ES2350378T3 - Uso de n-isopropilacrilamida para almacenar lentes de contacto. - Google Patents
Uso de n-isopropilacrilamida para almacenar lentes de contacto. Download PDFInfo
- Publication number
- ES2350378T3 ES2350378T3 ES08002333T ES08002333T ES2350378T3 ES 2350378 T3 ES2350378 T3 ES 2350378T3 ES 08002333 T ES08002333 T ES 08002333T ES 08002333 T ES08002333 T ES 08002333T ES 2350378 T3 ES2350378 T3 ES 2350378T3
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- Prior art keywords
- solution
- use according
- nipam
- lenses
- polymers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- QNILTEGFHQSKFF-UHFFFAOYSA-N n-propan-2-ylprop-2-enamide Chemical compound CC(C)NC(=O)C=C QNILTEGFHQSKFF-UHFFFAOYSA-N 0.000 title claims abstract description 8
- 229920000642 polymer Polymers 0.000 claims abstract description 69
- 239000000203 mixture Substances 0.000 claims abstract description 45
- 239000007864 aqueous solution Substances 0.000 claims abstract description 4
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- 102000004169 proteins and genes Human genes 0.000 claims description 38
- 108090000623 proteins and genes Proteins 0.000 claims description 38
- 239000000243 solution Substances 0.000 claims description 29
- 238000001179 sorption measurement Methods 0.000 claims description 11
- 239000004599 antimicrobial Substances 0.000 claims description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 claims description 5
- 239000004327 boric acid Substances 0.000 claims description 5
- 239000004094 surface-active agent Substances 0.000 claims description 4
- 229910021538 borax Inorganic materials 0.000 claims description 3
- 239000006172 buffering agent Substances 0.000 claims description 3
- 239000001509 sodium citrate Substances 0.000 claims description 3
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims description 3
- 235000010339 sodium tetraborate Nutrition 0.000 claims description 3
- BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 claims description 3
- 239000008363 phosphate buffer Substances 0.000 claims description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims 2
- 235000010338 boric acid Nutrition 0.000 claims 1
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- VTUFDOOSZOYXFC-UHFFFAOYSA-N 2-amino-1-(diaminomethylidene)guanidine Chemical class NNC(=N)NC(N)=N VTUFDOOSZOYXFC-UHFFFAOYSA-N 0.000 description 3
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- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 3
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- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 2
- 229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
- VAZJLPXFVQHDFB-UHFFFAOYSA-N 1-(diaminomethylidene)-2-hexylguanidine Polymers CCCCCCN=C(N)N=C(N)N VAZJLPXFVQHDFB-UHFFFAOYSA-N 0.000 description 1
- OSSNTDFYBPYIEC-UHFFFAOYSA-O 1-ethenylimidazole;hydron Chemical group C=CN1C=C[NH+]=C1 OSSNTDFYBPYIEC-UHFFFAOYSA-O 0.000 description 1
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- QCVGEOXPDFCNHA-UHFFFAOYSA-N 5,5-dimethyl-2,4-dioxo-1,3-oxazolidine-3-carboxamide Chemical compound CC1(C)OC(=O)N(C(N)=O)C1=O QCVGEOXPDFCNHA-UHFFFAOYSA-N 0.000 description 1
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 1
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- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 102100026735 Coagulation factor VIII Human genes 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
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- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 1
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- 102100032241 Lactotransferrin Human genes 0.000 description 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
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- 241000607720 Serratia Species 0.000 description 1
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- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 1
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- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 1
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- YLGYACDQVQQZSW-UHFFFAOYSA-N n,n-dimethylprop-2-enamide Chemical compound CN(C)C(=O)C=C YLGYACDQVQQZSW-UHFFFAOYSA-N 0.000 description 1
- RUSRUYULUAYXIP-UHFFFAOYSA-N n-acetylprop-2-enamide Chemical compound CC(=O)NC(=O)C=C RUSRUYULUAYXIP-UHFFFAOYSA-N 0.000 description 1
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- NLAIHECABDOZBR-UHFFFAOYSA-M sodium 2,2-bis(2-methylprop-2-enoyloxymethyl)butyl 2-methylprop-2-enoate 2-hydroxyethyl 2-methylprop-2-enoate 2-methylprop-2-enoate Chemical compound [Na+].CC(=C)C([O-])=O.CC(=C)C(=O)OCCO.CCC(COC(=O)C(C)=C)(COC(=O)C(C)=C)COC(=O)C(C)=C NLAIHECABDOZBR-UHFFFAOYSA-M 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/28—Materials for coating prostheses
- A61L27/34—Macromolecular materials
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/141—Biguanides, e.g. chlorhexidine
- A61L12/142—Polymeric biguanides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L12/00—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor
- A61L12/08—Methods or apparatus for disinfecting or sterilising contact lenses; Accessories therefor using chemical substances
- A61L12/14—Organic compounds not covered by groups A61L12/10 or A61L12/12
- A61L12/143—Quaternary ammonium compounds
- A61L12/145—Polymeric quaternary ammonium compounds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
- A61L31/10—Macromolecular materials
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/0005—Other compounding ingredients characterised by their effect
- C11D3/0078—Compositions for cleaning contact lenses, spectacles or lenses
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3703—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3719—Polyamides or polyimides
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D3/00—Other compounding ingredients of detergent compositions covered in group C11D1/00
- C11D3/16—Organic compounds
- C11D3/37—Polymers
- C11D3/3746—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds
- C11D3/3769—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines
- C11D3/3773—(Co)polymerised monomers containing nitrogen, e.g. carbonamides, nitriles or amines in liquid compositions
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/31504—Composite [nonstructural laminate]
- Y10T428/31725—Of polyamide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Surgery (AREA)
- Medicinal Chemistry (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Dermatology (AREA)
- Transplantation (AREA)
- Eyeglasses (AREA)
- Medicinal Preparation (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Materials For Medical Uses (AREA)
- Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
- Exhaust Silencers (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US43615902P | 2002-12-23 | 2002-12-23 | |
| US436159P | 2002-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2350378T3 true ES2350378T3 (es) | 2011-01-21 |
Family
ID=32713057
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES08002333T Expired - Lifetime ES2350378T3 (es) | 2002-12-23 | 2003-12-11 | Uso de n-isopropilacrilamida para almacenar lentes de contacto. |
| ES03814697T Expired - Lifetime ES2298629T3 (es) | 2002-12-23 | 2003-12-11 | Composiciones que comprenden n-isopropilacrilamida y metodos para inhibir la adsorcion de proteinas sobre superficies. |
| ES08019648T Active ES2350379T3 (es) | 2002-12-23 | 2008-11-11 | Elemento de conducto flexible para una instalación de gas de escape. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES03814697T Expired - Lifetime ES2298629T3 (es) | 2002-12-23 | 2003-12-11 | Composiciones que comprenden n-isopropilacrilamida y metodos para inhibir la adsorcion de proteinas sobre superficies. |
| ES08019648T Active ES2350379T3 (es) | 2002-12-23 | 2008-11-11 | Elemento de conducto flexible para una instalación de gas de escape. |
Country Status (15)
| Country | Link |
|---|---|
| US (4) | US20040131870A1 (https=) |
| EP (2) | EP1575634B1 (https=) |
| JP (1) | JP2006515685A (https=) |
| KR (2) | KR20120059618A (https=) |
| CN (1) | CN100346846C (https=) |
| AR (1) | AR042633A1 (https=) |
| AT (2) | ATE385813T1 (https=) |
| AU (1) | AU2003296443B2 (https=) |
| BR (1) | BR0317689A (https=) |
| CA (1) | CA2508282C (https=) |
| DE (2) | DE60319133T2 (https=) |
| DK (1) | DK1938846T3 (https=) |
| ES (3) | ES2350378T3 (https=) |
| TW (1) | TWI354021B (https=) |
| WO (1) | WO2004060429A1 (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI354021B (en) * | 2002-12-23 | 2011-12-11 | Alcon Inc | Compositions and methods for inhibiting protein on |
| US20060063930A1 (en) * | 2004-08-20 | 2006-03-23 | Agoston Gregory E | Compositions and methods comprising proteinase activated receptor antagonists |
| EP2042912A4 (en) * | 2006-07-14 | 2010-08-11 | Tomey Co Ltd | LIQUID FOR CONTACT LENSES AND METHOD FOR HYDROPHILIZING A CONTACT LENS THROUGH ITS USE |
| US7968650B2 (en) | 2006-10-31 | 2011-06-28 | Johnson & Johnson Vision Care, Inc. | Polymeric compositions comprising at least one volume excluding polymer |
| US20090171049A1 (en) * | 2007-12-27 | 2009-07-02 | Linhardt Jeffrey G | Segmented reactive block copolymers |
| US20090295004A1 (en) * | 2008-06-02 | 2009-12-03 | Pinsly Jeremy B | Silicone hydrogel contact lenses displaying reduced protein uptake |
| US8534031B2 (en) * | 2008-12-30 | 2013-09-17 | Bausch & Lomb Incorporated | Packaging solutions |
| US8240849B2 (en) | 2009-03-31 | 2012-08-14 | Johnson & Johnson Vision Care, Inc. | Free form lens with refractive index variations |
| WO2014165582A1 (en) * | 2013-04-03 | 2014-10-09 | Southern Research Institute | Articles and methods related to transdermal delivery of a therapeutic agent |
| KR101599916B1 (ko) | 2014-06-10 | 2016-03-04 | 동신대학교산학협력단 | 콘택트 렌즈의 단백질 흡착을 방지하는 하이드로겔 콘택트 렌즈 및 이의 제조방법 |
| WO2015190857A1 (ko) * | 2014-06-12 | 2015-12-17 | 충남대학교산학협력단 | 효소를 이용하여 ｐＨ를 조절하는 무세포 단백질 합성 방법 |
| CN114689538A (zh) * | 2020-12-30 | 2022-07-01 | 苏州三个臭皮匠生物科技有限公司 | 一种有效测量软性亲水角膜接触镜泪蛋白含量的方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4452925A (en) * | 1981-02-09 | 1984-06-05 | National Patent Development Corporation | Biologically stabilized compositions comprising collagen as the minor component with ethylenically unsaturated compounds used as contact lenses |
| US4388428A (en) * | 1981-07-20 | 1983-06-14 | National Patent Development Corporation | Biologically stabilized compositions comprising collagen as the major component with ethylenically unsaturated compounds used as contact lenses |
| US4411932A (en) * | 1981-11-23 | 1983-10-25 | Alcon Laboratories, Inc. | Method for the prevention of soilant deposits on contact lenses |
| JPH0519213A (ja) * | 1991-07-10 | 1993-01-29 | Seiko Epson Corp | コンタクトレンズの製造方法 |
| JPH0580276A (ja) * | 1991-09-24 | 1993-04-02 | Seiko Epson Corp | コンタクトレンズ |
| JP3085480B2 (ja) * | 1991-10-02 | 2000-09-11 | セイコーエプソン株式会社 | ホルモン徐放性コンタクトレンズ |
| JPH05285164A (ja) * | 1992-04-03 | 1993-11-02 | Unitika Ltd | 抗血栓性眼内レンズ |
| JP3324156B2 (ja) * | 1992-10-12 | 2002-09-17 | セイコーエプソン株式会社 | コンタクトレンズ |
| CA2184814A1 (en) * | 1994-03-04 | 1995-09-14 | Allan S. Hoffman | Block and graft copolymers and methods relating thereto |
| AU716154B2 (en) * | 1995-09-01 | 2000-02-17 | University Of Washington | Interactive molecular conjugates |
| KR0173089B1 (ko) * | 1996-01-30 | 1999-03-20 | 윤덕용 | N-이소프로필아크릴아미드/옥타데실아크릴레이트/아크릴산 공중합체로 피복된 방출온도 제어형 리포솜 및 그의 제조방법 |
| US6096138A (en) | 1997-04-30 | 2000-08-01 | Bausch & Lomb Incorporated | Method for inhibiting the deposition of protein on contact lens |
| US6494861B1 (en) * | 1997-01-15 | 2002-12-17 | Boston Scientific Corporation | Drug delivery system |
| JPH10333103A (ja) * | 1997-05-28 | 1998-12-18 | Mitsuru Akashi | 生体適合性眼用レンズ及び生体適合性眼用レンズの製造方法 |
| US6153568A (en) * | 1997-11-12 | 2000-11-28 | Mccanna; David J. | Compositions comprising polyquaterniums in combination with polymeric biguanides for disinfecting contact lenses |
| ZA9811445B (en) | 1997-12-19 | 1999-08-16 | Alcon Lab Inc | Aminobiguanides and the use thereof to disinfect contact lenses and preserve pharmaceutical compositions. |
| US6426086B1 (en) * | 1998-02-03 | 2002-07-30 | The Regents Of The University Of California | pH-sensitive, serum-stable liposomes |
| US6447897B1 (en) * | 1998-03-06 | 2002-09-10 | Battelle Memorial Institute | Temperature sensitive surfaces and methods of making same |
| US5997961A (en) * | 1998-03-06 | 1999-12-07 | Battelle Memorial Institute | Method of bonding functional surface materials to substrates and applications in microtechnology and antifouling |
| US6274133B1 (en) | 1998-12-22 | 2001-08-14 | Bausch & Lomb Incorporated | Method for treating extended-wear contact lenses in the eyes |
| WO2000056774A1 (en) * | 1999-03-19 | 2000-09-28 | Duke University | Methods of using bioelastomers |
| US6790816B2 (en) * | 1999-09-24 | 2004-09-14 | Bausch & Lomb Incorporated | High osmolyte cleaning and disinfection method and solution for contact lenses |
| JP2001256075A (ja) * | 2000-03-13 | 2001-09-21 | Nec Software Hokuriku Ltd | 開発システム、開発方法、記録媒体 |
| US6579519B2 (en) * | 2000-09-18 | 2003-06-17 | Registrar, University Of Delhi | Sustained release and long residing ophthalmic formulation and the process of preparing the same |
| ES2267828T3 (es) * | 2000-10-10 | 2007-03-16 | Serono Genetics Institute S.A. | Polimeros que se adsorben sobre superficies y su uso para tratar superficies hidrofobas o hidrofilas. |
| US20020155241A1 (en) * | 2001-02-26 | 2002-10-24 | Tarasevich Barbara J. | Surface modifications of medical devices to reduce protein adsorption |
| JP3838882B2 (ja) * | 2001-02-28 | 2006-10-25 | 株式会社Ｐｈｇ | 温度応答性材料およびそれを含む組成物 |
| EP1381406A1 (en) * | 2001-04-20 | 2004-01-21 | Medtronic, Inc. | Enhanced chronic lead removal |
| WO2003079985A2 (en) * | 2002-03-18 | 2003-10-02 | Carnegie Mellon University | Method and apparatus for preparing biomimetic scaffold |
| MXPA05001570A (es) * | 2002-08-09 | 2005-08-19 | Ottawa Health Research Inst | Matriz biosintetica y sus usos. |
| TWI354021B (en) | 2002-12-23 | 2011-12-11 | Alcon Inc | Compositions and methods for inhibiting protein on |
-
2003
- 2003-11-07 TW TW92131215A patent/TWI354021B/zh not_active IP Right Cessation
- 2003-12-11 AT AT03814697T patent/ATE385813T1/de active
- 2003-12-11 JP JP2004565332A patent/JP2006515685A/ja not_active Withdrawn
- 2003-12-11 ES ES08002333T patent/ES2350378T3/es not_active Expired - Lifetime
- 2003-12-11 EP EP20030814697 patent/EP1575634B1/en not_active Expired - Lifetime
- 2003-12-11 EP EP08002333A patent/EP1938846B1/en not_active Expired - Lifetime
- 2003-12-11 DE DE2003619133 patent/DE60319133T2/de not_active Expired - Lifetime
- 2003-12-11 CA CA2508282A patent/CA2508282C/en not_active Expired - Fee Related
- 2003-12-11 AT AT08002333T patent/ATE481117T1/de not_active IP Right Cessation
- 2003-12-11 BR BR0317689A patent/BR0317689A/pt not_active IP Right Cessation
- 2003-12-11 DK DK08002333T patent/DK1938846T3/da active
- 2003-12-11 WO PCT/US2003/039250 patent/WO2004060429A1/en not_active Ceased
- 2003-12-11 AU AU2003296443A patent/AU2003296443B2/en not_active Ceased
- 2003-12-11 US US10/732,934 patent/US20040131870A1/en not_active Abandoned
- 2003-12-11 KR KR1020127009256A patent/KR20120059618A/ko not_active Ceased
- 2003-12-11 KR KR1020057011884A patent/KR20050086939A/ko not_active Ceased
- 2003-12-11 ES ES03814697T patent/ES2298629T3/es not_active Expired - Lifetime
- 2003-12-11 CN CNB2003801074303A patent/CN100346846C/zh not_active Expired - Fee Related
- 2003-12-11 DE DE60334255T patent/DE60334255D1/de not_active Expired - Lifetime
- 2003-12-19 AR ARP030104753 patent/AR042633A1/es unknown
-
2005
- 2005-11-15 US US11/273,778 patent/US7276552B2/en not_active Expired - Lifetime
-
2007
- 2007-08-16 US US11/839,932 patent/US7468344B2/en not_active Expired - Lifetime
-
2008
- 2008-05-27 US US12/127,050 patent/US7485607B2/en not_active Expired - Lifetime
- 2008-11-11 ES ES08019648T patent/ES2350379T3/es active Active
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