UY34679A - ?PROCEDIMIENTO PARA OBTENER UNA COMPOSICIÓN DE IgG MEDIANTE TRATAMIENTO TÉRMICO? - Google Patents

?PROCEDIMIENTO PARA OBTENER UNA COMPOSICIÓN DE IgG MEDIANTE TRATAMIENTO TÉRMICO?

Info

Publication number
UY34679A
UY34679A UY0001034679A UY34679A UY34679A UY 34679 A UY34679 A UY 34679A UY 0001034679 A UY0001034679 A UY 0001034679A UY 34679 A UY34679 A UY 34679A UY 34679 A UY34679 A UY 34679A
Authority
UY
Uruguay
Prior art keywords
igg
procedure
composition
thermal treatment
thermal
Prior art date
Application number
UY0001034679A
Other languages
English (en)
Inventor
Ristol Debart Pere
Grancha Gamon Salvador
Original Assignee
Grifols Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46053016&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UY34679(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Grifols Sa filed Critical Grifols Sa
Publication of UY34679A publication Critical patent/UY34679A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39516—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum from serum, plasma
    • A61K39/39525—Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Transplantation (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Confectionery (AREA)

Abstract

La presente invención se refiere a un nuevo procedimiento de obtención de una composición de IgG a partir de una solución de IgG parcialmente purificada de plasma humano, en el que aplicando un tratamiento térmico intermedio y sin utilizar reactivo s para la precipitación de agregados/polímeros y/o proteínas de alto peso molecular, se obtiene una eliminación prácticamente total de los polímeros de IgG generados durante el proceso. Por otra par te, con la utilización de dicho procedimiento se proporciona estabilidad al producto final en líquido.
UY0001034679A 2012-03-20 2013-03-15 ?PROCEDIMIENTO PARA OBTENER UNA COMPOSICIÓN DE IgG MEDIANTE TRATAMIENTO TÉRMICO? UY34679A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES201230413A ES2381828B1 (es) 2012-03-20 2012-03-20 PROCEDIMIENTO PARA OBTENER UNA COMPOSICION DE IgG MEDIANTE TRATAMIENTO TERMICO

Publications (1)

Publication Number Publication Date
UY34679A true UY34679A (es) 2013-10-31

Family

ID=46053016

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034679A UY34679A (es) 2012-03-20 2013-03-15 ?PROCEDIMIENTO PARA OBTENER UNA COMPOSICIÓN DE IgG MEDIANTE TRATAMIENTO TÉRMICO?

Country Status (22)

Country Link
US (1) US9200032B2 (es)
EP (1) EP2641912B1 (es)
JP (2) JP6048936B2 (es)
KR (1) KR101840064B1 (es)
CN (1) CN103319592B (es)
AR (1) AR090337A1 (es)
AU (1) AU2013201853B2 (es)
BR (1) BR102013006411A2 (es)
CA (1) CA2809513C (es)
CL (1) CL2013000688A1 (es)
ES (2) ES2381828B1 (es)
HK (1) HK1185625A1 (es)
HU (1) HUE027915T2 (es)
IL (1) IL225197A (es)
MX (1) MX339268B (es)
MY (1) MY165024A (es)
PL (1) PL2641912T3 (es)
PT (1) PT2641912T (es)
RU (1) RU2636049C2 (es)
SG (1) SG193738A1 (es)
TW (1) TWI554283B (es)
UY (1) UY34679A (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2990033A1 (fr) * 2014-08-26 2016-03-02 Carlina Technologies Procédé de préparation de nanoprécipites de peptide ou protéine de faible poids moléculaire
PL3135687T3 (pl) * 2015-08-31 2019-09-30 Instituto Grifols, S.A. Sposób wytwarzania immunoglobulin
RU2708394C2 (ru) * 2016-09-26 2019-12-06 Институто Грифольс,С.А. Способ получения иммуноглобулинов
JP7465215B2 (ja) * 2018-04-12 2024-04-10 アムジェン インコーポレイテッド 安定なタンパク質組成物を製造する方法
CN112557643B (zh) * 2019-09-26 2023-04-14 菲鹏生物股份有限公司 变性IgG和类风湿因子免疫抗原及制备方法
CN112858671B (zh) * 2019-11-27 2022-12-27 菲鹏生物股份有限公司 制备类风湿因子检测试剂的方法、类风湿因子检测试剂、试剂盒和检测方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US514375A (en) 1894-02-06 miller
CA1064396A (en) 1975-02-18 1979-10-16 Myer L. Coval Fractional precipitation of gamma globulin with polyethylene glycol
US4165370A (en) 1976-05-21 1979-08-21 Coval M L Injectable gamma globulin
EP0035204B2 (en) 1980-03-05 1991-05-22 Miles Inc. Pasteurized therapeutically active protein compositions
US4396608A (en) 1981-08-24 1983-08-02 Cutter Laboratories Intravenously injectable immune serum globulin
ES506679A0 (es) 1981-10-29 1982-08-16 Green Cross Corp Un procedimiento para preparar una immunoglobulina adecuada para inyeccion intravenosa
US4540573A (en) 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
JPH0825902B2 (ja) 1985-02-21 1996-03-13 株式会社ミドリ十字 γ−グロブリンの加熱処理方法
JPH0662436B2 (ja) 1986-05-19 1994-08-17 株式会社ミドリ十字 静注用免疫グロブリン製剤の製造方法
CA1310267C (en) 1986-07-09 1992-11-17 Yutaka Hirao Process for heat treating chemically unmodified _-globulin
JP2547556B2 (ja) 1987-02-06 1996-10-23 株式会社 ミドリ十字 ｒ−グロブリンの液状製剤
US4876241A (en) * 1987-05-22 1989-10-24 Armour Pharmaceutical Company Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants
ES2091161B1 (es) * 1995-04-12 1997-05-16 Grifols Grupo Sa Procedimiento para la produccion de gammaglobulina intramuscular inactivada por pasteurizacion.
AT403989B (de) * 1996-09-16 1998-07-27 Immuno Ag Verfahren zur herstellung eines plasmaprotein-hältigen arzneimittels
US5886154A (en) 1997-06-20 1999-03-23 Lebing; Wytold R. Chromatographic method for high yield purification and viral inactivation of antibodies
UA64742C2 (uk) * 1997-12-24 2004-03-15 Альфа Терапевтик Корпорейшн СПОСІБ ОДЕРЖАННЯ РОЗЧИНУ <font face="Symbol">g</font>-ГЛОБУЛІНУ, ПРИЗНАЧЕНОГО ДЛЯ ВНУТРІШНЬОВЕННОГО ВВЕДЕННЯ, І ПРОДУКТ, ЩО ОДЕРЖУЄТЬСЯ У ЦЕЙ СПОСІБ (ВАРІАНТИ)
DK2270044T3 (en) * 1998-06-09 2015-01-26 Csl Behring Ag Liquid immunoglobulin G (IgG) product
AU753468B2 (en) * 1998-06-09 2002-10-17 Csl Behring Ag Process for producing immunoglobulins for intravenous administration and other immunoglobulin products
CN1137727C (zh) * 1998-06-25 2004-02-11 四川远大蜀阳药业有限公司 无保护剂双重病毒灭活制备静注免疫球蛋白工艺
ES2184594B1 (es) * 2001-01-17 2004-01-01 Probitas Pharma Sa Procedimiento para la produccion de gammaglobulina g humana inactivada de virus.
WO2005110112A1 (en) * 2004-05-07 2005-11-24 Wisconsin Alumni Research Foundation Methods and compositions involving whey protein isolates
MX2009012786A (es) * 2007-06-01 2009-12-10 Hoffmann La Roche Purificacion de inmunoglobulina.
US8796430B2 (en) * 2010-05-26 2014-08-05 Baxter International Inc. Method to produce an immunoglobulin preparation with improved yield

Also Published As

Publication number Publication date
BR102013006411A2 (pt) 2015-06-09
KR20130106792A (ko) 2013-09-30
EP2641912A1 (en) 2013-09-25
CA2809513C (en) 2016-09-27
KR101840064B1 (ko) 2018-03-19
JP2013194054A (ja) 2013-09-30
PT2641912T (pt) 2016-08-12
US20140113355A1 (en) 2014-04-24
ES2590045T3 (es) 2016-11-17
PL2641912T3 (pl) 2016-11-30
CN103319592B (zh) 2020-03-03
JP2016199586A (ja) 2016-12-01
RU2013112276A (ru) 2014-09-27
IL225197A0 (en) 2013-06-27
IL225197A (en) 2017-06-29
AR090337A1 (es) 2014-11-05
TW201343179A (zh) 2013-11-01
AU2013201853B2 (en) 2014-07-03
MX2013002910A (es) 2013-09-19
CL2013000688A1 (es) 2014-02-28
CA2809513A1 (en) 2013-09-20
ES2381828B1 (es) 2012-11-16
SG193738A1 (en) 2013-10-30
HK1185625A1 (zh) 2014-02-21
US9200032B2 (en) 2015-12-01
JP6048936B2 (ja) 2016-12-21
CN103319592A (zh) 2013-09-25
EP2641912B1 (en) 2016-06-15
HUE027915T2 (en) 2016-11-28
MY165024A (en) 2018-02-28
RU2636049C2 (ru) 2017-11-17
MX339268B (es) 2016-05-18
AU2013201853A1 (en) 2013-10-10
ES2381828A1 (es) 2012-06-01
TWI554283B (zh) 2016-10-21

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Legal Events

Date Code Title Description
109 Application deemed to be withdrawn

Effective date: 20210526