ES2248998T3 - Utilizacion de las osteoprotegerina para la prevencion y el tratamiento de enfermedades cardiovasculares. - Google Patents
Utilizacion de las osteoprotegerina para la prevencion y el tratamiento de enfermedades cardiovasculares.Info
- Publication number
- ES2248998T3 ES2248998T3 ES99918766T ES99918766T ES2248998T3 ES 2248998 T3 ES2248998 T3 ES 2248998T3 ES 99918766 T ES99918766 T ES 99918766T ES 99918766 T ES99918766 T ES 99918766T ES 2248998 T3 ES2248998 T3 ES 2248998T3
- Authority
- ES
- Spain
- Prior art keywords
- opg
- use according
- osteoprotegerin
- polypeptide
- administration
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
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| IL117175A (en) | 1995-02-20 | 2005-11-20 | Sankyo Co | Osteoclastogenesis inhibitory factor protein |
| WO1998028424A2 (en) | 1996-12-23 | 1998-07-02 | Immunex Corporation | Receptor activator of nf-kappa b, receptor is member of tnf receptor superfamily |
| NZ332995A (en) | 1997-04-15 | 2000-07-28 | Snow Brand Milk Products Co Ltd | A protein which binds to osteoclastogenesis inhibitory factor (OCIF) |
| US6316408B1 (en) | 1997-04-16 | 2001-11-13 | Amgen Inc. | Methods of use for osetoprotegerin binding protein receptors |
| BR9808545A (pt) | 1997-04-16 | 2000-05-23 | Amgen Inc | ácido nucleico isolado, vetor de expressão, célula hospedeira, processos para produzir uma proteìna de ligação da osteoprotegerina, para detectar a presença de uma proteìna de ligação à osteoprotegerina em uma amostra biológica, para avaliar a capacidade de um composto candidato de ligar-se a uma proteìna de ligação da osteoprotegerina e de um composto de teste para aumentar ou reduzir a ligação da proteìna de ligação da osteoprotegerina a odar, para regular a expressão de uma proteìna de ligação da osteoprotegerina em um animal e para prevenir ou tratar de doença óssea em um mamìfero, polipeptìdeo, protéina de ligação da osteroprotegerina purificada e isolada, ou seu fragmento, análogo ou derivado, e, anticorpo ou seu fragmento |
| US6878811B1 (en) * | 1998-04-23 | 2005-04-12 | Ajinomoto Co., Inc. | Substance with antithrombotic activity and method for detecting glycokallidin |
| ATE412746T1 (de) | 1998-05-14 | 2008-11-15 | Immunex Corp | Verfahren zur hemmung der wirkung der osteoklasten |
| RU2324705C2 (ru) * | 2001-04-03 | 2008-05-20 | Сосьете Де Продюи Нестле С.А. | Остеопротегерин, применение его для изготовления фармацевтической композиции (варианты) и получения пищевого продукта (варианты) и корма для животных, пищевой продукт, корм для животных и фармацевтическая композиция для профилактики или лечения расстройств, связанных с костным ремоделированием, и/или иммунных расстройств |
| US7198798B2 (en) * | 2001-05-10 | 2007-04-03 | University Of Washington | Methods and devices for promoting endothelial morphogenesis |
| DK1572874T3 (da) | 2001-05-25 | 2013-12-16 | Human Genome Sciences Inc | Antistoffer, der immunospecifikt binder til TRAIL receptorer |
| US8649843B2 (en) * | 2001-11-24 | 2014-02-11 | Ben A. Arnold | Automated calcium scoring of the aorta |
| US7718776B2 (en) | 2002-04-05 | 2010-05-18 | Amgen Inc. | Human anti-OPGL neutralizing antibodies as selective OPGL pathway inhibitors |
| US7585840B2 (en) | 2002-04-10 | 2009-09-08 | Merck Serono S.A. | Use of osteoprotegerin for the treatment and/or prevention of fibrotic disease |
| CN1658895A (zh) * | 2002-04-10 | 2005-08-24 | 应用研究系统Ars股份公司 | 护骨素在治疗和／或预防纤维变性疾病中的应用 |
| WO2006047419A2 (en) | 2004-10-25 | 2006-05-04 | Intezyne Technologies, Incorporated | Heterobifunctional poly(ethylene glycol) and uses thereof |
| WO2006074202A2 (en) | 2005-01-04 | 2006-07-13 | Intezyne Technologies, Incorporated | Synthesis of hybrid block copolymers and uses thereof |
| US7561727B2 (en) * | 2005-06-02 | 2009-07-14 | Nordic Bioscience Imaging A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| US7463758B2 (en) * | 2005-06-02 | 2008-12-09 | Nordio Bioscience A/S | Method of deriving a quantitative measure of a degree of calcification of an aorta |
| EP2433644A1 (en) * | 2010-09-22 | 2012-03-28 | IMBA-Institut für Molekulare Biotechnologie GmbH | Breast cancer therapeutics |
| FR2970870A1 (fr) * | 2011-01-31 | 2012-08-03 | Centre Nat Rech Scient | Modulation de la proliferation des cellules epitheliales de l'unite epidermo-pilo-sebacee via rank |
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| US4179337A (en) | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| US6936694B1 (en) | 1982-05-06 | 2005-08-30 | Intermune, Inc. | Manufacture and expression of large structural genes |
| JP2877509B2 (ja) | 1989-05-19 | 1999-03-31 | アムジエン・インコーポレーテツド | メタロプロテイナーゼ阻害剤 |
| US5580722A (en) * | 1989-07-18 | 1996-12-03 | Oncogene Science, Inc. | Methods of determining chemicals that modulate transcriptionally expression of genes associated with cardiovascular disease |
| US6369027B1 (en) | 1995-12-22 | 2002-04-09 | Amgen Inc. | Osteoprotegerin |
-
1998
- 1998-04-23 US US09/064,832 patent/US6790823B1/en not_active Expired - Fee Related
-
1999
- 1999-04-21 CA CA002325360A patent/CA2325360C/en not_active Expired - Fee Related
- 1999-04-21 WO PCT/US1999/008793 patent/WO1999053942A1/en not_active Ceased
- 1999-04-21 DK DK99918766T patent/DK1073456T3/da active
- 1999-04-21 JP JP2000544345A patent/JP4776774B2/ja not_active Expired - Fee Related
- 1999-04-21 AT AT99918766T patent/ATE303817T1/de active
- 1999-04-21 AU AU36605/99A patent/AU757806B2/en not_active Ceased
- 1999-04-21 ES ES99918766T patent/ES2248998T3/es not_active Expired - Lifetime
- 1999-04-21 DE DE69927147T patent/DE69927147T2/de not_active Expired - Lifetime
- 1999-04-21 EP EP99918766A patent/EP1073456B1/en not_active Expired - Lifetime
- 1999-04-21 SI SI9930826T patent/SI1073456T1/sl unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE69927147T2 (de) | 2006-01-26 |
| WO1999053942A8 (en) | 1999-12-02 |
| JP4776774B2 (ja) | 2011-09-21 |
| US6790823B1 (en) | 2004-09-14 |
| CA2325360A1 (en) | 1999-10-28 |
| AU757806B2 (en) | 2003-03-06 |
| ATE303817T1 (de) | 2005-09-15 |
| AU3660599A (en) | 1999-11-08 |
| EP1073456A1 (en) | 2001-02-07 |
| SI1073456T1 (sl) | 2005-12-31 |
| DK1073456T3 (da) | 2005-10-24 |
| DE69927147D1 (de) | 2005-10-13 |
| CA2325360C (en) | 2008-11-04 |
| EP1073456B1 (en) | 2005-09-07 |
| JP2002512199A (ja) | 2002-04-23 |
| WO1999053942A1 (en) | 1999-10-28 |
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