ES2330095T3 - Procedimiento para preparar un derivado de tiazol y compuestos intermedios para su preperacion. - Google Patents

Procedimiento para preparar un derivado de tiazol y compuestos intermedios para su preperacion. Download PDF

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Publication number
ES2330095T3
ES2330095T3 ES03721130T ES03721130T ES2330095T3 ES 2330095 T3 ES2330095 T3 ES 2330095T3 ES 03721130 T ES03721130 T ES 03721130T ES 03721130 T ES03721130 T ES 03721130T ES 2330095 T3 ES2330095 T3 ES 2330095T3
Authority
ES
Spain
Prior art keywords
formula
compound
alkyl
reaction
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES03721130T
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English (en)
Spanish (es)
Inventor
Heonjoong Kang
Jungyeob Ham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Seoul National University Industry Foundation
Original Assignee
Seoul National University Industry Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Seoul National University Industry Foundation filed Critical Seoul National University Industry Foundation
Application granted granted Critical
Publication of ES2330095T3 publication Critical patent/ES2330095T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES03721130T 2002-05-04 2003-05-01 Procedimiento para preparar un derivado de tiazol y compuestos intermedios para su preperacion. Expired - Lifetime ES2330095T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2002-0024595 2002-05-04
KR10-2002-0024595A KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체

Publications (1)

Publication Number Publication Date
ES2330095T3 true ES2330095T3 (es) 2009-12-04

Family

ID=29728605

Family Applications (1)

Application Number Title Priority Date Filing Date
ES03721130T Expired - Lifetime ES2330095T3 (es) 2002-05-04 2003-05-01 Procedimiento para preparar un derivado de tiazol y compuestos intermedios para su preperacion.

Country Status (8)

Country Link
US (2) US7241901B2 (https=)
EP (1) EP1501811B1 (https=)
JP (1) JP2005536480A (https=)
KR (1) KR100474202B1 (https=)
CN (1) CN100457744C (https=)
DE (1) DE60328376D1 (https=)
ES (1) ES2330095T3 (https=)
WO (1) WO2003106442A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100753860B1 (ko) * 2004-12-31 2007-08-31 재단법인서울대학교산학협력재단 유기 셀레늄 함유 화합물 및 이들 화합물의 용도
AU2005320387A1 (en) * 2004-12-31 2006-07-06 Seoul National University Industry Foundation Organoselenium containing compounds and their use
WO2006091047A1 (en) * 2005-02-25 2006-08-31 Heonjoong Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
US20090054493A1 (en) * 2005-02-25 2009-02-26 Heonjoong Kang Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
CN101193876B (zh) * 2005-05-07 2011-05-11 财团法人首尔大学校产学协力财团 制备PPARδ的配体的方法和用于制备该配体的中间化合物
JP2009523132A (ja) * 2006-01-10 2009-06-18 スミスクライン ビーチャム コーポレーション ｛２−メチル−４−［４−メチル−２−（４−トリフルオロメチルフェニル）チアゾール−５−イルメチルチオ］フェノキシ｝−酢酸の多形体形態
KR101005020B1 (ko) 2006-12-13 2010-12-30 대전대학교 산학협력단 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물
JP5367584B2 (ja) 2007-01-08 2013-12-11 ソウル ナショナル ユニバーシティー インダストリー ファンデーション ペルオキシソーム増殖因子活性化受容体δリガンドチアゾール化合物及びこれを含有する医薬、化粧品及び健康食品組成物
CN107879994A (zh) * 2017-10-31 2018-04-06 广西师范大学 一种噻唑类化合物的合成方法
CN109897013B (zh) * 2019-03-31 2023-04-07 无锡科华生物科技有限公司 一种选择性PPARδ激动剂GW501516的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727187A (en) * 1984-06-15 1988-02-23 Ciba-Geigy Corporation Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
JPH06306005A (ja) * 1993-04-23 1994-11-01 Nippon Kayaku Co Ltd エーテル系化合物及びその製法
CN1233241A (zh) * 1996-08-19 1999-10-27 日本烟草产业株式会社 丙酸衍生物及其用途
ATE451346T1 (de) * 1998-03-10 2009-12-15 Ono Pharmaceutical Co Carbonsäurederivate und medikamente die diese als aktiven wirkstoff enthalten
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
GB9914977D0 (en) * 1999-06-25 1999-08-25 Glaxo Group Ltd Chemical compounds
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2001354671A (ja) * 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
EP1310494B1 (en) * 2000-08-11 2012-01-25 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
AU2002233271A1 (en) 2000-12-20 2002-07-01 Glaxo Group Limited Substitued oxazoles and thiazoles as hppar alpha agonists
WO2002070011A2 (en) * 2001-02-02 2002-09-12 Smithkline Beecham Corporation Treatment of ppar mediated diseases
AU2003213281A1 (en) * 2002-02-28 2003-09-16 Smithkline Beecham Corporation Process and intermediates for preparing phenylthiomethyl-thiazoles or oxazoles

Also Published As

Publication number Publication date
EP1501811A1 (en) 2005-02-02
KR100474202B1 (ko) 2005-03-08
WO2003106442A1 (en) 2003-12-24
US20050176785A1 (en) 2005-08-11
DE60328376D1 (de) 2009-08-27
CN1649854A (zh) 2005-08-03
CN100457744C (zh) 2009-02-04
JP2005536480A (ja) 2005-12-02
EP1501811B1 (en) 2009-07-15
KR20030086373A (ko) 2003-11-10
US20070179300A1 (en) 2007-08-02
EP1501811A4 (en) 2006-02-08
US7241901B2 (en) 2007-07-10

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