ES2278449T3 - Composiciones para el tratamiento de trastornos asociados a la chlamydia. - Google Patents
Composiciones para el tratamiento de trastornos asociados a la chlamydia. Download PDFInfo
- Publication number
- ES2278449T3 ES2278449T3 ES99928901T ES99928901T ES2278449T3 ES 2278449 T3 ES2278449 T3 ES 2278449T3 ES 99928901 T ES99928901 T ES 99928901T ES 99928901 T ES99928901 T ES 99928901T ES 2278449 T3 ES2278449 T3 ES 2278449T3
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- infection
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP4376/98 | 1998-06-30 | ||
| AUPP4376A AUPP437698A0 (en) | 1998-06-30 | 1998-06-30 | Methods for treatment of coronary, carotid and other vascular disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2278449T3 true ES2278449T3 (es) | 2007-08-01 |
Family
ID=3808619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99928901T Expired - Lifetime ES2278449T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados a la chlamydia. |
| ES06023648.6T Expired - Lifetime ES2514469T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados con Chlamydia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06023648.6T Expired - Lifetime ES2514469T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados con Chlamydia |
Country Status (10)
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|---|---|
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| EP (2) | EP1754472B1 (enExample) |
| JP (3) | JP4651816B2 (enExample) |
| AT (1) | ATE345115T1 (enExample) |
| AU (2) | AUPP437698A0 (enExample) |
| CA (2) | CA2684402C (enExample) |
| DE (1) | DE69934010T2 (enExample) |
| ES (2) | ES2278449T3 (enExample) |
| NZ (1) | NZ509504A (enExample) |
| WO (1) | WO2000001378A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710033B1 (en) | 1996-08-14 | 2004-03-23 | Vanderbilt University | Methods and treatment of multiple sclerosis |
| US6258532B1 (en) | 1997-08-14 | 2001-07-10 | Vanderbilt University | Methods for in vitro susceptibility testing of chlamydia |
| US6890526B2 (en) | 1997-05-06 | 2005-05-10 | Vanderbilt University | Methods and reagents for the treatment of multiple sclerosis |
| US6756369B2 (en) * | 1997-05-06 | 2004-06-29 | Vanderbilt University | Diagnosis and management of infection caused by Chlamydia |
| WO2000057187A2 (en) * | 1999-03-19 | 2000-09-28 | Vanderbilt University | Diagnosis and treatment of multiple sclerosis |
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| HRP20020765A2 (en) * | 2000-03-22 | 2003-12-31 | Upjohn Co | Oxazolidinone tablet formulation |
| IT1318459B1 (it) * | 2000-04-11 | 2003-08-25 | Zambon Spa | Uso del tiamfenicolo e di suoi derivati per la preparazione dicomposizioni farmaceutiche utili per il trattamento di infezioni da |
| US20020169112A1 (en) * | 2001-05-08 | 2002-11-14 | Luc Montagnier | Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections |
| EP1262185A1 (en) * | 2001-05-30 | 2002-12-04 | New Pharma Research Sweden AB | Synergistic antibiotic compositions |
| KR20040019034A (ko) * | 2001-07-06 | 2004-03-04 | 수캄포 아게 | 인터루킨 2 억제제 및 항미생물제를 포함하는 국소 투여용조성물 |
| UA79952C2 (en) * | 2001-12-10 | 2007-08-10 | Kabulesh Mafatlal Khamar | MYCOBACTERIUM w APPLICATIONS FOR CANCER TREATMENT |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
| AUPS088702A0 (en) | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| JP2005526059A (ja) * | 2002-03-07 | 2005-09-02 | アドバンシス ファーマスーティカル コーポレイション | 抗生物質組成物 |
| US20090149453A1 (en) * | 2002-05-23 | 2009-06-11 | Activbiotics Pharma Llc | Methods and compositions for treating bacterial infections and diseases associated therewith |
| US20040077533A1 (en) * | 2002-05-23 | 2004-04-22 | Sayada Chalom B. | Methods and compositions for treating bacterial infections and diseases associated therewith |
| WO2003099217A2 (en) * | 2002-05-23 | 2003-12-04 | Activbiotics, Inc. | Methods of treating bacterial infections and diseases associated therewith |
| US6916627B2 (en) * | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US7108992B2 (en) * | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| JP2006515294A (ja) * | 2002-12-12 | 2006-05-25 | アクティブバイオティクス インコーポレイティッド | アテローム性動脈硬化症およびその関連疾患を治療または予防するための方法および試薬 |
| AU2003296963A1 (en) * | 2002-12-12 | 2004-07-09 | Activbiotics, Inc. | Methods and compositions for treating and preventing ear infections |
| US20050013835A1 (en) * | 2003-07-15 | 2005-01-20 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| RU2254123C2 (ru) * | 2003-08-11 | 2005-06-20 | Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВСиДВ СО РАСХН) | Препарат для лечения гемобартонеллеза кошек и способ его применения |
| WO2005027961A2 (en) * | 2003-09-23 | 2005-03-31 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Chlamydia pmpd autotransporter and its role as adhesin |
| HUE029189T2 (en) | 2004-02-06 | 2017-02-28 | Pharmatel (R&D) Pty Ltd As Trustee For The Pharmatel (R & D) Trust | The use of aminosalicylates in diarrhea prodominant irritable bowel syndrome |
| JP5009152B2 (ja) * | 2004-05-28 | 2012-08-22 | サリックス ファーマシューティカルズ， インコーポレイテッド | 放射線誘発性腸炎の予防、処置、および回復 |
| UA88321C2 (ru) * | 2004-09-30 | 2009-10-12 | Ковалон Текнолоджиз Инк. | Неадгезивные эластичные желатиновые матрицы |
| JPWO2006057429A1 (ja) * | 2004-11-24 | 2008-06-05 | ナノキャリア株式会社 | ブロックコポリマーのモーフォロジーの変化方法 |
| EP2586427A3 (en) * | 2005-08-24 | 2013-05-29 | Salix Pharmaceuticals, Inc. | Balsalazide formulations and manufacture thereof |
| US7452872B2 (en) * | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| FR2891744B1 (fr) * | 2005-10-06 | 2009-10-09 | France Etat Armement | Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline |
| US8647673B2 (en) * | 2007-07-24 | 2014-02-11 | Wayne State University | Nanoparticles for imaging and treating chlamydial infection |
| CN102292078A (zh) | 2008-11-11 | 2011-12-21 | 得克萨斯大学体系董事会 | 哺乳动物雷帕霉素靶蛋白的抑制 |
| US8999360B2 (en) * | 2009-10-22 | 2015-04-07 | Thomas Julius Borody | Compositions and methods for treating extracellular parasitic infections |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| EP2563117B1 (en) | 2010-04-26 | 2018-02-21 | Salix Pharmaceuticals, Ltd. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives for the treatment of males |
| PL2651415T3 (pl) | 2010-12-13 | 2021-04-19 | Rite-Prep Pty Ltd. | Formulacje dożołądkowe i dookrężnicze oraz sposoby ich wytwarzania i zastosowania |
| US9376364B2 (en) * | 2011-08-16 | 2016-06-28 | Purac Biochem B.V. | Acid/salt separation |
| NZ704014A (en) | 2012-07-27 | 2017-10-27 | Redhill Biopharma Ltd | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| DK2968281T3 (da) | 2013-03-13 | 2020-11-02 | Univ Texas | Mtor-hæmmere til forebyggelse af vækst af tarmpolyp |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CA2933908C (en) | 2013-12-31 | 2024-01-30 | Rapamycin Holdings, Llc | Oral rapamycin nanoparticle preparations and use |
| RU2727474C2 (ru) * | 2015-10-06 | 2020-07-21 | Редхилл Байофарма Лтд. | Виды комбинированной терапии для лечения рака |
| WO2018195434A1 (en) | 2017-04-21 | 2018-10-25 | Lisanti Michael P | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| EP3612177A4 (en) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY |
| EP3624897A4 (en) | 2017-05-19 | 2021-07-14 | Lunella Biotech, Inc. | COMPANION DIAGNOSIS FOR MITOCHONDRIAL INHIBITORS |
| CA3063717C (en) | 2017-05-19 | 2021-08-24 | Lunella Biotech, Inc. | Antimitoscins: targeted inhibitors of mitochondrial biogenesis for eradicating cancer stem cells |
| CR20200033A (es) | 2017-06-26 | 2020-03-05 | Lunella Biotech Inc | Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas |
| CA3086850A1 (en) * | 2018-02-01 | 2019-08-08 | Centre For Digestive Diseases | Compositions for treating infective arterial diseases and related conditions |
| RU2684728C1 (ru) * | 2018-05-21 | 2019-04-12 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный аграрный университет" | Препарат на основе пчелиного маточного молочка для лечения мелких домашних животных при гемобартонеллезе |
| CA3180390A1 (en) * | 2020-03-27 | 2021-09-30 | Fergus MANFORD | Compositions for the treatment of a respiratory condition |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US588550A (en) | 1897-08-24 | Alarm-clock | ||
| GB1463550A (en) | 1974-08-06 | 1977-02-02 | Bodrero G | Pharmaceutical composition |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| FI883067A7 (fi) * | 1988-06-27 | 1989-12-28 | Labsystems Oy | Foerfarande foer behandling av koronarkaerlsjukdom. |
| US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| GB9416600D0 (en) | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5624704A (en) | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
| US6080757A (en) * | 1996-06-06 | 2000-06-27 | Pfizer Inc | Antibiotic quinolones and derivatives |
| US6838552B1 (en) * | 1997-08-14 | 2005-01-04 | Vanderbilt University | Diagnosis and management of infection caused by Chlamydia |
| US5811121A (en) | 1997-01-29 | 1998-09-22 | Eastman Chemical Company | PH-sensitive coatings based on cellulose acetoacetate |
| JP2002512622A (ja) * | 1997-05-06 | 2002-04-23 | バンダービルト ユニバーシティー | クラミジアにより引き起こされる感染の診断および管理のための抗クラミジア剤の組成物 |
-
1998
- 1998-06-30 AU AUPP4376A patent/AUPP437698A0/en not_active Abandoned
-
1999
- 1999-06-20 US US09/736,029 patent/US6475518B1/en not_active Expired - Lifetime
- 1999-06-30 DE DE69934010T patent/DE69934010T2/de not_active Expired - Lifetime
- 1999-06-30 CA CA2684402A patent/CA2684402C/en not_active Expired - Lifetime
- 1999-06-30 CA CA2336593A patent/CA2336593C/en not_active Expired - Lifetime
- 1999-06-30 ES ES99928901T patent/ES2278449T3/es not_active Expired - Lifetime
- 1999-06-30 ES ES06023648.6T patent/ES2514469T3/es not_active Expired - Lifetime
- 1999-06-30 EP EP06023648.6A patent/EP1754472B1/en not_active Expired - Lifetime
- 1999-06-30 JP JP2000557825A patent/JP4651816B2/ja not_active Expired - Lifetime
- 1999-06-30 WO PCT/AU1999/000528 patent/WO2000001378A1/en not_active Ceased
- 1999-06-30 AU AU45919/99A patent/AU757293B2/en not_active Expired
- 1999-06-30 AT AT99928901T patent/ATE345115T1/de not_active IP Right Cessation
- 1999-06-30 NZ NZ509504A patent/NZ509504A/en not_active IP Right Cessation
- 1999-06-30 EP EP99928901A patent/EP1093363B1/en not_active Expired - Lifetime
-
2010
- 2010-03-29 JP JP2010074109A patent/JP5335726B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-02 JP JP2013076511A patent/JP2013147504A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2013147504A (ja) | 2013-08-01 |
| JP5335726B2 (ja) | 2013-11-06 |
| CA2336593C (en) | 2010-06-29 |
| DE69934010T2 (de) | 2007-06-21 |
| NZ509504A (en) | 2004-04-30 |
| CA2684402C (en) | 2012-10-30 |
| AU757293B2 (en) | 2003-02-13 |
| EP1754472A2 (en) | 2007-02-21 |
| JP4651816B2 (ja) | 2011-03-16 |
| AU4591999A (en) | 2000-01-24 |
| JP2010174030A (ja) | 2010-08-12 |
| CA2684402A1 (en) | 2000-01-13 |
| CA2336593A1 (en) | 2000-01-13 |
| EP1093363A1 (en) | 2001-04-25 |
| WO2000001378A1 (en) | 2000-01-13 |
| HK1037864A1 (en) | 2002-02-22 |
| ES2514469T3 (es) | 2014-10-28 |
| ATE345115T1 (de) | 2006-12-15 |
| EP1754472B1 (en) | 2014-07-23 |
| DE69934010D1 (de) | 2006-12-28 |
| US6475518B1 (en) | 2002-11-05 |
| EP1093363B1 (en) | 2006-11-15 |
| JP2002519374A (ja) | 2002-07-02 |
| AUPP437698A0 (en) | 1998-07-23 |
| EP1093363A4 (en) | 2003-09-24 |
| EP1754472A3 (en) | 2009-08-26 |
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