ES2226805T3 - Esterpodes nitrados para el tratamiento de las alteraciones causadas por oxidantes y el disfuncionamiento endotelial. - Google Patents
Esterpodes nitrados para el tratamiento de las alteraciones causadas por oxidantes y el disfuncionamiento endotelial.Info
- Publication number
- ES2226805T3 ES2226805T3 ES00917075T ES00917075T ES2226805T3 ES 2226805 T3 ES2226805 T3 ES 2226805T3 ES 00917075 T ES00917075 T ES 00917075T ES 00917075 T ES00917075 T ES 00917075T ES 2226805 T3 ES2226805 T3 ES 2226805T3
- Authority
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- Spain
- Prior art keywords
- acid
- compound
- compounds
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- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
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- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
Landscapes
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| IT1320176B1 (it) * | 2000-12-22 | 2003-11-26 | Nicox Sa | Dispersioni solide di principi attivi nitrati. |
| EP1219306A1 (en) | 2000-12-29 | 2002-07-03 | Nicox S.A. | Compositions comprising cyclodextrins and NO- releasing drugs |
| US6696592B2 (en) | 2001-05-22 | 2004-02-24 | Nicox-S.A. | Methods of making 21-[4′-(nitrooxyalkyl)benzoate] corticosteroid derivatives and intermediates useful in the synthesis thereof |
| ITMI20011307A1 (it) * | 2001-06-21 | 2002-12-21 | Nicox Sa | Farmaci per l'epilessia |
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| ITMI20021025A1 (it) * | 2002-05-14 | 2003-11-14 | Nicox Sa | Farmaci per il trattamento acuto di disfunzioni del circolo venoso epatico e portale |
| EP1539134A4 (en) | 2002-06-11 | 2007-04-11 | Nitromed Inc | SELECTIVE INHIBITORS OF CYCLOOXIGENASE-2 NITROSIS AND / OR NITROSYLES, COMPOSITIONS AND METHODS OF USE |
| US7211598B2 (en) | 2002-06-28 | 2007-05-01 | Nitromed, Inc. | Oxime and/or hydrozone containing nitrosated and/or nitrosylated cyclooxygenase-2 selective inhibitors, compositions and methods of use |
| US7163958B2 (en) | 2002-07-03 | 2007-01-16 | Nitromed Inc. | Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use |
| AU2003261281A1 (en) | 2002-07-29 | 2004-02-16 | Nicox S.A. | Cyclooxygenase- 2 selective inhibitors, compositions and methods of use |
| CN100513415C (zh) * | 2005-08-03 | 2009-07-15 | 中国人民解放军军事医学科学院毒物药物研究所 | 胆汁酸衍生物及其医药用途 |
| AU2006286838C1 (en) | 2005-09-02 | 2013-05-02 | Ferrer Internacional S.A. | Nitrooxy derivatives of glucocorticoids |
| US8802726B2 (en) | 2006-02-03 | 2014-08-12 | Nicox S.A. | Use of nitrooxyderivative of drug for the treatment of muscular dystrophies |
| US7645748B2 (en) * | 2006-04-03 | 2010-01-12 | Forbes Medi-Tech Inc. | Sterol/stanol phosphorylnitroderivatives and use thereof |
| US7645749B2 (en) * | 2006-04-03 | 2010-01-12 | Forbes Medi-Tech Inc. | Sterol/stanol nitroderivatives and use thereof |
| CN101652380A (zh) * | 2007-02-05 | 2010-02-17 | 尼科克斯公司 | 释放一氧化氮的类固醇 |
| CA2695435A1 (en) * | 2007-08-10 | 2009-03-26 | Nicox S.A. | Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease |
| WO2009071990A2 (en) * | 2007-08-31 | 2009-06-11 | Topigen Pharmaceuticals Inc. | No-donating cordicosteroid with improved pharmacokinetic, anti-inflammatory and vasodilatory properties |
| CA2703723A1 (en) * | 2007-10-19 | 2009-04-23 | Burnham Institute Of Medical Research | Inhibitors of anti-apoptotic proteins |
| US20110130375A1 (en) | 2008-08-05 | 2011-06-02 | Nicox S.A. | New no-releasing steroids for the treatment of retina and macula lutea diseases |
| AU2011243947A1 (en) | 2010-04-23 | 2012-12-06 | Piramal Enterprises Limited | Nitric oxide releasing prodrugs of therapeutic agents |
| CU20110244A7 (es) | 2011-12-27 | 2013-08-29 | Ct De Investigación Y Desarrollo De Medicamentos Cidem | Sistemas espiroesteroidales con efectos neuroactivos y anti-inflamatorios |
| CA2897571C (en) | 2013-01-21 | 2018-12-18 | Apparao Satyam | Nitric oxide releasing prodrugs of therapeutic agents containing at least one carboxylic acid group |
| KR101711513B1 (ko) * | 2015-06-26 | 2017-03-02 | 주식회사 엘지생활건강 | 피부 개선용 조성물 |
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| JPS5845724A (ja) | 1981-09-11 | 1983-03-17 | Oriza Yuka Kk | オリザノ−ル乳化液の製造法 |
| FR2600653B1 (fr) | 1986-06-24 | 1988-12-16 | Pasteur Strasbourg Universite | Composes de synthese associative d'acides amines soufres ou non soufres avec des derives du d-4 pregnene 3,20-dione ou avec des derives du d-1,4 pregnadiene 3,20-dione aux proprietes glucocorticoides et anti-inflammatoires, procedes d'obtention, compositions pharmaceutiques les contenant. proprietes pharmacologiques et applications |
| IT1204571B (it) | 1987-05-08 | 1989-03-10 | Chiesi Farma Spa | Esteri di 1,4:3,6-dianidrosorbitolo-2-mononitrato e 5-mononitrato,loro procedimento di preparazione e loro composizioni farmaceutiche |
| EP0688865B1 (en) * | 1987-06-29 | 2002-01-16 | Massachusetts Institute Of Technology | Nucleotide sequence encoding acetoacetyl-CoA reductase and a method for producing polyester biopolymers |
| DE4000397A1 (de) * | 1990-01-09 | 1991-07-11 | Hoechst Ag | Lipidselektive antioxidantien sowie deren herstellung und verwendung |
| JPH04273892A (ja) | 1991-02-27 | 1992-09-30 | Kao Corp | 新規な２１−置換ステロイド化合物 |
| JP3108474B2 (ja) | 1991-08-07 | 2000-11-13 | 日清製粉株式会社 | 活性型ビタミンｄ誘導体 |
| AU656829B2 (en) | 1991-12-26 | 1995-02-16 | Wisconsin Alumni Research Foundation | 26, 27-dimethylene-1 alpha, 25-dihydroxyvitamin D2 and 26,27-dihydroxyvitamin D2 and methods for preparing same |
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| US5194431A (en) | 1992-07-08 | 1993-03-16 | Wisconsin Alumni Research Foundation | 24-cyclopropane vitamin D derivatives |
| US5707984A (en) | 1995-12-08 | 1998-01-13 | G. D. Searle & Co. | Steroid nitrite/nitrate ester derivatives useful as anti-inflammatory drugs |
| US5837698A (en) | 1996-05-02 | 1998-11-17 | G. D. Searle & Co. | Steroid nitrite and nitrate ester derivatives useful as anti-inflammatory drugs |
| US5985862A (en) * | 1996-05-02 | 1999-11-16 | G.D. Searle & Co. | Pharmaceutical compositions having steroid nitrate ester derivatives useful as anti-inflammatory drugs |
| DE19634793A1 (de) | 1996-08-29 | 1998-03-05 | Sanol Arznei Schwarz Gmbh | S- und O-Nitratoacylverbindungen |
| IT1285770B1 (it) * | 1996-10-04 | 1998-06-18 | Nicox Sa | Composti corticoidei |
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1999
- 1999-04-13 IT IT1999MI000751A patent/IT1311922B1/it active
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2000
- 2000-04-11 BR BR0009696-2A patent/BR0009696A/pt not_active IP Right Cessation
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- 2000-04-11 MX MXPA01010212A patent/MXPA01010212A/es active IP Right Grant
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- 2000-04-11 AU AU38201/00A patent/AU766798B2/en not_active Ceased
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- 2000-04-11 CN CNA2006101516855A patent/CN1916013A/zh active Pending
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- 2000-04-11 EP EP04102751A patent/EP1475386A3/en not_active Withdrawn
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2001
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2004
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2005
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2006
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