DE602005005512D1 - Den vanilliod-trpv1-rezeptor antagonisierende sulfonamidoverbindungen - Google Patents
Den vanilliod-trpv1-rezeptor antagonisierende sulfonamidoverbindungenInfo
- Publication number
- DE602005005512D1 DE602005005512D1 DE602005005512T DE602005005512T DE602005005512D1 DE 602005005512 D1 DE602005005512 D1 DE 602005005512D1 DE 602005005512 T DE602005005512 T DE 602005005512T DE 602005005512 T DE602005005512 T DE 602005005512T DE 602005005512 D1 DE602005005512 D1 DE 602005005512D1
- Authority
- DE
- Germany
- Prior art keywords
- vanilliod
- sulfonamide compounds
- trpv1 receptor
- receptor antagonizing
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 SULFONAMIDE COMPOUNDS Chemical class 0.000 title 1
- 108010025083 TRPV1 receptor Proteins 0.000 title 1
- 230000003042 antagnostic effect Effects 0.000 title 1
- 229940124530 sulfonamide Drugs 0.000 title 1
- 102000011040 TRPV Cation Channels Human genes 0.000 abstract 1
- 108010062740 TRPV Cation Channels Proteins 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C335/18—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
- C07C311/47—Y being a hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/06—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms
- C07C335/10—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C335/12—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C335/04—Derivatives of thiourea
- C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT002042A ITMI20042042A1 (it) | 2004-10-26 | 2004-10-26 | Derivati solfonammidici antagonisti del recettore dei vanilloidi trpv1 |
| ITMI20042042 | 2004-10-26 | ||
| PCT/EP2005/011206 WO2006045498A1 (en) | 2004-10-26 | 2005-10-18 | Sulfonamido compounds that antagonise the vanilloid trpv1 receptor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE602005005512D1 true DE602005005512D1 (de) | 2008-04-30 |
| DE602005005512T2 DE602005005512T2 (de) | 2009-04-16 |
Family
ID=35501228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602005005512T Active DE602005005512T2 (de) | 2004-10-26 | 2005-10-18 | Antagonisten des Vanilloid-Rezeptors, insbesondere Sulfonamidderivate, welche den TRPV1-Rezeptor antagonisieren |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7579378B2 (de) |
| EP (1) | EP1805138B1 (de) |
| JP (1) | JP5080260B2 (de) |
| AT (1) | ATE389634T1 (de) |
| DE (1) | DE602005005512T2 (de) |
| ES (1) | ES2303275T3 (de) |
| IT (1) | ITMI20042042A1 (de) |
| WO (1) | WO2006045498A1 (de) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5159604B2 (ja) * | 2005-03-19 | 2013-03-06 | アモーレパシフィック コーポレイション | バニロイド受容体拮抗薬としての新規な化合物、その異性体又はその薬剤学的に許容される塩、及びこれを含む医薬組成物 |
| WO2009081222A1 (en) | 2007-12-21 | 2009-07-02 | Glenmark Pharmaceuticals, S.A. | Substituted tricyclic pyridine or pyrimidine vanilloid receptor ligands |
| CN106146362B (zh) * | 2015-04-15 | 2018-04-03 | 南京理工大学 | 一种合成c‑7280948的方法 |
| CN107759477A (zh) * | 2017-11-20 | 2018-03-06 | 阿里化学(常州)有限公司 | 一种对硝基苯乙胺盐酸盐的生产制备方法 |
| EP4074317A1 (de) | 2021-04-14 | 2022-10-19 | Bayer AG | Phosphorderivate als neuartige sos1-inhibitoren |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0693386B1 (de) * | 1994-07-21 | 1997-02-05 | Nippon Paper Industries Co., Ltd. | Aminobenzenesulphonamidderivate als Farbentwickler für wärmeempfindliche Aufzeichnungsmaterialien |
| WO2002016318A1 (en) * | 2000-08-21 | 2002-02-28 | Pacific Corporation | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| US20030153596A1 (en) * | 2000-08-21 | 2003-08-14 | Suh Young Ger | Novel thiourea derivatives and the pharmaceutical compositions containing the same |
| US6949567B2 (en) * | 2001-02-26 | 2005-09-27 | 4Sc Ag | Compounds for the treatment of protozoal diseases |
-
2004
- 2004-10-26 IT IT002042A patent/ITMI20042042A1/it unknown
-
2005
- 2005-10-18 EP EP05796943A patent/EP1805138B1/de not_active Not-in-force
- 2005-10-18 JP JP2007537190A patent/JP5080260B2/ja not_active Expired - Fee Related
- 2005-10-18 DE DE602005005512T patent/DE602005005512T2/de active Active
- 2005-10-18 AT AT05796943T patent/ATE389634T1/de not_active IP Right Cessation
- 2005-10-18 WO PCT/EP2005/011206 patent/WO2006045498A1/en active IP Right Grant
- 2005-10-18 ES ES05796943T patent/ES2303275T3/es active Active
- 2005-10-18 US US11/577,857 patent/US7579378B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP5080260B2 (ja) | 2012-11-21 |
| ES2303275T3 (es) | 2008-08-01 |
| WO2006045498A1 (en) | 2006-05-04 |
| US7579378B2 (en) | 2009-08-25 |
| EP1805138B1 (de) | 2008-03-19 |
| ITMI20042042A1 (it) | 2005-01-26 |
| DE602005005512T2 (de) | 2009-04-16 |
| ATE389634T1 (de) | 2008-04-15 |
| EP1805138A1 (de) | 2007-07-11 |
| JP2008517884A (ja) | 2008-05-29 |
| US20090118374A1 (en) | 2009-05-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |