ES2321114T3 - Camptotecinas conjugadas en posicion 7 con peptidos ciclicos como agentes citostacios. - Google Patents

Camptotecinas conjugadas en posicion 7 con peptidos ciclicos como agentes citostacios. Download PDF

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Publication number
ES2321114T3
ES2321114T3 ES05742726T ES05742726T ES2321114T3 ES 2321114 T3 ES2321114 T3 ES 2321114T3 ES 05742726 T ES05742726 T ES 05742726T ES 05742726 T ES05742726 T ES 05742726T ES 2321114 T3 ES2321114 T3 ES 2321114T3
Authority
ES
Spain
Prior art keywords
group
branched
linear
alkyl
alkylene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05742726T
Other languages
English (en)
Spanish (es)
Inventor
Alma Dal Pozzo
Sergio Penco
Lucio Merlini
Giuseppe Giannini
Maria Ornella Tinti
Claudio Pisano
Franco Zunino
Domenico Alloatti
Loredana Vesci
Sabrina Dallavalle
Ming Hong Ni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale", Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale"
Application granted granted Critical
Publication of ES2321114T3 publication Critical patent/ES2321114T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/52—Cyclic peptides containing at least one abnormal peptide link with only normal peptide links in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ES05742726T 2004-05-13 2005-05-04 Camptotecinas conjugadas en posicion 7 con peptidos ciclicos como agentes citostacios. Expired - Lifetime ES2321114T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITRM04A0024 2004-05-13
IT000240A ITRM20040240A1 (it) 2004-05-13 2004-05-13 Camptotecine coniugate in posizione 7 con antagonisti delle integrine.

Publications (1)

Publication Number Publication Date
ES2321114T3 true ES2321114T3 (es) 2009-06-02

Family

ID=34968014

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05742726T Expired - Lifetime ES2321114T3 (es) 2004-05-13 2005-05-04 Camptotecinas conjugadas en posicion 7 con peptidos ciclicos como agentes citostacios.

Country Status (23)

Country Link
US (1) US7705012B2 (enExample)
EP (1) EP1753776B1 (enExample)
JP (1) JP4805917B2 (enExample)
KR (1) KR101145815B1 (enExample)
CN (1) CN1953989B (enExample)
AR (1) AR048949A1 (enExample)
AT (1) ATE420891T1 (enExample)
AU (1) AU2005243417B2 (enExample)
BR (1) BRPI0510983A (enExample)
CA (1) CA2563708A1 (enExample)
CY (1) CY1108985T1 (enExample)
DE (1) DE602005012390D1 (enExample)
DK (1) DK1753776T3 (enExample)
ES (1) ES2321114T3 (enExample)
HR (1) HRP20090146T3 (enExample)
IT (1) ITRM20040240A1 (enExample)
MX (1) MXPA06012884A (enExample)
PL (1) PL1753776T3 (enExample)
PT (1) PT1753776E (enExample)
RS (1) RS51169B (enExample)
SI (1) SI1753776T1 (enExample)
TW (1) TWI352703B (enExample)
WO (1) WO2005111063A1 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITRM20040239A1 (it) * 2004-05-13 2004-08-13 Sigma Tau Ind Farmaceuti Derivati ciclopeptidici ad attivita' antintegrine.
US8853233B2 (en) * 2007-02-13 2014-10-07 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Broad-spectrum anti-cancer treatment based on iminocamptothecin derivatives
TW201004647A (en) * 2008-05-20 2010-02-01 Sigma Tau Ind Farmaceuti Novel dual targeting antitumoural conjugates
US8853151B2 (en) * 2009-06-30 2014-10-07 The Regents Of The University Of Michigan Pro-drug complexes and related methods of use
US9073974B2 (en) 2009-12-21 2015-07-07 The Regents Of The University Of California RGD-containing cyclic peptides
WO2011100688A1 (en) 2010-02-12 2011-08-18 Dana-Farber Cancer Institute, Inc. Improved antagonists of muc1
US20130101664A1 (en) 2011-08-18 2013-04-25 Donald W. Kufe Muc1 ligand traps for use in treating cancers
CN102516258B (zh) * 2011-11-11 2014-06-25 正大天晴药业集团股份有限公司 水溶性维生素e衍生物修饰的脂溶性抗癌药物化合物和制剂、该化合物的制备方法及应用
US9044421B2 (en) 2012-03-28 2015-06-02 Genus Oncology, Llc Treating MUC1-expressing cancers with combination therapies
ES2786725T3 (es) 2015-06-18 2020-10-13 Univ Ramot Fármacos heteroaromáticos que pueden marcarse y sus conjugados
US10494403B2 (en) * 2018-03-06 2019-12-03 Ciphore Biomed Technology Limited Company Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
CN115590975A (zh) * 2022-11-15 2023-01-13 无锡福祈制药有限公司（Cn） 丝裂霉素-rgd肽偶联物及其制备方法
CN120078902A (zh) * 2023-12-01 2025-06-03 深圳碳云智肽药物科技有限公司 一种多肽偶联喜树碱衍生物及其抗肿瘤应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0540099T3 (da) * 1991-10-29 1996-06-17 Glaxo Wellcome Inc Vandopløselige camptothecinderivater
US5646159A (en) * 1994-07-20 1997-07-08 Research Triangle Institute Water-soluble esters of camptothecin compounds
CA2192725C (en) 1995-12-28 2004-04-20 Kenji Tsujihara Camptothecin derivatives
DE69834923T2 (de) * 1997-02-14 2006-10-19 Bionumerik Pharmaceuticals, Inc., San Antonio Hochgradig lipophile camptothecin-derivate
DE19815812A1 (de) 1998-04-08 1999-10-14 Bayer Ag Modifizierte Cytostatika
DK1044977T3 (da) * 1999-03-09 2002-07-08 Sigma Tau Ind Farmaceuti Camptothecinderivater med antitumoraktivitet
ES2330079T3 (es) * 1999-09-08 2009-12-04 Bayer Schering Pharma Aktiengesellschaft Direccionamiento de farmaco mediado par la integrina.
EP1373501A2 (en) * 2000-10-06 2004-01-02 Novartis AG Targeting molecules for adenoviral vectors
WO2002096367A2 (en) * 2001-05-30 2002-12-05 Targesome, Inc. Targeted multivalent macromolecules

Also Published As

Publication number Publication date
JP2008504235A (ja) 2008-02-14
MXPA06012884A (es) 2007-02-15
PT1753776E (pt) 2009-03-05
KR20070012530A (ko) 2007-01-25
JP4805917B2 (ja) 2011-11-02
DE602005012390D1 (de) 2009-03-05
PL1753776T3 (pl) 2009-06-30
ATE420891T1 (de) 2009-01-15
CN1953989B (zh) 2012-10-10
EP1753776B1 (en) 2009-01-14
CA2563708A1 (en) 2005-11-24
KR101145815B1 (ko) 2012-05-16
ITRM20040240A1 (it) 2004-08-13
DK1753776T3 (da) 2009-05-11
AU2005243417B2 (en) 2011-07-07
SI1753776T1 (sl) 2009-06-30
US7705012B2 (en) 2010-04-27
EP1753776A1 (en) 2007-02-21
US20080033003A1 (en) 2008-02-07
CY1108985T1 (el) 2014-07-02
TW200606165A (en) 2006-02-16
AR048949A1 (es) 2006-06-14
HRP20090146T3 (hr) 2009-05-31
RS51169B (sr) 2010-10-31
BRPI0510983A (pt) 2007-12-04
WO2005111063A1 (en) 2005-11-24
TWI352703B (en) 2011-11-21
CN1953989A (zh) 2007-04-25
AU2005243417A1 (en) 2005-11-24
AU2005243417A2 (en) 2005-11-24

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