BR9811865A - Isolamento de um novo gene de fator de senescência, p23 - Google Patents
Isolamento de um novo gene de fator de senescência, p23Info
- Publication number
- BR9811865A BR9811865A BR9811865-0A BR9811865A BR9811865A BR 9811865 A BR9811865 A BR 9811865A BR 9811865 A BR9811865 A BR 9811865A BR 9811865 A BR9811865 A BR 9811865A
- Authority
- BR
- Brazil
- Prior art keywords
- senescence
- isolation
- new
- factor gene
- polypeptide
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- General Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Microbiology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Patente da Invenção: <B>"ISOLAMENTO DE UM NOVO GENE DE FATOR DE SENESCêNCIA, p23"<D>. São fornecidos uma molécula de ácido nucléico relacionada à senescência isolada que codifica um polipeptídeo de 23 quilodáltons (p23), métodos para expressar o polipeptídeo de 23 quilodáltons em células cultivadas, polipeptídeos p23 recombinantes vetores de expressão e células hospedeiras que expressam p23 e anticorpos contra p23. Também são fornecidos métodos para usar p23 para modular senescência e para determinar a expressão de p23 em amostras biológicas.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US90887397A | 1997-08-08 | 1997-08-08 | |
PCT/US1998/016343 WO1999007893A1 (en) | 1997-08-08 | 1998-08-05 | ISOLATION OF A NOVEL SENESCENCE-FACTOR GENE, p23 |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9811865A true BR9811865A (pt) | 2000-08-15 |
Family
ID=25426353
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9811865-0A BR9811865A (pt) | 1997-08-08 | 1998-08-05 | Isolamento de um novo gene de fator de senescência, p23 |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP1012333A4 (pt) |
JP (1) | JP2001512698A (pt) |
KR (1) | KR20010022741A (pt) |
CN (1) | CN1270637A (pt) |
AU (1) | AU8693598A (pt) |
BR (1) | BR9811865A (pt) |
CA (1) | CA2296598A1 (pt) |
TR (1) | TR200000331T2 (pt) |
WO (1) | WO1999007893A1 (pt) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2344400T3 (es) * | 2000-01-21 | 2010-08-26 | Polymun Scientific Immunbiologische Forschung Gmbh | Marcador tumoral y de senescencia. |
AU750296B2 (en) * | 2000-06-23 | 2002-07-11 | F. Hoffmann-La Roche Ag | Antibodies against SEMP1, methods for their production and uses thereof |
EP1325020A4 (en) * | 2000-09-20 | 2004-12-15 | Human Genome Sciences Inc | 21 HUMANE SECONDED PROTEINS |
US7125663B2 (en) | 2001-06-13 | 2006-10-24 | Millenium Pharmaceuticals, Inc. | Genes, compositions, kits and methods for identification, assessment, prevention, and therapy of cervical cancer |
US20110105961A1 (en) * | 2008-05-23 | 2011-05-05 | Gruber Lewis S | Methods, compositions and apparatuses for facilitating regeneration |
ES2725852T3 (es) | 2010-09-27 | 2019-09-27 | Siwa Corp | Eliminación selectiva de células modificadas por AGE para el tratamiento de la aterosclerosis |
US8721571B2 (en) | 2010-11-22 | 2014-05-13 | Siwa Corporation | Selective removal of cells having accumulated agents |
ES2908203T3 (es) | 2014-09-19 | 2022-04-28 | Siwa Corp | Anticuerpos anti-age para el tratamiento de inflamación y trastornos autoinmunes |
US10358502B2 (en) | 2014-12-18 | 2019-07-23 | Siwa Corporation | Product and method for treating sarcopenia |
US9993535B2 (en) | 2014-12-18 | 2018-06-12 | Siwa Corporation | Method and composition for treating sarcopenia |
RU2728964C2 (ru) | 2016-02-19 | 2020-08-03 | Сива Корпорейшн | Способ и композиция для лечения рака, уничтожения метастатических раковых клеток и профилактики метастазов рака, используя антитела к конечным продуктам повышенного гликирования ( AGE) |
CN109311975A (zh) | 2016-04-15 | 2019-02-05 | Siwa有限公司 | 用于治疗神经退行性紊乱的抗age抗体 |
US11213585B2 (en) | 2016-06-23 | 2022-01-04 | Siwa Corporation | Vaccines for use in treating various diseases and disorders |
US10858449B1 (en) | 2017-01-06 | 2020-12-08 | Siwa Corporation | Methods and compositions for treating osteoarthritis |
US10925937B1 (en) | 2017-01-06 | 2021-02-23 | Siwa Corporation | Vaccines for use in treating juvenile disorders associated with inflammation |
US10995151B1 (en) | 2017-01-06 | 2021-05-04 | Siwa Corporation | Methods and compositions for treating disease-related cachexia |
US10961321B1 (en) | 2017-01-06 | 2021-03-30 | Siwa Corporation | Methods and compositions for treating pain associated with inflammation |
CA3059803A1 (en) | 2017-04-13 | 2018-10-18 | Siwa Corporation | Humanized monoclonal advanced glycation end-product antibody |
US11518801B1 (en) | 2017-12-22 | 2022-12-06 | Siwa Corporation | Methods and compositions for treating diabetes and diabetic complications |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744300A (en) * | 1993-03-24 | 1998-04-28 | Geron Corporation | Methods and reagents for the identification and regulation of senescence-related genes |
US5580726A (en) * | 1994-04-29 | 1996-12-03 | Geron Corporation | Method and Kit for enhanced differential display |
US6416974B1 (en) * | 1997-08-06 | 2002-07-09 | Millennium Pharmaceuticals, Inc. | Tango 71 nucleic acids |
ES2312205T3 (es) * | 1998-03-10 | 2009-02-16 | Genentech, Inc. | Nuevo polipeptido y acidos nucleicos que lo codifican. |
WO2000000609A2 (en) * | 1998-06-29 | 2000-01-06 | Incyte Pharmaceuticals, Inc. | Molecules associated with apoptosis |
-
1998
- 1998-08-05 WO PCT/US1998/016343 patent/WO1999007893A1/en active Search and Examination
- 1998-08-05 EP EP98938406A patent/EP1012333A4/en not_active Withdrawn
- 1998-08-05 AU AU86935/98A patent/AU8693598A/en not_active Abandoned
- 1998-08-05 TR TR2000/00331T patent/TR200000331T2/xx unknown
- 1998-08-05 CA CA002296598A patent/CA2296598A1/en not_active Abandoned
- 1998-08-05 BR BR9811865-0A patent/BR9811865A/pt not_active Application Discontinuation
- 1998-08-05 CN CN98807887A patent/CN1270637A/zh active Pending
- 1998-08-05 JP JP2000506375A patent/JP2001512698A/ja not_active Withdrawn
- 1998-08-05 KR KR1020007001338A patent/KR20010022741A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
EP1012333A1 (en) | 2000-06-28 |
KR20010022741A (ko) | 2001-03-26 |
JP2001512698A (ja) | 2001-08-28 |
AU8693598A (en) | 1999-03-01 |
WO1999007893A1 (en) | 1999-02-18 |
EP1012333A4 (en) | 2003-01-02 |
CN1270637A (zh) | 2000-10-18 |
TR200000331T2 (tr) | 2000-05-22 |
CA2296598A1 (en) | 1999-02-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FA10 | Dismissal: dismissal - article 33 of industrial property law | ||
B11Y | Definitive dismissal acc. article 33 of ipl - extension of time limit for request of examination expired |