ES2259190T3 - Composiciones y metodos para la biosintesis de taxol. - Google Patents

Composiciones y metodos para la biosintesis de taxol.

Info

Publication number
ES2259190T3
ES2259190T3 ES97923414T ES97923414T ES2259190T3 ES 2259190 T3 ES2259190 T3 ES 2259190T3 ES 97923414 T ES97923414 T ES 97923414T ES 97923414 T ES97923414 T ES 97923414T ES 2259190 T3 ES2259190 T3 ES 2259190T3
Authority
ES
Spain
Prior art keywords
taxol
biosynthesis
compositions
methods
cloned
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97923414T
Other languages
English (en)
Inventor
Mark R Wildung
Rodney B Croteau
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Washington
Washington State University Research Foundation
Original Assignee
University of Washington
Washington State University Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Washington, Washington State University Research Foundation filed Critical University of Washington
Application granted granted Critical
Publication of ES2259190T3 publication Critical patent/ES2259190T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
    • C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
    • C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
    • C12N15/8243—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits involving biosynthetic or metabolic pathways, i.e. metabolic engineering, e.g. nicotine, caffeine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Nutrition Science (AREA)
  • Cell Biology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Epoxy Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

EL GEN DE LA SINTASA TAXADIENO DEL TEJO DEL PACIFICO HA SIDO CLONADO, Y SE PRESENTA SU SECUENCIA DE POLIPEPTIDOS Y SU ACIDO NUCLEICO. EL TRUNCAMIENTO O RETIRADA DEL PEPTIDO DE TRANSITO AUMENTA LA EXPRESION DEL GEN CLONADO DE LA SINTASA TAXADIENO EN CELULAS DE E. COLI.
ES97923414T 1996-04-15 1997-04-15 Composiciones y metodos para la biosintesis de taxol. Expired - Lifetime ES2259190T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US1599396P 1996-04-15 1996-04-15

Publications (1)

Publication Number Publication Date
ES2259190T3 true ES2259190T3 (es) 2006-09-16

Family

ID=21774770

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97923414T Expired - Lifetime ES2259190T3 (es) 1996-04-15 1997-04-15 Composiciones y metodos para la biosintesis de taxol.

Country Status (9)

Country Link
US (3) US5994114A (es)
EP (1) EP0907312B1 (es)
JP (1) JP2000508902A (es)
AT (1) ATE319297T1 (es)
AU (1) AU710405B2 (es)
CA (1) CA2250693C (es)
DE (1) DE69735419T2 (es)
ES (1) ES2259190T3 (es)
WO (1) WO1997038571A1 (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8106260B2 (en) 1996-04-12 2012-01-31 The Board Of Trustees Of The University Of Kentucky Chimeric isoprenoid synthases and uses thereof
US6265639B1 (en) * 1998-01-22 2001-07-24 Washington State University Foundation Gymnosperm nucleic acid molecules encoding sesquiterpene synthases and methods of use
US6342380B1 (en) * 1998-02-02 2002-01-29 The Regents Of The University Of California Germacrene C synthase gene of Lycopersicon esculentum
CA2336122A1 (en) * 1998-07-02 2000-01-13 David M. Long Taxol production via generation of extrachromosomal dnas in the fungus pestalotiopsis
AR022383A1 (es) 1998-09-18 2002-09-04 Univ Kentucky Res Found Sintasas
AU2001278098A1 (en) 2000-07-31 2002-02-13 Frederick M. Hahn Manipulation of genes of the mevalonate and isoprenoid pathways to create novel traits in transgenic organisms
EP1337657A2 (en) * 2000-11-17 2003-08-27 Novozymes A/S Heterologous expression of taxanes
CA2954889A1 (en) 2001-03-09 2002-09-19 University Of Kentucky Research Foundation Cytochrome p450s and uses thereof
ES2201933B1 (es) * 2001-08-23 2005-02-01 Sociedad Española De Carburos Metalicos, S.A. Utilizacion de co2 para incrementar la concentracion de metabolitos secundarios en plantas.
US7172886B2 (en) * 2001-12-06 2007-02-06 The Regents Of The University Of California Biosynthesis of isopentenyl pyrophosphate
US7192751B2 (en) * 2001-12-06 2007-03-20 The Regents Of The University Of California Biosynthesis of amorpha-4,11-diene
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
GB0403847D0 (en) * 2004-02-20 2004-03-24 Plant Bioscience Ltd Methods and means
US8802422B2 (en) 2007-06-01 2014-08-12 Solazyme, Inc. Renewable diesel and jet fuel from microbial sources
JP5859311B2 (ja) 2008-11-28 2016-02-10 ソラザイム, インコーポレイテッドSolazyme Inc 組み換え従属栄養微生物における、用途に応じた油の生産
US8927241B2 (en) 2009-11-10 2015-01-06 Massachusetts Institute Of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
EP2499257A1 (en) 2009-11-10 2012-09-19 Massachusetts Institute of Technology Microbial engineering for the production of chemical and pharmaceutical products from the isoprenoid pathway
CA3039432A1 (en) 2010-05-28 2011-12-01 Corbion Biotech, Inc. Tailored oils produced from recombinant heterotrophic microorganisms
WO2012075030A1 (en) 2010-11-30 2012-06-07 Massachusetts Institute Of Technology Microbial production of natural sweeteners, diterpenoid steviol glycosides
CA2825691C (en) 2011-02-02 2020-08-25 Solazyme, Inc. Tailored oils produced from recombinant oleaginous microorganisms
CN103146728B (zh) * 2013-02-28 2015-05-20 天津大学 一种生产紫杉二烯的酵母菌及构建方法
WO2017047651A1 (ja) * 2015-09-18 2017-03-23 神戸天然物化学株式会社 形質転換体、およびテルペノイドの製造方法
WO2019118701A1 (en) * 2017-12-13 2019-06-20 Purdue Research Foundation Tunable transcriptional regulators reponsive to environmental triggers

Also Published As

Publication number Publication date
AU710405B2 (en) 1999-09-16
EP0907312A4 (en) 2001-06-06
AU2922597A (en) 1997-11-07
EP0907312A1 (en) 1999-04-14
DE69735419D1 (de) 2006-05-04
US6610527B1 (en) 2003-08-26
CA2250693A1 (en) 1997-10-23
WO1997038571A1 (en) 1997-10-23
DE69735419T2 (de) 2006-11-09
EP0907312B1 (en) 2006-03-08
US5994114A (en) 1999-11-30
ATE319297T1 (de) 2006-03-15
CA2250693C (en) 2005-09-06
JP2000508902A (ja) 2000-07-18
US6114160A (en) 2000-09-05

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