BR9713248A - Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso - Google Patents

Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso

Info

Publication number
BR9713248A
BR9713248A BR9713248-9A BR9713248A BR9713248A BR 9713248 A BR9713248 A BR 9713248A BR 9713248 A BR9713248 A BR 9713248A BR 9713248 A BR9713248 A BR 9713248A
Authority
BR
Brazil
Prior art keywords
sequence
phosphorylated
mamastatin
mamstatin
proteins
Prior art date
Application number
BR9713248-9A
Other languages
English (en)
Inventor
Paul R Ervin Jr.
Original Assignee
Biotherapies Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotherapies Inc filed Critical Biotherapies Inc
Publication of BR9713248A publication Critical patent/BR9713248A/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção:<B>"SEQuêNCIA DE NUCLEOTìDEOS E DE PROTEìNAS DE MAMASTATINA E PROCESSOS DE USO". Uma seq³ência de ácidos nucléicos que codifica mamastatina, um inibidor de crescimento de células mamárias específico. A mamastatina é codificada por uma única seq³ência de ácidos nucléicos e tem um peso molecular aproximado de 44KDa em sua forma não fosforilada, inativa. Células mamárias normais expressam formas fosforiladas funcionais tendo pesos moleculares aproximados de 53KDa e 49KDa. Células mamárias metastáticas ou absolutamente não expressam a mamastatina, ou não expressam as formas fosforiladas de 53KDa e de 49KDa. Células de câncer mamárias são inibidas em seu crescimento pela administração de mamastatina fosforilada.
BR9713248-9A 1996-10-03 1997-10-03 Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso BR9713248A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US2731596P 1996-10-03 1996-10-03
PCT/US1997/018026 WO1998014577A2 (en) 1996-10-03 1997-10-03 Nucleotide and protein sequence of mammastatin and methods of use

Publications (1)

Publication Number Publication Date
BR9713248A true BR9713248A (pt) 2000-01-18

Family

ID=21836977

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9713248-9A BR9713248A (pt) 1996-10-03 1997-10-03 Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso

Country Status (8)

Country Link
US (6) US6451765B1 (pt)
EP (2) EP1935899A1 (pt)
JP (2) JP4452331B2 (pt)
AU (1) AU733380B2 (pt)
BR (1) BR9713248A (pt)
CA (1) CA2267095C (pt)
EA (1) EA199900256A1 (pt)
WO (1) WO1998014577A2 (pt)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6500937B1 (en) 1996-10-03 2002-12-31 University Of Michigan Nucleotide sequence encoding a mammary cell growth inhibitor
EP1935899A1 (en) * 1996-10-03 2008-06-25 The Regents Of The University Of Michigan Nucleotide and protein sequence of mammastatin and methods of use
US6939714B2 (en) 1999-06-18 2005-09-06 Biotherapies, Inc. Epithelial cell growth inhibitors
NZ516545A (en) * 1999-06-18 2004-06-25 Biotherapies Inc Epithelial cell growth inhibitors
EP2339003A3 (en) 1999-06-28 2011-10-19 Genentech, Inc. Apo-2 ligand substitutional variants
AU2000257514A1 (en) * 2000-06-19 2002-01-02 The University Of Michigan Mammastatin sequence variant c
US20030212263A1 (en) * 2000-06-19 2003-11-13 The University Of Michigan Mammastatin sequence variant C
KR20210090634A (ko) * 2018-10-19 2021-07-20 트랜슬레이트 바이오 인코포레이티드 전령 rna의 무펌프 캡슐화

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4379839A (en) 1977-05-23 1983-04-12 The Trustees Of Columbia University In The City Of New York Method for detecting cancer
US4753894A (en) 1984-02-08 1988-06-28 Cetus Corporation Monoclonal anti-human breast cancer antibodies
WO1989011492A1 (en) * 1988-05-20 1989-11-30 The Regents Of The University Of Michigan Human mammary cell growth inhibitor and methods of production and use
EP0417168A4 (en) * 1988-05-20 1991-09-11 The Regents Of The University Of Michigan Antibodies to human mammary cell growth inhibitor and methods of production and use
US6500937B1 (en) * 1996-10-03 2002-12-31 University Of Michigan Nucleotide sequence encoding a mammary cell growth inhibitor
EP1935899A1 (en) * 1996-10-03 2008-06-25 The Regents Of The University Of Michigan Nucleotide and protein sequence of mammastatin and methods of use

Also Published As

Publication number Publication date
AU733380B2 (en) 2001-05-10
US20090011434A1 (en) 2009-01-08
US6451765B1 (en) 2002-09-17
US6492504B2 (en) 2002-12-10
US20110039279A1 (en) 2011-02-17
WO1998014577A2 (en) 1998-04-09
US7332287B2 (en) 2008-02-19
US20030108961A1 (en) 2003-06-12
US20020072592A1 (en) 2002-06-13
EP0929675A2 (en) 1999-07-21
US7323173B2 (en) 2008-01-29
JP2001502533A (ja) 2001-02-27
EP1935899A1 (en) 2008-06-25
US20030095972A1 (en) 2003-05-22
CA2267095C (en) 2010-08-10
AU4670997A (en) 1998-04-24
WO1998014577A3 (en) 1998-04-09
CA2267095A1 (en) 1998-04-09
EA199900256A1 (ru) 2000-02-28
JP4452331B2 (ja) 2010-04-21
JP2010031013A (ja) 2010-02-12

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Legal Events

Date Code Title Description
B09B Patent application refused [chapter 9.2 patent gazette]

Free format text: DE ACORDO COM O ART 36 DA LPI (LEI 9.279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR.

B15K Others concerning applications: alteration of classification

Ipc: C07K 14/47 (2006.01), A61K 48/00 (2006.0