ES2273831T3 - Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. - Google Patents

Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. Download PDF

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Publication number
ES2273831T3
ES2273831T3 ES01926924T ES01926924T ES2273831T3 ES 2273831 T3 ES2273831 T3 ES 2273831T3 ES 01926924 T ES01926924 T ES 01926924T ES 01926924 T ES01926924 T ES 01926924T ES 2273831 T3 ES2273831 T3 ES 2273831T3
Authority
ES
Spain
Prior art keywords
compound
react
7alfa
hydroxi
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01926924T
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English (en)
Spanish (es)
Inventor
William A. Kinney
Xuehai Zhang
Ronald Michalak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genaera Corp
Original Assignee
Genaera Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genaera Corp filed Critical Genaera Corp
Application granted granted Critical
Publication of ES2273831T3 publication Critical patent/ES2273831T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ES01926924T 2000-04-12 2001-04-12 Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido. Expired - Lifetime ES2273831T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US19664600P 2000-04-12 2000-04-12
US196646P 2000-04-12

Publications (1)

Publication Number Publication Date
ES2273831T3 true ES2273831T3 (es) 2007-05-16

Family

ID=22726246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01926924T Expired - Lifetime ES2273831T3 (es) 2000-04-12 2001-04-12 Procedimiento para la preparacion de 7alfa-hidroxi 3-amino sustituidos esteroles usando intermedios con un grupo 7alfa-hidroxi no protegido.

Country Status (12)

Country Link
US (2) US6933383B2 (cg-RX-API-DMAC10.html)
EP (1) EP1274718B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003531148A (cg-RX-API-DMAC10.html)
AT (1) ATE342912T1 (cg-RX-API-DMAC10.html)
AU (2) AU5342701A (cg-RX-API-DMAC10.html)
CA (1) CA2406847C (cg-RX-API-DMAC10.html)
CY (1) CY1105870T1 (cg-RX-API-DMAC10.html)
DE (1) DE60123939T2 (cg-RX-API-DMAC10.html)
DK (1) DK1274718T3 (cg-RX-API-DMAC10.html)
ES (1) ES2273831T3 (cg-RX-API-DMAC10.html)
PT (1) PT1274718E (cg-RX-API-DMAC10.html)
WO (1) WO2001079255A1 (cg-RX-API-DMAC10.html)

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DK3076969T3 (da) 2013-12-06 2021-11-22 Novartis Ag Doseringsregime for en alfa-isoform-selektiv phosphatidylinositol-3-kinase-hæmmer
CN108472289A (zh) 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN109734765B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙产品的制备方法
CN109734764B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙的制备方法
CN109651475B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙的新方法
AU2021244786A1 (en) 2020-03-25 2022-11-03 Risen (Suzhou) Pharma Tech Co., Ltd. Stable heavy isotopes in amide functional groups and uses thereof
CN113621016B (zh) * 2021-09-06 2022-05-17 北京泛球生物科技有限公司 一种地屈孕酮关键中间体的合成方法

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Also Published As

Publication number Publication date
AU2001253427B2 (en) 2007-02-08
EP1274718B1 (en) 2006-10-18
US6933383B2 (en) 2005-08-23
JP2003531148A (ja) 2003-10-21
WO2001079255A1 (en) 2001-10-25
US20030171576A1 (en) 2003-09-11
DE60123939T2 (de) 2007-05-31
AU5342701A (en) 2001-10-30
US7728157B2 (en) 2010-06-01
PT1274718E (pt) 2007-01-31
CY1105870T1 (el) 2011-02-02
DE60123939D1 (de) 2006-11-30
ATE342912T1 (de) 2006-11-15
US20050187202A1 (en) 2005-08-25
CA2406847A1 (en) 2001-10-25
DK1274718T3 (da) 2007-02-12
CA2406847C (en) 2009-11-17
EP1274718A1 (en) 2003-01-15

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