ES2260098T3 - Gel polimero hinchable en agua y procedimiento de preparacion del mismo. - Google Patents
Gel polimero hinchable en agua y procedimiento de preparacion del mismo.Info
- Publication number
- ES2260098T3 ES2260098T3 ES01101182T ES01101182T ES2260098T3 ES 2260098 T3 ES2260098 T3 ES 2260098T3 ES 01101182 T ES01101182 T ES 01101182T ES 01101182 T ES01101182 T ES 01101182T ES 2260098 T3 ES2260098 T3 ES 2260098T3
- Authority
- ES
- Spain
- Prior art keywords
- gel
- water
- polymer gel
- solution
- foam
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title claims abstract description 161
- 229920000642 polymer Polymers 0.000 title claims abstract description 106
- 238000000034 method Methods 0.000 title claims description 63
- 238000002360 preparation method Methods 0.000 title claims description 31
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- 229920000615 alginic acid Polymers 0.000 claims abstract description 22
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- 229960001126 alginic acid Drugs 0.000 claims abstract description 16
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 12
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 10
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 10
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- 150000002148 esters Chemical class 0.000 claims abstract description 9
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- 208000027418 Wounds and injury Diseases 0.000 claims description 22
- 206010052428 Wound Diseases 0.000 claims description 21
- 238000006243 chemical reaction Methods 0.000 claims description 21
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 20
- -1 alginic acid ester Chemical class 0.000 claims description 17
- 238000005187 foaming Methods 0.000 claims description 10
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 claims description 8
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- 238000004519 manufacturing process Methods 0.000 claims description 3
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims description 2
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- 239000004472 Lysine Substances 0.000 abstract description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract description 3
- 239000000499 gel Substances 0.000 description 207
- 150000004804 polysaccharides Chemical class 0.000 description 66
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 21
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- 230000000052 comparative effect Effects 0.000 description 16
- 108010025899 gelatin film Proteins 0.000 description 16
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 15
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 15
- 239000003795 chemical substances by application Substances 0.000 description 15
- 235000013305 food Nutrition 0.000 description 14
- 239000000126 substance Substances 0.000 description 14
- 229920002873 Polyethylenimine Polymers 0.000 description 13
- NBVXSUQYWXRMNV-UHFFFAOYSA-N fluoromethane Chemical compound FC NBVXSUQYWXRMNV-UHFFFAOYSA-N 0.000 description 13
- 239000002504 physiological saline solution Substances 0.000 description 13
- 239000011347 resin Substances 0.000 description 13
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- 108010010803 Gelatin Proteins 0.000 description 9
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 9
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 9
- 235000019322 gelatine Nutrition 0.000 description 9
- 235000011852 gelatine desserts Nutrition 0.000 description 9
- 230000008569 process Effects 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
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- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 6
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 229920001661 Chitosan Polymers 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 239000002253 acid Substances 0.000 description 6
- 229940072056 alginate Drugs 0.000 description 6
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- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 5
- 238000004090 dissolution Methods 0.000 description 5
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- 235000010413 sodium alginate Nutrition 0.000 description 5
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- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 4
- 229920001817 Agar Polymers 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 4
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- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 description 4
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Classifications
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- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/60—Liquid-swellable gel-forming materials, e.g. super-absorbents
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
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- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
Landscapes
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- Medicinal Preparation (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2000014626 | 2000-01-24 | ||
| JP2000-14626 | 2000-01-24 |
Publications (1)
| Publication Number | Publication Date |
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| ES2260098T3 true ES2260098T3 (es) | 2006-11-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES01101182T Expired - Lifetime ES2260098T3 (es) | 2000-01-24 | 2001-01-24 | Gel polimero hinchable en agua y procedimiento de preparacion del mismo. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US6486285B2 (de) |
| EP (1) | EP1120428B1 (de) |
| KR (1) | KR100721752B1 (de) |
| DE (1) | DE60118637T2 (de) |
| ES (1) | ES2260098T3 (de) |
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| US6592860B1 (en) * | 2000-05-30 | 2003-07-15 | Soluble Systems, Llc | Composition and applicator for topical substance delivery |
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| US8741335B2 (en) | 2002-06-14 | 2014-06-03 | Hemcon Medical Technologies, Inc. | Hemostatic compositions, assemblies, systems, and methods employing particulate hemostatic agents formed from hydrophilic polymer foam such as Chitosan |
| WO2002102276A2 (en) | 2001-06-14 | 2002-12-27 | Providence Health System-Oregon | Wound dressing and method for controlling severe, life-threatening bleeding |
| US20060004314A1 (en) * | 2001-06-14 | 2006-01-05 | Hemcon, Inc. | Antimicrobial barriers, systems, and methods formed from hydrophilic polymer structures such as chistosan |
| EP1469865A4 (de) * | 2001-12-31 | 2010-04-14 | Crosslink D Inc | Hämostatische zusammensetzungen und verfahren zur kontrolle von blutungen |
| TWI255224B (en) * | 2002-01-09 | 2006-05-21 | Novartis Ag | Polymeric articles having a lubricious coating and method for making the same |
| US8269058B2 (en) | 2002-06-14 | 2012-09-18 | Hemcon Medical Technologies, Inc. | Absorbable tissue dressing assemblies, systems, and methods formed from hydrophilic polymer sponge structures such as chitosan |
| US20050137512A1 (en) * | 2003-12-23 | 2005-06-23 | Campbell Todd D. | Wound dressing and method for controlling severe, life-threatening bleeding |
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| ATE489062T1 (de) * | 2003-09-12 | 2010-12-15 | Z Medica Corp | Teilweise hydriertes hämostatisches mittel |
| RU2240830C1 (ru) * | 2003-12-26 | 2004-11-27 | ФГУП Государственный научно-исследовательский институт особо чистых биопрепаратов | Раневое покрытие и способ его получения |
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| US20130096518A1 (en) | 2007-12-06 | 2013-04-18 | Smith & Nephew Plc | Wound filling apparatuses and methods |
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| CN101649005B (zh) * | 2009-09-09 | 2011-06-08 | 中国海洋大学 | 对氨基苯甲酰壳聚糖及其制备方法 |
| US8623403B2 (en) * | 2009-12-02 | 2014-01-07 | University Of Virginia Patent Foundation | Methods for regulating gelation of hydrogel solutions and uses thereof |
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| US9061095B2 (en) | 2010-04-27 | 2015-06-23 | Smith & Nephew Plc | Wound dressing and method of use |
| USRE48117E1 (en) | 2010-05-07 | 2020-07-28 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| GB201011173D0 (en) | 2010-07-02 | 2010-08-18 | Smith & Nephew | Provision of wound filler |
| US8858969B2 (en) | 2010-09-22 | 2014-10-14 | Z-Medica, Llc | Hemostatic compositions, devices, and methods |
| KR101821842B1 (ko) | 2010-10-15 | 2018-01-24 | 스트라우만 홀딩 에이쥐 | Ｐｇａ를 포함하는 새로운 ｅｍｄ 제제 |
| CN107033596A (zh) | 2010-11-25 | 2017-08-11 | 史密夫及内修公开有限公司 | 组合物i – ii及其产品和用途 |
| GB201020005D0 (en) | 2010-11-25 | 2011-01-12 | Smith & Nephew | Composition 1-1 |
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| KR101620241B1 (ko) * | 2011-08-02 | 2016-05-11 | 다이니치 세이카 고교 가부시키가이샤 | 유착 방지용 의료용 재료 및 그 제조 방법 |
| KR20220013588A (ko) * | 2011-09-14 | 2022-02-04 | 알러간, 인코포레이티드 | 잔주름 치료를 위한 진피 필러 조성물 |
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| WO2013112381A2 (en) | 2012-01-24 | 2013-08-01 | Bvw Holding Ag | New class of anti-adhesion hydrogels with healing aspects |
| WO2013137302A1 (ja) * | 2012-03-13 | 2013-09-19 | 国立大学法人 岡山大学 | リジンオリゴマー誘導体及びそれからなる軟骨組織マーカー |
| KR101240518B1 (ko) | 2012-03-26 | 2013-03-11 | 주식회사 제네웰 | 생체 적합성 고분자를 이용한 이식용 재료 |
| US20130303631A1 (en) * | 2012-05-11 | 2013-11-14 | Conopco, Inc., D/B/A Unilever | Environmentally Friendly and Aerated Topical Benefit Composition |
| WO2013191836A1 (en) | 2012-06-22 | 2013-12-27 | Z-Medica, Llc | Hemostatic devices |
| US20160120706A1 (en) | 2013-03-15 | 2016-05-05 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| EP2968647B1 (de) | 2013-03-15 | 2022-06-29 | Smith & Nephew plc | Wundverbanddichtmasse und verwendung davon |
| CN103223190B (zh) * | 2013-04-26 | 2014-05-28 | 天津大学 | ε-聚赖氨酸-DOHA原位凝胶粘合材料及其制备方法 |
| US20160051723A1 (en) * | 2014-08-21 | 2016-02-25 | Gregory J. Pomrink | Bioresorbable tissue repair composition |
| WO2017082538A1 (ko) * | 2015-11-13 | 2017-05-18 | 서강대학교산학협력단 | 유착 방지용 하이드로젤 및 이의 제조 방법 |
| CN110087705B (zh) | 2016-05-03 | 2022-08-05 | Bvw控股公司 | 多相凝胶 |
| CA3057057A1 (en) * | 2017-03-21 | 2018-09-27 | Cj Cheiljedang Corporation | Adhesive composition and method for preparing same |
| EP3659631B1 (de) * | 2017-07-26 | 2023-08-30 | Youreh Co., Ltd. | Wundverband mit hyaluronsäure-calcium und polylysin und verfahren zu seiner herstellung |
| GB201811449D0 (en) | 2018-07-12 | 2018-08-29 | Smith & Nephew | Apparatuses and methods for negative pressure wound therapy |
| KR102284844B1 (ko) | 2018-08-31 | 2021-08-03 | 씨제이제일제당 주식회사 | 먼지 생성을 억제하는 방법, 토양안정제 조성물, 및 이를 포함하는 분무 장치 |
| KR102280739B1 (ko) | 2018-08-31 | 2021-07-27 | 씨제이제일제당 주식회사 | 라벨용 점착 조성물, 이의 제조 방법, 이를 포함하는 점착 시트 및 물품 |
| US20220186055A1 (en) * | 2019-04-18 | 2022-06-16 | The Johns Hopkins University | Fluoropolymer shear-thinning inks and methods of making and using same |
| CN110124117B (zh) * | 2019-06-28 | 2020-12-11 | 北京化工大学 | 一种可注射水凝胶及其制备方法 |
| GB202000574D0 (en) | 2020-01-15 | 2020-02-26 | Smith & Nephew | Fluidic connectors for negative pressure wound therapy |
| CN114099768B (zh) * | 2021-11-30 | 2022-11-01 | 中国科学院长春应用化学研究所 | 一种创面缓释吸收型医用敷料材料及其制备方法 |
| CN115475271B (zh) * | 2022-08-19 | 2023-11-24 | 上海纳米技术及应用国家工程研究中心有限公司 | 一种氨基酸/稀土纳米晶/纳米纤维素抗菌止血敷料的制备方法 |
| EP4710952A1 (de) * | 2024-09-16 | 2026-03-18 | Paul Hartmann AG | Wundauflage zur wundbehandiung im feuchten oder feucht-nassen milieu |
| EP4710953A1 (de) * | 2024-09-16 | 2026-03-18 | Paul Hartmann AG | Vliesstoff mit infektionshemmenden eigenschaften |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE612782A (de) | 1961-01-18 | |||
| US3873749A (en) * | 1972-07-03 | 1975-03-25 | Lever Brothers Ltd | Process for producing a fish product |
| US4582865A (en) | 1984-12-06 | 1986-04-15 | Biomatrix, Inc. | Cross-linked gels of hyaluronic acid and products containing such gels |
| JPS6356501A (ja) | 1986-08-26 | 1988-03-11 | Chisso Corp | アフイニテイークロマトグラフイー用カラム充填剤及びその製造方法 |
| JPH0669490A (ja) | 1992-08-14 | 1994-03-11 | Fujitsu Ltd | 電子光回路 |
| FR2703927B1 (fr) | 1993-04-13 | 1995-07-13 | Coletica | Utilisation d'une réaction de transacylation entre un polysaccharide estérifié et une polyamine pour former en milieu aqueux une membrane au moins en surface de particules gélifiées. |
| US5827937A (en) | 1995-07-17 | 1998-10-27 | Q Med Ab | Polysaccharide gel composition |
| JPH09278803A (ja) * | 1996-04-09 | 1997-10-28 | Kuraray Co Ltd | 医療用手当材 |
-
2001
- 2001-01-20 KR KR1020010003389A patent/KR100721752B1/ko not_active Expired - Lifetime
- 2001-01-23 US US09/767,227 patent/US6486285B2/en not_active Expired - Lifetime
- 2001-01-24 EP EP01101182A patent/EP1120428B1/de not_active Expired - Lifetime
- 2001-01-24 DE DE60118637T patent/DE60118637T2/de not_active Expired - Lifetime
- 2001-01-24 ES ES01101182T patent/ES2260098T3/es not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| US6486285B2 (en) | 2002-11-26 |
| EP1120428A3 (de) | 2001-08-22 |
| DE60118637T2 (de) | 2007-01-11 |
| KR20010076418A (ko) | 2001-08-11 |
| US20010018464A1 (en) | 2001-08-30 |
| KR100721752B1 (ko) | 2007-05-25 |
| EP1120428A2 (de) | 2001-08-01 |
| EP1120428B1 (de) | 2006-04-12 |
| DE60118637D1 (de) | 2006-05-24 |
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