ES2241305T3 - Combinaciones contra la diabetes que contienen gliburide, troglitazona (y una biguanida). - Google Patents
Combinaciones contra la diabetes que contienen gliburide, troglitazona (y una biguanida).Info
- Publication number
- ES2241305T3 ES2241305T3 ES99939130T ES99939130T ES2241305T3 ES 2241305 T3 ES2241305 T3 ES 2241305T3 ES 99939130 T ES99939130 T ES 99939130T ES 99939130 T ES99939130 T ES 99939130T ES 2241305 T3 ES2241305 T3 ES 2241305T3
- Authority
- ES
- Spain
- Prior art keywords
- troglitazone
- patients
- glitazone
- metformin
- combination
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
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- 206010012601 diabetes mellitus Diseases 0.000 title claims description 18
- 229960001641 troglitazone Drugs 0.000 claims abstract description 100
- GXPHKUHSUJUWKP-NTKDMRAZSA-N troglitazone Natural products C([C@@]1(OC=2C(C)=C(C(=C(C)C=2CC1)O)C)C)OC(C=C1)=CC=C1C[C@H]1SC(=O)NC1=O GXPHKUHSUJUWKP-NTKDMRAZSA-N 0.000 claims abstract description 99
- 229940100389 Sulfonylurea Drugs 0.000 claims abstract description 56
- YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 claims abstract description 50
- NKOHRVBBQISBSB-UHFFFAOYSA-N 5-[(4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione Chemical compound C1=CC(O)=CC=C1CC1C(=O)NC(=O)S1 NKOHRVBBQISBSB-UHFFFAOYSA-N 0.000 claims abstract description 36
- 239000003472 antidiabetic agent Substances 0.000 claims abstract description 26
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Classifications
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Obesity (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US189132 | 1998-11-09 | ||
| US09/189,132 US6011049A (en) | 1997-02-19 | 1998-11-09 | Combinations for diabetes |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2241305T3 true ES2241305T3 (es) | 2005-10-16 |
Family
ID=22696072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES99939130T Expired - Lifetime ES2241305T3 (es) | 1998-11-09 | 1999-08-11 | Combinaciones contra la diabetes que contienen gliburide, troglitazona (y una biguanida). |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US6011049A (enExample) |
| EP (2) | EP1514550A3 (enExample) |
| JP (1) | JP2002529417A (enExample) |
| AR (1) | AR020973A1 (enExample) |
| AT (1) | ATE293980T1 (enExample) |
| AU (1) | AU5347399A (enExample) |
| CA (1) | CA2345524C (enExample) |
| CO (1) | CO5150152A1 (enExample) |
| CR (1) | CR6128A (enExample) |
| DE (1) | DE69925019T2 (enExample) |
| DK (1) | DK1128834T3 (enExample) |
| ES (1) | ES2241305T3 (enExample) |
| GT (1) | GT199900158A (enExample) |
| HN (1) | HN1999000184A (enExample) |
| PA (1) | PA8484901A1 (enExample) |
| PE (1) | PE20001235A1 (enExample) |
| PT (1) | PT1128834E (enExample) |
| SI (1) | SI1128834T1 (enExample) |
| UY (1) | UY25791A1 (enExample) |
| WO (1) | WO2000027401A1 (enExample) |
Families Citing this family (139)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| US6291495B1 (en) * | 1997-02-24 | 2001-09-18 | Robert B. Rieveley | Method and composition for the treatment of diabetes |
| WO1998039344A1 (en) | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| US6099859A (en) * | 1998-03-20 | 2000-08-08 | Andrx Pharmaceuticals, Inc. | Controlled release oral tablet having a unitary core |
| US6099862A (en) * | 1998-08-31 | 2000-08-08 | Andrx Corporation | Oral dosage form for the controlled release of a biguanide and sulfonylurea |
| CN1215076C (zh) | 1998-09-09 | 2005-08-17 | 症变治疗公司 | 新的果糖1,6－二磷酸酶的杂芳族抑制剂 |
| US20040081697A1 (en) * | 1998-11-12 | 2004-04-29 | Smithkline Beecham P.L.C. | Pharmaceutical composition for modified release of an insulin sensitiser and another antidiabetic agent |
| GB9824893D0 (en) * | 1998-11-12 | 1999-01-06 | Smithkline Beckman Corp | Novel method of treatment |
| US20030153607A1 (en) * | 1998-11-12 | 2003-08-14 | Smithkline Beecham P.L.C. | Novel composition and use |
| US20040102486A1 (en) * | 1998-11-12 | 2004-05-27 | Smithkline Beecham Corporation | Novel method of treatment |
| US6559188B1 (en) | 1999-09-17 | 2003-05-06 | Novartis Ag | Method of treating metabolic disorders especially diabetes, or a disease or condition associated with diabetes |
| US6878749B2 (en) | 1999-09-17 | 2005-04-12 | Novartis Ag | Method of treating metabolic disorders, especially diabetes, or a disease or condition associated with diabetes |
| US6586438B2 (en) * | 1999-11-03 | 2003-07-01 | Bristol-Myers Squibb Co. | Antidiabetic formulation and method |
| CN1516705A (zh) | 2000-03-08 | 2004-07-28 | ֢�����ƹ�˾ | 新的芳基果糖-1,6-二磷酸酶抑制剂 |
| US6296874B1 (en) * | 2000-05-01 | 2001-10-02 | Aeropharm Technology Incorporated | Core formulation comprising troglitazone and abiguanide |
| DE60129425T2 (de) * | 2000-05-01 | 2008-04-17 | Aeropharm Technology LLC, Dover | Kernformulierung |
| US6610272B1 (en) | 2000-05-01 | 2003-08-26 | Aeropharm Technology Incorporated | Medicinal aerosol formulation |
| US6780432B1 (en) * | 2000-05-01 | 2004-08-24 | Aeropharm Technology, Inc. | Core formulation |
| US7563774B2 (en) | 2000-06-29 | 2009-07-21 | Metabasis Therapeutics, Inc. | Combination of FBPase inhibitors and antidiabetic agents useful for the treatment of diabetes |
| JP2004510716A (ja) * | 2000-10-02 | 2004-04-08 | ユーエスヴイ リミテッド | メトフォルミン含有持続性放出薬理組成物とその製造方法 |
| US6866866B1 (en) * | 2000-11-03 | 2005-03-15 | Andrx Labs, Llc | Controlled release metformin compositions |
| EP1738751B1 (en) | 2001-01-12 | 2011-05-11 | Sun Pharma Advanced Research Company Ltd | Spaced drug delivery system |
| KR200249057Y1 (ko) * | 2001-03-22 | 2001-10-19 | 김진환 | 뚜껑, 받침대에 합체된 하수역류. 악취방지 장치 |
| FR2823225B1 (fr) * | 2001-04-04 | 2004-09-17 | Pierre Desreumaux | Utilisation de composes modulant l'activite de l'heterodimere rxr-ppar a titre de medicament pour le traitement de l'hepatite c, et procede de criblage correspondant |
| ES2373873T3 (es) * | 2001-04-10 | 2012-02-09 | Sun Pharma Advanced Research Company Limited | Composición de liberación por impulso temporizado. |
| US20040156903A1 (en) * | 2002-05-22 | 2004-08-12 | Abrams Andrew L.. | Metering and packaging of controlled release medication |
| SE0101980D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| SE0101982D0 (sv) * | 2001-06-01 | 2001-06-01 | Astrazeneca Ab | Pharmaceutical combination |
| EP1429747A4 (en) * | 2001-07-10 | 2005-01-05 | Kos Life Sciences Inc | CORE FORMULATION WITH PIOGLITAZONE HYDROCHLORIDE AND A BIGUANIDE |
| AU2001273310B2 (en) * | 2001-07-10 | 2004-10-07 | Kos Life Sciences, Inc. | A core formulation |
| CA2453782A1 (en) * | 2001-07-10 | 2003-01-23 | Kos Life Sciences, Inc. | Core formulation comprising troglitazone and a biguanide |
| PL205826B1 (pl) | 2001-07-17 | 2010-05-31 | N Gene Res Lab Inc | Synergistyczna kombinacja farmaceutyczna do zapobiegania lub leczenia cukrzycy i zastosowanie |
| EP1414476A1 (en) * | 2001-07-27 | 2004-05-06 | MERCK PATENT GmbH | Bauhinia extracts |
| CN1270724C (zh) | 2001-07-30 | 2006-08-23 | 三菱制药株式会社 | 餐后高血糖改善剂 |
| FR2832633B1 (fr) * | 2001-11-28 | 2004-09-24 | Lipha | Composition pharmaceutique comprenant une association metformine et un acide 4-oxo-butanoique et son utilisation pour traiter le diabete |
| US7183321B2 (en) * | 2001-12-17 | 2007-02-27 | Bristol-Myers Squibb Company | Antidiabetic formulation and method |
| FR2834640B1 (fr) * | 2002-01-11 | 2004-09-24 | Lipha | Composition pharmaceutique comprenant une glitazone et un acide 4-oxobutanoique et son utilisation pour traiter le diabete |
| US9045438B2 (en) * | 2002-01-25 | 2015-06-02 | Silanes S.A. De C.V. | Pharmaceutical composition containing glimepiride and metformin hydrochloride |
| US6682759B2 (en) | 2002-02-01 | 2004-01-27 | Depomed, Inc. | Manufacture of oral dosage forms delivering both immediate-release and sustained-release drugs |
| US20030187074A1 (en) * | 2002-03-04 | 2003-10-02 | Javed Hussain | Oral compositions for treatment of diabetes |
| EP1515701B1 (en) | 2002-06-17 | 2014-09-17 | Inventia Healthcare Private Limited | Process for the manufacture of multilayer tablet compositions comprising thiazolidinedione and biguanide |
| US8821915B2 (en) | 2002-08-09 | 2014-09-02 | Veroscience, Llc | Therapeutic process for the treatment of the metabolic syndrome and associated metabolic disorders |
| US20040081678A1 (en) * | 2002-08-09 | 2004-04-29 | Anthony Cincotta | Therapeutic process for the treatment of obesity and associated metabolic disorders |
| US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
| US8084058B2 (en) | 2002-09-20 | 2011-12-27 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US7785627B2 (en) * | 2002-09-20 | 2010-08-31 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| US9060941B2 (en) * | 2002-09-20 | 2015-06-23 | Actavis, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| JP4694841B2 (ja) | 2002-09-20 | 2011-06-08 | アンドルックス ラボズ リミテッド ライアビリティ カンパニー | ビグアニドおよびチアゾリジンジオン誘導体を含有する多段階製剤 |
| US7959946B2 (en) * | 2002-09-20 | 2011-06-14 | Watson Pharmaceuticals, Inc. | Pharmaceutical formulation containing a biguanide and a thiazolidinedione derivative |
| CA2498423A1 (en) * | 2002-09-26 | 2004-04-08 | Eisai Co., Ltd. | Combination drug |
| IN192749B (enExample) * | 2002-11-15 | 2004-05-15 | Ranbaxy Lab Ltd | |
| US20060210633A1 (en) * | 2003-04-03 | 2006-09-21 | Sun Pharmaceutical Industries Limited | Programmed drug delivery system |
| US20050013863A1 (en) | 2003-07-18 | 2005-01-20 | Depomed, Inc., A Corporation Of The State Of California | Dual drug dosage forms with improved separation of drugs |
| AU2003249492A1 (en) * | 2003-07-24 | 2005-02-14 | Eswaran Krishnan Iyer | Oral compositions for treatment of diseases |
| US20050054731A1 (en) * | 2003-09-08 | 2005-03-10 | Franco Folli | Multi-system therapy for diabetes, the metabolic syndrome and obesity |
| NZ546337A (en) | 2003-10-31 | 2009-03-31 | Takeda Pharmaceutical | Solid preparation comprising an insulin sensitizer such as pioglitazone hydrochloride, an insulin secretagogue such as glimepiride and a polyoxyethylene sorbitan fatty acid ester such as Polysorbate 80 |
| US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
| CN101035522B (zh) * | 2004-10-25 | 2011-12-07 | 诺瓦提斯公司 | Dpp-ⅳ抑制剂、ppar抗糖尿病剂和二甲双胍的组合 |
| DE102004054054A1 (de) | 2004-11-05 | 2006-05-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine |
| US20060188590A1 (en) * | 2005-01-05 | 2006-08-24 | Mitsunori Ono | Compositions for treating diabetes or obesity |
| EP1906934A4 (en) * | 2005-07-14 | 2012-03-07 | Franco Folli | DAILY DOSAGE SCHEME FOR THE TREATMENT OF DIABETES, OBESITY, METABOLIC SYNDROME AND POLYKYSTIC OVAIRE SYNDROME |
| MXPA05009633A (es) * | 2005-09-08 | 2007-03-07 | Silanes Sa De Cv Lab | Composicion farmaceutica estable de glimepirida de liberacion inmediata y metformina de liberacion prolongada. |
| MXPA05010977A (es) * | 2005-10-12 | 2007-04-11 | Abdala Leopoldo Espinosa | Composiciones farmaceuticas que comprenden sustancias antidiabeticas combinadas para su uso en diabetes mellitus. |
| MXPA05014092A (es) * | 2005-12-20 | 2007-06-20 | Leopoldo De Jesus Espinosa Abdala | Composiciones farmaceuticas que comprenden sustancias derivadas de la tiazolidinedionas combinadas con una biguanida para su uso en diabetes mellitus tipo 2. |
| FR2896159B1 (fr) * | 2006-01-13 | 2008-09-12 | Merck Sante Soc Par Actions Si | Combinaison de derives de triazine et d'agents sensibilisateurs a l'insuline. |
| WO2007127791A2 (en) * | 2006-04-25 | 2007-11-08 | The Administrators Of The Tulane Educational Fund | New pharmacological method for treatment of neuropathic pain |
| EP1852108A1 (en) | 2006-05-04 | 2007-11-07 | Boehringer Ingelheim Pharma GmbH & Co.KG | DPP IV inhibitor formulations |
| CA2873524C (en) | 2006-05-04 | 2018-02-20 | Boehringer Ingelheim International Gmbh | A polymeric form of 1-((4-methyl-quinazolin-2-yl)methyl)-3-7-(2-butyn-1-yl)-8-(3-(r)-aminopiperidin-1-yl)xanthine |
| PE20110235A1 (es) | 2006-05-04 | 2011-04-14 | Boehringer Ingelheim Int | Combinaciones farmaceuticas que comprenden linagliptina y metmorfina |
| US20090238763A1 (en) | 2006-07-09 | 2009-09-24 | Chongxi Yu | High penetration compositions and uses thereof |
| US20090221703A1 (en) | 2006-07-09 | 2009-09-03 | Chongxi Yu | High penetration composition and uses thereof |
| TW200816995A (en) * | 2006-08-31 | 2008-04-16 | Daiichi Sankyo Co Ltd | Pharmaceutical composition containing insulin sensitizers |
| EP2084124B9 (en) | 2006-10-02 | 2015-07-01 | Techfields Biochem Co. Ltd | Positively charged water-soluble prodrugs of prostaglandins and related compounds with very high skin penetration rates |
| EP2091914A4 (en) | 2006-11-08 | 2010-12-29 | Chongxi Yu | TRANSDERMAL ADMINISTRATION SYSTEMS FOR PEPTIDES AND RELATED CONNECTIONS |
| EP2121593B1 (en) | 2006-12-10 | 2015-06-17 | Chongxi Yu | Transdermal delivery systems of beta-lactam antibiotics |
| EP3181132A1 (en) | 2007-01-15 | 2017-06-21 | Chongxi Yu | Positively charged water-soluble prodrugs of retinoids and retinoid-like compounds with very high skin penetration rates |
| PL2115140T3 (pl) | 2007-01-31 | 2017-03-31 | Yu | Dodatnio naładowane rozpuszczalne w wodzie proleki 1H-imidazo[4,5-c]chinolino-4-amin i powiązane związki o bardzo wysokich wskaźnikach penetracji przez skórę |
| US20080064701A1 (en) * | 2007-04-24 | 2008-03-13 | Ramesh Sesha | Anti-diabetic combinations |
| US20070172525A1 (en) * | 2007-03-15 | 2007-07-26 | Ramesh Sesha | Anti-diabetic combinations |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| MX356965B (es) * | 2007-04-11 | 2018-06-21 | Omeros Corp | Composiciones y metodos para profilaxis y tratamiento de adicciones. |
| ES2922425T3 (es) * | 2007-06-04 | 2022-09-14 | Techfields Inc | Profármacos de NSAIA con velocidades de penetración en piel y membranas muy elevadas y sus nuevos usos medicinales |
| CN101784278A (zh) * | 2007-08-17 | 2010-07-21 | 贝林格尔.英格海姆国际有限公司 | 用于治疗fab-相关的疾病的嘌呤衍生物 |
| US8551524B2 (en) * | 2008-03-14 | 2013-10-08 | Iycus, Llc | Anti-diabetic combinations |
| PE20140960A1 (es) | 2008-04-03 | 2014-08-15 | Boehringer Ingelheim Int | Formulaciones que comprenden un inhibidor de dpp4 |
| PE20100156A1 (es) * | 2008-06-03 | 2010-02-23 | Boehringer Ingelheim Int | Tratamiento de nafld |
| WO2010011860A1 (en) * | 2008-07-23 | 2010-01-28 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes |
| BRPI0916997A2 (pt) | 2008-08-06 | 2020-12-15 | Boehringer Ingelheim International Gmbh | Inibidor de dpp-4 e seu uso |
| UY32030A (es) * | 2008-08-06 | 2010-03-26 | Boehringer Ingelheim Int | "tratamiento para diabetes en pacientes inapropiados para terapia con metformina" |
| MX370599B (es) * | 2008-08-15 | 2019-12-18 | Boehringer Ingelheim Int | Derivados de purina para su uso en el tratamiento de enfermedades relacionadas con fab. |
| EP2361092A4 (en) * | 2008-09-04 | 2012-07-11 | Anthony I Rozmanith | HEALTH CARE |
| US20100075937A1 (en) * | 2008-09-24 | 2010-03-25 | Hollis-Eden Pharmaceuticals, Inc. | Patient populations and treatment methods |
| US20200155558A1 (en) | 2018-11-20 | 2020-05-21 | Boehringer Ingelheim International Gmbh | Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug |
| JP2012511027A (ja) * | 2008-12-04 | 2012-05-17 | チョンシー ユー | 高透過性組成物およびその用途 |
| MX2011006713A (es) | 2008-12-23 | 2011-07-13 | Boehringer Ingelheim Int | Formas salinas de compuesto organico. |
| TW201036975A (en) | 2009-01-07 | 2010-10-16 | Boehringer Ingelheim Int | Treatment for diabetes in patients with inadequate glycemic control despite metformin therapy |
| EP3398599A1 (en) | 2009-03-11 | 2018-11-07 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| AU2010241571B2 (en) | 2009-04-29 | 2014-06-26 | Amarin Pharmaceuticals Ireland Limited | Stable pharmaceutical composition and methods of using same |
| EP4008327A1 (en) | 2009-04-29 | 2022-06-08 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same |
| WO2010127640A1 (en) | 2009-05-08 | 2010-11-11 | Techfields Biochem Co., Ltd. | High penetration prodrug compositions of peptides and peptide-related compounds |
| US9352025B2 (en) | 2009-06-05 | 2016-05-31 | Veroscience Llc | Combination of dopamine agonists plus first phase insulin secretagogues for the treatment of metabolic disorders |
| US9969751B2 (en) | 2009-06-10 | 2018-05-15 | Techfields Pharma Co., Ltd. | High penetration prodrug compositions of antimicrobials and antimicrobial-related compounds |
| LT2443246T (lt) | 2009-06-15 | 2018-03-26 | Amarin Pharmaceuticals Ireland Limited | Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją |
| US20110065756A1 (en) * | 2009-09-17 | 2011-03-17 | De Taeye Bart M | Methods and compositions for treatment of obesity-related diseases |
| MX364651B (es) | 2009-11-27 | 2019-05-03 | Boehringer Ingelheim Int Gmbh Star | Inhibidores de dpp-iv, tales como la linagliptina, y composiciones farmacéuticas o combinaciones que comprenden los mismos, para usarse en el tratamiento de pacientes diabéticos tipificados genéticamente. |
| WO2011128782A2 (en) * | 2010-04-13 | 2011-10-20 | Jorge Luis Rosado | Compositions and methods for treating type ii diabetes and related disorders |
| BR112012028136A2 (pt) | 2010-05-05 | 2016-08-09 | Boehringer Ingelheim Int | terapia de combinaçao |
| AU2011257964B2 (en) | 2010-05-24 | 2014-10-30 | Ozstar Therapeutics Pty Ltd | Anti-diabetic compositions and methods |
| MX2012014247A (es) | 2010-06-24 | 2013-01-18 | Boehringer Ingelheim Int | Terapia para la diabetes. |
| US9034883B2 (en) | 2010-11-15 | 2015-05-19 | Boehringer Ingelheim International Gmbh | Vasoprotective and cardioprotective antidiabetic therapy |
| WO2012074930A2 (en) | 2010-11-29 | 2012-06-07 | Amarin Pharma, Inc. | Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity |
| US8962636B2 (en) | 2011-07-15 | 2015-02-24 | Boehringer Ingelheim International Gmbh | Substituted quinazolines, the preparation thereof and the use thereof in pharmaceutical compositions |
| US11291643B2 (en) | 2011-11-07 | 2022-04-05 | Amarin Pharmaceuticals Ireland Limited | Methods of treating hypertriglyceridemia |
| CN103159651B (zh) * | 2011-12-14 | 2015-06-17 | 安徽贝克联合制药有限公司 | 磺酰脲胍及其制备方法和用途 |
| IN2014KN02583A (enExample) | 2012-01-18 | 2015-05-08 | Techfields Pharma Co Ltd | |
| US9555001B2 (en) | 2012-03-07 | 2017-01-31 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition and uses thereof |
| JP6218811B2 (ja) | 2012-05-14 | 2017-10-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｓｉｒｓ及び／又は敗血症の治療に用いるｄｐｐ−４阻害薬としてのキサンチン誘導体 |
| US20130303462A1 (en) | 2012-05-14 | 2013-11-14 | Boehringer Ingelheim International Gmbh | Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome |
| WO2013174767A1 (en) | 2012-05-24 | 2013-11-28 | Boehringer Ingelheim International Gmbh | A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference |
| US20140187633A1 (en) | 2012-12-31 | 2014-07-03 | Amarin Pharmaceuticals Ireland Limited | Methods of treating or preventing nonalcoholic steatohepatitis and/or primary biliary cirrhosis |
| US20140271841A1 (en) | 2013-03-15 | 2014-09-18 | Amarin Pharmaceuticals Ireland Limited | Pharmaceutical composition comprising eicosapentaenoic acid and derivatives thereof and a statin |
| US9585859B2 (en) | 2013-10-10 | 2017-03-07 | Amarin Pharmaceuticals Ireland Limited | Compositions and methods for lowering triglycerides without raising LDL-C levels in a subject on concomitant statin therapy |
| US9526728B2 (en) | 2014-02-28 | 2016-12-27 | Boehringer Ingelheim International Gmbh | Medical use of a DPP-4 inhibitor |
| WO2015195662A1 (en) | 2014-06-16 | 2015-12-23 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing or preventing oxidation of small dense ldl or membrane polyunsaturated fatty acids |
| NL2015957B1 (en) | 2015-12-14 | 2017-06-29 | Scala Pharma B V | Compositions and methods for inducing beige or brown fat tissue. |
| EP3184106A1 (en) | 2015-12-23 | 2017-06-28 | Sanofi-Aventis Deutschland GmbH | Growth differentiation factor 15 as biomarker for metformin |
| CA3022202A1 (en) | 2016-06-10 | 2017-12-14 | Boehringer Ingelheim International Gmbh | Combinations of linagliptin and metformin |
| US12310967B2 (en) | 2017-12-21 | 2025-05-27 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising motor neuron diseases |
| US12274703B2 (en) | 2017-12-21 | 2025-04-15 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising a dementia |
| SI4056176T1 (sl) | 2018-09-24 | 2024-09-30 | Amarin Pharmaceuticals Ireland Limited | Metode zmanjševanja tveganja za kardiovaskularne dogodke pri subjektu |
| WO2020132378A2 (en) | 2018-12-22 | 2020-06-25 | Gliapharm Sa | Compositions and methods of treatment for neurological disorders comprising depression |
| BR112022009189A2 (pt) | 2019-11-12 | 2022-07-26 | Amarin Pharmaceuticals Ie Ltd | Métodos para reduzir o risco de eventos cardiovasculares em um sujeito com fibrilação atrial e/ou palpitação atrial |
| NL2024493B1 (en) | 2019-12-16 | 2021-09-02 | Logick Energetics B V | Pharmaceutical composition for preventing or stopping metastases |
| EP4076439A1 (en) | 2019-12-18 | 2022-10-26 | Logick Energetics | Pharmaceutical composition for use in preventing or stopping metastases |
| NL2025335B1 (en) | 2020-04-10 | 2021-10-26 | Logick Energetics B V | Pharmaceutical composition for treatment of corona virus infection |
| AU2022263358A1 (en) | 2021-04-21 | 2023-11-30 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
| NL2028476B1 (en) | 2021-06-17 | 2022-12-27 | Logick Energetics B V | Pharmaceutical composition for increasing mitochondrial activity and/or improving adiponectin production |
| NL2029634B1 (en) | 2021-11-04 | 2023-06-02 | Logick Energetics B V | Pharmaceutical composition for increasing mitochondrial activity and/or improving adiponectin production |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5917052A (en) * | 1994-09-28 | 1999-06-29 | Shaman Pharmaceuticals, Inc. | Hypoglycemic agent from cryptolepis |
| TWI238064B (en) * | 1995-06-20 | 2005-08-21 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| HUP9601808A3 (en) * | 1995-07-03 | 2000-06-28 | Sankyo Co | Treatment of arteriosclerosis and xanthoma |
| GB9715295D0 (en) * | 1997-07-18 | 1997-09-24 | Smithkline Beecham Plc | Novel method of treatment |
-
1998
- 1998-11-09 US US09/189,132 patent/US6011049A/en not_active Expired - Fee Related
-
1999
- 1999-06-01 HN HN1999000184A patent/HN1999000184A/es unknown
- 1999-08-11 AT AT99939130T patent/ATE293980T1/de not_active IP Right Cessation
- 1999-08-11 PT PT99939130T patent/PT1128834E/pt unknown
- 1999-08-11 ES ES99939130T patent/ES2241305T3/es not_active Expired - Lifetime
- 1999-08-11 WO PCT/US1999/018140 patent/WO2000027401A1/en not_active Ceased
- 1999-08-11 CA CA002345524A patent/CA2345524C/en not_active Expired - Fee Related
- 1999-08-11 DE DE69925019T patent/DE69925019T2/de not_active Expired - Fee Related
- 1999-08-11 EP EP04029821A patent/EP1514550A3/en not_active Withdrawn
- 1999-08-11 JP JP2000580630A patent/JP2002529417A/ja active Pending
- 1999-08-11 SI SI9930780T patent/SI1128834T1/xx unknown
- 1999-08-11 EP EP99939130A patent/EP1128834B1/en not_active Expired - Lifetime
- 1999-08-11 DK DK99939130T patent/DK1128834T3/da active
- 1999-08-11 AU AU53473/99A patent/AU5347399A/en not_active Abandoned
- 1999-09-17 GT GT199900158A patent/GT199900158A/es unknown
- 1999-10-26 AR ARP990105394A patent/AR020973A1/es unknown
- 1999-10-29 PA PA19998484901A patent/PA8484901A1/es unknown
- 1999-11-05 UY UY25791A patent/UY25791A1/es unknown
- 1999-11-05 CR CR6128A patent/CR6128A/es unknown
- 1999-11-05 CO CO99070009A patent/CO5150152A1/es unknown
- 1999-11-05 PE PE1999001121A patent/PE20001235A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69925019T2 (de) | 2006-03-02 |
| US6011049A (en) | 2000-01-04 |
| JP2002529417A (ja) | 2002-09-10 |
| HN1999000184A (es) | 2000-02-10 |
| SI1128834T1 (enExample) | 2005-08-31 |
| EP1514550A2 (en) | 2005-03-16 |
| CO5150152A1 (es) | 2002-04-29 |
| CA2345524C (en) | 2005-09-20 |
| EP1514550A3 (en) | 2009-04-29 |
| GT199900158A (es) | 2001-03-10 |
| ATE293980T1 (de) | 2005-05-15 |
| CA2345524A1 (en) | 2000-05-18 |
| PA8484901A1 (es) | 2000-09-29 |
| CR6128A (es) | 2000-11-30 |
| UY25791A1 (es) | 2001-03-16 |
| PT1128834E (pt) | 2005-07-29 |
| EP1128834B1 (en) | 2005-04-27 |
| DK1128834T3 (da) | 2005-07-04 |
| PE20001235A1 (es) | 2000-11-08 |
| AR020973A1 (es) | 2002-06-05 |
| EP1128834A1 (en) | 2001-09-05 |
| WO2000027401A1 (en) | 2000-05-18 |
| AU5347399A (en) | 2000-05-29 |
| DE69925019D1 (de) | 2005-06-02 |
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