CN100457744C - 噻唑衍生物的制备方法和用于制备噻唑衍生物的中间体化合物 - Google Patents

噻唑衍生物的制备方法和用于制备噻唑衍生物的中间体化合物 Download PDF

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Publication number
CN100457744C
CN100457744C CNB038100819A CN03810081A CN100457744C CN 100457744 C CN100457744 C CN 100457744C CN B038100819 A CNB038100819 A CN B038100819A CN 03810081 A CN03810081 A CN 03810081A CN 100457744 C CN100457744 C CN 100457744C
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China
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formula
compound
methyl
alkyl
reaction
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Expired - Fee Related
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CNB038100819A
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Chinese (zh)
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CN1649854A (zh
Inventor
姜宪中
咸政烨
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Seoul National University Industry Foundation
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Seoul National University Industry Foundation
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/26—Radicals substituted by sulfur atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB038100819A 2002-05-04 2003-05-01 噻唑衍生物的制备方法和用于制备噻唑衍生物的中间体化合物 Expired - Fee Related CN100457744C (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
KR1020020024595 2002-05-04
KR10-2002-0024595 2002-05-04
KR10-2002-0024595A KR100474202B1 (ko) 2002-05-04 2002-05-04 티아졸 유도체의 제조방법 및 이를 제조하기 위한 중간체

Publications (2)

Publication Number Publication Date
CN1649854A CN1649854A (zh) 2005-08-03
CN100457744C true CN100457744C (zh) 2009-02-04

Family

ID=29728605

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038100819A Expired - Fee Related CN100457744C (zh) 2002-05-04 2003-05-01 噻唑衍生物的制备方法和用于制备噻唑衍生物的中间体化合物

Country Status (8)

Country Link
US (2) US7241901B2 (https=)
EP (1) EP1501811B1 (https=)
JP (1) JP2005536480A (https=)
KR (1) KR100474202B1 (https=)
CN (1) CN100457744C (https=)
DE (1) DE60328376D1 (https=)
ES (1) ES2330095T3 (https=)
WO (1) WO2003106442A1 (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100753860B1 (ko) * 2004-12-31 2007-08-31 재단법인서울대학교산학협력재단 유기 셀레늄 함유 화합물 및 이들 화합물의 용도
AU2005320387A1 (en) * 2004-12-31 2006-07-06 Seoul National University Industry Foundation Organoselenium containing compounds and their use
WO2006091047A1 (en) * 2005-02-25 2006-08-31 Heonjoong Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
US20090054493A1 (en) * 2005-02-25 2009-02-26 Heonjoong Kang Kang Thiazole derivatives as ppar delta ligands and their manufacturing process
CN101193876B (zh) * 2005-05-07 2011-05-11 财团法人首尔大学校产学协力财团 制备PPARδ的配体的方法和用于制备该配体的中间化合物
JP2009523132A (ja) * 2006-01-10 2009-06-18 スミスクライン ビーチャム コーポレーション ｛２−メチル−４−［４−メチル−２−（４−トリフルオロメチルフェニル）チアゾール−５−イルメチルチオ］フェノキシ｝−酢酸の多形体形態
KR101005020B1 (ko) 2006-12-13 2010-12-30 대전대학교 산학협력단 신규 쿠마린 유도체 및 이를 함유하는 항염증, 항알러지용조성물
JP5367584B2 (ja) 2007-01-08 2013-12-11 ソウル ナショナル ユニバーシティー インダストリー ファンデーション ペルオキシソーム増殖因子活性化受容体δリガンドチアゾール化合物及びこれを含有する医薬、化粧品及び健康食品組成物
CN107879994A (zh) * 2017-10-31 2018-04-06 广西师范大学 一种噻唑类化合物的合成方法
CN109897013B (zh) * 2019-03-31 2023-04-07 无锡科华生物科技有限公司 一种选择性PPARδ激动剂GW501516的制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727187A (en) * 1984-06-15 1988-02-23 Ciba-Geigy Corporation Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
JPH06306005A (ja) * 1993-04-23 1994-11-01 Nippon Kayaku Co Ltd エーテル系化合物及びその製法
WO2001000603A1 (en) * 1999-06-25 2001-01-04 Glaxo Group Limited Thiazole and oxazole derivatives and their pharmaceutical use
EP1067109A1 (en) * 1998-03-10 2001-01-10 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1233241A (zh) * 1996-08-19 1999-10-27 日本烟草产业株式会社 丙酸衍生物及其用途
GB9817118D0 (en) * 1998-08-07 1998-10-07 Glaxo Group Ltd Pharmaceutical compounds
PE20011010A1 (es) * 1999-12-02 2001-10-18 Glaxo Group Ltd Oxazoles y tiazoles sustituidos como agonista del receptor activado por el proliferador de peroxisomas humano
JP2001354671A (ja) * 2000-04-14 2001-12-25 Nippon Chemiphar Co Ltd ペルオキシソーム増殖剤応答性受容体δの活性化剤
EP1310494B1 (en) * 2000-08-11 2012-01-25 Nippon Chemiphar Co., Ltd. PPAR (delta) ACTIVATORS
AU2002233271A1 (en) 2000-12-20 2002-07-01 Glaxo Group Limited Substitued oxazoles and thiazoles as hppar alpha agonists
WO2002070011A2 (en) * 2001-02-02 2002-09-12 Smithkline Beecham Corporation Treatment of ppar mediated diseases
AU2003213281A1 (en) * 2002-02-28 2003-09-16 Smithkline Beecham Corporation Process and intermediates for preparing phenylthiomethyl-thiazoles or oxazoles

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727187A (en) * 1984-06-15 1988-02-23 Ciba-Geigy Corporation Process for the preparation of α, α-difluoroalkyl phenyl ether derivatives
JPH06306005A (ja) * 1993-04-23 1994-11-01 Nippon Kayaku Co Ltd エーテル系化合物及びその製法
EP1067109A1 (en) * 1998-03-10 2001-01-10 Ono Pharmaceutical Co., Ltd. Carboxylic acid derivatives and drugs containing the same as the active ingredient
WO2001000603A1 (en) * 1999-06-25 2001-01-04 Glaxo Group Limited Thiazole and oxazole derivatives and their pharmaceutical use

Also Published As

Publication number Publication date
EP1501811A1 (en) 2005-02-02
KR100474202B1 (ko) 2005-03-08
WO2003106442A1 (en) 2003-12-24
US20050176785A1 (en) 2005-08-11
DE60328376D1 (de) 2009-08-27
CN1649854A (zh) 2005-08-03
ES2330095T3 (es) 2009-12-04
JP2005536480A (ja) 2005-12-02
EP1501811B1 (en) 2009-07-15
KR20030086373A (ko) 2003-11-10
US20070179300A1 (en) 2007-08-02
EP1501811A4 (en) 2006-02-08
US7241901B2 (en) 2007-07-10

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