ES2253398T3 - Camptotecinas liposomales mejoradas y sus usos. - Google Patents

Camptotecinas liposomales mejoradas y sus usos.

Info

Publication number
ES2253398T3
ES2253398T3 ES01949169T ES01949169T ES2253398T3 ES 2253398 T3 ES2253398 T3 ES 2253398T3 ES 01949169 T ES01949169 T ES 01949169T ES 01949169 T ES01949169 T ES 01949169T ES 2253398 T3 ES2253398 T3 ES 2253398T3
Authority
ES
Spain
Prior art keywords
topotecan
dose
liposomal
drug
lipid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES01949169T
Other languages
English (en)
Spanish (es)
Inventor
Thomas D. Madden
Sean C. Semple
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Inex Pharmaceuticals Corp
Original Assignee
Inex Pharmaceuticals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inex Pharmaceuticals Corp filed Critical Inex Pharmaceuticals Corp
Application granted granted Critical
Publication of ES2253398T3 publication Critical patent/ES2253398T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
ES01949169T 2000-06-30 2001-06-29 Camptotecinas liposomales mejoradas y sus usos. Expired - Lifetime ES2253398T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US21555600P 2000-06-30 2000-06-30
US215556P 2000-06-30
US26461601P 2001-01-26 2001-01-26
US264616P 2001-01-26

Publications (1)

Publication Number Publication Date
ES2253398T3 true ES2253398T3 (es) 2006-06-01

Family

ID=26910152

Family Applications (1)

Application Number Title Priority Date Filing Date
ES01949169T Expired - Lifetime ES2253398T3 (es) 2000-06-30 2001-06-29 Camptotecinas liposomales mejoradas y sus usos.

Country Status (12)

Country Link
US (7) US7244448B2 (https=)
EP (2) EP1299085B1 (https=)
JP (3) JP2004501955A (https=)
CN (1) CN1245977C (https=)
AT (2) ATE309787T1 (https=)
AU (3) AU2001270413A1 (https=)
CA (2) CA2412795C (https=)
DE (2) DE60115045T2 (https=)
ES (1) ES2253398T3 (https=)
IL (2) IL153676A0 (https=)
MX (1) MXPA02012817A (https=)
WO (2) WO2002002077A2 (https=)

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Also Published As

Publication number Publication date
CN1446079A (zh) 2003-10-01
IL153676A0 (en) 2003-07-06
DE60115044D1 (de) 2005-12-22
AU7038501A (en) 2002-01-14
JP2014088444A (ja) 2014-05-15
JP2012092148A (ja) 2012-05-17
EP1299084A2 (en) 2003-04-09
US20130136787A1 (en) 2013-05-30
IL153676A (en) 2007-06-17
US7244448B2 (en) 2007-07-17
ATE309786T1 (de) 2005-12-15
MXPA02012817A (es) 2004-07-30
WO2002002078A2 (en) 2002-01-10
DE60115044T2 (de) 2006-08-03
US20060269594A1 (en) 2006-11-30
WO2002002078A3 (en) 2002-12-27
US20020119990A1 (en) 2002-08-29
CA2412795A1 (en) 2002-01-10
CA2412795C (en) 2012-10-02
US20040170678A1 (en) 2004-09-02
DE60115045T2 (de) 2006-08-03
WO2002002077A2 (en) 2002-01-10
US20060093662A1 (en) 2006-05-04
DE60115045D1 (de) 2005-12-22
US20110086826A1 (en) 2011-04-14
US20020110586A1 (en) 2002-08-15
AU2001270385B2 (en) 2006-05-25
AU2001270413A1 (en) 2002-01-14
US7060828B2 (en) 2006-06-13
CA2412790C (en) 2012-11-06
ATE309787T1 (de) 2005-12-15
JP2004501955A (ja) 2004-01-22
CN1245977C (zh) 2006-03-22
CA2412790A1 (en) 2002-01-10
WO2002002077A3 (en) 2002-12-12
EP1299084B1 (en) 2005-11-16
EP1299085A2 (en) 2003-04-09
EP1299085B1 (en) 2005-11-16

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