TWI554283B - 經由熱處理獲得ＩｇＧ組成物的方法 - Google Patents
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- TWI554283B TWI554283B TW102109161A TW102109161A TWI554283B TW I554283 B TWI554283 B TW I554283B TW 102109161 A TW102109161 A TW 102109161A TW 102109161 A TW102109161 A TW 102109161A TW I554283 B TWI554283 B TW I554283B
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- 210000002966 serum Anatomy 0.000 description 1
- 239000007974 sodium acetate buffer Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000006076 specific stabilizer Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000012799 strong cation exchange Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000057 synthetic resin Substances 0.000 description 1
- 229920003002 synthetic resin Polymers 0.000 description 1
- 229960004072 thrombin Drugs 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- GPRLSGONYQIRFK-MNYXATJNSA-N triton Chemical compound [3H+] GPRLSGONYQIRFK-MNYXATJNSA-N 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
- A61K39/39525—Purification
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- General Chemical & Material Sciences (AREA)
- Transplantation (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Confectionery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES201230413A ES2381828B1 (es) | 2012-03-20 | 2012-03-20 | PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201343179A TW201343179A (zh) | 2013-11-01 |
| TWI554283B true TWI554283B (zh) | 2016-10-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW102109161A TWI554283B (zh) | 2012-03-20 | 2013-03-15 | 經由熱處理獲得ＩｇＧ組成物的方法 |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US9200032B2 (enExample) |
| EP (1) | EP2641912B1 (enExample) |
| JP (2) | JP6048936B2 (enExample) |
| KR (1) | KR101840064B1 (enExample) |
| CN (1) | CN103319592B (enExample) |
| AR (1) | AR090337A1 (enExample) |
| AU (1) | AU2013201853B2 (enExample) |
| BR (1) | BR102013006411A2 (enExample) |
| CA (1) | CA2809513C (enExample) |
| CL (1) | CL2013000688A1 (enExample) |
| ES (2) | ES2381828B1 (enExample) |
| HU (1) | HUE027915T2 (enExample) |
| IL (1) | IL225197A (enExample) |
| MX (1) | MX339268B (enExample) |
| MY (1) | MY165024A (enExample) |
| PL (1) | PL2641912T3 (enExample) |
| PT (1) | PT2641912T (enExample) |
| RU (1) | RU2636049C2 (enExample) |
| SG (1) | SG193738A1 (enExample) |
| TW (1) | TWI554283B (enExample) |
| UY (1) | UY34679A (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2990033A1 (fr) * | 2014-08-26 | 2016-03-02 | Carlina Technologies | Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire |
| HUE042984T2 (hu) * | 2015-08-31 | 2019-07-29 | Inst Grifols S A | Eljárás immunglobulinok elõállítására |
| RU2708394C2 (ru) * | 2016-09-26 | 2019-12-06 | Институто Грифольс,С.А. | Способ получения иммуноглобулинов |
| IL277797B1 (en) * | 2018-04-12 | 2024-11-01 | Amgen Inc | Methods for making stable protein compositions |
| CN112557643B (zh) * | 2019-09-26 | 2023-04-14 | 菲鹏生物股份有限公司 | 变性IgG和类风湿因子免疫抗原及制备方法 |
| CN112858671B (zh) * | 2019-11-27 | 2022-12-27 | 菲鹏生物股份有限公司 | 制备类风湿因子检测试剂的方法、类风湿因子检测试剂、试剂盒和检测方法 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311797A (zh) * | 1998-06-09 | 2001-09-05 | 斯塔滕斯血清研究所 | 生产用于静脉给药的免疫球蛋白和其他免疫球蛋白产品的方法 |
| CN101679509A (zh) * | 2007-06-01 | 2010-03-24 | 弗·哈夫曼-拉罗切有限公司 | 免疫球蛋白纯化 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US514375A (en) | 1894-02-06 | miller | ||
| CA1064396A (en) | 1975-02-18 | 1979-10-16 | Myer L. Coval | Fractional precipitation of gamma globulin with polyethylene glycol |
| US4165370A (en) | 1976-05-21 | 1979-08-21 | Coval M L | Injectable gamma globulin |
| EP0035204B2 (en) | 1980-03-05 | 1991-05-22 | Miles Inc. | Pasteurized therapeutically active protein compositions |
| US4396608A (en) | 1981-08-24 | 1983-08-02 | Cutter Laboratories | Intravenously injectable immune serum globulin |
| ES506679A0 (es) | 1981-10-29 | 1982-08-16 | Green Cross Corp | Un procedimiento para preparar una immunoglobulina adecuada para inyeccion intravenosa |
| US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| JPH0825902B2 (ja) | 1985-02-21 | 1996-03-13 | 株式会社ミドリ十字 | γ−グロブリンの加熱処理方法 |
| JPH0662436B2 (ja) | 1986-05-19 | 1994-08-17 | 株式会社ミドリ十字 | 静注用免疫グロブリン製剤の製造方法 |
| CA1310267C (en) | 1986-07-09 | 1992-11-17 | Yutaka Hirao | Process for heat treating chemically unmodified _-globulin |
| JP2547556B2 (ja) | 1987-02-06 | 1996-10-23 | 株式会社 ミドリ十字 | ｒ−グロブリンの液状製剤 |
| US4876241A (en) * | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
| ES2091161B1 (es) * | 1995-04-12 | 1997-05-16 | Grifols Grupo Sa | Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion. |
| AT403989B (de) * | 1996-09-16 | 1998-07-27 | Immuno Ag | Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels |
| US5886154A (en) | 1997-06-20 | 1999-03-23 | Lebing; Wytold R. | Chromatographic method for high yield purification and viral inactivation of antibodies |
| UA64742C2 (uk) * | 1997-12-24 | 2004-03-15 | Альфа Терапевтик Корпорейшн | СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ) |
| US6281336B1 (en) * | 1998-06-09 | 2001-08-28 | Statens Serum Institut | Process for producing immunoglobulins for intravenous administration and other immunoglobulin products |
| CN1137727C (zh) * | 1998-06-25 | 2004-02-11 | 四川远大蜀阳药业有限公司 | 无保护剂双重病毒灭活制备静注免疫球蛋白工艺 |
| ES2184594B1 (es) * | 2001-01-17 | 2004-01-01 | Probitas Pharma Sa | Procedimiento para la produccion de gammaglobulina g humana inactivada de virus. |
| US7378123B2 (en) * | 2004-05-07 | 2008-05-27 | Wisconsin Alumni Research | Methods involving whey protein isolates |
| US8796430B2 (en) * | 2010-05-26 | 2014-08-05 | Baxter International Inc. | Method to produce an immunoglobulin preparation with improved yield |
-
2012
- 2012-03-20 ES ES201230413A patent/ES2381828B1/es not_active Expired - Fee Related
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2013
- 2013-03-11 PL PL13158552.3T patent/PL2641912T3/pl unknown
- 2013-03-11 HU HUE13158552A patent/HUE027915T2/en unknown
- 2013-03-11 ES ES13158552.3T patent/ES2590045T3/es active Active
- 2013-03-11 EP EP13158552.3A patent/EP2641912B1/en active Active
- 2013-03-11 PT PT131585523T patent/PT2641912T/pt unknown
- 2013-03-13 CL CL2013000688A patent/CL2013000688A1/es unknown
- 2013-03-13 IL IL225197A patent/IL225197A/en active IP Right Grant
- 2013-03-14 CA CA2809513A patent/CA2809513C/en active Active
- 2013-03-14 MX MX2013002910A patent/MX339268B/es active IP Right Grant
- 2013-03-14 AR ARP130100825A patent/AR090337A1/es unknown
- 2013-03-15 UY UY0001034679A patent/UY34679A/es not_active Application Discontinuation
- 2013-03-15 TW TW102109161A patent/TWI554283B/zh not_active IP Right Cessation
- 2013-03-15 US US13/838,424 patent/US9200032B2/en active Active
- 2013-03-18 BR BRBR102013006411-4A patent/BR102013006411A2/pt not_active Application Discontinuation
- 2013-03-18 MY MYPI2013700437A patent/MY165024A/en unknown
- 2013-03-19 RU RU2013112276A patent/RU2636049C2/ru not_active IP Right Cessation
- 2013-03-19 AU AU2013201853A patent/AU2013201853B2/en active Active
- 2013-03-19 JP JP2013056191A patent/JP6048936B2/ja active Active
- 2013-03-19 SG SG2013020169A patent/SG193738A1/en unknown
- 2013-03-20 KR KR1020130029551A patent/KR101840064B1/ko not_active Expired - Fee Related
- 2013-03-20 CN CN201310090730.0A patent/CN103319592B/zh active Active
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2016
- 2016-08-18 JP JP2016160479A patent/JP2016199586A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1311797A (zh) * | 1998-06-09 | 2001-09-05 | 斯塔滕斯血清研究所 | 生产用于静脉给药的免疫球蛋白和其他免疫球蛋白产品的方法 |
| CN101679509A (zh) * | 2007-06-01 | 2010-03-24 | 弗·哈夫曼-拉罗切有限公司 | 免疫球蛋白纯化 |
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| Title |
|---|
| 2010年，Aghaie, A., et al.," Preparation, Purification and Virus Inactivation of Intravenous Immunoglobulin from Human Plasma", Hum. Antibodies, 2010, Vol.19, No.1, P.1-6. * |
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