JP2001502533A - ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 - Google Patents
ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法Info
- Publication number
- JP2001502533A JP2001502533A JP10516955A JP51695598A JP2001502533A JP 2001502533 A JP2001502533 A JP 2001502533A JP 10516955 A JP10516955 A JP 10516955A JP 51695598 A JP51695598 A JP 51695598A JP 2001502533 A JP2001502533 A JP 2001502533A
- Authority
- JP
- Japan
- Prior art keywords
- mamastatin
- cells
- kda
- protein
- breast
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Zoology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Oncology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Claims (1)
- 【特許請求の範囲】 1.配列番号:1の核酸配列のコーディング配列を含む実質的に精製しかつ単離 した核酸。 2.配列番号:2アミノ酸を含む実質的に精製しかつ単離した核酸。 3.請求項1に記載の核酸配列から製造される組換えタンパク質。 4.請求項1に記載の核酸配列のコーディング配列を含むプラスミドまたはベク ター。 5.請求項1に記載の組成物を含むママスタチンの決定用診断キット。 6.抗−ママスタチン抗体およびママスタチン標準を含むママスタチンの決定用 診断キット。 7.請求項2に記載の組成物を含む医薬組成物。 8.pMammB、ATCC受託番号第97451号のヒト核酸配列インサートを含む 組成物。 9.ママスタチンタンパク質の存在に関して患者の血液または組織を分析し、つ いで、ママスタチンの不在または減少を正常コントロールに比較し、乳癌細胞に 相関させることを含む乳細胞癌腫の診断またはモニタリングの方法。 10.該分析が患者のサンプル中に53kDa、49kDaおよび44kDaママスタチ ンの存在または不在を決定し;および 該相関が53kDa、49kDaママスタチンの不在または減少を正常コントロールに 比較し、乳癌細胞の存在と相関させることである請求項8に記載の方法。 11.約53kDa、49kDaおよび44kDaママスタチンを有するママスタチンの 3つの分子量形態の存在に関して患者の血液または組織の生物学的サンプルを分 析し;および 約53kDa、49kDaおよび44kDaママスタチンの量の減少を正常または患者の サンプルコントロール以前に、機能的ママスタチンの減少量と相関があるかどう かの工程を含むヒト患者における機能的なママスタチンのレベルのモニター法。 12.乳細胞増殖抑制量のママスタチンを患者に投与する工程を含む乳癌の罹患 者の治療法。 13.該投与工程がイン・ビボにおいてママスタチンの治療上有効なレベルを維 持するために繰り返される請求項11に記載の方法。 14.該細胞をママスタチンの増殖抑制量を投与することを含むヒト乳細胞の増 殖の抑制方法。 15.該ママスタチンが請求項1に記載の組成物によってコードされる請求項1 1に記載の方法。 16.該ママスタチンが請求項2に記載の組成物を含む請求項11に記載の方法 。 17.該ママスタチンが請求項7に記載の組成物を含む請求項11に記載の方法 。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2731596P | 1996-10-03 | 1996-10-03 | |
US60/027,315 | 1996-10-03 | ||
PCT/US1997/018026 WO1998014577A2 (en) | 1996-10-03 | 1997-10-03 | Nucleotide and protein sequence of mammastatin and methods of use |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009188028A Division JP2010031013A (ja) | 1996-10-03 | 2009-08-14 | ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2001502533A true JP2001502533A (ja) | 2001-02-27 |
JP2001502533A5 JP2001502533A5 (ja) | 2005-06-16 |
JP4452331B2 JP4452331B2 (ja) | 2010-04-21 |
Family
ID=21836977
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP51695598A Expired - Fee Related JP4452331B2 (ja) | 1996-10-03 | 1997-10-03 | ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 |
JP2009188028A Pending JP2010031013A (ja) | 1996-10-03 | 2009-08-14 | ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2009188028A Pending JP2010031013A (ja) | 1996-10-03 | 2009-08-14 | ママスタチンのヌクレオチドおよびタンパク質配列およびその使用法 |
Country Status (8)
Country | Link |
---|---|
US (6) | US6451765B1 (ja) |
EP (2) | EP1935899A1 (ja) |
JP (2) | JP4452331B2 (ja) |
AU (1) | AU733380B2 (ja) |
BR (1) | BR9713248A (ja) |
CA (1) | CA2267095C (ja) |
EA (1) | EA199900256A1 (ja) |
WO (1) | WO1998014577A2 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
EP1935899A1 (en) * | 1996-10-03 | 2008-06-25 | The Regents Of The University Of Michigan | Nucleotide and protein sequence of mammastatin and methods of use |
US6939714B2 (en) | 1999-06-18 | 2005-09-06 | Biotherapies, Inc. | Epithelial cell growth inhibitors |
MXPA01013242A (es) * | 1999-06-18 | 2002-11-04 | Biotherapies Inc | Inhibidores del crecimiento de celulas epiteliales. |
JP5118796B2 (ja) | 1999-06-28 | 2013-01-16 | ジェネンテック, インコーポレイテッド | 二価の金属イオンを利用したApo−2リガンドの製造方法 |
WO2001098496A1 (en) * | 2000-06-19 | 2001-12-27 | The University Of Michigan | Mammastatin sequence variant c |
US20030212263A1 (en) * | 2000-06-19 | 2003-11-13 | The University Of Michigan | Mammastatin sequence variant C |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4379839A (en) | 1977-05-23 | 1983-04-12 | The Trustees Of Columbia University In The City Of New York | Method for detecting cancer |
US4753894A (en) | 1984-02-08 | 1988-06-28 | Cetus Corporation | Monoclonal anti-human breast cancer antibodies |
WO1989011492A1 (en) * | 1988-05-20 | 1989-11-30 | The Regents Of The University Of Michigan | Human mammary cell growth inhibitor and methods of production and use |
EP0417168A4 (en) * | 1988-05-20 | 1991-09-11 | The Regents Of The University Of Michigan | Antibodies to human mammary cell growth inhibitor and methods of production and use |
US6500937B1 (en) * | 1996-10-03 | 2002-12-31 | University Of Michigan | Nucleotide sequence encoding a mammary cell growth inhibitor |
EP1935899A1 (en) * | 1996-10-03 | 2008-06-25 | The Regents Of The University Of Michigan | Nucleotide and protein sequence of mammastatin and methods of use |
-
1997
- 1997-10-03 EP EP07019672A patent/EP1935899A1/en not_active Withdrawn
- 1997-10-03 BR BR9713248-9A patent/BR9713248A/pt not_active Application Discontinuation
- 1997-10-03 EA EA199900256A patent/EA199900256A1/ru unknown
- 1997-10-03 CA CA2267095A patent/CA2267095C/en not_active Expired - Fee Related
- 1997-10-03 JP JP51695598A patent/JP4452331B2/ja not_active Expired - Fee Related
- 1997-10-03 AU AU46709/97A patent/AU733380B2/en not_active Ceased
- 1997-10-03 WO PCT/US1997/018026 patent/WO1998014577A2/en active Application Filing
- 1997-10-03 EP EP97945531A patent/EP0929675A2/en not_active Ceased
-
1999
- 1999-04-02 US US09/285,379 patent/US6451765B1/en not_active Expired - Fee Related
- 1999-08-06 US US09/369,912 patent/US6492504B2/en not_active Expired - Fee Related
-
2002
- 2002-07-09 US US10/192,915 patent/US7332287B2/en not_active Expired - Fee Related
- 2002-07-09 US US10/193,524 patent/US7323173B2/en not_active Expired - Fee Related
-
2008
- 2008-02-07 US US12/027,799 patent/US20090011434A1/en not_active Abandoned
-
2009
- 2009-08-14 JP JP2009188028A patent/JP2010031013A/ja active Pending
-
2010
- 2010-09-22 US US12/888,214 patent/US20110039279A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EA199900256A1 (ru) | 2000-02-28 |
US6492504B2 (en) | 2002-12-10 |
BR9713248A (pt) | 2000-01-18 |
CA2267095A1 (en) | 1998-04-09 |
AU733380B2 (en) | 2001-05-10 |
US7323173B2 (en) | 2008-01-29 |
US20110039279A1 (en) | 2011-02-17 |
JP4452331B2 (ja) | 2010-04-21 |
WO1998014577A3 (en) | 1998-04-09 |
US20090011434A1 (en) | 2009-01-08 |
EP0929675A2 (en) | 1999-07-21 |
CA2267095C (en) | 2010-08-10 |
JP2010031013A (ja) | 2010-02-12 |
US20030095972A1 (en) | 2003-05-22 |
US20030108961A1 (en) | 2003-06-12 |
US7332287B2 (en) | 2008-02-19 |
US6451765B1 (en) | 2002-09-17 |
US20020072592A1 (en) | 2002-06-13 |
WO1998014577A2 (en) | 1998-04-09 |
AU4670997A (en) | 1998-04-24 |
EP1935899A1 (en) | 2008-06-25 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US7816097B2 (en) | Nucleotide and protein sequence of Mammastatin and methods of use | |
JPH04502143A (ja) | 癌診断および管理における自己分泌運動性因子 | |
US20110039279A1 (en) | Methods and compositions for diagnosing breast cancer | |
EP0505148A1 (en) | Stimulating factor of the neu receptor | |
Schultz-Hector et al. | Cellular localization of endothelial alkaline phosphatase reaction product and enzyme protein in the myocardium. | |
WO1998014577A9 (en) | Nucleotide and protein sequence of mammastatin and methods of use | |
JP2003507029A (ja) | Notchレセプターリガンドおよびその使用 | |
AU782473B2 (en) | Mammastatin diagnostics and therapeutics | |
JP3778366B2 (ja) | 細胞成長調節因子 | |
JP2003513615A (ja) | 上皮細胞増殖インヒビター | |
US5147798A (en) | Monophenotypic xenograft of megakaryocytic lineage and origin | |
EP0681480B1 (en) | Recognin vaccines | |
MXPA99003100A (en) | Nucleotide and protein sequence of mammastatin and methods of use | |
Liu | Androgens regulate cell proliferation of human prostate cancer in culture by up-regulating an autocrine growth loop involving EGF receptor and its ligand, TGF-[alpha] | |
Henderson | Macromolecular Synthesis and DNA Polymerase Activity in Mammary Tumor Cells (MCF-7) Following Growth in Plasma-derived Human Serum | |
Sil Subha Sen | Angiotensin II and Myocyte Growth: Role of Fibroblasts |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20041004 |
|
A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20041004 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070403 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070702 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070820 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070802 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20070910 |
|
A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20070903 |
|
A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20071015 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071003 |
|
A524 | Written submission of copy of amendment under section 19 (pct) |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20071003 |
|
A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20090414 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20090814 |
|
A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20091022 |
|
A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091027 |
|
A521 | Written amendment |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20091203 |
|
TRDD | Decision of grant or rejection written | ||
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100105 |
|
A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100201 |
|
R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20130205 Year of fee payment: 3 |
|
LAPS | Cancellation because of no payment of annual fees |