CA2406847C - Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols - Google Patents

Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols Download PDF

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Publication number
CA2406847C
CA2406847C CA002406847A CA2406847A CA2406847C CA 2406847 C CA2406847 C CA 2406847C CA 002406847 A CA002406847 A CA 002406847A CA 2406847 A CA2406847 A CA 2406847A CA 2406847 C CA2406847 C CA 2406847C
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CA
Canada
Prior art keywords
compound
fused ring
conditions sufficient
reacting
under conditions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA002406847A
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English (en)
French (fr)
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CA2406847A1 (en
Inventor
William A. Kinney
Xuehai Zhang
Ronald Michalak
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Genaera Corp
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Genaera Corp
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Publication of CA2406847A1 publication Critical patent/CA2406847A1/en
Application granted granted Critical
Publication of CA2406847C publication Critical patent/CA2406847C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J21/005—Ketals
    • C07J21/006—Ketals at position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002406847A 2000-04-12 2001-04-12 Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols Expired - Lifetime CA2406847C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19664600P 2000-04-12 2000-04-12
US60/196,646 2000-04-12
PCT/US2001/012004 WO2001079255A1 (en) 2000-04-12 2001-04-12 A process for the preparation of 7.alpha.-hydroxy 3-aminosubstituted sterols using intermediates with an unprotected 7.alpha.-hydroxy group

Publications (2)

Publication Number Publication Date
CA2406847A1 CA2406847A1 (en) 2001-10-25
CA2406847C true CA2406847C (en) 2009-11-17

Family

ID=22726246

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002406847A Expired - Lifetime CA2406847C (en) 2000-04-12 2001-04-12 Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols

Country Status (12)

Country Link
US (2) US6933383B2 (cg-RX-API-DMAC10.html)
EP (1) EP1274718B1 (cg-RX-API-DMAC10.html)
JP (1) JP2003531148A (cg-RX-API-DMAC10.html)
AT (1) ATE342912T1 (cg-RX-API-DMAC10.html)
AU (2) AU5342701A (cg-RX-API-DMAC10.html)
CA (1) CA2406847C (cg-RX-API-DMAC10.html)
CY (1) CY1105870T1 (cg-RX-API-DMAC10.html)
DE (1) DE60123939T2 (cg-RX-API-DMAC10.html)
DK (1) DK1274718T3 (cg-RX-API-DMAC10.html)
ES (1) ES2273831T3 (cg-RX-API-DMAC10.html)
PT (1) PT1274718E (cg-RX-API-DMAC10.html)
WO (1) WO2001079255A1 (cg-RX-API-DMAC10.html)

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DK3076969T3 (da) 2013-12-06 2021-11-22 Novartis Ag Doseringsregime for en alfa-isoform-selektiv phosphatidylinositol-3-kinase-hæmmer
CN108472289A (zh) 2015-11-02 2018-08-31 诺华股份有限公司 磷脂酰肌醇3-激酶抑制剂的给药方案
WO2018060833A1 (en) 2016-09-27 2018-04-05 Novartis Ag Dosage regimen for alpha-isoform selective phosphatidylinositol 3-kinase inhibitor alpelisib
CN109575096B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙产品的新方法
CN109734765B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙产品的制备方法
CN109734764B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种17a-脱羟醋酸泼尼松龙的制备方法
CN109651475B (zh) * 2019-01-20 2021-01-01 湖南科瑞生物制药股份有限公司 一种制备16a-羟基泼尼松龙的新方法
AU2021244786A1 (en) 2020-03-25 2022-11-03 Risen (Suzhou) Pharma Tech Co., Ltd. Stable heavy isotopes in amide functional groups and uses thereof
CN113621016B (zh) * 2021-09-06 2022-05-17 北京泛球生物科技有限公司 一种地屈孕酮关键中间体的合成方法

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Also Published As

Publication number Publication date
AU2001253427B2 (en) 2007-02-08
EP1274718B1 (en) 2006-10-18
US6933383B2 (en) 2005-08-23
JP2003531148A (ja) 2003-10-21
WO2001079255A1 (en) 2001-10-25
US20030171576A1 (en) 2003-09-11
DE60123939T2 (de) 2007-05-31
AU5342701A (en) 2001-10-30
US7728157B2 (en) 2010-06-01
ES2273831T3 (es) 2007-05-16
PT1274718E (pt) 2007-01-31
CY1105870T1 (el) 2011-02-02
DE60123939D1 (de) 2006-11-30
ATE342912T1 (de) 2006-11-15
US20050187202A1 (en) 2005-08-25
CA2406847A1 (en) 2001-10-25
DK1274718T3 (da) 2007-02-12
EP1274718A1 (en) 2003-01-15

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