ES2320699T3 - Derivados de azabiciclo(3.1.0)hexilfelino como moduladores de receptores d3 de dopamina. - Google Patents
Derivados de azabiciclo(3.1.0)hexilfelino como moduladores de receptores d3 de dopamina. Download PDFInfo
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- ES2320699T3 ES2320699T3 ES06791595T ES06791595T ES2320699T3 ES 2320699 T3 ES2320699 T3 ES 2320699T3 ES 06791595 T ES06791595 T ES 06791595T ES 06791595 T ES06791595 T ES 06791595T ES 2320699 T3 ES2320699 T3 ES 2320699T3
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- phenyl
- azabicyclo
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- 101150097070 Drd3 gene Proteins 0.000 title description 3
- 150000001875 compounds Chemical class 0.000 claims abstract description 222
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 59
- 150000003839 salts Chemical class 0.000 claims abstract description 49
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 44
- 238000000034 method Methods 0.000 claims abstract description 42
- -1 haloC1-6alkyl Chemical group 0.000 claims abstract description 33
- 239000001257 hydrogen Substances 0.000 claims abstract description 31
- 150000002431 hydrogen Chemical group 0.000 claims abstract description 18
- 208000011117 substance-related disease Diseases 0.000 claims abstract description 15
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 13
- 150000002367 halogens Chemical group 0.000 claims abstract description 13
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 10
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- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 4
- 238000002560 therapeutic procedure Methods 0.000 claims abstract description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 63
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 47
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- 125000001188 haloalkyl group Chemical group 0.000 claims description 7
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- 125000004438 haloalkoxy group Chemical group 0.000 claims description 4
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- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 3
- HNEGJTWNOOWEMH-UHFFFAOYSA-N 1-fluoropropane Chemical group [CH2]CCF HNEGJTWNOOWEMH-UHFFFAOYSA-N 0.000 claims description 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 3
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Classifications
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- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
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- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P25/20—Hypnotics; Sedatives
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P25/22—Anxiolytics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
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- Life Sciences & Earth Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Otolaryngology (AREA)
- Gynecology & Obstetrics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0517175 | 2005-08-22 | ||
| GBGB0517175.6A GB0517175D0 (en) | 2005-08-22 | 2005-08-22 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2320699T3 true ES2320699T3 (es) | 2009-05-27 |
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| ES06791595T Active ES2320699T3 (es) | 2005-08-22 | 2006-08-18 | Derivados de azabiciclo(3.1.0)hexilfelino como moduladores de receptores d3 de dopamina. |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7776904B2 (OSRAM) |
| EP (1) | EP1917242B1 (OSRAM) |
| JP (1) | JP5084731B2 (OSRAM) |
| AT (1) | ATE420859T1 (OSRAM) |
| DE (1) | DE602006004882D1 (OSRAM) |
| ES (1) | ES2320699T3 (OSRAM) |
| GB (1) | GB0517175D0 (OSRAM) |
| WO (1) | WO2007022935A1 (OSRAM) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101143718B1 (ko) * | 2004-02-23 | 2012-07-05 | 글락소 그룹 리미티드 | 도파민 ｄ3 수용체의 조절제로서 유용한 아자비시클로(3.1.0) 헥산 유도체 |
| GB0507602D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0512099D0 (en) * | 2005-06-14 | 2005-07-20 | Glaxo Group Ltd | Compounds |
| JP5068747B2 (ja) * | 2005-06-14 | 2012-11-07 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体 |
| WO2007016155A2 (en) | 2005-07-27 | 2007-02-08 | Dov Pharmaceutical, Inc. | Novel 1-aryl-3-azabicyclo[3.1.0]hexanes: preparation and use to treat neuropsychiatric disorders |
| ATE487715T1 (de) * | 2005-08-22 | 2010-11-15 | Glaxo Group Ltd | Triazolderivate als modulatoren von dopamin-d3- rezeptoren |
| GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
| GB0517191D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517187D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| WO2007113260A1 (en) * | 2006-04-03 | 2007-10-11 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexyl derivatives as modulators of dopamine d3 receptors |
| EP2010518B1 (en) * | 2006-04-03 | 2011-02-16 | Glaxo Group Limited | Azabicyclo [3. 1. o] hexane derivatives as modulators of dopamine d3 receptors |
| EP2445887B1 (en) | 2009-06-26 | 2014-11-05 | Panacea Biotec Limited | Novel azabicyclohexanes |
| US20140206740A1 (en) | 2011-07-30 | 2014-07-24 | Neurovance, Inc. | Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters |
| EA202190285A1 (ru) | 2016-07-20 | 2021-08-31 | Новартис Аг | Производные аминопиридина и их применение в качестве селективных ингибиторов alk–2 |
| CN108997177A (zh) * | 2018-09-04 | 2018-12-14 | 邵阳学院 | 一种微波促进n-苯磺酰基硝基苯胺类化合物合成的方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL65843A (en) * | 1977-08-11 | 1986-12-31 | American Cyanamid Co | Pharmaceutical compositions for the treatment of depression containing 3-aza-bicyclo(3.1.0)hexane derivatives and certain novel compounds of this type |
| US4435419A (en) * | 1981-07-01 | 1984-03-06 | American Cyanamid Company | Method of treating depression using azabicyclohexanes |
| US6204284B1 (en) * | 1991-12-20 | 2001-03-20 | American Cyanamid Company | Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies |
| KR101143718B1 (ko) * | 2004-02-23 | 2012-07-05 | 글락소 그룹 리미티드 | 도파민 ｄ3 수용체의 조절제로서 유용한 아자비시클로(3.1.0) 헥산 유도체 |
| GB0507601D0 (en) * | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507602D0 (en) | 2005-04-14 | 2005-05-18 | Glaxo Group Ltd | Compounds |
| GB0507680D0 (en) * | 2005-04-15 | 2005-05-25 | Glaxo Group Ltd | Compounds |
| JP5068747B2 (ja) * | 2005-06-14 | 2012-11-07 | グラクソ グループ リミテッド | ドーパミンｄ３受容体のモジュレーターとしてのアザビシクロ［３．１．０］ヘキサン誘導体 |
| EP1904059A2 (en) * | 2005-07-21 | 2008-04-02 | Wyeth a Corporation of the State of Delaware | Method for treating nervous system disorders and conditions |
| GB0517191D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517187D0 (en) | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Compounds |
| GB0517193D0 (en) * | 2005-08-22 | 2005-09-28 | Glaxo Group Ltd | Novel use |
| ATE487715T1 (de) * | 2005-08-22 | 2010-11-15 | Glaxo Group Ltd | Triazolderivate als modulatoren von dopamin-d3- rezeptoren |
| US7727988B2 (en) * | 2006-04-03 | 2010-06-01 | Glaxo Group Limited | Azabicyclo[3.1.0]hex-3-yl}alkyl)pyrimidinedione |
| GB0616574D0 (en) | 2006-08-21 | 2006-09-27 | Glaxo Group Ltd | Compounds |
| DE102006035468A1 (de) * | 2006-11-29 | 2008-06-05 | Dilo Trading Ag | Modifizierte Elektroden für elektrische Energiespeicher |
-
2005
- 2005-08-22 GB GBGB0517175.6A patent/GB0517175D0/en not_active Ceased
-
2006
- 2006-08-18 US US12/064,121 patent/US7776904B2/en not_active Expired - Fee Related
- 2006-08-18 JP JP2008527372A patent/JP5084731B2/ja not_active Expired - Fee Related
- 2006-08-18 AT AT06791595T patent/ATE420859T1/de not_active IP Right Cessation
- 2006-08-18 WO PCT/EP2006/008202 patent/WO2007022935A1/en not_active Ceased
- 2006-08-18 DE DE602006004882T patent/DE602006004882D1/de active Active
- 2006-08-18 ES ES06791595T patent/ES2320699T3/es active Active
- 2006-08-18 EP EP06791595A patent/EP1917242B1/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE420859T1 (de) | 2009-01-15 |
| EP1917242A1 (en) | 2008-05-07 |
| US20090030062A1 (en) | 2009-01-29 |
| JP2009504793A (ja) | 2009-02-05 |
| DE602006004882D1 (de) | 2009-03-05 |
| GB0517175D0 (en) | 2005-09-28 |
| EP1917242B1 (en) | 2009-01-14 |
| WO2007022935A1 (en) | 2007-03-01 |
| JP5084731B2 (ja) | 2012-11-28 |
| US7776904B2 (en) | 2010-08-17 |
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