ES2327279T3 - Procedimiento de inactivacion viral mediante calentamiento en seco. - Google Patents
Procedimiento de inactivacion viral mediante calentamiento en seco. Download PDFInfo
- Publication number
- ES2327279T3 ES2327279T3 ES06847095T ES06847095T ES2327279T3 ES 2327279 T3 ES2327279 T3 ES 2327279T3 ES 06847095 T ES06847095 T ES 06847095T ES 06847095 T ES06847095 T ES 06847095T ES 2327279 T3 ES2327279 T3 ES 2327279T3
- Authority
- ES
- Spain
- Prior art keywords
- biological product
- viral
- product
- glass transition
- transition temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 230000003612 virological effect Effects 0.000 title claims abstract description 61
- 230000002779 inactivation Effects 0.000 title claims abstract description 53
- 238000000034 method Methods 0.000 title claims abstract description 37
- 238000010438 heat treatment Methods 0.000 claims abstract description 58
- 230000009477 glass transition Effects 0.000 claims abstract description 30
- 241000700605 Viruses Species 0.000 claims abstract description 29
- 230000009467 reduction Effects 0.000 claims description 37
- 238000011282 treatment Methods 0.000 claims description 15
- 238000000926 separation method Methods 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 9
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 7
- 210000002381 plasma Anatomy 0.000 claims description 7
- 230000007704 transition Effects 0.000 claims description 7
- 102000004169 proteins and genes Human genes 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 230000007423 decrease Effects 0.000 claims description 4
- 150000003839 salts Chemical class 0.000 claims description 3
- 230000003247 decreasing effect Effects 0.000 claims description 2
- 241000702619 Porcine parvovirus Species 0.000 description 13
- 241000709721 Hepatovirus A Species 0.000 description 12
- 241000035705 Enterobacteria phage PR772 Species 0.000 description 9
- 108010054218 Factor VIII Proteins 0.000 description 9
- 102000001690 Factor VIII Human genes 0.000 description 9
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 description 8
- 229960000301 factor viii Drugs 0.000 description 8
- 241000725303 Human immunodeficiency virus Species 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 238000009472 formulation Methods 0.000 description 6
- 210000004369 blood Anatomy 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 229920000642 polymer Polymers 0.000 description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
- 239000004014 plasticizer Substances 0.000 description 4
- 102000015081 Blood Coagulation Factors Human genes 0.000 description 3
- 108010039209 Blood Coagulation Factors Proteins 0.000 description 3
- 230000005540 biological transmission Effects 0.000 description 3
- 239000003114 blood coagulation factor Substances 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 239000003599 detergent Substances 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000004448 titration Methods 0.000 description 3
- 238000010792 warming Methods 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 241000701922 Bovine parvovirus Species 0.000 description 2
- 241000701022 Cytomegalovirus Species 0.000 description 2
- 108010054265 Factor VIIa Proteins 0.000 description 2
- 241000125945 Protoparvovirus Species 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000004108 freeze drying Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940106780 human fibrinogen Drugs 0.000 description 2
- RZJRJXONCZWCBN-UHFFFAOYSA-N octadecane Chemical compound CCCCCCCCCCCCCCCCCC RZJRJXONCZWCBN-UHFFFAOYSA-N 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 241001515965 unidentified phage Species 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 241000701931 Canine parvovirus Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 206010061041 Chlamydial infection Diseases 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 206010061598 Immunodeficiency Diseases 0.000 description 1
- 208000029462 Immunodeficiency disease Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229920002367 Polyisobutene Polymers 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 241000606651 Rickettsiales Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000282887 Suidae Species 0.000 description 1
- 102100021696 Syncytin-1 Human genes 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 229920006125 amorphous polymer Polymers 0.000 description 1
- 238000000889 atomisation Methods 0.000 description 1
- 229960000074 biopharmaceutical Drugs 0.000 description 1
- 238000009529 body temperature measurement Methods 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000004027 cell Anatomy 0.000 description 1
- 201000000902 chlamydia Diseases 0.000 description 1
- 208000012538 chlamydia trachomatis infectious disease Diseases 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000002405 diagnostic procedure Methods 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 241001493065 dsRNA viruses Species 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 229940012414 factor viia Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 208000005252 hepatitis A Diseases 0.000 description 1
- 230000007813 immunodeficiency Effects 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 125000003473 lipid group Chemical group 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 210000004779 membrane envelope Anatomy 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 244000309711 non-enveloped viruses Species 0.000 description 1
- 102000039446 nucleic acids Human genes 0.000 description 1
- 108020004707 nucleic acids Proteins 0.000 description 1
- 150000007523 nucleic acids Chemical class 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 238000005373 pervaporation Methods 0.000 description 1
- 229920001195 polyisoprene Polymers 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 230000010512 thermal transition Effects 0.000 description 1
- 238000001757 thermogravimetry curve Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 108010047303 von Willebrand Factor Proteins 0.000 description 1
- 102100036537 von Willebrand factor Human genes 0.000 description 1
- 229960001134 von willebrand factor Drugs 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/02—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor using physical phenomena
- A61L2/04—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
- A61L2/0023—Heat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0512875A FR2894830B1 (fr) | 2005-12-19 | 2005-12-19 | Procede d'inactivation virale par chauffage a sec selon la temperature de transition vitreuse |
| FR0512875 | 2005-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2327279T3 true ES2327279T3 (es) | 2009-10-27 |
Family
ID=36698885
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06847095T Active ES2327279T3 (es) | 2005-12-19 | 2006-12-19 | Procedimiento de inactivacion viral mediante calentamiento en seco. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8252227B2 (enExample) |
| EP (1) | EP1981549B1 (enExample) |
| JP (1) | JP5085558B2 (enExample) |
| KR (1) | KR101162060B1 (enExample) |
| CN (1) | CN101355972B (enExample) |
| AT (1) | ATE431162T1 (enExample) |
| AU (1) | AU2006328804B2 (enExample) |
| BR (1) | BRPI0621074B1 (enExample) |
| CA (1) | CA2633338C (enExample) |
| DE (1) | DE602006006875D1 (enExample) |
| DK (1) | DK1981549T3 (enExample) |
| ES (1) | ES2327279T3 (enExample) |
| FR (1) | FR2894830B1 (enExample) |
| IL (1) | IL192194A (enExample) |
| PL (1) | PL1981549T3 (enExample) |
| WO (1) | WO2007071845A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PH12013501365A1 (en) | 2010-12-30 | 2013-09-16 | Laboratoire Francais Du Fractionnment Et Des Biotechnologies | Glycols as pathogen inactivating agents |
| USD689039S1 (en) * | 2012-07-12 | 2013-09-03 | Alljack Co., Ltd. | Stereo set |
| CN109444209A (zh) * | 2018-10-26 | 2019-03-08 | 北京食品科学研究院 | 一种测量蛋清粉玻璃化转变温度的方法 |
| CN116059410A (zh) * | 2021-08-19 | 2023-05-05 | 南京金斯瑞生物科技有限公司 | 一种去除生物样本中噬菌体的方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2248817C2 (de) * | 1972-10-05 | 1981-09-24 | Bayer Ag, 5090 Leverkusen | Polycarbonatmischungen |
| US4456590B2 (en) * | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
| GB9424732D0 (en) * | 1994-12-08 | 1995-02-08 | Common Services Agency | Heat treated blood plasma proteins |
| US5837519A (en) * | 1996-11-21 | 1998-11-17 | Bayer Corporation | Dry-heat viral inactivation under controlled moisture conditions |
| ATE429491T1 (de) * | 1997-09-23 | 2009-05-15 | Ib2 L L C | Verfahren und vorrichtung für schnelle thermozyklen |
| CN1286725A (zh) * | 1997-11-26 | 2001-03-07 | 环球保藏技术股份有限公司 | 敏感性生物样品的玻化保质法 |
| DK1121015T4 (da) * | 1998-10-14 | 2012-05-21 | Katrina T Forest | Fremgangsmåde til forglasning af et biologisk materiale |
| WO2001049112A2 (en) * | 2000-01-04 | 2001-07-12 | University Of Connecticut | Oocyte vitrification technique |
| JP2007501224A (ja) * | 2003-08-05 | 2007-01-25 | フジ フォト フィルム ビー．ブイ． | 安定剤としての組換え又は合成ゼラチン様タンパク質の、凍結乾燥医薬組成物中の使用 |
-
2005
- 2005-12-19 FR FR0512875A patent/FR2894830B1/fr not_active Expired - Lifetime
-
2006
- 2006-12-19 WO PCT/FR2006/002817 patent/WO2007071845A2/fr not_active Ceased
- 2006-12-19 CN CN2006800479202A patent/CN101355972B/zh active Active
- 2006-12-19 DK DK06847095T patent/DK1981549T3/da active
- 2006-12-19 CA CA2633338A patent/CA2633338C/en active Active
- 2006-12-19 BR BRPI0621074A patent/BRPI0621074B1/pt not_active IP Right Cessation
- 2006-12-19 ES ES06847095T patent/ES2327279T3/es active Active
- 2006-12-19 US US12/097,860 patent/US8252227B2/en active Active
- 2006-12-19 AT AT06847095T patent/ATE431162T1/de active
- 2006-12-19 JP JP2008545048A patent/JP5085558B2/ja not_active Expired - Fee Related
- 2006-12-19 AU AU2006328804A patent/AU2006328804B2/en not_active Ceased
- 2006-12-19 DE DE602006006875T patent/DE602006006875D1/de active Active
- 2006-12-19 PL PL06847095T patent/PL1981549T3/pl unknown
- 2006-12-19 KR KR1020087016839A patent/KR101162060B1/ko not_active Expired - Fee Related
- 2006-12-19 EP EP06847095A patent/EP1981549B1/fr active Active
-
2008
- 2008-06-15 IL IL192194A patent/IL192194A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL192194A0 (en) | 2009-02-11 |
| WO2007071845A3 (fr) | 2007-08-16 |
| KR101162060B1 (ko) | 2012-07-03 |
| CN101355972A (zh) | 2009-01-28 |
| PL1981549T3 (pl) | 2009-10-30 |
| KR20080093098A (ko) | 2008-10-20 |
| WO2007071845A2 (fr) | 2007-06-28 |
| IL192194A (en) | 2010-12-30 |
| US8252227B2 (en) | 2012-08-28 |
| CA2633338A1 (en) | 2007-06-28 |
| FR2894830A1 (fr) | 2007-06-22 |
| EP1981549A2 (fr) | 2008-10-22 |
| ATE431162T1 (de) | 2009-05-15 |
| FR2894830B1 (fr) | 2008-04-04 |
| AU2006328804B2 (en) | 2012-08-02 |
| US20090297398A1 (en) | 2009-12-03 |
| CA2633338C (en) | 2012-02-28 |
| BRPI0621074B1 (pt) | 2016-07-26 |
| JP2009519920A (ja) | 2009-05-21 |
| CN101355972B (zh) | 2012-07-04 |
| DE602006006875D1 (de) | 2009-06-25 |
| EP1981549B1 (fr) | 2009-05-13 |
| BRPI0621074A2 (pt) | 2011-11-29 |
| DK1981549T3 (da) | 2009-08-17 |
| JP5085558B2 (ja) | 2012-11-28 |
| AU2006328804A1 (en) | 2007-06-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI98491C (fi) | Menetelmä virusinaktivoidun verituotteen valmistamiseksi | |
| JPH0739348B2 (ja) | 血液生産物中の増殖性を有する▲ろ▼過性病原体の不活性化法および血液生産物の製造方法 | |
| JPH025957A (ja) | 血液、血液誘導体、血漿乃至は血漿誘導体の殺菌方法 | |
| ES2226587B1 (es) | Composicion de trombina estable. | |
| ES2382934T3 (es) | Procedimiento de estabilización de un crioprecipitado de proteinas plasmáticas destinado a someterse a un tratamiento térmico de inactivación viral | |
| ES2327279T3 (es) | Procedimiento de inactivacion viral mediante calentamiento en seco. | |
| KR100383467B1 (ko) | 아크리딘또는아크리딘유도체보조하의바이러스의불활성화방법 | |
| JP2506370B2 (ja) | 増殖性濾過性病原体の不活化法 | |
| JP2879427B2 (ja) | ウイルスおよびバクテリア汚染物の熱的不活性化中の生物学的および製薬的生成物の安定化 | |
| JPS6054287B2 (ja) | 血漿蛋白の加熱処理方法 | |
| KR950010321B1 (ko) | 인간 트롬빈 제제의 가열처리방법 | |
| ES2590150T3 (es) | Inactivación viral por caprilato | |
| EP1286706A2 (en) | Gamma irradiation of protein-based pharmaceutical products | |
| EP1415669A1 (en) | Process for sterilization of protein containing biological compositions | |
| JP3024073B2 (ja) | タンパク質中のウイルスを不活性化する方法 | |
| SK7582000A3 (en) | Use of tranexamic acid for the preparation of a human fibrinogen composition | |
| AU1756301A (en) | Method of inactivating pathogens | |
| JPS6210019A (ja) | 人血液凝固第９因子含有製剤の加熱処理方法 | |
| SOUZANGARZADEH et al. | Inactivation of poliovirus type-1 and HSV-1 in human coagulation factor VII concentrate by pasteurization | |
| EP1400248A1 (en) | Process for sterilization of protein containing biological compositions | |
| JP2002537024A (ja) | 迅速なクリオバリック滅菌及びワクチン調製 | |
| FI82381B (fi) | Kontrollindikator foer gassterilisering. | |
| CZ20001909A3 (cs) | Použití tranexamové kyseliny pro výrobu prostředku lidského fibrinogenu a lidský fíbrinogenový prostředek | |
| MXPA00004085A (en) | Use of tranexamic acid for the preparation of a human fibrinogen composition | |
| JPH0348172B2 (enExample) |