CA2412795C - Improved liposomal camptothecins and uses thereof - Google Patents

Improved liposomal camptothecins and uses thereof Download PDF

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Publication number
CA2412795C
CA2412795C CA2412795A CA2412795A CA2412795C CA 2412795 C CA2412795 C CA 2412795C CA 2412795 A CA2412795 A CA 2412795A CA 2412795 A CA2412795 A CA 2412795A CA 2412795 C CA2412795 C CA 2412795C
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CA
Canada
Prior art keywords
dosage form
topotecan
unit dosage
liposomal
drug
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2412795A
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English (en)
French (fr)
Other versions
CA2412795A1 (en
Inventor
Thomas D. Madden
Sean C. Semple
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Talon Therapeutics Inc
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Talon Therapeutics Inc
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Publication date
Application filed by Talon Therapeutics Inc filed Critical Talon Therapeutics Inc
Publication of CA2412795A1 publication Critical patent/CA2412795A1/en
Application granted granted Critical
Publication of CA2412795C publication Critical patent/CA2412795C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A61K9/1278—Post-loading, e.g. by ion or pH gradient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CA2412795A 2000-06-30 2001-06-29 Improved liposomal camptothecins and uses thereof Expired - Lifetime CA2412795C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US21555600P 2000-06-30 2000-06-30
US60/215,556 2000-06-30
US26461601P 2001-01-26 2001-01-26
US60/264,616 2001-01-26
PCT/CA2001/000981 WO2002002078A2 (en) 2000-06-30 2001-06-29 Improved liposomal camptothecins and uses thereof

Publications (2)

Publication Number Publication Date
CA2412795A1 CA2412795A1 (en) 2002-01-10
CA2412795C true CA2412795C (en) 2012-10-02

Family

ID=26910152

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2412795A Expired - Lifetime CA2412795C (en) 2000-06-30 2001-06-29 Improved liposomal camptothecins and uses thereof
CA2412790A Expired - Lifetime CA2412790C (en) 2000-06-30 2001-06-29 Liposomal antineoplastic drugs and uses thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2412790A Expired - Lifetime CA2412790C (en) 2000-06-30 2001-06-29 Liposomal antineoplastic drugs and uses thereof

Country Status (12)

Country Link
US (7) US7244448B2 (https=)
EP (2) EP1299085B1 (https=)
JP (3) JP2004501955A (https=)
CN (1) CN1245977C (https=)
AT (2) ATE309787T1 (https=)
AU (3) AU2001270413A1 (https=)
CA (2) CA2412795C (https=)
DE (2) DE60115045T2 (https=)
ES (1) ES2253398T3 (https=)
IL (2) IL153676A0 (https=)
MX (1) MXPA02012817A (https=)
WO (2) WO2002002077A2 (https=)

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Also Published As

Publication number Publication date
CN1446079A (zh) 2003-10-01
IL153676A0 (en) 2003-07-06
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