ES2297147T3 - Valvula artificial. - Google Patents
Valvula artificial. Download PDFInfo
- Publication number
- ES2297147T3 ES2297147T3 ES03716963T ES03716963T ES2297147T3 ES 2297147 T3 ES2297147 T3 ES 2297147T3 ES 03716963 T ES03716963 T ES 03716963T ES 03716963 T ES03716963 T ES 03716963T ES 2297147 T3 ES2297147 T3 ES 2297147T3
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- cusp
- lamella
- cusps
- body lumen
- wall
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2475—Venous valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/24—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body
- A61F2/2412—Heart valves ; Vascular valves, e.g. venous valves; Heart implants, e.g. passive devices for improving the function of the native valve or the heart muscle; Transmyocardial revascularisation [TMR] devices; Valves implantable in the body with soft flexible valve members, e.g. tissue valves shaped like natural valves
Abstract
Una cúspide de válvula implantable (30) para formar una válvula dentro de un lumen corporal (44), la cual comprende: una laminilla triangular (42) formada por un material delgado y flexible y que tiene una cara interna y una cara externa; siendo la laminilla invertiblemente deformable entre una primera posición, en la cual la cara interna de la laminilla es cóncava, y una segunda posición en la cual la cara interna de la laminilla es convexa; y un elemento de anclaje (38); y caracterizada porque el elemento de anclaje (38) está situado en un ápice de la laminilla triangular y es operable para sujetar la laminilla a la pared del lumen corporal (44) sólo por el ápice.
Description
Válvula artificial.
Esta invención se refiere a dispositivos médicos
para usar en un lumen corporal.
Una válvula venosa sirve para impedir el flujo
retrógrado de sangre y permitir únicamente el flujo anterógrado de
sangre hacia el corazón. Refiriéndose a la Fig. 1A, se ilustra una
válvula venosa 12 sana en un vaso 10. La válvula es bicúspide, con
unas cúspides 14 opuestas. En condición cerrada, las cúspides 14 se
juntan para impedir el flujo retrógrado (flecha 16) de la sangre.
Refiriéndose a la Fig. 1B, si la válvula es deficiente, las
cúspides 14 no sellan adecuadamente y se produce un flujo retrógrado
de sangre. Se considera que la deficiencia de una válvula venosa
está producida por al menos las dos condiciones médicas siguientes:
venas varicosas e insuficiencia venosa crónica.
El documento
WO-A-0156500 describe un dispositivo
de válvula implantable que comprende un bastidor de alambre que
soporta dos hojas de válvula convergentes y flexibles bajo tensión.
Las hojas de válvula son obligadas a separarse por el flujo de
sangre en una dirección, y obligadas a juntarse por el flujo de
sangre en una segunda dirección.
Esta invención se refiere a dispositivos médicos
para usar en un lumen corporal. En un aspecto, la invención
proporciona una cúspide de válvula según se define en la
reivindicación 1, incluyendo una membrana implantable en un lumen
corporal e invertiblemente deformable entre una primera posición y
una segunda posición. La membrana es invertible en respuesta a la
dirección del flujo de fluido a través del lumen y puede ser
deformable por el flujo de fluido por el lumen corporal. La
membrana puede ser invertible con respecto a una dirección radial
del lumen corporal. La membrana puede ser reversiblemente deformable
entre la primera posición y la segunda posición.
Las puestas en práctica pueden incluir una o más
de las siguientes. La membrana puede definir una porción de un
cono, e incluir un elemento de anclaje adyacente al vértice del
cono. La membrana puede incluir un elemento de anclaje configurado
para encajar dentro del lumen corporal, o que alternativamente esté
configurado para penetrar a través del lumen corporal. El elemento
de anclaje puede ser, por ejemplo, un bucle o una barba. La
membrana puede estar formada por un polímero, por ejemplo
poliuretano, polietileno o fluoroplástico.
En otro aspecto, la invención proporciona un
sistema médico según se define en la reivindicación 8. El sistema
incluye múltiples membranas, siendo cada membrana implantable en un
lumen corporal e invertiblemente deformable entre una primera
posición y una segunda posición. Cada membrana es invertible en
respuesta a la dirección del flujo de fluido a través del lumen.
Las puestas en práctica del sistema pueden incluir una o varias de
las siguientes. Las membranas pueden ser simétricamente implantables
en el lumen corporal. Cada membrana puede ser invertible con
respecto a una dirección radial del lumen corporal y puede ser
deformable por el flujo de fluido en el lumen corporal. Al menos
una membrana puede ser reversiblemente deformable entre la primera
posición y la segunda posición. Al menos una membrana puede definir
una porción de un cono e incluir un elemento de anclaje adyacente
al vértice del cono. Al menos una membrana puede incluir un elemento
de anclaje configurado para encajar dentro del lumen corporal, o
que alternativamente esté configurado para penetrar a través del
lumen corporal. El elemento de anclaje puede ser, por ejemplo, un
bucle o una barba. Al menos una membrana puede estar formada por un
polímero, por ejemplo poliuretano, polietileno o fluoroplástico.
Las realizaciones pueden tener una o más de las
siguientes ventajas. Una o más membranas invertibles, que pueden
actuar como cúspides de una válvula artificial, pueden ser
implantadas en un sitio a tratar utilizando un catéter. Como tal,
la implantación es mínimamente invasiva y reduce la posibilidad de
las complicaciones inherentes. La membrana se fabrica con un
polímero tal que poliuretano, polietileno o fluoroplástico, cuyos
materiales son más fácilmente accesibles que un tejido natural
extirpado de un animal, y pueden ser fabricados con una
consistencia y una eficacia que serían más difíciles o más costosas
de conseguir utilizando un tejido natural.
Se apreciarán otras características, objetivos y
ventajas de la invención en la descripción y los dibujos, y en las
reivindicaciones.
Las Figs. 1A y 1B son ilustraciones de una
válvula venosa y una válvula venosa deficiente, respectivamente.
Las Figs. 2A, 2B y 2C son vistas parciales en
perspectiva de una realización de una cúspide de válvula.
La Fig. 3 es una vista de la cúspide de válvula
de la Fig. 2A en sección transversal tomada por la línea
3-3.
La Fig. 4 es una vista de la cúspide de válvula
de la Fig. 2C en sección transversal tomada por la línea
4-4.
Las Figs. 5A, 5B, 5C, 5D y 5E son vistas
esquemáticas de una realización de un procedimiento para implantar
una cúspide de válvula.
Las Figs. 6A y 6B son vistas parciales en
perspectiva de una realización de una cúspide de válvula.
Las Figs. 7A y 7B son vistas parciales en
perspectiva de una realización de una cúspide de válvula.
La Fig. 8 es una vista de la cúspide de válvula
de la Fig. 7A en sección transversal tomada por la línea
8-8.
La Fig. 9 es una vista de la cúspide de válvula
de la Fig. 7B en sección transversal tomada por la línea
9-9.
La Fig. 10 es una vista parcial en perspectiva
de una realización de elemento de anclaje.
La Fig. 11 es una vista parcial en perspectiva
de una realización de elemento de anclaje.
Refiriéndose desde las Figs.
2A-2C hasta la Fig. 4, se ilustra un par de cúspides
30 de válvula situadas dentro de un vaso 46, por ejemplo, una vena.
Las cúspides 30 pueden colocarse aguas arriba o aguas abajo con
respecto a una válvula venosa deficiente, tal como la válvula
representada en la Fig. 1B. Cada cúspide 30 de una válvula
artificial incluye al menos un elemento de anclaje 38 unido a una
porción invertible 42. En este caso, la porción invertible 42 es
una membrana flexible, aproximadamente triangular, con un elemento
de anclaje 38 unido a un ápice 36 de la membrana. El elemento de
anclaje 38 está configurado generalmente para mantener la porción
invertible 42 en una posición deseada en el vaso 46. Por ejemplo, el
elemento de anclaje 38 puede encajarse dentro de una pared 44 del
vaso 46, o penetrar a través de la pared para sujetar la cúspide 30
al vaso. La porción invertible 42 puede deformarse entre una
primera posición y una segunda posición, por ejemplo entre una
condición abierta y una condición cerrada, en respuesta al flujo de
un fluido corporal por el vaso 46, para permitir o reducir el flujo
por el vaso.
Refiriéndose particularmente a la Fig. 2A y la
Fig. 3, las cúspides 30 están representadas en una posición en la
cual cada cúspide 30 forma un semicono aproximado, por lo que las
superficies curvadas de las cúspides 30 forman una abertura 50. La
abertura 50 permite el flujo anterógrado de un fluido a través del
vaso en la dirección indicada por la flecha 48. Las membranas de
las porciones invertibles 42 son relativamente delgadas y pueden
adaptarse estrechamente a la pared 44 del vaso para maximizar el
tamaño de la abertura 50. Sin embargo, cada cúspide 30 también es
mantenida ligeramente separada de la pared 44 del vaso por el
elemento de anclaje 38, de tal modo que entre la porción invertible
42 y la pared 44 se forma un huelgo 52.
Refiriéndose particularmente a la Fig. 2B, el
flujo retrógrado de fluido (flechas 51) por el vaso puede acumularse
en el huelgo 52 y ejercer presión sobre la porción invertible 42 de
la cúspide 30. Puesto que la porción invertible 42 es flexible,
puede deformarse bajo la presión ejercida e invertirse para formar
otro semicono aproximado, según se muestra en la Fig. 2C. Esto es,
cada cúspide 30 que forma un semicono en la primera posición puede
invertirse o bascular con respecto a un eje radial del vaso 46 para
formar un segundo semicono que es aproximadamente la imagen
simétrica del primer semicono. A medida que el interior 32 del
segundo semicono acumula fluido con flujo retrógrado, se ejerce
presión en el interior de la cúspide 30, haciendo que la cúspide se
separe de la pared 44 del vaso. Como consecuencia, el espacio 53
entre las dos cúspides 30 se estrecha, el tamaño de la abertura 50
disminuye, y el flujo de fluido que atraviesa el vaso y pasa por las
cúspides se reduce
(Fig. 4).
(Fig. 4).
Las cúspides 30 pueden permanecer en la segunda
posición hasta que el flujo anterógrado de fluido ejerza una
presión suficiente sobre la superficie de las cúspides 30 opuesta al
interior 32 e invierta las cúspides hasta la primera posición. De
este modo las cúspides 30 proporcionan una válvula artificial que
responde automáticamente al flujo de fluido o a los cambios de
presión en el vaso 46.
Las Figs. 5A a 5E muestran un procedimiento de
colocación de las cúspides 30 en un sitio a tratar en el vaso 46
utilizando un catéter 18 que puede introducirse en el vaso 46
percutáneamente. El catéter 18 está adaptado generalmente para ser
introducido a través del vaso 46, por ejemplo utilizando un cable
guía. El catéter 18 incluye un cuerpo largo y flexible que tiene
una porción central 21, y una funda retraíble 22 por encima de la
porción central. Refiriéndose particularmente a la Fig. 5B, una
vista en sección tomada por la línea 5-5 de la Fig.
5A, existen dos ranuras 25 formadas a cada lado de la porción
central 21, y dentro de cada una de las ranuras 25 está colocada
una varilla de empuje 28. Cada cúspide 30 es situada en una ranura
25 en estado compactado y mantenida en su lugar mediante la funda
retraíble 22 hasta su colocación en el sitio a tratar.
El catéter 18 puede ser conducido hasta el sitio
a tratar utilizando técnicas de colocación de endoprótesis, por
ejemplo mediante traceado de un cable guía emplazado con el lumen
central 101. En el sitio a tratar, la funda retraíble 22 es
retraída proximalmente para formar una abertura 26 en cada extremo
de cada ranura 25. Refiriéndose particularmente a la Fig. 5C, las
varillas de empuje 28 se utilizan para empujar distalmente cada
cúspide 30 hacia la abertura 26 para sacar el elemento de anclaje 38
de la abertura 26. Se empujan las cúspides 30 por las aberturas 26
hasta que los elementos de anclaje 38 sujeten las cúspides 30 a la
pared 44 del vaso 46. Por ejemplo, los elementos de anclaje 38
pueden encajarse dentro de la pared 44 o perforar la pared 44 y
sujetarse al exterior del vaso 46.
Después de haber sujetado cada cúspide 30 al
vaso 46, se retrae la funda retraíble 22 para descubrir por completo
las cúspides 30 (Fig. 5D). A continuación se arrastra proximalmente
la porción central 21, hasta sobrepasar las cúspides 30 flexibles
(y deflectables), y se extrae del vaso 46 (Fig. 5E). Las cúspides
30, sujetas ahora a la pared 44, pueden deformarse entre la primera
y la segunda posición, según se describió anteriormente.
Las cúspides 30 se hacen preferiblemente de un
material biocompatible capaz de una deformación reversible según se
describió anteriormente. Cada cúspide 30 puede estar formada por un
material delgado y flexible, tal como poliuretano, polietileno o
fluoroplástico, por ejemplo, politetrafluoroetileno (PTFE). La
porción invertible 42 puede estar formada por uno o más materiales.
Por ejemplo, la porción invertible 42 puede incluir una porción de
borde 40 que sea relativamente más flexible o más adaptable que otra
porción de la porción invertible para ayudar a que los bordes se
junten y se sellen cuando las cúspides 30 se encuentren en la
segunda posición. Las cúspides 30 pueden incluir un material radio
opaco tal como un polímero que incluya un radio opacificador, por
ejemplo metal tantalio u oxicloruro de bismuto, para posicionar y
monitorizar las cúspides.
Similarmente, el elemento de anclaje 38 es
preferiblemente biocompatible. El elemento de anclaje 38 puede
estar formado por un material relativamente rígido, tal como un
polímero que tenga una dureza adecuada, por ejemplo,
acrilonitrilo-butadieno-estireno
(ABS). Pueden utilizarse otros materiales, tales como metales (por
ejemplo, tantalio, tungsteno u oro), aleaciones (por ejemplo, acero
inoxidable o Nitinol), y cerámicas. Los elementos de anclaje 38
pueden incluir un material radio opaco para posicionar y monitorizar
las cúspides 30. El elemento de anclaje puede ser embebido en la
porción invertible o fijado a una superficie de la porción
invertible con, por ejemplo, un adhesivo.
En otras realizaciones, pueden anclarse a la
pared 44 del vaso 46 cualquier número de cúspides para que actúen
como válvula para impedir el flujo retrógrado de sangre a través del
vaso sanguíneo 46.
Refiriéndose a las Figs. 6A y 6B, puede usarse
una sola cúspide 60. La cúspide 60 puede ser transportada hasta el
sitio a tratar y anclada a la pared 44 de un vaso 46, de la misma
manera descrita anteriormente, utilizando un catéter. En una
primera posición, la cúspide 60 forma un semicono aproximado, con
los bordes 63 del semicono encarados hacia la pared 44 opuesta al
lugar en donde la cúspide 60 está anclada a la pared 44. El interior
del cono forma un canal 64 que permite al fluido sobrepasar la
cúspide 60. El elemento de anclaje 65, unido a la cúspide 60 por el
ápice 61, mantiene la cúspide 30 ligeramente separada de la pared
44, por lo que se forma un huelgo 66 entre la cúspide 60 y la pared
44. El fluido con flujo retrógrado puede acumularse en el huelgo 66
y ejercer presión sobre la cúspide 60, deformando la cúspide 60 y
ensanchando el huelgo 66 hasta que la presión sobre la cúspide 60
invierta la cúspide. Refiriéndose particularmente a la Fig. 6B, en
una posición invertida, la cúspide 60 forma un cono aproximado con
la pared 44 y acumula fluido con flujo retrógrado en una bolsa 68
formada por el interior del cono. El fluido acumulado puede ejercer
presión sobre la cúspide 60, haciendo que la cúspide 60 se aleje de
la pared 44. Como consecuencia, el espacio 66 entre la cúspide 60 y
la pared 44 opuesta al elemento de anclaje se estrecha, hasta que la
cúspide 60 toque la pared 44, en una segunda posición, según se
muestra. En la segunda posición, el flujo que sobrepasa la cúspide
60 es menor que el flujo que había cuando la cúspide 60 se
encontraba en la primera posición. La cúspide 60 permanece en la
segunda posición hasta que la presión ejercida sobre la cúspide 60
por el flujo anterógrado del fluido sea suficiente para invertir la
cúspide 60 hasta la primera posición.
Refiriéndose a las Figs. 7A-7B,
pueden sujetarse simétricamente tres cúspides
70a-70c a la pared 44 de un vaso 46 de una manera
similar a la descrita anteriormente. Refiriéndose particularmente a
la Fig. 7A, las cúspides 70a-70c están
representadas en una primera posición que no impide substancialmente
el flujo de un fluido a través del vaso 46. Según se muestra en la
Fig. 8, las superficies de las cúspides 70a-70c se
adaptan a la pared 44 del vaso 46, permitiendo una substancial
abertura 72 para el flujo que sobrepasa las cúspides
70a-70c. Cada cúspide 70a-70c se
mantiene separada de la pared 44 por unos elementos de anclaje
71a-71c, de manera que entre cada cúspide y la
pared 44 se forme un huelgo 76. Según se describió anteriormente, el
fluido con flujo retrógrado se acumula en el huelgo 76 y ejerce
presión sobre la cúspide 70, haciendo que la cúspide se deforme,
alejándose de la pared 44, hasta que la cúspide se invierta.
Refiriéndose particularmente a la Fig.7B, en una
posición invertida, el interior de cada cúspide
70a-70c acumula fluido con flujo retrógrado. La
aplicación de presión sobre las cúspides hace que se desplacen las
unas hacia las otras, hasta que las cúspides
70a-70c se juntan en una segunda posición y reducen
el flujo que sobrepasa las cúspides 70a-70c con
respecto al existente cuando las cúspides 70a-70c
están en la primera posición. Refiriéndose a la Fig. 9, la abertura
72 se reduce significativamente, restringiendo con ello el flujo de
fluido. Las cúspides 70a-70c permanecen en la
segunda posición hasta que la presión ejercida sobre las cúspides
70a-70c por el flujo anterógrado del fluido
invierta las cúspides hasta la primera posición.
Aunque las realizaciones anteriores describen un
dispositivo que tiene entre una y tres cúspides, puede usarse
cualquier número de cúspides para impedir el flujo retrógrado a
través de un vaso. Las cúspides pueden disponerse simétricamente,
según se muestra, o pueden disponerse en cualquier otra
configuración.
Aunque las realizaciones descritas anteriormente
incluían cúspides de tamaño y configuración similares, pueden
usarse cúspides de diferentes tamaños y configuraciones conjuntadas
entre sí.
El elemento de anclaje puede adoptar un número
de formas diferentes que permitan al extremo de la cúspide penetrar
la pared de un vaso sanguíneo e impedir que el extremo de la cúspide
vuelva a entrar en el vaso. Por ejemplo, el elemento de anclaje
puede ser un elemento de barba, según se muestra en las
realizaciones descritas anteriormente. Alternativamente, el
elemento de anclaje puede ser un dispositivo de arpón 80 según se
muestra en la Fig. 10, en el cual el arpón 80 penetra en la pared de
un vaso y las puntas 82 impiden que el ancla vuelva a entrar en el
vaso. En otra realización, el elemento de anclaje puede definir un
bucle 84, según se muestra en la Fig. 11, en el cual el extremo 86
en bucle impide que el ancla vuelva a entrar en el vaso.
En otras realizaciones, una cúspide puede
incluir más de un elemento de anclaje. Una cúspide puede tener otras
configuraciones poligonales. Por ejemplo, una cúspide generalmente
rectangular puede sujetarse a un vaso usando dos elementos de
anclaje adyacentes a dos esquinas de la cúspide. La cúspide puede
formar un semicilindro.
Existen otras realizaciones dentro del alcance
de las siguientes reivindicaciones.
Claims (11)
1. Una cúspide de válvula implantable (30) para
formar una válvula dentro de un lumen corporal (44), la cual
comprende:
una laminilla triangular (42) formada por un
material delgado y flexible y que tiene una cara interna y una cara
externa;
siendo la laminilla invertiblemente deformable
entre una primera posición, en la cual la cara interna de la
laminilla es cóncava, y una segunda posición en la cual la cara
interna de la laminilla es convexa; y
un elemento de anclaje (38);
y caracterizada porque
el elemento de anclaje (38) está situado en un
ápice de la laminilla triangular y es operable para sujetar la
laminilla a la pared del lumen corporal (44) sólo por el ápice.
2. Una cúspide de válvula implantable (30) según
la reivindicación 1, en la cual la laminilla (42) incluye una
porción de borde adaptable (40) que es mas flexible que la parte
principal de la laminilla, extendiéndose la porción de borde
adaptable a lo largo del borde de la laminilla opuesto al ápice en
el cual está situado el elemento de anclaje.
3. Una cúspide de válvula implantable según la
reivindicación 1 o la reivindicación 2, en la cual, en la primera
posición,
la cúspide forma un semicono y la cara interna
de la laminilla define un canal de flujo.
4. Una cúspide de válvula implantable según
cualquier reivindicación precedente, en la cual el elemento de
anclaje (38) es una barba, un arpón (80) o un bucle (84).
5. Una cúspide de válvula implantable según
cualquier reivindicación precedente, en la cual el elemento de
anclaje está configurado para encajarse dentro de la pared del lumen
corporal.
6. Una cúspide de válvula implantable según
cualquiera de las reivindicaciones 1 a 4, en la cual el elemento de
anclaje está configurado para penetrar a través de la pared del
lumen corporal.
7. Una cúspide de válvula implantable según
cualquier reivindicación precedente, en la cual la cúspide está
formada integralmente por un material delgado y flexible tal como
poliuretano, polietileno o fluoroplástico tal como
politetrafluoroetileno.
8. Una cúspide de válvula implantable según
cualquiera de las reivindicaciones 1 a 6, en la cual el elemento de
anclaje (38) está formado por un metal, una cerámica, una aleación,
o un polímero tal como
acrilonitrilo-butadieno-estireno.
9. Un sistema médico que comprende una cúspide
de válvula implantable, según cualquiera de las reivindicaciones
precedentes, implantada dentro de un lumen corporal mediante la
sujeción de su elemento de anclaje a la pared del lumen corporal,
de tal modo que cuando la laminilla de la cúspide está en su segunda
posición, el borde de la laminilla opuesto al ápice en el cual está
situado el elemento de anclaje entra en contacto con una pared del
lumen corporal opuesta a la pared enganchada por el elemento de
anclaje.
10. Un sistema médico que comprende una
pluralidad de cúspides de válvula implantables, según cualquiera de
las reivindicaciones 1 a 8, implantadas dentro de un lumen corporal
de tal modo que cuando las laminillas de las cúspides están en sus
respectivas segundas posiciones, los bordes (40) de las laminillas
(42) opuestos a sus respectivos ápices en los cuales están situados
sus respectivos elementos de anclaje (38) entran en contacto entre
sí.
11. Un sistema médico según la reivindicación
10, en el cual el número de cúspides de válvula implantadas es 2, 3
ó más, y las cúspides están distribuidas simétricamente en la
dirección circunferencial del lumen corporal.
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US115557 | 2002-04-03 | ||
US10/115,557 US6752828B2 (en) | 2002-04-03 | 2002-04-03 | Artificial valve |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2297147T3 true ES2297147T3 (es) | 2008-05-01 |
Family
ID=28673799
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES03716963T Expired - Lifetime ES2297147T3 (es) | 2002-04-03 | 2003-04-03 | Valvula artificial. |
Country Status (7)
Country | Link |
---|---|
US (3) | US6752828B2 (es) |
EP (1) | EP1489996B1 (es) |
AT (1) | ATE379999T1 (es) |
AU (1) | AU2003220646A1 (es) |
DE (1) | DE60317886T2 (es) |
ES (1) | ES2297147T3 (es) |
WO (1) | WO2003084443A1 (es) |
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-
2002
- 2002-04-03 US US10/115,557 patent/US6752828B2/en not_active Expired - Fee Related
-
2003
- 2003-04-03 AU AU2003220646A patent/AU2003220646A1/en not_active Abandoned
- 2003-04-03 AT AT03716963T patent/ATE379999T1/de not_active IP Right Cessation
- 2003-04-03 EP EP03716963A patent/EP1489996B1/en not_active Expired - Lifetime
- 2003-04-03 DE DE60317886T patent/DE60317886T2/de not_active Expired - Lifetime
- 2003-04-03 ES ES03716963T patent/ES2297147T3/es not_active Expired - Lifetime
- 2003-04-03 WO PCT/US2003/010168 patent/WO2003084443A1/en active IP Right Grant
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2004
- 2004-06-22 US US10/873,052 patent/US7081131B2/en not_active Expired - Lifetime
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2006
- 2006-07-03 US US11/480,717 patent/US7682385B2/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
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WO2003084443A1 (en) | 2003-10-16 |
US7081131B2 (en) | 2006-07-25 |
DE60317886D1 (de) | 2008-01-17 |
US6752828B2 (en) | 2004-06-22 |
DE60317886T2 (de) | 2008-12-11 |
AU2003220646A1 (en) | 2003-10-20 |
US20060253189A1 (en) | 2006-11-09 |
US20030191525A1 (en) | 2003-10-09 |
EP1489996A1 (en) | 2004-12-29 |
US20040230297A1 (en) | 2004-11-18 |
ATE379999T1 (de) | 2007-12-15 |
EP1489996B1 (en) | 2007-12-05 |
US7682385B2 (en) | 2010-03-23 |
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