JP5080260B2 - バニロイドｔｒｐｖ１受容体に拮抗するスルホンアミド化合物 - Google Patents

バニロイドｔｒｐｖ１受容体に拮抗するスルホンアミド化合物 Download PDF

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Publication number
JP5080260B2
JP5080260B2 JP2007537190A JP2007537190A JP5080260B2 JP 5080260 B2 JP5080260 B2 JP 5080260B2 JP 2007537190 A JP2007537190 A JP 2007537190A JP 2007537190 A JP2007537190 A JP 2007537190A JP 5080260 B2 JP5080260 B2 JP 5080260B2
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Japan
Prior art keywords
benzyl
methoxy
hydroxy
compound
iodo
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JP2007537190A
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Japanese (ja)
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JP2008517884A (ja
JP2008517884A5 (https=
Inventor
バラルディ，ピエル・ジョヴァンニ
ボレア，ピエル・アンドレーア
ジェペッティ，ピエランジェロ
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Pharmeste SRL
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Pharmeste SRL
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
    • C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
JP2007537190A 2004-10-26 2005-10-18 バニロイドｔｒｐｖ１受容体に拮抗するスルホンアミド化合物 Expired - Fee Related JP5080260B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IT002042A ITMI20042042A1 (it) 2004-10-26 2004-10-26 Derivati solfonammidici antagonisti del recettore dei vanilloidi trpv1
ITMI2004A002042 2004-10-26
PCT/EP2005/011206 WO2006045498A1 (en) 2004-10-26 2005-10-18 Sulfonamido compounds that antagonise the vanilloid trpv1 receptor

Publications (3)

Publication Number Publication Date
JP2008517884A JP2008517884A (ja) 2008-05-29
JP2008517884A5 JP2008517884A5 (https=) 2008-12-25
JP5080260B2 true JP5080260B2 (ja) 2012-11-21

Family

ID=35501228

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007537190A Expired - Fee Related JP5080260B2 (ja) 2004-10-26 2005-10-18 バニロイドｔｒｐｖ１受容体に拮抗するスルホンアミド化合物

Country Status (8)

Country Link
US (1) US7579378B2 (https=)
EP (1) EP1805138B1 (https=)
JP (1) JP5080260B2 (https=)
AT (1) ATE389634T1 (https=)
DE (1) DE602005005512T2 (https=)
ES (1) ES2303275T3 (https=)
IT (1) ITMI20042042A1 (https=)
WO (1) WO2006045498A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101304981B1 (ko) * 2005-03-19 2013-09-06 (주)아모레퍼시픽 바닐로이드 수용체 길항물질로서의 신규 화합물, 이의이성체 또는 이의 약학적으로 허용가능한 염, 및 이를함유하는 약학 조성물
WO2009081222A1 (en) 2007-12-21 2009-07-02 Glenmark Pharmaceuticals, S.A. Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands
CN106146362B (zh) * 2015-04-15 2018-04-03 南京理工大学 一种合成c‑7280948的方法
CN107759477A (zh) * 2017-11-20 2018-03-06 阿里化学(常州)有限公司 一种对硝基苯乙胺盐酸盐的生产制备方法
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0693386B1 (en) 1994-07-21 1997-02-05 Nippon Paper Industries Co., Ltd. Aminobenzenesulfonamide derivatives as colour-developers for thermosensitive recording materials
ATE328868T1 (de) * 2000-08-21 2006-06-15 Pacific Corp Neue (thio)harnstoffverbindungen und arzneimittelkompositionen, die diese enthalten
AU2001280229B2 (en) * 2000-08-21 2006-12-07 Pacific Corporation Novel thiourea derivatives and the pharmaceutical compositions containing the same
US6949567B2 (en) * 2001-02-26 2005-09-27 4Sc Ag Compounds for the treatment of protozoal diseases

Also Published As

Publication number Publication date
EP1805138A1 (en) 2007-07-11
ATE389634T1 (de) 2008-04-15
DE602005005512D1 (de) 2008-04-30
DE602005005512T2 (de) 2009-04-16
ES2303275T3 (es) 2008-08-01
JP2008517884A (ja) 2008-05-29
WO2006045498A1 (en) 2006-05-04
EP1805138B1 (en) 2008-03-19
US7579378B2 (en) 2009-08-25
US20090118374A1 (en) 2009-05-07
ITMI20042042A1 (it) 2005-01-26

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