ES2303275T3 - Compuestos sulfonamido que antagonizan con el receptor vaniloide trpv1. - Google Patents

Compuestos sulfonamido que antagonizan con el receptor vaniloide trpv1. Download PDF

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Publication number
ES2303275T3
ES2303275T3 ES05796943T ES05796943T ES2303275T3 ES 2303275 T3 ES2303275 T3 ES 2303275T3 ES 05796943 T ES05796943 T ES 05796943T ES 05796943 T ES05796943 T ES 05796943T ES 2303275 T3 ES2303275 T3 ES 2303275T3
Authority
ES
Spain
Prior art keywords
compounds
benzyl
methoxy
hydroxy
baselineskip
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES05796943T
Other languages
English (en)
Spanish (es)
Inventor
Pier Giovanni Baraldi
Pier Andrea Borea
Pierangelo Geppetti
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmeste SRL
Original Assignee
Pharmeste SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmeste SRL filed Critical Pharmeste SRL
Application granted granted Critical
Publication of ES2303275T3 publication Critical patent/ES2303275T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
ES05796943T 2004-10-26 2005-10-18 Compuestos sulfonamido que antagonizan con el receptor vaniloide trpv1. Expired - Lifetime ES2303275T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ITMI04A2042 2004-10-26
IT002042A ITMI20042042A1 (it) 2004-10-26 2004-10-26 Derivati solfonammidici antagonisti del recettore dei vanilloidi trpv1

Publications (1)

Publication Number Publication Date
ES2303275T3 true ES2303275T3 (es) 2008-08-01

Family

ID=35501228

Family Applications (1)

Application Number Title Priority Date Filing Date
ES05796943T Expired - Lifetime ES2303275T3 (es) 2004-10-26 2005-10-18 Compuestos sulfonamido que antagonizan con el receptor vaniloide trpv1.

Country Status (8)

Country Link
US (1) US7579378B2 (https=)
EP (1) EP1805138B1 (https=)
JP (1) JP5080260B2 (https=)
AT (1) ATE389634T1 (https=)
DE (1) DE602005005512T2 (https=)
ES (1) ES2303275T3 (https=)
IT (1) ITMI20042042A1 (https=)
WO (1) WO2006045498A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101304981B1 (ko) * 2005-03-19 2013-09-06 (주)아모레퍼시픽 바닐로이드 수용체 길항물질로서의 신규 화합물, 이의이성체 또는 이의 약학적으로 허용가능한 염, 및 이를함유하는 약학 조성물
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
CN106146362B (zh) * 2015-04-15 2018-04-03 南京理工大学 一种合成c‑7280948的方法
CN107759477A (zh) * 2017-11-20 2018-03-06 阿里化学(常州)有限公司 一种对硝基苯乙胺盐酸盐的生产制备方法
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693386B1 (en) 1994-07-21 1997-02-05 Nippon Paper Industries Co., Ltd. Aminobenzenesulfonamide derivatives as colour-developers for thermosensitive recording materials
ATE328868T1 (de) * 2000-08-21 2006-06-15 Pacific Corp Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
AU2001280229B2 (en) * 2000-08-21 2006-12-07 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US6949567B2 (en) * 2001-02-26 2005-09-27 4Sc Ag Compounds for the treatment of protozoal diseases

Also Published As

Publication number Publication date
EP1805138A1 (en) 2007-07-11
ATE389634T1 (de) 2008-04-15
DE602005005512D1 (de) 2008-04-30
DE602005005512T2 (de) 2009-04-16
JP2008517884A (ja) 2008-05-29
JP5080260B2 (ja) 2012-11-21
WO2006045498A1 (en) 2006-05-04
EP1805138B1 (en) 2008-03-19
US7579378B2 (en) 2009-08-25
US20090118374A1 (en) 2009-05-07
ITMI20042042A1 (it) 2005-01-26

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