KR101840064B1 - 열처리를 통해 IgG 조성물을 획득하는 방법 - Google Patents

열처리를 통해 IgG 조성물을 획득하는 방법 Download PDF

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Publication number
KR101840064B1
KR101840064B1 KR1020130029551A KR20130029551A KR101840064B1 KR 101840064 B1 KR101840064 B1 KR 101840064B1 KR 1020130029551 A KR1020130029551 A KR 1020130029551A KR 20130029551 A KR20130029551 A KR 20130029551A KR 101840064 B1 KR101840064 B1 KR 101840064B1
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South Korea
Prior art keywords
igg
solution
polymer
concentration
dialysis filtration
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Expired - Fee Related
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KR1020130029551A
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Korean (ko)
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KR20130106792A (ko
Inventor
페레 리스톨 디바트
살바도르 그란차 게이몬
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그리폴스, 에스.에이.
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Confectionery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020130029551A 2012-03-20 2013-03-20 열처리를 통해 IgG 조성물을 획득하는 방법 Expired - Fee Related KR101840064B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ESP201230413 2012-03-20
ES201230413A ES2381828B1 (es) 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO

Publications (2)

Publication Number Publication Date
KR20130106792A KR20130106792A (ko) 2013-09-30
KR101840064B1 true KR101840064B1 (ko) 2018-03-19

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KR1020130029551A Expired - Fee Related KR101840064B1 (ko) 2012-03-20 2013-03-20 열처리를 통해 IgG 조성물을 획득하는 방법

Country Status (21)

Country Link
US (1) US9200032B2 (enExample)
EP (1) EP2641912B1 (enExample)
JP (2) JP6048936B2 (enExample)
KR (1) KR101840064B1 (enExample)
CN (1) CN103319592B (enExample)
AR (1) AR090337A1 (enExample)
AU (1) AU2013201853B2 (enExample)
BR (1) BR102013006411A2 (enExample)
CA (1) CA2809513C (enExample)
CL (1) CL2013000688A1 (enExample)
ES (2) ES2381828B1 (enExample)
HU (1) HUE027915T2 (enExample)
IL (1) IL225197A (enExample)
MX (1) MX339268B (enExample)
MY (1) MY165024A (enExample)
PL (1) PL2641912T3 (enExample)
PT (1) PT2641912T (enExample)
RU (1) RU2636049C2 (enExample)
SG (1) SG193738A1 (enExample)
TW (1) TWI554283B (enExample)
UY (1) UY34679A (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990033A1 (fr) * 2014-08-26 2016-03-02 Carlina Technologies Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire
PL3135687T3 (pl) * 2015-08-31 2019-09-30 Instituto Grifols, S.A. Sposób wytwarzania immunoglobulin
RU2708394C2 (ru) * 2016-09-26 2019-12-06 Институто Грифольс,С.А. Способ получения иммуноглобулинов
MA52204A (fr) * 2018-04-12 2021-02-17 Amgen Inc Procédés de préparation de compositions protéiques stables
CN112557643B (zh) * 2019-09-26 2023-04-14 菲鹏生物股份有限公司 变性IgG和类风湿因子免疫抗原及制备方法
CN112858671B (zh) * 2019-11-27 2022-12-27 菲鹏生物股份有限公司 制备类风湿因子检测试剂的方法、类风湿因子检测试剂、试剂盒和检测方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Family Cites Families (22)

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Publication number Priority date Publication date Assignee Title
US514375A (en) 1894-02-06 miller
CA1064396A (en) 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
US4165370A (en) 1976-05-21 1979-08-21 Coval M L Injectable gamma globulin
DE3176491D1 (en) 1980-03-05 1987-11-26 Miles Lab Pasteurized therapeutically active protein compositions
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
ES8206184A1 (es) 1981-10-29 1982-08-16 Green Cross Corp Un procedimiento para preparar una immunoglobulina adecuada para inyeccion intravenosa
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
JPH0825902B2 (ja) 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
JPH0662436B2 (ja) 1986-05-19 1994-08-17 株式会社ミドリ十字 静注用免疫グロブリン製剤の製造方法
CA1310267C (en) 1986-07-09 1992-11-17 Yutaka Hirao Process for heat treating chemically unmodified _-globulin
JP2547556B2 (ja) 1987-02-06 1996-10-23 株式会社 ミドリ十字 ｒ−グロブリンの液状製剤
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
ES2091161B1 (es) * 1995-04-12 1997-05-16 Grifols Grupo Sa Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion.
AT403989B (de) * 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
UA64742C2 (uk) * 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ)
ES2421736T3 (es) * 1998-06-09 2013-09-05 Csl Behring Ag Procedimiento para la preparación de inmunoglobulinas para administración intravenosa y otros productos inmunoglobulínicos
CN1137727C (zh) * 1998-06-25 2004-02-11 四川远大蜀阳药业有限公司 无保护剂双重病毒灭活制备静注免疫球蛋白工艺
ES2184594B1 (es) 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
ATE468755T1 (de) * 2004-05-07 2010-06-15 Wisconsin Alumni Res Found Verfahren und zusammensetzungen mit molkeproteinisolaten
KR101226353B1 (ko) * 2007-06-01 2013-01-24 에프. 호프만-라 로슈 아게 면역글로불린 정제
US8796430B2 (en) * 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999064462A1 (en) * 1998-06-09 1999-12-16 Statens Serum Institut Process for producing immunoglobulins for intravenous administration and other immunoglobulin products

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Human Antibodies 19 (2010) 1-6*

Also Published As

Publication number Publication date
AU2013201853A1 (en) 2013-10-10
TW201343179A (zh) 2013-11-01
IL225197A0 (en) 2013-06-27
EP2641912B1 (en) 2016-06-15
SG193738A1 (en) 2013-10-30
MX339268B (es) 2016-05-18
MX2013002910A (es) 2013-09-19
UY34679A (es) 2013-10-31
ES2381828A1 (es) 2012-06-01
US20140113355A1 (en) 2014-04-24
TWI554283B (zh) 2016-10-21
AR090337A1 (es) 2014-11-05
JP6048936B2 (ja) 2016-12-21
IL225197A (en) 2017-06-29
HK1185625A1 (en) 2014-02-21
JP2016199586A (ja) 2016-12-01
CN103319592A (zh) 2013-09-25
PT2641912T (pt) 2016-08-12
CL2013000688A1 (es) 2014-02-28
CA2809513A1 (en) 2013-09-20
MY165024A (en) 2018-02-28
ES2381828B1 (es) 2012-11-16
US9200032B2 (en) 2015-12-01
BR102013006411A2 (pt) 2015-06-09
PL2641912T3 (pl) 2016-11-30
HUE027915T2 (en) 2016-11-28
KR20130106792A (ko) 2013-09-30
AU2013201853B2 (en) 2014-07-03
JP2013194054A (ja) 2013-09-30
RU2013112276A (ru) 2014-09-27
RU2636049C2 (ru) 2017-11-17
EP2641912A1 (en) 2013-09-25
ES2590045T3 (es) 2016-11-17
CN103319592B (zh) 2020-03-03
CA2809513C (en) 2016-09-27

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