BR9713248A - Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso - Google Patents
Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de usoInfo
- Publication number
- BR9713248A BR9713248A BR9713248-9A BR9713248A BR9713248A BR 9713248 A BR9713248 A BR 9713248A BR 9713248 A BR9713248 A BR 9713248A BR 9713248 A BR9713248 A BR 9713248A
- Authority
- BR
- Brazil
- Prior art keywords
- sequence
- phosphorylated
- mamastatin
- mamstatin
- proteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente de Invenção:<B>"SEQuêNCIA DE NUCLEOTìDEOS E DE PROTEìNAS DE MAMASTATINA E PROCESSOS DE USO". Uma seq³ência de ácidos nucléicos que codifica mamastatina, um inibidor de crescimento de células mamárias específico. A mamastatina é codificada por uma única seq³ência de ácidos nucléicos e tem um peso molecular aproximado de 44KDa em sua forma não fosforilada, inativa. Células mamárias normais expressam formas fosforiladas funcionais tendo pesos moleculares aproximados de 53KDa e 49KDa. Células mamárias metastáticas ou absolutamente não expressam a mamastatina, ou não expressam as formas fosforiladas de 53KDa e de 49KDa. Células de câncer mamárias são inibidas em seu crescimento pela administração de mamastatina fosforilada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2731596P | 1996-10-03 | 1996-10-03 | |
PCT/US1997/018026 WO1998014577A2 (en) | 1996-10-03 | 1997-10-03 | Nucleotide and protein sequence of mammastatin and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9713248A true BR9713248A (pt) | 2000-01-18 |
Family
ID=21836977
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9713248-9A BR9713248A (pt) | 1996-10-03 | 1997-10-03 | Sequência de nucleotìdeos e de proteìnas de mamastatina e processos de uso |
Country Status (8)
Country | Link |
---|---|
US (6) | US6451765B1 (pt) |
EP (2) | EP1935899A1 (pt) |
JP (2) | JP4452331B2 (pt) |
AU (1) | AU733380B2 (pt) |
BR (1) | BR9713248A (pt) |
CA (1) | CA2267095C (pt) |
EA (1) | EA199900256A1 (pt) |
WO (1) | WO1998014577A2 (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500937B1 (en) | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
EP1935899A1 (en) * | 1996-10-03 | 2008-06-25 | The Regents Of The University Of Michigan | Nucleotide and protein sequence of mammastatin and methods of use |
US6939714B2 (en) | 1999-06-18 | 2005-09-06 | Biotherapies, Inc. | Epithelial cell growth inhibitors |
NZ516545A (en) * | 1999-06-18 | 2004-06-25 | Biotherapies Inc | Epithelial cell growth inhibitors |
EP2339003A3 (en) | 1999-06-28 | 2011-10-19 | Genentech, Inc. | Apo-2 ligand substitutional variants |
AU2000257514A1 (en) * | 2000-06-19 | 2002-01-02 | The University Of Michigan | Mammastatin sequence variant c |
US20030212263A1 (en) * | 2000-06-19 | 2003-11-13 | The University Of Michigan | Mammastatin sequence variant C |
KR20210090634A (ko) * | 2018-10-19 | 2021-07-20 | 트랜슬레이트 바이오 인코포레이티드 | 전령 rna의 무펌프 캡슐화 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379839A (en) | 1977-05-23 | 1983-04-12 | The Trustees Of Columbia University In The City Of New York | Method for detecting cancer |
US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
WO1989011492A1 (en) * | 1988-05-20 | 1989-11-30 | The Regents Of The University Of Michigan | Human mammary cell growth inhibitor and methods of production and use |
EP0417168A4 (en) * | 1988-05-20 | 1991-09-11 | The Regents Of The University Of Michigan | Antibodies to human mammary cell growth inhibitor and methods of production and use |
US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
EP1935899A1 (en) * | 1996-10-03 | 2008-06-25 | The Regents Of The University Of Michigan | Nucleotide and protein sequence of mammastatin and methods of use |
-
1997
- 1997-10-03 EP EP07019672A patent/EP1935899A1/en not_active Withdrawn
- 1997-10-03 AU AU46709/97A patent/AU733380B2/en not_active Ceased
- 1997-10-03 WO PCT/US1997/018026 patent/WO1998014577A2/en active Application Filing
- 1997-10-03 JP JP51695598A patent/JP4452331B2/ja not_active Expired - Fee Related
- 1997-10-03 EP EP97945531A patent/EP0929675A2/en not_active Ceased
- 1997-10-03 BR BR9713248-9A patent/BR9713248A/pt not_active Application Discontinuation
- 1997-10-03 EA EA199900256A patent/EA199900256A1/ru unknown
- 1997-10-03 CA CA2267095A patent/CA2267095C/en not_active Expired - Fee Related
-
1999
- 1999-04-02 US US09/285,379 patent/US6451765B1/en not_active Expired - Fee Related
- 1999-08-06 US US09/369,912 patent/US6492504B2/en not_active Expired - Fee Related
-
2002
- 2002-07-09 US US10/193,524 patent/US7323173B2/en not_active Expired - Fee Related
- 2002-07-09 US US10/192,915 patent/US7332287B2/en not_active Expired - Fee Related
-
2008
- 2008-02-07 US US12/027,799 patent/US20090011434A1/en not_active Abandoned
-
2009
- 2009-08-14 JP JP2009188028A patent/JP2010031013A/ja active Pending
-
2010
- 2010-09-22 US US12/888,214 patent/US20110039279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU733380B2 (en) | 2001-05-10 |
US20090011434A1 (en) | 2009-01-08 |
US6451765B1 (en) | 2002-09-17 |
US6492504B2 (en) | 2002-12-10 |
US20110039279A1 (en) | 2011-02-17 |
WO1998014577A2 (en) | 1998-04-09 |
US7332287B2 (en) | 2008-02-19 |
US20030108961A1 (en) | 2003-06-12 |
US20020072592A1 (en) | 2002-06-13 |
EP0929675A2 (en) | 1999-07-21 |
US7323173B2 (en) | 2008-01-29 |
JP2001502533A (ja) | 2001-02-27 |
EP1935899A1 (en) | 2008-06-25 |
US20030095972A1 (en) | 2003-05-22 |
CA2267095C (en) | 2010-08-10 |
AU4670997A (en) | 1998-04-24 |
WO1998014577A3 (en) | 1998-04-09 |
CA2267095A1 (en) | 1998-04-09 |
EA199900256A1 (ru) | 2000-02-28 |
JP4452331B2 (ja) | 2010-04-21 |
JP2010031013A (ja) | 2010-02-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: DE ACORDO COM O ART 36 DA LPI (LEI 9.279/96) 2O, O PEDIDO VOLTA A EXAME SENDO CONSIDERADO NAO PATENTEAVEL PELAS RAZOES EXPOSTAS NO PARECER TECNICO ANTERIOR. |
|
B15K | Others concerning applications: alteration of classification |
Ipc: C07K 14/47 (2006.01), A61K 48/00 (2006.0 |