US9200032B2 (en) 2015-12-01
BR102013006411A2 (pt) 2015-06-09
PL2641912T3 (pl) 2016-11-30
HUE027915T2 (en) 2016-11-28
KR20130106792A (ko) 2013-09-30
AU2013201853B2 (en) 2014-07-03
JP2013194054A (ja) 2013-09-30
RU2013112276A (ru) 2014-09-27
RU2636049C2 (ru) 2017-11-17
EP2641912A1 (en) 2013-09-25
ES2590045T3 (es) 2016-11-17
CN103319592B (zh) 2020-03-03
CA2809513C (en) 2016-09-27

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