ES2278449T3 - Composiciones para el tratamiento de trastornos asociados a la chlamydia. - Google Patents
Composiciones para el tratamiento de trastornos asociados a la chlamydia. Download PDFInfo
- Publication number
- ES2278449T3 ES2278449T3 ES99928901T ES99928901T ES2278449T3 ES 2278449 T3 ES2278449 T3 ES 2278449T3 ES 99928901 T ES99928901 T ES 99928901T ES 99928901 T ES99928901 T ES 99928901T ES 2278449 T3 ES2278449 T3 ES 2278449T3
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- infection
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Landscapes
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPP4376/98 | 1998-06-30 | ||
| AUPP4376A AUPP437698A0 (en) | 1998-06-30 | 1998-06-30 | Methods for treatment of coronary, carotid and other vascular disease |
Publications (1)
| Publication Number | Publication Date |
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| ES2278449T3 true ES2278449T3 (es) | 2007-08-01 |
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ID=3808619
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
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| ES99928901T Expired - Lifetime ES2278449T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados a la chlamydia. |
| ES06023648.6T Expired - Lifetime ES2514469T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados con Chlamydia |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES06023648.6T Expired - Lifetime ES2514469T3 (es) | 1998-06-30 | 1999-06-30 | Composiciones para el tratamiento de trastornos asociados con Chlamydia |
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| EP (2) | EP1754472B1 (enExample) |
| JP (3) | JP4651816B2 (enExample) |
| AT (1) | ATE345115T1 (enExample) |
| AU (2) | AUPP437698A0 (enExample) |
| CA (2) | CA2684402C (enExample) |
| DE (1) | DE69934010T2 (enExample) |
| ES (2) | ES2278449T3 (enExample) |
| NZ (1) | NZ509504A (enExample) |
| WO (1) | WO2000001378A1 (enExample) |
Families Citing this family (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6710033B1 (en) | 1996-08-14 | 2004-03-23 | Vanderbilt University | Methods and treatment of multiple sclerosis |
| US6258532B1 (en) | 1997-08-14 | 2001-07-10 | Vanderbilt University | Methods for in vitro susceptibility testing of chlamydia |
| US6756369B2 (en) * | 1997-05-06 | 2004-06-29 | Vanderbilt University | Diagnosis and management of infection caused by Chlamydia |
| US6890526B2 (en) | 1997-05-06 | 2005-05-10 | Vanderbilt University | Methods and reagents for the treatment of multiple sclerosis |
| EP1166117A2 (en) * | 1999-03-19 | 2002-01-02 | Vanderbilt University | Diagnosis and treatment of multiple sclerosis |
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| EP1265608B1 (en) * | 2000-03-22 | 2008-10-29 | Pharmacia & Upjohn Company LLC | Oxazolidinone tablet formulation |
| US6514529B2 (en) | 2000-03-22 | 2003-02-04 | Pharmacia & Upjohn Company | Oxazolidinone tablet formulation |
| IT1318459B1 (it) * | 2000-04-11 | 2003-08-25 | Zambon Spa | Uso del tiamfenicolo e di suoi derivati per la preparazione dicomposizioni farmaceutiche utili per il trattamento di infezioni da |
| US20020169112A1 (en) * | 2001-05-08 | 2002-11-14 | Luc Montagnier | Combined treatments and methods for treatment of mycoplasma and mycoplasma-like organism infections |
| EP1262185A1 (en) * | 2001-05-30 | 2002-12-04 | New Pharma Research Sweden AB | Synergistic antibiotic compositions |
| EP1406700A1 (en) * | 2001-07-06 | 2004-04-14 | Sucampo AG | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| UA79952C2 (en) * | 2001-12-10 | 2007-08-10 | Kabulesh Mafatlal Khamar | MYCOBACTERIUM w APPLICATIONS FOR CANCER TREATMENT |
| AUPS017702A0 (en) * | 2002-01-25 | 2002-02-14 | Atopic Pty Ltd | Methods and compositions for the treatment of asthma and related disorders |
| AUPS088702A0 (en) * | 2002-03-04 | 2002-03-28 | Borody, Thomas Julius | Electrolyte purgative |
| CA2478121A1 (en) * | 2002-03-07 | 2003-09-18 | Advancis Pharmaceutical Corporation | Antibiotic composition |
| US20040077533A1 (en) * | 2002-05-23 | 2004-04-22 | Sayada Chalom B. | Methods and compositions for treating bacterial infections and diseases associated therewith |
| AU2003265241A1 (en) * | 2002-05-23 | 2003-12-12 | Activbiotics, Inc. | Methods of treating bacterial infections and diseases associated therewith |
| US20090149453A1 (en) * | 2002-05-23 | 2009-06-11 | Activbiotics Pharma Llc | Methods and compositions for treating bacterial infections and diseases associated therewith |
| US6916627B2 (en) * | 2002-11-27 | 2005-07-12 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US7108992B2 (en) * | 2002-11-27 | 2006-09-19 | St. Jude Children's Research Hospital | ATM kinase compositions and methods |
| US20040126414A1 (en) * | 2002-12-12 | 2004-07-01 | Michaelis Arthur F. | Methods and compositions for treating and preventing ear infections |
| US20040176404A1 (en) * | 2002-12-12 | 2004-09-09 | Sayada Chalom B. | Methods and reagents for treating or preventing atherosclerosis and diseases associated therewith |
| US20050013835A1 (en) * | 2003-07-15 | 2005-01-20 | Pfizer Inc. | Stable non-dihydrate azithromycin oral suspensions |
| RU2254123C2 (ru) * | 2003-08-11 | 2005-06-20 | Государственное научное учреждение Институт экспериментальной ветеринарии Сибири и Дальнего Востока Сибирского отделения Россельхозакадемии (ГНУ ИЭВСиДВ СО РАСХН) | Препарат для лечения гемобартонеллеза кошек и способ его применения |
| WO2005027961A2 (en) * | 2003-09-23 | 2005-03-31 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Chlamydia pmpd autotransporter and its role as adhesin |
| JP2007520495A (ja) | 2004-02-06 | 2007-07-26 | ボロディー トーマス ユリウス | 下痢型過敏性腸症候群におけるアミノサリチル酸の使用法 |
| US20080306029A1 (en) * | 2004-05-28 | 2008-12-11 | Salix Pharmaceuticals, Inc. | Prevention, Treatment, and Amelioration of Radiation Induced Enteritis |
| JP5047797B2 (ja) * | 2004-09-30 | 2012-10-10 | コヴァロン・テクノロジーズ・インコーポレーテッド | 非接着性の弾性ゼラチンマトリックス |
| EP1815869A4 (en) * | 2004-11-24 | 2011-04-06 | Nanocarrier Co Ltd | PROCESS FOR CHANGING THE MORPHOLOGY OF BLOCK COPOLYMERS |
| US8921344B2 (en) * | 2006-11-03 | 2014-12-30 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| CA2816276A1 (en) * | 2005-08-24 | 2007-03-01 | Salix Pharmaceuticals, Inc. | Balsalazide formulations and manufacture and use thereof |
| US7452872B2 (en) | 2005-08-24 | 2008-11-18 | Salix Pharmaceuticals, Inc. | Formulations and uses of 2-hydroxy-5-phenylazobenzoic acid derivatives |
| FR2891744B1 (fr) * | 2005-10-06 | 2009-10-09 | France Etat Armement | Application a la chimioprophylaxie du paludisme d'une association de chloroquine et de doxycycline |
| US8647673B2 (en) * | 2007-07-24 | 2014-02-11 | Wayne State University | Nanoparticles for imaging and treating chlamydial infection |
| CA2937492C (en) | 2008-11-11 | 2019-08-13 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
| DE112010004110T8 (de) | 2009-10-22 | 2012-12-06 | Thomas Julius Borody | Neue parasitentherapie |
| US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
| US10391059B2 (en) | 2009-11-11 | 2019-08-27 | Rapamycin Holdings, Inc. | Oral rapamycin nanoparticle preparations and use |
| BR122014009845A2 (pt) | 2010-04-26 | 2015-12-29 | Salix Pharmaceuticals Ltd | usos de balsalazida para preparação de composição farmacêutica para tratamento de distúrbio gastrointestinal e induzir remissão clínica de colite ulcerativa em indivíduos do sexo masculino, bem como para diminuir o escore de mmdai e cicatrização da mucosa em indivíduos do sexo masculino com colite ulcerativa |
| BR112013014827A2 (pt) | 2010-12-13 | 2016-10-04 | Antony Wettstein | formulações gástricas e colônicas e métodos para produzir e usar as mesmas |
| JP6146922B2 (ja) * | 2011-08-16 | 2017-06-14 | ピュラック バイオケム ビー． ブイ． | 発酵ブロス処理にとって有用な、塩化水素酸を用いた沈殿によるカルボン酸のそれらのマグネシウム塩からの回収 |
| NZ704014A (en) | 2012-07-27 | 2017-10-27 | Redhill Biopharma Ltd | Formulations and methods of manufacturing formulations for use in colonic evacuation |
| US20160030401A1 (en) | 2013-03-13 | 2016-02-04 | The Board Of Regents Of The University Of Texas System | Use of mtor inhibitors for prevention of intestinal polyp growth and cancer |
| US9700544B2 (en) | 2013-12-31 | 2017-07-11 | Neal K Vail | Oral rapamycin nanoparticle preparations |
| CA2997671A1 (en) * | 2015-10-06 | 2017-04-13 | Redhill Biopharma Ltd. | Combination therapies for treating cancer |
| CA3060510A1 (en) | 2017-04-21 | 2018-10-25 | Lunella Biotech, Inc. | Vitamin c and doxycycline: a synthetic lethal combination therapy for eradicating cancer stem cells (cscs) |
| EP3612177A4 (en) | 2017-04-21 | 2021-01-13 | Lunella Biotech, Inc. | TARGETING HYPOXIC CARCINOUS STEM CELLS (SCC) USING DOXYCYCLINE: IMPLICATIONS FOR IMPROVING ANTI-ANGIOGENIC THERAPY |
| JP6938682B2 (ja) | 2017-05-19 | 2021-09-22 | ルネラ・バイオテック・インコーポレーテッド | アンチミトシン：癌幹細胞を根絶するためのミトコンドリア生合成の標的阻害薬 |
| US12006553B2 (en) | 2017-05-19 | 2024-06-11 | Lunella Biotech, Inc. | Companion diagnostics for mitochondrial inhibitors |
| CU20190106A7 (es) | 2017-06-26 | 2020-11-30 | Lunella Biotech Inc | Mitocetoscinas: agentes terapéuticos basados en mitocondrias que fijan como objetivo el metabolismo de cetonas en células cancerosas |
| CN111757732A (zh) * | 2018-02-01 | 2020-10-09 | 消化系统疾病中心 | 用于治疗感染性动脉疾病和相关病状的组合物 |
| RU2684728C1 (ru) * | 2018-05-21 | 2019-04-12 | федеральное государственное бюджетное образовательное учреждение высшего образования "Ставропольский государственный аграрный университет" | Препарат на основе пчелиного маточного молочка для лечения мелких домашних животных при гемобартонеллезе |
| CN115867288A (zh) * | 2020-03-27 | 2023-03-28 | 维克多瑞有限公司 | 用于治疗呼吸系统病症的组合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US588550A (en) | 1897-08-24 | Alarm-clock | ||
| GB1463550A (en) | 1974-08-06 | 1977-02-02 | Bodrero G | Pharmaceutical composition |
| GB2189699A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated acid-labile medicaments |
| FI883067A7 (fi) * | 1988-06-27 | 1989-12-28 | Labsystems Oy | Foerfarande foer behandling av koronarkaerlsjukdom. |
| US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
| GB9416600D0 (en) | 1994-08-17 | 1994-10-12 | Smithkline Beecham Plc | Pharmaceutical formulation |
| US5624704A (en) | 1995-04-24 | 1997-04-29 | Baylor College Of Medicine | Antimicrobial impregnated catheters and other medical implants and method for impregnating catheters and other medical implants with an antimicrobial agent |
| US6080757A (en) * | 1996-06-06 | 2000-06-27 | Pfizer Inc | Antibiotic quinolones and derivatives |
| US6838552B1 (en) * | 1997-08-14 | 2005-01-04 | Vanderbilt University | Diagnosis and management of infection caused by Chlamydia |
| US5811121A (en) | 1997-01-29 | 1998-09-22 | Eastman Chemical Company | PH-sensitive coatings based on cellulose acetoacetate |
| JP2002512622A (ja) * | 1997-05-06 | 2002-04-23 | バンダービルト ユニバーシティー | クラミジアにより引き起こされる感染の診断および管理のための抗クラミジア剤の組成物 |
-
1998
- 1998-06-30 AU AUPP4376A patent/AUPP437698A0/en not_active Abandoned
-
1999
- 1999-06-20 US US09/736,029 patent/US6475518B1/en not_active Expired - Lifetime
- 1999-06-30 JP JP2000557825A patent/JP4651816B2/ja not_active Expired - Lifetime
- 1999-06-30 DE DE69934010T patent/DE69934010T2/de not_active Expired - Lifetime
- 1999-06-30 NZ NZ509504A patent/NZ509504A/en not_active IP Right Cessation
- 1999-06-30 EP EP06023648.6A patent/EP1754472B1/en not_active Expired - Lifetime
- 1999-06-30 CA CA2684402A patent/CA2684402C/en not_active Expired - Lifetime
- 1999-06-30 AU AU45919/99A patent/AU757293B2/en not_active Expired
- 1999-06-30 ES ES99928901T patent/ES2278449T3/es not_active Expired - Lifetime
- 1999-06-30 EP EP99928901A patent/EP1093363B1/en not_active Expired - Lifetime
- 1999-06-30 ES ES06023648.6T patent/ES2514469T3/es not_active Expired - Lifetime
- 1999-06-30 CA CA2336593A patent/CA2336593C/en not_active Expired - Lifetime
- 1999-06-30 WO PCT/AU1999/000528 patent/WO2000001378A1/en not_active Ceased
- 1999-06-30 AT AT99928901T patent/ATE345115T1/de not_active IP Right Cessation
-
2010
- 2010-03-29 JP JP2010074109A patent/JP5335726B2/ja not_active Expired - Lifetime
-
2013
- 2013-04-02 JP JP2013076511A patent/JP2013147504A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000001378A1 (en) | 2000-01-13 |
| EP1754472B1 (en) | 2014-07-23 |
| AU757293B2 (en) | 2003-02-13 |
| CA2336593C (en) | 2010-06-29 |
| EP1754472A2 (en) | 2007-02-21 |
| JP2002519374A (ja) | 2002-07-02 |
| EP1093363A1 (en) | 2001-04-25 |
| JP5335726B2 (ja) | 2013-11-06 |
| HK1037864A1 (en) | 2002-02-22 |
| EP1093363A4 (en) | 2003-09-24 |
| CA2684402C (en) | 2012-10-30 |
| JP2010174030A (ja) | 2010-08-12 |
| CA2684402A1 (en) | 2000-01-13 |
| CA2336593A1 (en) | 2000-01-13 |
| ATE345115T1 (de) | 2006-12-15 |
| DE69934010D1 (de) | 2006-12-28 |
| EP1754472A3 (en) | 2009-08-26 |
| JP2013147504A (ja) | 2013-08-01 |
| AU4591999A (en) | 2000-01-24 |
| DE69934010T2 (de) | 2007-06-21 |
| EP1093363B1 (en) | 2006-11-15 |
| ES2514469T3 (es) | 2014-10-28 |
| AUPP437698A0 (en) | 1998-07-23 |
| NZ509504A (en) | 2004-04-30 |
| JP4651816B2 (ja) | 2011-03-16 |
| US6475518B1 (en) | 2002-11-05 |
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